Cancer Metabolism: A Modeling Perspective.

abstract：:The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer's and Huntington's. Glaucomatous optic neuropathy - the world's le...

journal_title：Frontiers in physiology

authors： McGrady NR,Risner ML,Vest V,Calkins DJ

更新日期：2020-03-26 00:00:00

abstract：:Spermatogenesis is a complicated process including spermatogonial stem cells self-renewal and differentiates into mature spermatozoa. MicroRNAs (miRNAs) as a class of small non-coding RNAs play a crucial role during the process of spermatogenesis. However, the function of a plenty of miRNAs on spermatogenesis and the ...

journal_title：Frontiers in physiology

authors： Gao H,Wen H,Cao C,Dong D,Yang C,Xie S,Zhang J,Huang X,Huang X,Yuan S,Dong W

更新日期：2019-06-18 00:00:00

abstract：Purpose:To examine physiological and technical responses to repeated-sprint training in normobaric hypoxia at ∼3,000 m (RSH, n = 11) or in normoxia (RSN, n = 11) compared to a control group (CON, n = 8) in well-trained tennis players. Participants were 28.8 ± 5.9 years old without any previous experience of training in...

journal_title：Frontiers in physiology

authors： Brechbuhl C,Brocherie F,Willis SJ,Blokker T,Montalvan B,Girard O,Millet GP,Schmitt L

更新日期：2020-12-18 00:00:00

abstract：:Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or s...

journal_title：Frontiers in physiology

authors： Zhang C,Lee S,Mardinoglu A,Hua Q

更新日期：2016-05-02 00:00:00

abstract：:Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fun...

journal_title：Frontiers in physiology

authors： Aon MA,Bhatt N,Cortassa SC

更新日期：2014-07-31 00:00:00

abstract：:Global environmental change is leading to an increase in the frequency, intensity, and duration of extreme weather events, so effective environmental management requires an understanding not only of the physiological response of organisms to increased mean temperatures, but also to extreme environmental conditions. To...

journal_title：Frontiers in physiology

authors： Cooper CE,Withers PC,Hurley LL,Griffith SC

更新日期：2019-11-20 00:00:00

abstract：:This study aimed to test the hypothesis that branchial osmoregulatory acclimation involved increased apoptosis and replacement of mitochdonrion-rich cells (MRCs) in the climbing perch, Anabas testudineus, during a progressive acclimation from freshwater to seawater. A significant increase in branchial caspase-3/-7 act...

journal_title：Frontiers in physiology

authors： Ching B,Chen XL,Yong JH,Wilson JM,Hiong KC,Sim EW,Wong WP,Lam SH,Chew SF,Ip YK

更新日期：2013-06-07 00:00:00

abstract：:Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

journal_title：Frontiers in physiology

authors： Zhang J,Ma A,Shang L

更新日期：2018-05-29 00:00:00

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：:Hyperglycemia is the main feature of diabetes and may increase the risk of vascular calcification (VC), which is an independent predictor for cardiovascular and cerebrovascular diseases (CCD). Selenium (Se) may decrease the risk of CCD, and previous studies confirmed that Se-containing protein from Se-enriched Spiruli...

journal_title：Frontiers in physiology

authors： Lin C,Zhang LJ,Li B,Zhang F,Shen QR,Kong GQ,Wang XF,Cui SH,Dai R,Cao WQ,Zhang P

更新日期：2020-07-09 00:00:00

abstract：:Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the...

journal_title：Frontiers in physiology

authors： Ravi DK,Marmelat V,Taylor WR,Newell KM,Stergiou N,Singh NB

更新日期：2020-06-23 00:00:00

abstract：:Pinocembrin (PIN) is a natural flavonoid widely found in bee propolis with potent gastrointestinal protective effects. In consequence, PIN has great potential in preventing inflammatory bowel diseases (IBDs) while scant information is available. In this study, a dextran sulfate sodium (DSS)-induced rats ulcerative col...

journal_title：Frontiers in physiology

authors： Hu L,Wu C,Zhang Z,Liu M,Maruthi Prasad E,Chen Y,Wang K

更新日期：2019-07-19 00:00:00

abstract：:Background: Previous studies have observed significant heterogeneity in the magnitude of change in measures of metabolic response to exercise training. There are a lack of studies examining the prevalence of non-responders (NRs) in children while considering other potential environmental factors involved such as biolo...

journal_title：Frontiers in physiology

authors： Alvarez C,Ramírez-Campillo R,Ramírez-Vélez R,Izquierdo M

更新日期：2017-06-29 00:00:00

abstract：:Circulating microRNAs have proven to be reliable biomarkers, due to their high stability, both in vivo in the circulation, and ex vivo during sample preparation and storage. Small nucleolar RNAs (snoRNAs) are a different type of small non-coding RNAs that can also be reliably measured in plasma, but have only been stu...

journal_title：Frontiers in physiology

authors： Håkansson KEJ,Sollie O,Simons KH,Quax PHA,Jensen J,Nossent AY

更新日期：2018-08-22 00:00:00

abstract：:We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...

