CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis.


:Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activity and slowing of the electroencephalogram, progressive memory disturbances, as well as a variety of other behavioral, emotional, and cognitive changes. Magnetic resonance imaging exhibits volume and signal changes of the amygdala and hippocampus, and specific anti-neuronal antibodies binding to either intracellular or plasma membrane neuronal antigens can be detected in serum and cerebrospinal fluid. While effects of plasma cell-derived antibodies on neuronal function and integrity are increasingly becoming characterized, potentially contributing effects of T cell-mediated immune mechanisms remain poorly understood. CD8(+) T cells are known to directly interact with major histocompatibility complex class I-expressing neurons in an antigen-specific manner. Here, we summarize current knowledge on how such direct CD8(+) T cell-neuron interactions may impact neuronal excitability, plasticity, and integrity on a single cell and network level and provide an overview on methods to further corroborate the in vivo relevance of these mechanisms mainly obtained from in vitro studies.


Front Neurol


Frontiers in neurology


Ehling P,Melzer N,Budde T,Meuth SG




Has Abstract


2015-07-15 00:00:00








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    abstract::The vestibular system plays a crucial role in the multisensory control of balance. When vestibular function is lost, essential tasks such as postural control, gaze stabilization, and spatial orientation are limited and the quality of life of patients is significantly impaired. Currently, there is no effective treatmen...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Perez Fornos A,Guinand N,van de Berg R,Stokroos R,Micera S,Kingma H,Pelizzone M,Guyot JP

    更新日期:2014-04-29 00:00:00

  • A fully integrated wireless system for intracranial direct cortical stimulation, real-time electrocorticography data transmission, and smart cage for wireless battery recharge.

    abstract::Wireless transmission of cortical signals is an essential step to improve the safety of epilepsy procedures requiring seizure focus localization and to provide chronic recording of brain activity for Brain Computer Interface (BCI) applications. Our group developed a fully implantable and externally rechargeable device...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Piangerelli M,Ciavarro M,Paris A,Marchetti S,Cristiani P,Puttilli C,Torres N,Benabid AL,Romanelli P

    更新日期:2014-08-25 00:00:00

  • Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.

    abstract::Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Choudhury S,Singh R,Chatterjee P,Trivedi S,Shubham S,Baker MR,Kumar H,Baker SN

    更新日期:2018-07-02 00:00:00

  • Motor Nerve Conduction Block Predicting Outcome of Guillain-Barre Syndrome.

    abstract::Introduction: Motor nerve conduction blocks (CBs) could be detected in both acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). We aimed to identify the correlation between CBs and functional outcome in the two subtypes of GBS. Methods: Motor nerve conduction studie...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Niu J,Liu M,Sun Q,Li Y,Wu S,Ding Q,Guan Y,Cui L

    更新日期:2018-06-01 00:00:00

  • Multiple Aspects of Gene Dysregulation in Huntington's Disease.

    abstract::Huntington's Disease (HD) is a genetic neurodegenerative disease caused by a CAG expansion in the gene encoding Huntingtin (Htt). It is characterized by chorea, cognitive, and psychiatric disorders. The most affected brain region is the striatum, and the clinical symptoms are directly correlated to the rate of striata...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Moumné L,Betuing S,Caboche J

    更新日期:2013-10-23 00:00:00

  • Cell-Based Therapies for Stroke: Are We There Yet?

    abstract::Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two deca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Krause M,Phan TG,Ma H,Sobey CG,Lim R

    更新日期:2019-06-25 00:00:00

  • Uric Acid and Clinical Outcomes Among Intracerebral Hemorrhage Patients: Results From the China Stroke Center Alliance.

    abstract::Background and Purpose: The effect of uric acid (UA) levels on severity and prognosis of spontaneous intracerebral hemorrhage (ICH) remains controversial. We aimed to explore the association of admission UA levels with stroke severity and outcomes in ICH patients. Materials and Methods: The patients enrolled in this s...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

    更新日期:2020-12-03 00:00:00

  • A Novel Sonification Approach to Support the Diagnosis of Alzheimer's Dementia.

    abstract::Alzheimer's disease is the most common neurodegenerative form of dementia that steadily worsens and eventually leads to death. Its set of symptoms include loss of cognitive function and memory decline. Structural and functional imaging methods such as CT, MRI, and PET scans play an essential role in the diagnosis proc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gionfrida L,Roginska A

    更新日期:2017-12-07 00:00:00

  • MMP-9, Vertebrobasilar Ectasia and Vertebral Artery Dominance in Vertigo or Dizziness Patients With Vascular Risk Factors.

    abstract::Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequency, it is not clear whether this is because of altered hemodynamics caused by the effects of matrix metalloproteinases (MMPs) and/or vertebral artery dominance (VAD). Therefore, we investigate the relationship between pl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhang HL,Peng YF,Zhang DP,Li D,Liu FX,Zhao M,Yin S,Liang JX,Wei TT

