Corrigendum: Voltage-controlled enzymes: the new Janus Bifrons.

abstract：:Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhib...

journal_title：Frontiers in pharmacology

authors： Huang Z,Su W,Lu T,Wang Y,Dong Y,Qin Y,Liu D,Sun L,Jiao W

更新日期：2020-10-07 00:00:00

abstract：:Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for a...

journal_title：Frontiers in pharmacology

authors： Ma DSL,Tan LT,Chan KG,Yap WH,Pusparajah P,Chuah LH,Ming LC,Khan TM,Lee LH,Goh BH

更新日期：2018-02-19 00:00:00

abstract：:Glucocorticoid (GC) therapy is the leading cause of secondary osteoporosis and the therapeutic and preventative drugs for GC-induced osteoporosis are limited. In this study, we investigated the protective effects of geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed t...

journal_title：Frontiers in pharmacology

authors： Xie B,Wu J,Li Y,Wu X,Zeng Z,Zhou C,Xu D,Wu L

更新日期：2019-04-18 00:00:00

abstract：:"Lipotoxicity" induced by free fatty acids (FAs) plays a central role in the pathogenesis of many metabolic diseases, with few treatment options available today. Hydrogen sulfide (H2S), a novel gaseous signaling molecule, has been reported to have a variety of pharmacological properties, but its effect on FAs metaboli...

journal_title：Frontiers in pharmacology

authors： Zhao C,Yu N,Li W,Cai H,Liu M,Hu Y,Liu Y,Tang M

更新日期：2020-09-23 00:00:00

abstract：:The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using the recently publis...

journal_title：Frontiers in pharmacology

authors： Pascual R,Almansa C,Plata-Salamán C,Vela JM

更新日期：2019-05-31 00:00:00

abstract：:Chinese formulas have been paid increasing attention in cancer multidisciplinary therapy due to their multi-targets and multi-substances property. Here, we aim to investigate the anti-breast cancer and chemosensitizing function of Ai Du Qing (ADQ) formula made up of Hedyotis diffusa, Curcuma zedoaria (Christm.) Rosc.,...

journal_title：Frontiers in pharmacology

authors： Wang N,Yang B,Zhang X,Wang S,Zheng Y,Li X,Liu S,Pan H,Li Y,Huang Z,Zhang F,Wang Z

更新日期：2018-10-02 00:00:00

abstract：:Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

journal_title：Frontiers in pharmacology

authors： Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

更新日期：2019-02-26 00:00:00

abstract：:The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated...

journal_title：Frontiers in pharmacology

authors： Thomas M,Winter S,Klumpp B,Turpeinen M,Klein K,Schwab M,Zanger UM

更新日期：2015-11-04 00:00:00

abstract：:Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to ...

journal_title：Frontiers in pharmacology

authors： Cenini G,Voos W

更新日期：2019-08-23 00:00:00

abstract：:The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central nervous system (CNS) disorders has a high failure rate. Personalized m...

journal_title：Frontiers in pharmacology

authors： Skelton RL,Kornhauser JM,Tate BA

更新日期：2015-06-19 00:00:00

abstract：Background:MicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is known to exert inhibitory effects on several forms of cancers, its effects on the growth and invasion of osteosarcoma have not been studied. Methods:We collected human osteosarcoma specimens and adjacent tissues to detect...

journal_title：Frontiers in pharmacology

authors： Gu Z,Li Z,Xu R,Zhu X,Hu R,Xue Y,Xu W

更新日期：2020-08-26 00:00:00

abstract：:As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2 channel activation and the IQ-like motif in th...

journal_title：Frontiers in pharmacology

authors： Luo Y,Yu X,Ma C,Luo J,Yang W

更新日期：2018-06-04 00:00:00

abstract：:Alzheimer's disease (AD) is the most widespread form of dementia, affecting about 45 million people worldwide. Although the β-amyloid peptide (Aβ) remains the most acknowledged culprit of AD, the multiple failures of Aβ-centric therapies call for alternative therapeutic approaches. Conceivably, the complexity of the A...

journal_title：Frontiers in pharmacology

authors： Balducci C,Forloni G

更新日期：2019-07-03 00:00:00

abstract：:The need for novel drugs for the treatment of autoimmune diseases is high, since available pharmaceuticals often have substantial side effects and limited efficacy. Natural products are a good starting point in the development of immunosuppressive leads. Since enhanced T cell proliferation is a common feature of autoi...

