Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients.

Abstract:

:Most solid tumors, including colorectal cancers, shed cell-free DNA (ctDNA) in the blood. ctDNA can be analyzed to generate molecular profiles which capture the heterogeneity of the disease more comprehensively then tumor tissue biopsies. This approach commonly called 'liquid biopsy' can be applied to monitor response to therapy, to assess minimal residual disease and to uncover the emergence of drug resistance. This review will discuss current and future developments of ctDNA analysis in the clinical management of colorectal cancer patients.

journal_name

Mol Oncol

journal_title

Molecular oncology

authors

Siravegna G,Bardelli A

doi

10.1016/j.molonc.2015.12.005

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

475-80

issue

3

eissn

1574-7891

issn

1878-0261

pii

S1574-7891(15)00241-0

journal_volume

10

pub_type

杂志文章,评审
  • Gene expression profiling of single circulating tumor cells in ovarian cancer - Establishment of a multi-marker gene panel.

    abstract::The presence of circulating tumor cells (CTCs) in the blood of ovarian cancer patients was shown to correlate with decreased overall survival, whereby CTCs with epithelial-mesenchymal-transition (EMT) or stem-like traits are supposed to be involved in metastatic progression and recurrence. Thus, investigating the tran...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2016.04.002

    authors: Blassl C,Kuhlmann JD,Webers A,Wimberger P,Fehm T,Neubauer H

    更新日期:2016-08-01 00:00:00

  • Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

    abstract::The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbi...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12307

    authors: Gerhards NM,Blomen VA,Mutlu M,Nieuwenhuis J,Howald D,Guyader C,Jonkers J,Brummelkamp TR,Rottenberg S

    更新日期:2018-06-01 00:00:00

  • Essential role of HDAC6 in the regulation of PD-L1 in melanoma.

    abstract::Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to target a variety of other proteins unrelated to the chromatin environment. In this context, our present work demonstrates that the pharmacological or genetic abrogation of HDAC6 in primary melanoma samples ...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2015.12.012

    authors: M L,P PV,T K,M P,E S,J P,K V W,C L,F C,S D,M SKS,M M,A K,J PI,A S,E S,J W,E M S,A V

    更新日期:2016-05-01 00:00:00

  • Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts.

    abstract::Bone morphogenetic proteins (BMPs) are a group of growth factors with dual functions in cancer development and progression. Recently, certain tumor-promoting roles have been identified for selected antagonists/inhibitors (BMPIs) of this developmental pathway. A recent focus on the implication of BMP in colorectal canc...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2014.04.004

    authors: Karagiannis GS,Treacy A,Messenger D,Grin A,Kirsch R,Riddell RH,Diamandis EP

    更新日期:2014-10-01 00:00:00

  • Discovery and validation of extracellular vesicle-associated miRNAs as noninvasive detection biomarkers for early-stage non-small-cell lung cancer.

    abstract::miRNAs in circulating extracellular vesicles (EVs) are promising biomarkers for cancer. However, their diagnostic ability for early-stage non-small-cell lung cancer (NSCLC) is not well known. In this study, the circulating EV miRNAs profiling was initially performed in 36 untreated NSCLC patients and 36 healthy contro...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12889

    authors: Zhong Y,Ding X,Bian Y,Wang J,Zhou W,Wang X,Li P,Shen Y,Wang JJ,Li J,Zhang C,Wang C

    更新日期:2020-12-19 00:00:00

  • Theranostic applications of antibodies in oncology.

    abstract::Targeted therapies, including antibodies, are becoming increasingly important in cancer therapy. Important limitations, however, are that not every patient benefits from a specific antibody therapy and that responses could be short-lived due to acquired resistance. In addition, targeted therapies are quite expensive a...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2014.03.010

    authors: Fleuren ED,Versleijen-Jonkers YM,Heskamp S,van Herpen CM,Oyen WJ,van der Graaf WT,Boerman OC

