Assessing the impact of dietary habits on health-related quality of life requires contextual measurement tools.

abstract：:Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects ...

journal_title：Frontiers in pharmacology

authors： Arora A,Bhuria V,Hazari PP,Pathak U,Mathur S,Roy BG,Sandhir R,Soni R,Dwarakanath BS,Bhatt AN

更新日期：2018-04-24 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：Background:The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream of the CYP2D6 gene ...

journal_title：Frontiers in pharmacology

authors： Boone EC,Wang WY,Gaedigk R,Cherner M,Bérard A,Leeder JS,Miller NA,Gaedigk A

更新日期：2020-05-08 00:00:00

abstract：:Hypoxia is an important micro-environmental characteristic of rheumatoid arthritis (RA). Hypoxia-inducible factors (HIF) are key transcriptional factors that are highly expressed in RA synovium to regulate the adaptive responses to this hypoxic milieu. Accumulating evidence supports hypoxia and HIFs in regulating a nu...

journal_title：Frontiers in pharmacology

authors： Hua S,Dias TH

更新日期：2016-06-27 00:00:00

abstract：:Drug scheduling within the international system of drug control and national legislation has been recently criticized as having insufficient footing in scientific evidence. The legal harms related to non-medical uses of certain drugs (e.g., cannabis) have arguably exceeded their physiological and social harmfulness co...

journal_title：Frontiers in pharmacology

authors： Dubljević V

更新日期：2018-08-20 00:00:00

abstract：:The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3-300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw e...

journal_title：Frontiers in pharmacology

authors： Bednarczyk-Cwynar B,Wachowiak N,Szulc M,Kamińska E,Bogacz A,Bartkowiak-Wieczorek J,Zaprutko L,Mikolajczak PL

更新日期：2016-07-12 00:00:00

abstract：:Hypertensive disorders of pregnancy (HDP) are a group of morbid pregnancy complications, with preeclampsia (PE) being the most common subclassification among them. PE affects 2%-8% of pregnancies globally and threatens maternal and fetal health seriously. However, the only effective treatment of PE to date is the time...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Liu X,Yang L,Zou L

更新日期：2020-12-14 00:00:00

abstract：:Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

journal_title：Frontiers in pharmacology

authors： Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

更新日期：2020-11-27 00:00:00

abstract：:Upon interaction, neutrophils can potentially release neutrophil extracellular traps (NETs) on the surface of an implanted electrospun template, which may be a significant preconditioning event for implantable biomaterials of yet unknown consequences. In this study, we investigated the potential of polydioxanone templ...

journal_title：Frontiers in pharmacology

authors： Fetz AE,Neeli I,Buddington KK,Read RW,Smeltzer MP,Radic MZ,Bowlin GL

更新日期：2018-03-28 00:00:00

abstract：:Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protective effects in apoptosis of cardiomyocytes. The present research was pe...

journal_title：Frontiers in pharmacology

authors： Tian Y,Du YY,Shang H,Wang M,Sun ZH,Wang BQ,Deng D,Wang S,Xu XD,Sun GB,Sun XB

更新日期：2017-11-23 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00

abstract：:Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are importan...

journal_title：Frontiers in pharmacology

authors： Fu L,Han B,Zhou Y,Ren J,Cao W,Patel G,Kai G,Zhang J

更新日期：2020-03-19 00:00:00

abstract：:The market authorization procedure for medicinal products for human use is relying on their demonstrated efficacy, safety, and pharmaceutical quality. This applies to all medicinal products whether of chemical or biological origin. Since October 2009, the first advanced therapy medicinal product (ATMP) has been author...

journal_title：Frontiers in pharmacology

authors： Van Wilder P

更新日期：2012-02-14 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

journal_title：Frontiers in pharmacology

authors： Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

更新日期：2020-09-11 00:00:00

abstract：:Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developi...

journal_title：Frontiers in pharmacology

authors： Yeung AWK,Heinrich M,Atanasov AG

更新日期：2018-03-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2018.00361.]. ...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Huang D,Xie S,Wang X,Pan Y,Yuan Z

