Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine.

abstract：INTRODUCTION:Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment. Thus, abrogation of ...

journal_title：Breast cancer research : BCR

authors： Ren XR,Wei J,Lei G,Wang J,Lu J,Xia W,Spector N,Barak LS,Clay TM,Osada T,Hamilton E,Blackwell K,Hobeika AC,Morse MA,Lyerly HK,Chen W

更新日期：2012-06-07 00:00:00

abstract：BACKGROUND:Well-tolerated and commonly used medications are increasingly assessed for reducing breast cancer risk. These include metformin and statins, both linked to reduced hormone availability and cell proliferation or growth and sometimes prescribed concurrently. We investigated independent and joint associations o...

journal_title：Breast cancer research : BCR

authors： Lee Argov EJ,Acheampong T,Terry MB,Rodriguez CB,Agovino M,Wei Y,Athilat S,Tehranifar P

更新日期：2020-09-15 00:00:00

abstract：:Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Ab...

journal_title：Breast cancer research : BCR

authors： Hui M,Cazet A,Nair R,Watkins DN,O'Toole SA,Swarbrick A

更新日期：2013-03-28 00:00:00

abstract：:Therapeutic choices for metastatic tumors are, in most cases, based upon the histological and molecular analysis of the corresponding primary tumor. Understanding whether and to what extent the genomic landscape of metastasis differs from the tumors from which they originated is critical yet largely unknown. A recent ...

journal_title：Breast cancer research : BCR

authors： Zecchin D,Bardelli A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Incidence of breast cancer is increasing around the world and it is still the leading cause of cancer mortality in low- and middle-income countries. We utilized Swedish nationwide registers to study breast cancer incidence and case fatality to disentangle the effect of socioeconomic position (SEP) and immi...

journal_title：Breast cancer research : BCR

authors： Beiki O,Hall P,Ekbom A,Moradi T

更新日期：2012-01-06 00:00:00

abstract：:The European Network for Breast Development and Cancer (ENBDC) Workshop on ‘Methods in Mammary Gland Development and Cancer’ has grown into the essential, international technical discussion forum for scientists with interests in the normal and neoplastic breast. The fifth ENBDC meeting was held in Weggis, Switzerland ...

journal_title：Breast cancer research : BCR

authors： Clarke RB,Stingl J,Vivanco M,Bentires-Alj M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:We have previously shown that galactosylceramide (GalCer) affects the tumourigenic and metastatic properties of breast cancer cells by acting as an anti-apoptotic molecule. Since GalCer is a precursor molecule in the synthesis of sulfatides, the present study was aimed to define the role of sulfatides in apo...

journal_title：Breast cancer research : BCR

authors： Suchanski J,Grzegrzolka J,Owczarek T,Pasikowski P,Piotrowska A,Kocbach B,Nowak A,Dziegiel P,Wojnar A,Ugorski M

更新日期：2018-11-06 00:00:00

abstract：INTRODUCTION:This study was designed to determine if and how a non-toxic, naturally occurring bioflavonoid, galangin, affects proliferation of human mammary tumor cells. Our previous studies demonstrated that, in other cell types, galangin is a potent inhibitor of the aryl hydrocarbon receptor (AhR), an environmental c...

journal_title：Breast cancer research : BCR

authors： Murray TJ,Yang X,Sherr DH

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:In 2001, data from the California Cancer Registry suggested that breast cancer incidence rates among non-Hispanic white (nHW) women in Marin County, California, had increased almost 60% between 1991 and 1999. This analysis examines the extent to which these and other breast cancer incidence trends could ha...

journal_title：Breast cancer research : BCR

authors： Phipps AI,Clarke CA,Ereman RR

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Aberrant activation of Wnt/β-catenin signaling plays an important role in the pathogenesis of breast cancer. DACT1 (Dapper/Frodo) has been identified as involved in antagonizing Wnt/β-catenin signaling through interacting with Dishevelled (Dvl), a central mediator of Wnt signaling, whereas its role in brea...

journal_title：Breast cancer research : BCR

authors： Yin X,Xiang T,Li L,Su X,Shu X,Luo X,Huang J,Yuan Y,Peng W,Oberst M,Kelly K,Ren G,Tao Q

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Although recent models suggest that the detection of Circulating Tumor Cells (CTC) in epithelial-to-mesenchymal transition (EM CTC) might be related to disease progression in metastatic breast cancer (MBC) patients, current detection methods are not efficient in identifying this subpopulation of cells. Furth...