    更新日期:2014-06-01 00:00:00

  • TrkA is a binding partner of NPM-ALK that promotes the survival of ALK+ T-cell lymphoma.

    abstract::Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+ ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK+ T-cell lymphoma is not completely understood. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in ...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12088

    authors: Shi W,George SK,George B,Curry CV,Murzabdillaeva A,Alkan S,Amin HM

    更新日期:2017-09-01 00:00:00

  • Circulating tumor cell detection and single-cell analysis using an integrated workflow based on ChimeraX® -i120 Platform: A prospective study.

    abstract::Circulating tumor cell (CTC) analysis holds great potential to be a noninvasive solution for clinical cancer management. A complete workflow that combined CTC detection and single-cell molecular analysis is required. We developed the ChimeraX® -i120 platform to facilitate negative enrichment, immunofluorescent labelin...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12876

    authors: Wang PX,Sun YF,Jin WX,Cheng JW,Peng HX,Xu Y,Zhou KQ,Chen LM,Huang K,Wu SY,Hu B,Zhang ZF,Guo W,Cao Y,Zhou J,Fan J,Yang XR

    更新日期:2020-12-10 00:00:00

  • Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients.

    abstract::Standard treatments for advanced high-grade serous ovarian carcinomas (HGSOCs) show significant side-effects and provide only short-term survival benefits due to disease recurrence. Thus, identification of novel prognostic and predictive biomarkers is urgently needed. We have used 42 paraffin-embedded HGSOCs, to evalu...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2014.09.010

    authors: Kamieniak MM,Rico D,Milne RL,Muñoz-Repeto I,Ibáñez K,Grillo MA,Domingo S,Borrego S,Cazorla A,García-Bueno JM,Hernando S,García-Donas J,Hernández-Agudo E,Y Cajal TR,Robles-Díaz L,Márquez-Rodas I,Cusidó M,Sáez R,Lacambr

    更新日期:2015-02-01 00:00:00

  • Combination therapy targeting the elevated interleukin-6 level reduces invasive migration of BRAF inhibitor-resistant melanoma cells.

    abstract::The identification of novel antimetastatic therapeutic targets is necessary for improved treatment of patients with acquired BRAF inhibitor-resistant (BRAFi-R) melanoma, in whom metastasis is a major concern. Our present study focused on the identification of such targets to explore novel antimetastatic therapeutic op...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12433

    authors: Mohapatra P,Prasad CP,Andersson T

    更新日期:2019-02-01 00:00:00

  • Excellent translational research in oncology: A journey towards novel and more effective anti-cancer therapies.

    abstract::Comprehensive Cancer Centres (CCCs) serve as critical drivers for improving cancer survival. In Europe, we have developed an Excellence Designation System (EDS) consisting of criteria to assess "excellence" of CCCs in translational research (bench to bedside and back), with the expectation that many European CCCs will...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2015.12.007

    authors: Rajan A,Berns A,Ringborg U,Celis J,Ponder B,Caldas C,Livingston D,Bristow RG,Hecht TT,Tursz T,van Luenen H,Bono P,Helander T,Seamon K,Smyth JF,Louvard D,Eggermont A,van Harten WH

    更新日期:2016-05-01 00:00:00

  • Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer.

    abstract::Mouse models of human cancers may provide a valuable resource for the discovery of cancer biomarkers. We have developed a practical strategy for profiling specific proteins in mouse plasma using low-volume sandwich-immunoassays. We used this method to profile the levels of 14 different cytokines, acute-phase reactants...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2007.06.001

    authors: Forrester S,Hung KE,Kuick R,Kucherlapati R,Haab BB

    更新日期:2007-09-01 00:00:00

  • Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.

    abstract::Gain-of-function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor-initiating cell functions. We determined that in cells expres...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12068

    authors: Vaughan CA,Singh S,Grossman SR,Windle B,Deb SP,Deb S

    更新日期:2017-06-01 00:00:00

  • A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition.

