The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia.

abstract：:Hybridization of sympatric closely related species may sometimes lead to introgression and speciation. The sister species Helicoverpa armigera and Helicoverpa assulta both use (Z)-11-hexadecenal and (Z)-9-hexadecenal as sex pheromone components but in reversed ratios. Female H. armigera and male H. assulta could hybri...

journal_title：Frontiers in cellular neuroscience

authors： Xu M,Dong JF,Wu H,Zhao XC,Huang LQ,Wang CZ

更新日期：2017-01-10 00:00:00

abstract：:Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less than 10% of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can p...

journal_title：Frontiers in cellular neuroscience

authors： Broughton BR,Lim R,Arumugam TV,Drummond GR,Wallace EM,Sobey CG

更新日期：2013-01-17 00:00:00

abstract：:Drebrin is an actin-binding protein that is preferentially expressed in the brain. It is highly localized in dendritic spines and regulates spine shapes. The embryonic-type (drebrin E) is expressed in the embryonic and early postnatal brain and is replaced by the adult-type (drebrin A) during development. In parallel,...

journal_title：Frontiers in cellular neuroscience

authors： Yasuda H,Kojima N,Hanamura K,Yamazaki H,Sakimura K,Shirao T

更新日期：2018-10-08 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Optogenetic and pharmacogenetic techniques have been effective to analyze the role of neuronal activity in controlling oligodendroglia lineage cells in behaving juvenile and adult mice. This kind of studies is also of high interest during early postnatal (PN) development since important changes in oligodendroglia dyna...

journal_title：Frontiers in cellular neuroscience

authors： Ortolani D,Manot-Saillet B,Orduz D,Ortiz FC,Angulo MC

更新日期：2018-12-06 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately shou...

journal_title：Frontiers in cellular neuroscience

authors： Basile JR,Binmadi NO,Zhou H,Yang YH,Paoli A,Proia P

更新日期：2013-05-09 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:Prenatal hypoxic injury (HI) is a leading cause of neurological disability. The immediate and long-term effects of hypoxia on progenitor homeostasis and developmental progression during early human brain development remain unclear. This gap is due to difficulty to access human fetal brain tissues and inadequate animal...

journal_title：Frontiers in cellular neuroscience

authors： Daviaud N,Chevalier C,Friedel RH,Zou H

更新日期：2019-07-30 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of male rats that were exposed to gestational stress or not. We hypot...

journal_title：Frontiers in cellular neuroscience

authors： Walf AA,Frye CA

更新日期：2012-12-18 00:00:00

abstract：:Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of exercise may vary with its regime. Less is known about how distinct e...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2017-01-31 00:00:00

abstract：:Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have est...

journal_title：Frontiers in cellular neuroscience

authors： Neuhaus W,Gaiser F,Mahringer A,Franz J,Riethmüller C,Förster C

更新日期：2014-10-28 00:00:00

abstract：:Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal...

journal_title：Frontiers in cellular neuroscience

authors： Anilkumar U,Prehn JH

更新日期：2014-09-30 00:00:00

abstract：:Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult neurons to grow axons are responsible for the diminished capacity...

journal_title：Frontiers in cellular neuroscience

authors： Ribas VT,Costa MR

更新日期：2017-08-07 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:Increased expression of S100B and its specific receptor for advanced glycation end products (RAGE) has been described in patients with multiple sclerosis (MS), being associated with an active demyelinating process. We previously showed that a direct neutralization of S100B reduces lysophosphatidylcholine (LPC)-induced...

journal_title：Frontiers in cellular neuroscience

authors： Santos G,Barateiro A,Brites D,Fernandes A

更新日期：2020-09-04 00:00:00

abstract：:The blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB) form the barriers of the brain. These barriers are essential not only for the protection of the brain, but also in regulating the exchange of cells and molecules in and out of the brain. The choroid plexus (CP) epithelial cells and the ara...

journal_title：Frontiers in cellular neuroscience

authors： Marques F,Sousa JC

更新日期：2015-04-13 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can...

journal_title：Frontiers in cellular neuroscience

authors： Gonzalez MC,Radiske A,Cammarota M

更新日期：2019-08-22 00:00:00

abstract：:There is growing recognition that fast mitochondrial transport in neurons is disrupted in multiple neurological diseases and psychiatric disorders. However, a major constraint in identifying novel therapeutics based on mitochondrial transport is that the large-scale analysis of fast transport is time consuming. Here w...

journal_title：Frontiers in cellular neuroscience

authors： Miller KE,Liu XA,Puthanveettil SV

更新日期：2015-11-03 00:00:00

abstract：:Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina but contribute weakly to tissue repa...

journal_title：Frontiers in cellular neuroscience

authors： Guimarães RPM,Landeira BS,Coelho DM,Golbert DCF,Silveira MS,Linden R,de Melo Reis RA,Costa MR

更新日期：2018-11-12 00:00:00

abstract：:Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during developm...

journal_title：Frontiers in cellular neuroscience

authors： Coppi E,Cellai L,Maraula G,Dettori I,Melani A,Pugliese AM,Pedata F

更新日期：2015-04-24 00:00:00

abstract：:In recent years, P2X receptors have attracted increasing attention as regulators of exocytosis and cellular secretion. In various cell types, P2X receptors have been found to stimulate vesicle exocytosis directly via Ca(2+) influx and elevation of the intracellular Ca(2+) concentration. Recently, a new role for P2X4 r...

journal_title：Frontiers in cellular neuroscience

authors： Miklavc P,Thompson KE,Frick M

更新日期：2013-10-08 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson's disease (PD), which is characterized by the DA deficiency due to the dopaminergic neurons loss in the substanti...

journal_title：Frontiers in cellular neuroscience

authors： Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

更新日期：2018-11-13 00:00:00

abstract：:It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child. Currently, common treatment for maternal depression has been the selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2-3% of pr...

journal_title：Frontiers in cellular neuroscience

authors： Olivier JD,Akerud H,Kaihola H,Pawluski JL,Skalkidou A,Högberg U,Sundström-Poromaa I

更新日期：2013-05-21 00:00:00

abstract：:Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals. A focus in our laboratory for over 25 years has been how production of the pregnane neurosteroid, allopregnanolone, is regulated and the novel (i.e...

journal_title：Frontiers in cellular neuroscience

authors： Frye CA,Koonce CJ,Walf AA

更新日期：2014-04-09 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local...

journal_title：Frontiers in cellular neuroscience

authors： Skardelly M,Gaber K,Burdack S,Scheidt F,Schuhmann MU,Hilbig H,Meixensberger J,Boltze J

更新日期：2014-10-14 00:00:00

abstract：:A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocy...

journal_title：Frontiers in cellular neuroscience

authors： Huntemer-Silveira A,Patil N,Brickner MA,Parr AM

更新日期：2021-01-11 00:00:00

abstract：:In this review, we discuss molecular and cellular mechanisms important for the function of neuronal progenitors during development, revealed by their perturbation in different cortical malformations. We focus on a class of neuronal progenitors, radial glial cells (RGCs), which are renowned for their unique morphologic...

journal_title：Frontiers in cellular neuroscience

authors： Bizzotto S,Francis F

更新日期：2015-02-12 00:00:00