journal_title：Breast cancer research : BCR

authors： Bulfoni M,Gerratana L,Del Ben F,Marzinotto S,Sorrentino M,Turetta M,Scoles G,Toffoletto B,Isola M,Beltrami CA,Di Loreto C,Beltrami AP,Puglisi F,Cesselli D

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:Inflammation is an important candidate mechanism underlying cancer and cancer treatment-related cognitive impairment. We investigated levels of blood cell-based inflammatory markers in breast cancer survivors on average 20 years after chemotherapy and explored the relation between these markers and global co...

journal_title：Breast cancer research : BCR

authors： van der Willik KD,Koppelmans V,Hauptmann M,Compter A,Ikram MA,Schagen SB

更新日期：2018-11-15 00:00:00

abstract：INTRODUCTION:The ataxia-telangiectasia mutated (ATM) gene (MIM ID 208900) encodes a protein kinase that plays a significant role in the activation of cellular responses to DNA double-strand breaks through subsequent phosphorylation of central players in the DNA damage-response pathway. Recent studies have confirmed tha...

journal_title：Breast cancer research : BCR

authors： Goldgar DE,Healey S,Dowty JG,Da Silva L,Chen X,Spurdle AB,Terry MB,Daly MJ,Buys SM,Southey MC,Andrulis I,John EM,BCFR.,kConFab.,Khanna KK,Hopper JL,Oefner PJ,Lakhani S,Chenevix-Trench G

更新日期：2011-07-25 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agents, therefore, further understanding of the biological properties of these cancer cells and develop...

journal_title：Breast cancer research : BCR

authors： Pelicano H,Zhang W,Liu J,Hammoudi N,Dai J,Xu RH,Pusztai L,Huang P

更新日期：2014-09-11 00:00:00

abstract：:Progesterone receptor status is a marker for hormone responsiveness and disease prognosis in breast cancer. Progesterone receptor negative tumours have generally been shown to have a poorer prognosis than progesterone receptor positive tumours. The observed loss of progesterone receptor could be through a range of mec...

journal_title：Breast cancer research : BCR

authors： Cork DM,Lennard TW,Tyson-Capper AJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan G. Komen for the Cure Tissue Bank at the IU Simon Ca...

journal_title：Breast cancer research : BCR

authors： Pardo I,Lillemoe HA,Blosser RJ,Choi M,Sauder CA,Doxey DK,Mathieson T,Hancock BA,Baptiste D,Atale R,Hickenbotham M,Zhu J,Glasscock J,Storniolo AM,Zheng F,Doerge RW,Liu Y,Badve S,Radovich M,Clare SE,Susan G. Komen f

更新日期：2014-03-17 00:00:00

abstract：INTRODUCTION:Obesity has been linked to increased risk of breast cancer in postmenopausal women. Increased peripheral production of estrogens has been regarded as the main cause for this association, but other features of increased body fat mass may also play a part. Leptin is a protein produced mainly by adipose tissu...

journal_title：Breast cancer research : BCR

authors： Stuedal A,Ursin G,Veierød MB,Bremnes Y,Reseland JE,Drevon CA,Gram IT

更新日期：2006-01-01 00:00:00

abstract：:Over the past 8 years there has been a wealth of breast cancer gene expression studies. The majority of these studies have focused upon characterising a tumour at presentation, before treatment, rather than looking at the effects of treatment on the tumour. More recently, a number of groups have moved from predicting ...

journal_title：Breast cancer research : BCR

authors： Sims AH,Bartlett JM

更新日期：2008-01-01 00:00:00

abstract：:Anti-angiogenic therapies have demonstrated their value in the setting of advanced cancer, and are being explored for use in micrometastatic disease. Recent preclinical studies suggest that adjuvant anti-vascular endothelial growth factor (VEGF) therapies may increase the risk of metastasis. How concerning are these p...

journal_title：Breast cancer research : BCR

authors： Schneider BP,Sledge GW Jr

更新日期：2009-01-01 00:00:00

abstract：:This cross-sectional investigation in Hawaii explored the relation between soy foods and mammographic characteristics using two food frequency questionnaires and a computer-assisted density assessment method. Japanese and Chinese women reported significantly greater soy food intake than Caucasian women. Whereas soy in...

journal_title：Breast cancer research : BCR

authors： Maskarinec G,Meng L

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Mutations in BRCA1 and BRCA2 confer a high risk of breast cancer (BC), but the magnitude of this risk seems to vary according to the study and various factors. Although controversial, there are data to support the hypothesis of allelic risk heterogeneity. METHODS:We assessed variation in BC risk according...

