Abstract:
:Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Castillo-Juárez I,Maeda T,Mandujano-Tinoco EA,Tomás M,Pérez-Eretza B,García-Contreras SJ,Wood TK,García-Contreras Rdoi
10.12998/wjcc.v3.i7.575subject
Has Abstractpub_date
2015-07-16 00:00:00pages
575-98issue
7issn
2307-8960journal_volume
3pub_type
杂志文章,评审abstract::Coumadin ridge is a normal anatomic variant that is occasionally found in the left atrium. It can present as a linear or nodular mass which can undulate with cardiac motion and if particularly prominent, can easily be mistaken for a tumor or thrombus. Careful evaluation and consideration of the common variants discuss...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i9.831
更新日期:2015-09-16 00:00:00
abstract:BACKGROUND:Fetal akinesia deformation sequence (FADS) is a broad spectrum disorder with absent fetal movements as the unifying feature. The etiology of FADS is heterogeneous and mostly still unknown. A prenatal diagnosis of FADS relies on clinical features obtained by ultrasound and fetal muscle pathology. However, the...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i21.3655
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:Scapular fracture has a low incidence rate, accounting for 0.4%-0.9% of all fractures, and scapular neck fractures are extremely rare, comprising approximately 7%-25% of all scapular fractures. Scapular neck fractures are often studied as case reports mostly accompanied by other injuries, thus leading to con...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i24.6450
更新日期:2020-12-26 00:00:00
abstract:BACKGROUND:Endoscopic retrograde cholangiopancreatography (ERCP) is a valuable therapeutic technique for pancreatobiliary diseases, and its application in the elderly is no longer limited. However, a higher incidence of procedure difficulty and periprocedural adverse events might be expected in elderly patients due to ...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i14.2988
更新日期:2020-07-26 00:00:00
abstract:BACKGROUND:Gemcitabine is a chemotherapy agent with relatively low toxicities, as a valid option for elderly patients with underlying diseases. Gemcitabine-induced pulmonary toxicities are rare and various, ranging from self-limited episodes of bronchospasm to fatal, progressive, severe, interstitial pneumonitis and re...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i19.4652
更新日期:2020-10-06 00:00:00
abstract:INTRODUCTION:World Health Organization announced on April 2009 a public health emergency of international concern caused by swine-origin influenza A (H1N1) virus. Acute respiratory distress syndrome (ARDS) has been reported to be the most devastating complications of this pathogen. Extracorporeal membrane oxygenator (E...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i10.578
更新日期:2014-10-16 00:00:00
abstract:BACKGROUND:Primary chondrosarcoma of the liver are extremely rare. Moreover, there are few reports focusing on typical clinical symptoms and imaging characteristics. Therefore, the diagnosis of chondrosarcoma of the liver remains a challenge. CASE SUMMARY:A 59-year-old male was admitted due to a lesion occupying the r...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i20.5042
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND:Pancreaticoduodenectomy (PD) is a complex surgical procedure with a high morbidity rate. The serious complications are major risk factors for poor long-term surgical outcome. Studies have reported an association between early postoperative prognostic nutritional index (PNI) and prediction of severe complicat...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i1.28
更新日期:2019-01-06 00:00:00
abstract:BACKGROUND:High-riding nipple is one of the common complications after mastopexty and breast reconstruction. However, to date, a limited number of techniques have concentrated on how to lower the high-riding nipple with enlarged areola. CASE SUMMARY:This is a case report describing a combination of surgical techniques...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i9.1674
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Sebaceous lymphadenoma is a benign tumor that occurs rarely in the salivary glands, most commonly in the parotid glands or periparotid lymph nodes, and even more rarely undergoes malignant transformation into a sebaceous lymphadenocarcinoma. CASE SUMMARY:We report an 82-year-old woman who presented with a p...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i22.5751
更新日期:2020-11-26 00:00:00
abstract::IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i12.1000
更新日期:2015-12-16 00:00:00
abstract:BACKGROUND:Generally, hemangiomas do not require surgical intervention; however, cases of large hemangiomas, potentially involving the throat and trachea, necessitate surgical therapy. Here, we present a case of hypopharyngeal hemangioma in an adult that was successfully treated with neodymium-doped yttrium aluminum ga...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i5.932
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Fecal microbiota transplantation (FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection (CDI). Many clinical trials focusing on different diseases are in progress. T...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v6.i16.1121
更新日期:2018-12-26 00:00:00
abstract::Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders caused by collagen synthesis defects. Several hemostatic abnormalities have been described in EDS patients that increase the bleeding tendencies of these patients. This case report illustrates a patient with an unusual presentation of a p...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i3.75
更新日期:2014-03-16 00:00:00
abstract::Esophageal atresia with tracheo-oesophageal fistula (TEF) occurs in 1 in 3500 live births. Anorectal malformation is found to be associated with 14% of TEF. Esophageal atresia with TEF is a congenital anomaly which classically presents as excessive frothing from the mouth and respiratory distress. Rarely gastric posit...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i7.309