journal_title：Frontiers in physiology

authors： Šket R,Debevec T,Kublik S,Schloter M,Schoeller A,Murovec B,Vogel Mikuš K,Makuc D,Pečnik K,Plavec J,Mekjavić IB,Eiken O,Prevoršek Z,Stres B

更新日期：2018-03-13 00:00:00

abstract：:Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extra...

journal_title：Frontiers in physiology

authors： Arin RM,Gorostidi A,Navarro-Imaz H,Rueda Y,Fresnedo O,Ochoa B

更新日期：2017-09-22 00:00:00

abstract：:Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate l...

journal_title：Frontiers in physiology

authors： Gambara G,Salanova M,Ciciliot S,Furlan S,Gutsmann M,Schiffl G,Ungethuem U,Volpe P,Gunga HC,Blottner D

更新日期：2017-05-05 00:00:00

abstract：UNLABELLED:Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. OBJECTIVE:...

journal_title：Frontiers in physiology

authors： Khaddam M,Salmon B,Le Denmat D,Tjaderhane L,Menashi S,Chaussain C,Rochefort GY,Boukpessi T

更新日期：2014-10-31 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：Objective:Develop an automated approach to detect flash (<1.0 s) or prolonged (>2.0 s) capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques to pulse oximeter plethysmography data. Materials and Methods:Data was collected in the Pediatric In...

journal_title：Frontiers in physiology

authors： Hunter RB,Jiang S,Nishisaki A,Nickel AJ,Napolitano N,Shinozaki K,Li T,Saeki K,Becker LB,Nadkarni VM,Masino AJ

更新日期：2020-10-06 00:00:00

abstract：:Triceps surae (TS) muscle volume can be estimated in young adults by only considering the maximal anatomical cross-sectional area (ACSAmax) and the length of the muscle due to the presence of a constant muscle-specific shape factor. This study aimed to investigate if this simplified muscle volume assessment is also ap...

journal_title：Frontiers in physiology

authors： Karamanidis K,Epro G,König M,Mersmann F,Arampatzis A

更新日期：2019-10-10 00:00:00

abstract：:Laodelphax striatellus is naturally infected with the Wolbachia strain wStri, which induces strong cytoplasmic incompatibility of its host. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that play a critical role in the regulation of gene expression at post-transcriptional level in various biologic...

journal_title：Frontiers in physiology

authors： Liu L,Zhang KJ,Rong X,Li YY,Liu H

更新日期：2019-07-24 00:00:00

abstract：:Exogenous dsRNA enters the insect body and can induce the RNAi effect only when it is cleaved into siRNA. However, what kinds of base composition are easier to cut and what kinds of siRNA will be produced in vivo is largely unknown. In this study, we found that dsRNA processing into siRNA has sequence preference and r...

journal_title：Frontiers in physiology

authors： Guan R,Hu S,Li H,Shi Z,Miao X

更新日期：2018-12-10 00:00:00

abstract：:It is commonly believed that higher values of heart rate variability (HRV) indices account for better organization of the network of feedback reflexes driving an organism's response to actual bodily needs. In order to evaluate this organization in heart transplant (HTX) recipients, 58 nocturnal Holter signals of 14 HT...

journal_title：Frontiers in physiology

authors： Wdowczyk J,Makowiec D,Gruchała M,Wejer D,Struzik ZR

更新日期：2018-04-09 00:00:00

abstract：:Patients undergoing the complex treatment for hematological malignancies are exposed to a high physiological and psychological distress inducing fatigue and physical inactivity. In line with cancer-related metabolic changes patients are predisposed for skeletal muscle mass loss that leads to a functional decline, affe...

journal_title：Frontiers in physiology

authors： Schink K,Reljic D,Herrmann HJ,Meyer J,Mackensen A,Neurath MF,Zopf Y

更新日期：2018-12-18 00:00:00

abstract：:A variety of biological networks can be modeled as logical or Boolean networks. However, a simplification of the reality to binary states of the nodes does not ease the difficulty of analyzing the dynamics of large, complex networks, such as signal transduction networks, due to the exponential dependence of the state ...

journal_title：Frontiers in physiology

authors： Pentzien T,Puniya BL,Helikar T,Matache MT

更新日期：2018-08-31 00:00:00

abstract：:Glucagon counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (BasG) and the GCR res...

journal_title：Frontiers in physiology

authors： Farhy LS,Chan A,Breton MD,Anderson SM,Kovatchev BP,McCall AL

更新日期：2012-02-28 00:00:00

abstract：:Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...

journal_title：Frontiers in physiology

authors： Sarkar J,Simanian EJ,Tuggy SY,Bartlett JD,Snead ML,Sugiyama T,Paine ML

更新日期：2014-07-25 00:00:00

abstract：:Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt...

journal_title：Frontiers in physiology

authors： Vigotsky AD,Halperin I,Lehman GJ,Trajano GS,Vieira TM

更新日期：2018-01-04 00:00:00

abstract：:Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

journal_title：Frontiers in physiology

authors： Pacheco MP,Pfau T,Sauter T

更新日期：2016-01-22 00:00:00