    更新日期:2020-08-25 00:00:00

  • Corrigendum: Serum MyomiRs as Biomarkers for Female Carriers of Duchenne/Becker Muscular Dystrophy.

    abstract::[This corrects the article DOI: 10.3389/fneur.2020.563609.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误


    authors: Zhang J,Meng Q,Zhong J,Zhang M,Qin X,Ni X,Ma J,He Y,Zeng D,Lan D

    更新日期:2020-11-12 00:00:00

  • Vascular Protection of Hydrogen Sulfide on Cerebral Ischemia/Reperfusion Injury in Rats.

    abstract::This study was undertaken to demonstrate the vascular protection of exogenous and endogenous hydrogen sulfide (H2S) on cerebral ischemia/reperfusion (I/R) injury. The effect of H2S on cerebrovascular dysfunction in middle cerebral artery (MCA) and neuronal damage were measured after cerebral I/R induced by transient m...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wen JY,Wang M,Li YN,Jiang HH,Sun XJ,Chen ZW

    更新日期:2018-10-19 00:00:00

  • A Family With a Complex Phenotype Caused by Two Different Rare Metabolic Disorders: GLUT1 and Very-Long-Chain Fatty Acid Dehydrogenase (VLCAD) Deficiencies.

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Musumeci O,Ferlazzo E,Rodolico C,Gambardella A,Gagliardi M,Aguglia U,Toscano A

    更新日期:2020-06-23 00:00:00

  • Access to Thrombolysis for Non-Resident and Resident Stroke Patients-A Registry-Based Comparative Study from Berlin.

    abstract:OBJECTIVES:Stroke can happen to people away from home. It is unknown whether non-resident and resident stroke patients have equal access to thrombolysis. MATERIALS AND METHODS:Consecutive patients cared for by the Stroke Emergency Mobile between 2011 and 2016 after prompting suspicion of acute stroke during the emerge...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Schlemm L,Turc G,Audebert HJ,Ebinger M

    更新日期:2017-06-30 00:00:00

  • Hemodynamic Characteristics Associated With Paraclinoid Aneurysm Recurrence in Patients After Embolization.

    abstract::Objective: To investigate the hemodynamic features before and after embolization of paraclinoidal aneurysms using hemodynamic numerical simulation and the influence of embolization on recurrence after embolization. Methods: From January 2016 to December 2017, we enrolled a total of 113 paraclinoidal aneurysms treated ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sheng B,Wu D,Yuan J,Xu S,Li Z,Dong J,Lai N,Fang X

    更新日期:2019-04-25 00:00:00

  • An Italian Neurorehabilitation Hospital Facing the SARS-CoV-2 Pandemic: Data From 1207 Patients and Workers.

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Salvia A,Morone G,Iosa M,Balice MP,Paolucci S,Grasso MG,Traballesi M,Nocentini U,Formisano R,Molinari M,Rossini A,Caltagirone C

    更新日期:2020-10-09 00:00:00

  • Single Molecule Molecular Inversion Probes for High Throughput Germline Screenings in Dystonia.

    abstract::Background: This study's aim was to investigate a large cohort of dystonia patients for pathogenic and rare variants in the ATM gene, making use of a new, cost-efficient enrichment technology for NGS-based screening. Methods: Single molecule Molecular Inversion Probes (smMIPs) were used for targeted enrichment and seq...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Pogoda M,Hilke FJ,Lohmann E,Sturm M,Lenz F,Matthes J,Muyas F,Ossowski S,Hoischen A,Faust U,Sepahi I,Casadei N,Poths S,Riess O,Schroeder C,Grundmann K

    更新日期:2019-12-18 00:00:00

  • Informed consent: the rate-limiting step in acute stroke trials.

    abstract::Successful implementation of a randomized clinical trial (RCT) for neuro-vascular emergencies such as cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage is extraordinarily challenging. Besides establishing an accurate, hyper-expedited diagnosis among many mimics in a person with acute neurologic...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rose DZ,Kasner SE

    更新日期:2011-10-17 00:00:00

  • Characterization of Iron Accumulation in Deep Gray Matter in Myotonic Dystrophy Type 1 and 2 Using Quantitative Susceptibility Mapping and R2* Relaxometry: A Magnetic Resonance Imaging Study at 3 Tesla.

    abstract::Quantitative mapping of the magnetic susceptibility and the effective transverse relaxation rate (R2*) are suitable to assess the iron content in distinct brain regions. In this prospective, explorative study the iron accumulation in deep gray matter nuclei (DGM) in myotonic dystrophy type 1 (DM1) and 2 (DM2) and its ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Ates S,Deistung A,Schneider R,Prehn C,Lukas C,Reichenbach JR,Schneider-Gold C,Bellenberg B

    更新日期:2019-12-13 00:00:00

  • The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease.

    abstract::It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Yang D,Zhao D,Ali Shah SZ,Wu W,Lai M,Zhang X,Li J,Guan Z,Zhao H,Li W,Gao H,Zhou X,Yang L