更新日期:2014-07-16 00:00:00
abstract:AIM:To investigate whether the change in pre-/post-operation serum alpha-fetoprotein (AFP) levels is a predictive factor for hepatocellular carcinoma (HCC) outcomes. METHODS:We retrospectively analyzed 334 HCC patients who underwent hepatic resection at our hospital between January 2006 and December 2016. The patients...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v6.i6.110
更新日期:2018-06-16 00:00:00
abstract:BACKGROUND:Previous publications indicated that genetic predisposition might play important roles in the onset of osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Some gene loci such as complement C3d receptor 2 (CR2), nitric oxide synthase 3 (NOS3), collagen type II alpha 1 chain (COL2A1...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i12.2530
更新日期:2020-06-26 00:00:00
abstract::Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containing grains are widely consumed; in particular, wheat is one of the world's primary sources of food, providing...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v3.i3.275
更新日期:2015-03-16 00:00:00
abstract:BACKGROUND:Mitochondrial diseases are a heterogenous group of multisystemic disorders caused by genetic mutations affecting mitochondrial oxidation function. Brain involvement is commonly found in most cases but rarely as the unique clinical manifestation. Since the knowledge of its clinical manifestation combined with...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i9.1066
更新日期:2019-05-06 00:00:00
abstract:BACKGROUND:Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare skin disorder that may be associated with cancer. CASE SUMMARY:A 58-year-old female presented with a cholestatic syndrome and significant weight loss three months before admission. Five months earlier, she had abruptly develope...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i18.4122
更新日期:2020-09-26 00:00:00
abstract::We describe clinical, diagnostic features and follow up of a patient with a vanishing brain lesion. A 14-year-old child admitted to the department of Neurology at September 2009 with a history of subacute onset of fever, anorexia, vomiting, blurring of vision and right hemiparesis since one month. Magnetic resonance i...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i11.956
更新日期:2015-11-16 00:00:00
abstract::IgG4-related disease (IgG4-RD) is an increasingly recognized pathological entity that tends to involve multiple organs with an elevated level of serum IgG4, which is easily misdiagnosed owing to sharing common clinical features with a variety of other diseases. Here, we report an interesting IgG4-RD case of a woman wi...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v6.i13.707
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Thyroid gland is an uncommon site for metastases from clear cell renal cell carcinoma (CCRCC) and literature is scarce. Due to the variable and often long lag time before development of metastases in patients with CCRCC, thyroid nodules may be misdiagnosed initially as benign. This systematic review aims at ...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i21.3474
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:Small cell lung cancer (SCLC) accounts for 15% of lung cancers, and it commonly expresses peptide and protein factors that are active as hormones. These secreting factors manifest as paraneoplastic disorders, such as ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS). The clinical features are abnorma...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v7.i10.1177
更新日期:2019-05-26 00:00:00
abstract:BACKGROUND:Medical robot is a promising surgical tool, but no specific one has been designed for interventional treatment of chronic pain. We developed a computed tomography-image based navigation robot using a new registration method with binocular vision. This kind of robot is appropriate for minimal invasive interve...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i16.3440
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:Postoperative unobstructed drainage is an important measure for avoiding hematoma formation and preventing complications from anterior cervical surgery. AIM:To discuss the characteristics and key points of clinical management of two types of commonly used negative pressure drainage systems in clinical setti...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i11.2201
更新日期:2020-06-06 00:00:00
abstract::Colorectal cancer (CRC) is one of the main reasons of tumor-related deaths worldwide. At present, the main treatment is surgery, but the results are unsatisfactory, and the prognosis is poor. The majority of patients die due to liver or lung metastasis or recurrence. In recent years, great progress has been made in th...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v7.i16.2143
更新日期:2019-08-26 00:00:00
abstract:BACKGROUND:Collagen proportionate area (CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari syndrome. AIM:To explore the role of CPA in predict...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i2.130
更新日期:2019-01-26 00:00:00
abstract:BACKGROUND:The incidence of pancreatic neuroendocrine tumors (PNETs) is now increasing rapidly. The tumor grade of PNETs significantly affects the treatment strategy and prognosis. However, there is still no effective way to non-invasively classify PNET grades. Machine learning (ML) algorithms have shown potential in i...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i13.1611
更新日期:2019-07-06 00:00:00
abstract:BACKGROUND:Giant paraesophageal hiatal hernias (HH) are very infrequent, and their spectrum of clinical manifestations is large. Giant HH mainly occurs in elderly patients, and its relationship with anemia has been reported. For the surgical treatment of large HH, Nissen fundoplication is the most common antireflux pro...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i6.1180
更新日期:2020-03-26 00:00:00