    abstract::As a critical feature of the tumor microenvironment, hypoxia is known to be a potent inducer of tumor metastasis, and it has been proposed that the initial steps in metastasis involve epithelial-mesenchymal transition (EMT). The strong correlation among hypoxia, EMT, and metastasis suggests that integrative assessment...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12491

    authors: Chen YL,Zhang Y,Wang J,Chen N,Fang W,Zhong J,Liu Y,Qin R,Yu X,Sun Z,Gao F

    更新日期:2019-07-01 00:00:00

  • EVI1 splice variants modulate functional responses in ovarian cancer cells.

    abstract::Amplification of 3q26.2, found in many cancer lineages, is a frequent and early event in ovarian cancer. We previously defined the most frequent region of copy number increase at 3q26.2 to EVI1 (ecotropic viral integration site-1) and MDS1 (myelodysplastic syndrome 1) (aka MECOM), an observation recently confirmed by ...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2013.02.008

    authors: Dutta P,Bui T,Bauckman KA,Keyomarsi K,Mills GB,Nanjundan M

    更新日期:2013-06-01 00:00:00

  • Methylation-associated miR-193b silencing activates master drivers of aggressive prostate cancer.

    abstract::Epigenetic silencing of miRNA is a primary mechanism of aberrant miRNA expression in cancer, and hypermethylation of miRNA promoters has been reported to contribute to prostate cancer initiation and progression. Recent data have shown that the miR-193b promoter is hypermethylated in prostate cancer compared with norma...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12536

    authors: Mazzu YZ,Yoshikawa Y,Nandakumar S,Chakraborty G,Armenia J,Jehane LE,Lee GM,Kantoff PW

    更新日期:2019-09-01 00:00:00

  • TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells.

    abstract::Transient receptor potential melastatin-4 channel (TRPM4) dysregulation contributes to heart conditions, immune diseases, and cervical and prostate cancer. Up to now, the involvement of TRPM4 in colorectal cancer (CRC) pathophysiology remains unknown. Here, we investigated tumor tissue microarrays from 379 CRC patient...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12566

    authors: Kappel S,Stokłosa P,Hauert B,Ross-Kaschitza D,Borgström A,Baur R,Galván JA,Zlobec I,Peinelt C

    更新日期:2019-11-01 00:00:00

  • Genetic susceptibility to breast cancer.

    abstract::Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer. This review summarizes the current state of knowledge on rare high penetrance mutations, as well as moderate and low-penetrance genetic variants implicated in breast cancer aetiology. We summarize recent discoveries from larg...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2010.04.011

    authors: Mavaddat N,Antoniou AC,Easton DF,Garcia-Closas M

    更新日期:2010-06-01 00:00:00

  • Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness.

    abstract::Epithelial-mesenchymal transition (EMT) is an important process in embryonic development, fibrosis, and cancer metastasis. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem-like properties. A growing body of evidence supports the critical link between EMT an...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1002/1878-0261.12096

    authors: Liao TT,Yang MH

    更新日期:2017-07-01 00:00:00

  • Subjecting appropriate lung adenocarcinoma samples to next-generation sequencing-based molecular testing: challenges and possible solutions.

    abstract::Next-generation sequencing (NGS) has recently been rapidly adopted in the molecular diagnosis of cancer, but it still faces some obstacles. In this study, 665 lung adenocarcinoma samples (558 TKI-naive and 107 TKI-relapsed samples) were interrogated using NGS, and the challenges and possible solutions of subjecting ap...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12190

    authors: Li W,Qiu T,Ling Y,Gao S,Ying J

    更新日期:2018-05-01 00:00:00

  • Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.

    abstract::Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuro...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2015.05.001

    authors: Pundavela J,Roselli S,Faulkner S,Attia J,Scott RJ,Thorne RF,Forbes JF,Bradshaw RA,Walker MM,Jobling P,Hondermarck H

    更新日期:2015-10-01 00:00:00

  • c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.

