Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer.

abstract：:Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 w...

journal_title：Frontiers in pharmacology

authors： Wang J,Lian DW,Yang XF,Xu YF,Chen FJ,Lin WJ,Wang R,Tang LY,Ren WK,Fu LJ,Huang P,Cao HY

更新日期：2019-05-24 00:00:00

abstract：:The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challe...

journal_title：Frontiers in pharmacology

authors： Choo WT,Teoh ML,Phang SM,Convey P,Yap WH,Goh BH,Beardall J

更新日期：2020-07-31 00:00:00

abstract：:The vast majority of states have enacted full or partial medical marijuana (MMJ) programs, causing the number of patients seeking certification for MMJ use to increase dramatically in recent years. Despite increased use of MMJ across the nation, no studies thus far have examined the specific impact of MMJ on cognitive...

journal_title：Frontiers in pharmacology

authors： Gruber SA,Sagar KA,Dahlgren MK,Gonenc A,Smith RT,Lambros AM,Cabrera KB,Lukas SE

更新日期：2018-01-17 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:The mTOR signaling pathway is abnormally activated in pancreatic cancer and is related to tumor glucose metabolism. However, its specific regulation mechanism is still unclear. Therefore, this study aims to investigate whether Sestrin2 affects the glucose metabolism of pancreatic cancer by modulating mTOR signal and t...

journal_title：Frontiers in pharmacology

authors： Guo Y,Zhu H,Weng M,Zhang H,Wang C,Sun L

更新日期：2020-11-11 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

journal_title：Frontiers in pharmacology

authors： Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

更新日期：2018-12-18 00:00:00

abstract：:Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral ...

journal_title：Frontiers in pharmacology

authors： Zhao Z,Li D,Wu Z,Wang Q,Ma Z,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:Βeta-cyclodextrin (β-CD) with a hydrophobic cavity enables the formation of inclusion complexes with organic molecules. The formation of host-guest complexes makes the application of β-CD popular in many fields, but their interaction with organisms is poorly understood. In the present study, the effect of β-CD on gut ...

journal_title：Frontiers in pharmacology

authors： Lv S,Zhang X,Feng Y,Jiang Q,Niu C,Yang Y,Wang X

更新日期：2021-01-14 00:00:00

abstract：:Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self...

journal_title：Frontiers in pharmacology

authors： Singh L,Joshi T,Tewari D,Echeverría J,Mocan A,Sah AN,Parvanov E,Tzvetkov NT,Ma ZF,Lee YY,Poznański P,Huminiecki L,Sacharczuk M,Jóźwik A,Horbańczuk JO,Feder-Kubis J,Atanasov AG

更新日期：2020-02-14 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild stress. In addition, icariin can exert the neuroprotective effects...

journal_title：Frontiers in pharmacology

authors： Zou X,Feng X,Fu Y,Zheng Y,Ma M,Wang C,Zhang Y

更新日期：2020-06-09 00:00:00

abstract：:Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP). Methods: This study adopted a multicenter, prospective, and real world design. BPH patients undergoing TUPKP ...

journal_title：Frontiers in pharmacology

authors： Li BH,Yu ZJ,Wang CY,Zi H,Li XD,Wang XH,Ren XY,Liu TZ,Zheng H

更新日期：2019-11-27 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed to investigate the hepatoprotective effects of costunolide again...

journal_title：Frontiers in pharmacology

authors： Mao J,Yi M,Wang R,Huang Y,Chen M

更新日期：2018-12-20 00:00:00

abstract：:Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

journal_title：Frontiers in pharmacology

authors： Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

更新日期：2017-01-13 00:00:00

abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...

journal_title：Frontiers in pharmacology

authors： Tomko A,O'Leary L,Trask H,Achenbach JC,Hall SR,Goralski KB,Ellis LD,Dupré DJ

更新日期：2019-09-27 00:00:00

abstract：:Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...

journal_title：Frontiers in pharmacology

authors： Bojanić L,Marković-Peković V,Škrbić R,Stojaković N,Ðermanović M,Bojanić J,Fürst J,Kurdi AB,Godman B

更新日期：2018-05-29 00:00:00

abstract：:Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

journal_title：Frontiers in pharmacology

authors： Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

更新日期：2020-06-05 00:00:00

abstract：:Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

journal_title：Frontiers in pharmacology

authors： Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

更新日期：2018-06-15 00:00:00

abstract：:Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician know...

journal_title：Frontiers in pharmacology

authors： Weller CD,Team V,Sussman G

更新日期：2020-02-28 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：:Quinoxaline 1,4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities. These diverse activities endow them broad applications and prospects in human and veterinary medicines. As QdNOs arouse widespread interest, the e...

journal_title：Frontiers in pharmacology

authors： Cheng G,Sa W,Cao C,Guo L,Hao H,Liu Z,Wang X,Yuan Z

更新日期：2016-03-21 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

journal_title：Frontiers in pharmacology

authors： Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

更新日期：2020-08-12 00:00:00

abstract：:Blockchain systems are a fast emerging and a currently widely discussed novel strategy for a decentralized cryptographically enhanced digital ledger recording transactions among stakeholders. This perspective paper looks at its potential uses in the context of high value and mostly low volume botanical material traded...

journal_title：Frontiers in pharmacology

authors： Heinrich M,Scotti F,Booker A,Fitzgerald M,Kum KY,Löbel K

更新日期：2019-04-24 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:Background and Aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases. Angiotensin-(1-7) is a member of the renin-angiotensin system (RAS) that binds Mas receptors and has gained growing attention in the last years as a reg...

journal_title：Frontiers in pharmacology

authors： Villalobos LA,San Hipólito-Luengo Á,Ramos-González M,Cercas E,Vallejo S,Romero A,Romacho T,Carraro R,Sánchez-Ferrer CF,Peiró C

更新日期：2016-12-15 00:00:00

abstract：:A large and growing body of literature has focused on the association between "white coat hypertension" (WCH) and the underlying target organ damage. The evidence suggests that WCH is may not an entirely benign phenomenon. However, whether patients with WCH should receive antihypertensive drugs is unresolved. Therefor...

journal_title：Frontiers in pharmacology

authors： Xiang H,Xue Y,Wang J,Weng Y,Rong F,Peng Y,Ji K

更新日期：2020-09-17 00:00:00

abstract：:Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subset of their constituent molecules-"toxins"-share this ecological function and are therefore molecules that mediate interactions between organisms. Such molecules have been referred to as "ex...

journal_title：Frontiers in pharmacology

authors： Jackson TNW,Koludarov I

更新日期：2020-12-14 00:00:00

abstract：:Background and Objectives: Limited research focuses on the risk of ischemic cerebrovascular disease associated with use of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) in patients with type 2 diabetes mellitus in Taiwan. This study aimed to investigate the association between DPP-4 inhibitors use and the first...

journal_title：Frontiers in pharmacology

authors： Lai SW,Liao KF,Lin CL,Lin HF

更新日期：2017-11-22 00:00:00