更新日期：2018-11-29 00:00:00

abstract：Introduction:Diabetes is a metabolic disease with a high incidence and serious harm to human health. Islet β-cell function defects can occur in the late stage of type 1 diabetes and type 2 diabetes. Studies have shown that stem cell is a promising new approach in bioengineering regenerative medicine. In the study of st...

journal_title：Frontiers in pharmacology

authors： Xu B,Fan D,Zhao Y,Li J,Wang Z,Wang J,Wang X,Guan Z,Niu B

更新日期：2020-01-24 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central nervous system, and conventional treatments have limited efficacy or side effects. Ghrelin, a 28-amino acid octanoylated peptide, has been reported to have neuroprotective effects, including anti-oxidation, anti-inflammation, and a...

journal_title：Frontiers in pharmacology

authors： Liu F,Li Z,He X,Yu H,Feng J

更新日期：2019-11-06 00:00:00

abstract：:Background: Details of the extraction and purification procedure can have a profound impact on the composition of plant-derived extracts, and thus on their efficacy and safety. So far, studies with head-to-head comparison of the pharmacology of Ginkgo extracts rendered by different procedures have been rare. Objective...

journal_title：Frontiers in pharmacology

authors： Bader BM,Jügelt K,Schultz L,Schroeder OH

更新日期：2018-08-03 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive. Recent studies have suggested novel roles of the habenula in the onset of depres...

journal_title：Frontiers in pharmacology

authors： Zhao YW,Pan YQ,Tang MM,Lin WJ

更新日期：2018-05-15 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in pediatrics. Objecti...

journal_title：Frontiers in pharmacology

authors： Verschuur A,Heng-Maillard MA,Dory-Lautrec P,Truillet R,Jouve E,Chastagner P,Leblond P,Aerts I,Honoré S,Entz-Werle N,Sirvent N,Gentet JC,Corradini N,André N

更新日期：2018-09-27 00:00:00

abstract：:The immunotherapy agent pembrolizumab has been approved for gastric cancer (GC) patients with recurrent or advanced disease who are PD-L1 positive. Mutations in the primary lesion may drive the expression of immune targets thereby priming the tumor to therapeutic sensitivity. In this study, we aimed to uncover mutatio...

journal_title：Frontiers in pharmacology

authors： Menyhárt O,Pongor LS,Győrffy B

更新日期：2019-01-08 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:Aflatoxin B1 (AFB1) is one of the most hazardous mycotoxins contamination in food and feed products, which leads to hepatocellular carcinoma in humans and animals. In the present study, we isolated and characterized an AFB1 degrading bacteria CG1061 from chicken cecum, exhibited an 93.7% AFB1 degradation rate by HPLC....

journal_title：Frontiers in pharmacology

authors： Wang L,Wu J,Liu Z,Shi Y,Liu J,Xu X,Hao S,Mu P,Deng F,Deng Y

更新日期：2019-01-17 00:00:00

abstract：:The Glp-1 analog, liraglutide (Lir), has been shown to reduce infarct size and improve cardiac function after myocardial ischemia in rodents with or without diabetes. However, the effect of Lir on angiotensin II (AngII) and pressure overload induced cardiac hypertrophy in nondiabetic mice and the underlying mechanisms...

journal_title：Frontiers in pharmacology

authors： Li R,Shan Y,Gao L,Wang X,Wang X,Wang F

更新日期：2019-06-05 00:00:00

abstract：:Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Three classes of kappa antagonists have been distinguished: non-selectiv...

journal_title：Frontiers in pharmacology

authors： Chavkin C,Cohen JH,Land BB

更新日期：2019-02-06 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pan...

journal_title：Frontiers in pharmacology

authors： Kamatham S,Shahjehan F,Kasi PM

更新日期：2020-02-10 00:00:00

abstract：:[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

journal_title：Frontiers in pharmacology

authors： Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

更新日期：2016-12-05 00:00:00