Quantitative analysis of axonal fiber activation evoked by deep brain stimulation via activation density heat maps.

abstract：:It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice. The leptin receptors in the hypothalamus are the main target for the homeostat...

journal_title：Frontiers in neuroscience

authors： Fujita Y,Yamashita T

更新日期：2019-08-07 00:00:00

abstract：:Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patt...

journal_title：Frontiers in neuroscience

authors： Luan Y,Wang C,Jiao Y,Tang T,Zhang J,Teng GJ

更新日期：2019-02-05 00:00:00

abstract：:There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequ...

journal_title：Frontiers in neuroscience

authors： Seymour RA,Rippon G,Kessler K

更新日期：2017-09-01 00:00:00

abstract：:Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms throughout adult life in most of the affected patients. This unfavorable course is associated with multiple episodes and residual symptoms, mainly negative symptoms and cognitive deficits. The neural diathesis-stress model proposes that p...

journal_title：Frontiers in neuroscience

authors： Popovic D,Schmitt A,Kaurani L,Senner F,Papiol S,Malchow B,Fischer A,Schulze TG,Koutsouleris N,Falkai P

更新日期：2019-03-21 00:00:00

abstract：:In this paper we review several ways of realizing asynchronous Spike-Timing-Dependent-Plasticity (STDP) using memristors as synapses. Our focus is on how to use individual memristors to implement synaptic weight multiplications, in a way such that it is not necessary to (a) introduce global synchronization and (b) to ...

journal_title：Frontiers in neuroscience

authors： Serrano-Gotarredona T,Masquelier T,Prodromakis T,Indiveri G,Linares-Barranco B

更新日期：2013-02-18 00:00:00

abstract：:Neuroprosthetic approaches have tremendous potential for the treatment of injuries to the brain and spinal cord by inducing appropriate neural activity in otherwise disordered circuits. Substantial work has demonstrated that stimulation applied to both the central and peripheral nervous system leads to immediate and i...

journal_title：Frontiers in neuroscience

authors： Mondello SE,Kasten MR,Horner PJ,Moritz CT

更新日期：2014-02-27 00:00:00

abstract：:Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infu...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Wey HY,Fox PT,Lancaster JL,Davis MD,Wang DJ,Lin AL,Bastarrachea RA,Andrade MC,Mattern V,Frost P,Higgins PB,Comuzzie AG,Voruganti VS

更新日期：2017-02-14 00:00:00

abstract：:Spike-Timing-Dependent Plasticity (STDP) is a bio-inspired local incremental weight update rule commonly used for online learning in spike-based neuromorphic systems. In STDP, the intensity of long-term potentiation and depression in synaptic efficacy (weight) between neurons is expressed as a function of the relative...

journal_title：Frontiers in neuroscience

authors： Pedroni BU,Joshi S,Deiss SR,Sheik S,Detorakis G,Paul S,Augustine C,Neftci EO,Cauwenberghs G

更新日期：2019-04-24 00:00:00

abstract：:Mu/beta rhythms are well-studied brain activities that originate from sensorimotor cortices. These rhythms reveal spectral changes in alpha and beta bands induced by movements of different body parts, e.g., hands and limbs, in electroencephalography (EEG) signals. However, less can be revealed in them about movements ...

journal_title：Frontiers in neuroscience

authors： Xiao R,Ding L

更新日期：2015-09-01 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00

abstract：:The combination of electromyography (EMG) and transcranial magnetic stimulation (TMS) offers a powerful non-invasive approach for investigating corticospinal excitability in both humans and animals. Acquiring and analyzing the data produced with this combination of tools requires overcoming multiple technical hurdles....

journal_title：Frontiers in neuroscience

authors： Jackson N,Greenhouse I

更新日期：2019-09-13 00:00:00

abstract：:With emerging evidence showing a wide distribution of secretin (SCT) and its receptor (SCTR) in the central nervous system (CNS), the putative neuropeptide role of SCT has become more appreciated since the disruption of SCT/SCTR axis affects various neural functions. This mini review thus focuses on the effects of SCT...

journal_title：Frontiers in neuroscience

authors： Wang L,Zhang L

更新日期：2020-05-06 00:00:00

abstract：:Women and men differ in a wide variety of behavioral traits and in their vulnerability to developing certain mental disorders. This review endeavors to explore how recent preclinical and clinical research findings have enhanced our understanding of the factors that underlie these disparities. We start with a brief ove...

journal_title：Frontiers in neuroscience

authors： Viveros MP,Mendrek A,Paus T,López-Rodríguez AB,Marco EM,Yehuda R,Cohen H,Lehrner A,Wagner EJ

更新日期：2012-06-12 00:00:00

abstract：:The auditory cortex integrates auditory information over time to obtain neural representations of sound events, the time scale of which critically affects perception. This work investigated the species differences in the time scale of integration by comparing humans and monkeys regarding how their scalp-recorded corti...

journal_title：Frontiers in neuroscience

authors： Itoh K,Nejime M,Konoike N,Nakamura K,Nakada T

更新日期：2019-06-24 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple biological levels, including molecular, genetic, epigenetic, cellular and large-scale brain networks. These alterations account for multiple pathophysiological me...

journal_title：Frontiers in neuroscience

authors： Zhao Y,Jaber V,Alexandrov PN,Vergallo A,Lista S,Hampel H,Lukiw WJ

更新日期：2020-10-30 00:00:00

abstract：:Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 be...

journal_title：Frontiers in neuroscience

authors： Lorke DE,Petroianu GA

更新日期：2019-05-22 00:00:00

abstract：Background:Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Ob...