    更新日期:2019-11-06 00:00:00

  • Identification and Clinical Analysis of the First Nonsense Mutation in the PSEN1 Gene in a Family With Acute Encephalopathy and Retinitis Pigmentosa.

    abstract::In the present study, we investigated the genetic variation in a family with acute encephalopathy and retinitis pigmentosa. Nine of 25 people in this family underwent genetic testing. Three family members, namely, the proband and the proband's two sisters, showed symptoms resembling those of meningoencephalitis and si...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: You C,Zeng W,Deng L,Lei Z,Gao X,Zhang VW,Wang Y

    更新日期:2020-05-05 00:00:00

  • Forecast or Fall: Prediction's Importance to Postural Control.

    abstract::To interact successfully with an uncertain environment, organisms must be able to respond to both unanticipated and anticipated events. For unanticipated events, organisms have evolved stereotyped motor behaviors mapped to the statistical regularities of the environment, which can be trigged by specific sensory stimul...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Dakin CJ,Bolton DAE

    更新日期:2018-10-30 00:00:00

  • Why Cognitive-Cognitive Dual-Task Testing Assessment Should Be Implemented in Studies on Multiple Sclerosis and in Regular Clinical Practice.

    abstract::Cognitive impairment is prevalent and disabling in multiple sclerosis (MS) and is severely impacting quality of life (QoL). Aside its routine assessment in clinical care, it should more often be implemented as endpoint/outcome measure in clinical trials. However, a fundamental aspect-often neglected in clinical practi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Beste C,Ziemssen T

    更新日期:2020-08-28 00:00:00

  • Unmet Needs in Dystonia: Genetics and Molecular Biology-How Many Dystonias?

    abstract::Genetic findings of the past years have provided ample evidence for a substantial etiologic heterogeneity of dystonic syndromes. While an increasing number of genes are being identified for Mendelian forms of isolated and combined dystonias using classical genetic mapping and whole-exome sequencing techniques, their p...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Verbeek DS,Gasser T

    更新日期:2017-01-16 00:00:00

  • Three Cases of Hemiconvulsion-Hemiplegia-Epilepsy Syndrome With Focal Cortical Dysplasia Type IIId.

    abstract::Hemiconvulsion-hemiplegia-epilepsy syndrome (HHES) is a subset of acute encephalopathy characterized by infantile-onset with acute hemiconvulsive febrile status and subsequent unilateral cerebral atrophy and hemiparesis. In the chronic phase, patients with HHES develop epilepsy, typically displayed as intractable foca...

    journal_title:Frontiers in neurology



    authors: Itamura S,Okanishi T,Arai Y,Nishimura M,Baba S,Ichikawa N,Hirayama Y,Ishihara N,Hiraide T,Ishigaki H,Fukuda T,Otsuki Y,Enoki H,Fujimoto A

    更新日期:2019-11-20 00:00:00

  • Stroke Lesion Segmentation in FLAIR MRI Datasets Using Customized Markov Random Fields.

    abstract::Robust and reliable stroke lesion segmentation is a crucial step toward employing lesion volume as an independent endpoint for randomized trials. The aim of this work was to develop and evaluate a novel method to segment sub-acute ischemic stroke lesions from fluid-attenuated inversion recovery (FLAIR) magnetic resona...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Subbanna NK,Rajashekar D,Cheng B,Thomalla G,Fiehler J,Arbel T,Forkert ND

    更新日期:2019-05-24 00:00:00

  • Primary Leptomeningeal Oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted.

    abstract::We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Intraoperative examination and exploration revealed an extr...

    journal_title:Frontiers in neurology



    authors: Ballester LY,Dunbar E,Guha-Thakurta N,Henson JW,Chandler H,Watkins J,Fuller GN

    更新日期:2018-08-27 00:00:00

  • Access to Expert Stroke Care with Telemedicine: REACH MUSC.

    abstract::Stroke is a leading cause of death and disability, and recombinant tissue plasminogen activator (rtPA) can significantly reduce the long-term impact of acute ischemic stroke (AIS) if given within 3 h of symptom onset. South Carolina is located in the "stroke belt" and has a high rate of stroke and stroke mortality. Ma...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kazley AS,Wilkerson RC,Jauch E,Adams RJ

    更新日期:2012-03-21 00:00:00

  • Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hlavatá P,Linhartová P,Šumec R,Filip P,Světlák M,Baláž M,Kašpárek T,Bareš M

    更新日期:2020-01-10 00:00:00

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    abstract::Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healt...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sartoretti E,Sartoretti T,Wyss M,Becker AS,Schwenk Á,van Smoorenburg L,Najafi A,Binkert C,Thoeny HC,Zhou J,Jiang S,Graf N,Czell D,Sartoretti-Schefer S,Reischauer C

    更新日期:2019-12-10 00:00:00

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Song J,Tucker DM,Gilbert T,Hou J,Mattson C,Luu P,Holmes MD

    更新日期:2013-05-15 00:00:00