journal_title：Breast cancer research : BCR

authors： Lecarpentier J,Noguès C,Mouret-Fourme E,Gauthier-Villars M,Lasset C,Fricker JP,Caron O,Stoppa-Lyonnet D,Berthet P,Faivre L,Bonadona V,Buecher B,Coupier I,Gladieff L,Gesta P,Eisinger F,Frénay M,Luporsi E,Lortholary A,

更新日期：2012-07-03 00:00:00

abstract：INTRODUCTION:Breast cancer is genetically and clinically a heterogeneous disease. However, the exact contribution of different cell types and oncogenic mutations to this heterogeneity are not well understood. Recently, we discovered an interaction between Wnt and integrin-linked kinase (ILK) within the signaling cascad...

journal_title：Breast cancer research : BCR

authors： Oloumi A,Maidan M,Lock FE,Tearle H,McKinney S,Muller WJ,Aparicio SA,Dedhar S

更新日期：2010-01-01 00:00:00

abstract：:Breast cancer risk is continuing to increase across all societies with rates in countries with traditionally lower risks catching up with the higher rates in the Western world. Although cure rates from breast cancer have continued to improve such that absolute numbers of breast cancer deaths have dropped in many count...

journal_title：Breast cancer research : BCR

authors： Evans DG,Howell A

更新日期：2015-07-09 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer does not express estrogen and progesterone receptors, and no overexpression/amplification of the HER2-neu gene occurs. Therefore, this subtype of breast cancer lacks the benefits of specific therapies that target these receptors. Today chemotherapy is the only systematic thera...

journal_title：Breast cancer research : BCR

authors： Gründker C,Föst C,Fister S,Nolte N,Günthert AR,Emons G

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Mammographic density is one of the strongest risk factors for breast cancer and is believed to represent epithelial and stromal proliferation. Because of the high heritability of breast density, and the role of the insulin-like growth factor (IGF) pathway in cellular proliferation and breast development, w...

journal_title：Breast cancer research : BCR

authors： Tamimi RM,Cox DG,Kraft P,Pollak MN,Haiman CA,Cheng I,Freedman ML,Hankinson SE,Hunter DJ,Colditz GA

更新日期：2007-01-01 00:00:00

abstract：:Women's perceptions of breast cancer risk are largely inaccurate and are often associated with high levels of anxiety about cancer. There are interesting cultural differences that are not well researched. Genetic risk counselling significantly improves accuracy of women's perceptions of risk, but not necessarily to th...

journal_title：Breast cancer research : BCR

authors： Hopwood P

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Menopausal hormone therapy (HT) is typically withheld from breast cancer survivors because of concerns about risk for recurrence. Our objectives were to estimate the effects of HT on recurrence in breast cancer survivors and to examine the reliability of these estimates. METHODS:In a systematic review of ...

journal_title：Breast cancer research : BCR

authors： Col NF,Kim JA,Chlebowski RT

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The association of breast cancer patients’ mortality with estrogen receptor (ER) status (ER + versus ER-) has been well studied. However, little attention has been paid to the relationship between the quantitative measures of ER expression and mortality. METHODS:We evaluated the association between semi-q...

journal_title：Breast cancer research : BCR

authors： Ma H,Lu Y,Marchbanks PA,Folger SG,Strom BL,McDonald JA,Simon MS,Weiss LK,Malone KE,Burkman RT,Sullivan-Halley J,Deapen DM,Press MF,Bernstein L

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have arrived at conflicting results. This study aimed to settle the question as to whether breast carcinoma belo...

journal_title：Breast cancer research : BCR

authors： Lotsari JE,Gylling A,Abdel-Rahman WM,Nieminen TT,Aittomäki K,Friman M,Pitkänen R,Aarnio M,Järvinen HJ,Mecklin JP,Kuopio T,Peltomäki P

更新日期：2012-06-12 00:00:00

abstract：INTRODUCTION:Phosphoinositide 3-kinase (PI3K)-activated signalling has a critical role in the evolution of aggressive tumourigenesis and is therefore a prime target for anticancer therapy. Previously we have shown that the beta galactoside binding protein (betaGBP) cytokine, an antiproliferative molecule, induces funct...

journal_title：Breast cancer research : BCR

authors： Wells V,Mallucci L

更新日期：2009-01-01 00:00:00