journal_title：Frontiers in neuroscience

authors： Hao L,Xing Y,Li X,Mu B,Zhao W,Wang G,Wang T,Jia J,Han Y

更新日期：2019-08-14 00:00:00

abstract：:The Artificial Intelligence (AI) revolution foretold of during the 1960s is well underway in the second decade of the twenty first century. Its period of phenomenal growth likely lies ahead. AI-operated machines and technologies will extend the reach of Homo sapiens far beyond the biological constraints imposed by evo...

journal_title：Frontiers in neuroscience

authors： Krichmar JL,Severa W,Khan MS,Olds JL

更新日期：2019-06-27 00:00:00

abstract：:The structure of gene coexpression networks reflects the activation and interaction of multiple cellular systems. Since the pathology of neuropsychiatric disorders is influenced by diverse cellular systems and pathways, we investigated gene coexpression networks in major depression, and searched for putative unifying ...

journal_title：Frontiers in neuroscience

authors： Gaiteri C,Sibille E

更新日期：2011-08-30 00:00:00

abstract：:Ongoing brain activity has been implicated in the modulation of cortical excitability. The combination of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in a real-time triggered setup is a novel method for testing hypotheses about the relationship between spontaneous neuronal oscillations, co...

journal_title：Frontiers in neuroscience

authors： Schaworonkow N,Caldana Gordon P,Belardinelli P,Ziemann U,Bergmann TO,Zrenner C

更新日期：2018-12-13 00:00:00

abstract：Objectives:The frontal-striatum-thalamus pathway is important in the glutamic neural circuit. The hypofunction of GRIN1 and GRIA2 subunits from glutamic receptors has been hypothesized as the primary process in the etiology of schizophrenia. Identified gene polymorphism involved in the pathogenesis of schizophrenia may...

journal_title：Frontiers in neuroscience

authors： Cai S,Lv Y,Huang K,Zhang W,Wang Q,Huang L,Wang J

更新日期：2020-04-21 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson's disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intriguingly, the presenc...

journal_title：Frontiers in neuroscience

authors： Dues DJ,Moore DJ

更新日期：2020-07-08 00:00:00

abstract：:Newborn neurons are continuously added to the hippocampal dentate gyrus throughout adulthood. In this review, we analyze the maturational stages that newborn granule neurons go through, with a focus on their unique morphological features during each stage under both physiological and pathological circumstances. In add...

journal_title：Frontiers in neuroscience

authors： Llorens-Martín M,Rábano A,Ávila J

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND AND AIMS:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS:Activity of human submucous ...

journal_title：Frontiers in neuroscience

authors： Ostertag D,Buhner S,Michel K,Pehl C,Kurjak M,Götzberger M,Schulte-Frohlinde E,Frieling T,Enck P,Phillip J,Schemann M

更新日期：2015-12-16 00:00:00

abstract：:Although, cochlear implants (CI) traditionally have been used to treat individuals with bilateral profound sensorineural hearing loss, a recent trend is to implant individuals with residual low-frequency hearing. Notably, many of these individuals demonstrate an air-bone gap (ABG) in low-frequency, pure-tone threshold...

journal_title：Frontiers in neuroscience

authors： Koka K,Saoji AA,Attias J,Litvak LM

更新日期：2017-04-18 00:00:00

abstract：:For brain-computer interfaces (BCIs) that utilize visual cues to direct the user, the neural signals extracted by the computer are representative of ongoing processes, visual evoked responses, and voluntary modulation. We proposed to use three brain signatures for predicting success on a single trial of a BCI task. Th...

journal_title：Frontiers in neuroscience

authors： Geronimo A,Kamrunnahar M,Schiff SJ

更新日期：2016-04-26 00:00:00

abstract：:High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to asc...

journal_title：Frontiers in neuroscience

authors： Boukadi M,Marcotte K,Bedetti C,Houde JC,Desautels A,Deslauriers-Gauthier S,Chapleau M,Boré A,Descoteaux M,Brambati SM

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:With the advent of the GeneChip Exon Arrays, it is now possible to extract "exon-level" expression estimates, allowing for detection of alternative splicing events, one of the primary mechanisms of transcript diversity. In the context of (1) a complex trait use case and (2) a human cerebellum vs. heart compa...

journal_title：Frontiers in neuroscience

authors： Laderas TG,Walter NA,Mooney M,Vartanian K,Darakjian P,Buck K,Harrington CA,Belknap J,Hitzemann R,McWeeney SK

更新日期：2011-05-13 00:00:00

abstract：:Ablation of adult neurogenesis in mice has revealed that young adult-born granule cells (abGCs) are required for some of the behavioral responses to antidepressants (ADs), yet the mechanism by which abGCs contribute to AD action remains unknown. During their maturation process, these immature neurons exhibit unique pr...

journal_title：Frontiers in neuroscience

authors： Tannenholz L,Hen R,Kheirbek MA

更新日期：2016-05-31 00:00:00

abstract：:Oxylipins are a series of bioactive lipid metabolites derived from polyunsaturated fatty acids that are involved in cerebral homeostasis and the development of intracerebral hemorrhage (ICH). However, comprehensive quantification of the oxylipin profile in ICH remains unknown. Therefore, an ICH mouse model was constru...

journal_title：Frontiers in neuroscience

authors： Yuan JJ,Chen Q,Xiong XY,Zhang Q,Xie Q,Huang JC,Yang GQ,Gong CX,Qiu ZM,Sang HF,Zi WJ,He Q,Xu R,Yang QW

更新日期：2020-09-23 00:00:00