    abstract::The tumor microenvironment may alter the original tumorigenic potential of tumor cells. Under harsh environmental conditions, genetic alterations conferring selective advantages may initiate the growth of tumor subclones, providing new opportunities for these tumors to grow. We performed a genetic loss-of-function scr...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12499

    authors: Felipe-Abrio B,Verdugo-Sivianes EM,Carnero A

    更新日期:2019-07-01 00:00:00

  • MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-β receptor I ubiquitination.

    abstract::SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor-β (TGF-β) signaling through ubiquitin-mediated degradation of TGF-β receptor I. However, the regulatory mechanism of SMURF2 is largely unknown. In this study, we identified that...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12581

    authors: Chae DK,Park J,Cho M,Ban E,Jang M,Yoo YS,Kim EE,Baik JH,Song EJ

    更新日期:2019-12-01 00:00:00

  • Epigenetic alterations involved in cancer stem cell reprogramming.

    abstract::Current hypotheses suggest that tumors originate from cells that carry out a process of "malignant reprogramming" driven by genetic and epigenetic alterations. Multiples studies reported the existence of stem-cell-like cells that acquire the ability to self-renew and are able to generate the bulk of more differentiate...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2012.10.006

    authors: Muñoz P,Iliou MS,Esteller M

    更新日期:2012-12-01 00:00:00

  • Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells.

    abstract::We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PG...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12321

    authors: Gong J,Lang BJ,Weng D,Eguchi T,Murshid A,Borges TJ,Doshi S,Song B,Stevenson MA,Calderwood SK

    更新日期:2018-08-01 00:00:00

  • Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells.

    abstract::Pancreatic adenocarcinomas express neurotensin receptors in up to 90% of cases, however, their role in tumor biology and as a drug target is not clear. In the present study, a stable neurotensin (NT) analog induced intracellular calcium release and intracellular alkalinization in BxPC-3 and PANC-1 pancreatic cancer ce...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2009.01.006

    authors: Olszewski U,Hamilton G

    更新日期:2009-06-01 00:00:00

  • Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.

    abstract::Natural products remain a significant source of anticancer chemotherapeutics. The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agents or in combination therapy. We examined the association of molecula...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1002/1878-0261.12849

    authors: Krushkal J,Negi S,Yee LM,Evans JR,Grkovic T,Palmisano A,Fang J,Sankaran H,McShane LM,Zhao Y,O'Keefe BR

    更新日期:2020-11-09 00:00:00

  • Allo-reactive T cells for the treatment of hematological malignancies.

    abstract::Several mechanisms can be responsible for control of hematological tumors by allo-reactive T cells. Following allogeneic stem cell transplantation (alloSCT) donor T cells recognizing genetic disparities presented on recipient cells and not on donor cells are main effectors of tumor control, but also of the detrimental...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.molonc.2015.10.014

    authors: Falkenburg JH,Jedema I

    更新日期:2015-12-01 00:00:00

  • Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma.

    abstract::Periampullary adenocarcinomas can be of two histological subtypes, intestinal or pancreatobiliary. The latter is more frequent and aggressive, and characterized by a prominent desmoplastic stroma, which is tightly related to the biology of the cancer, including its poor response to chemotherapy. Whereas miRNAs are kno...

    journal_title:Molecular oncology

    pub_type: 杂志文章

    doi:10.1016/j.molonc.2015.10.011

    authors: Sandhu V,Bowitz Lothe IM,Labori KJ,Skrede ML,Hamfjord J,Dalsgaard AM,Buanes T,Dube G,Kale MM,Sawant S,Kulkarni-Kale U,Børresen-Dale AL,Lingjærde OC,Kure EH

    更新日期:2016-02-01 00:00:00

  • Translational cancer research - a coherent cancer research continuum.

    abstract::The main components of the cancer research continuum are basic/preclinical research, early and late clinical research and, after the adoption of an innovation by the healthcare or health organisations, outcomes research. Translational cancer research, defined as a coherent cancer research continuum, is mandatory to ad...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审

    doi:10.1002/1878-0261.12450

    authors: Ringborg U

    更新日期:2019-03-01 00:00:00