journal_title：Frontiers in pharmacology

authors： Zimmermann-Klemd AM,Reinhardt JK,Morath A,Schamel WW,Steinberger P,Leitner J,Huber R,Hamburger M,Gründemann C

更新日期：2020-04-08 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：:Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

journal_title：Frontiers in pharmacology

authors： Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

更新日期：2017-05-30 00:00:00

abstract：:As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZ...

journal_title：Frontiers in pharmacology

authors： Ma HJ,Gai C,Chai Y,Feng WD,Cheng CC,Zhang JK,Zhang YX,Yang LP,Guo ZY,Gao YS,Sun HM

更新日期：2020-12-18 00:00:00

abstract：:The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 ...

journal_title：Frontiers in pharmacology

authors： Barlow N,Thompson PE

更新日期：2020-09-25 00:00:00

abstract：:Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

journal_title：Frontiers in pharmacology

authors： McVicker BL,Bennett RG

更新日期：2017-05-31 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Zhao L,Hu C,Wang T,Lu J,Wu C,Chen L,Jin M,Hu H,Ji G,Cao Q,Jiang Y

更新日期：2020-02-28 00:00:00

abstract：:Background: Several initiatives have assessed if mining electronic health records (EHRs) may accelerate the process of drug safety signal detection. In Europe, Exploring and Understanding Adverse Drug Reactions (EU-ADR) Project Focused on utilizing clinical data from EHRs of over 30 million patients from several Europ...

journal_title：Frontiers in pharmacology

authors： Patadia VK,Schuemie MJ,Coloma PM,Herings R,van der Lei J,Sturkenboom M,Trifirò G

更新日期：2018-06-06 00:00:00

abstract：:Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in...

journal_title：Frontiers in pharmacology

authors： Lu YS,Jiang Y,Yuan JP,Jiang SB,Yang Y,Zhu PY,Sun YZ,Qi RQ,Liu T,Wang HX,Wu Y,Gao XH,Chen HD

更新日期：2020-05-15 00:00:00

abstract：:Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adult...

journal_title：Frontiers in pharmacology

authors： Ragavendran C,Srinivasan R,Kim M,Natarajan D

更新日期：2018-11-26 00:00:00

abstract：:Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., a type of sensiti...

journal_title：Frontiers in pharmacology

authors： Wuo-Silva R,Fukushiro-Lopes DF,Fialho BP,Hollais AW,Santos-Baldaia R,Marinho EAV,Mári-Kawamoto E,Yokoyama TS,Lopes-Silva LB,Berro LF,Frussa-Filho R,Longo BM

更新日期：2019-03-11 00:00:00

abstract：:Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for medical purposes. The term 'medical cannabis' refers to physician-recommended use o...

journal_title：Frontiers in pharmacology

authors： Vučković S,Srebro D,Vujović KS,Vučetić Č,Prostran M

更新日期：2018-11-13 00:00:00

abstract：:Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid receptors. CB1 receptors are highly expressed in projection neurons and s...

journal_title：Frontiers in pharmacology

authors： Van Waes V,Beverley JA,Siman H,Tseng KY,Steiner H

更新日期：2012-03-12 00:00:00

abstract：:Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-ind...

journal_title：Frontiers in pharmacology

authors： Franks LN,Ford BM,Prather PL

更新日期：2016-12-22 00:00:00

abstract：:Βeta-cyclodextrin (β-CD) with a hydrophobic cavity enables the formation of inclusion complexes with organic molecules. The formation of host-guest complexes makes the application of β-CD popular in many fields, but their interaction with organisms is poorly understood. In the present study, the effect of β-CD on gut ...

journal_title：Frontiers in pharmacology

authors： Lv S,Zhang X,Feng Y,Jiang Q,Niu C,Yang Y,Wang X

更新日期：2021-01-14 00:00:00

abstract：:This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities. A retrospective study of 42 cases on paraffin-embedded tissue specimens diagnosed with DLBCL was performed using immunohistochemistry (IHC) and fluoresce...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Wang H,Ren C,Yu H,Fang W,Zhang N,Gao S,Hou Q

更新日期：2019-01-07 00:00:00

abstract：:Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological methods. Here, we first explored the mechanism of action of DSD with the as...

journal_title：Frontiers in pharmacology

authors： Pan B,Wang Y,Wu C,Jia J,Huang C,Fang S,Liu L

更新日期：2021-01-11 00:00:00