Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana.

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa. The source population of this colony is unclear and its genetic dive...

journal_title：PLoS neglected tropical diseases

authors： Ciosi M,Masiga DK,Turner CM

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...

journal_title：PLoS neglected tropical diseases

authors： Bayer AM,Hunter GC,Gilman RH,Cornejo Del Carpio JG,Naquira C,Bern C,Levy MZ

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS:We conducted a hospital-based case-control study covering 215 UGIB ...

journal_title：PLoS neglected tropical diseases

authors： Ubeira FM,Anadón AM,Salgado A,Carvajal A,Ortega S,Aguirre C,López-Goikoetxea MJ,Ibanez L,Figueiras A

更新日期：2011-06-01 00:00:00

abstract：:Infection with the intracellular protozoan parasite Leishmania mexicana causes chronic disease in C57BL/6 mice, in which cutaneous lesions persist for many months with high parasite burdens (10(7)-10(8) parasites). This chronic disease process requires host IL-10 and FcγRIII. When Leishmania amastigotes are released f...

journal_title：PLoS neglected tropical diseases

authors： Buxbaum LU

更新日期：2013-05-09 00:00:00

abstract：BACKGROUND:The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this ...

journal_title：PLoS neglected tropical diseases

authors： Courtenay O,Carson C,Calvo-Bado L,Garcez LM,Quinnell RJ

更新日期：2014-01-09 00:00:00

abstract：:West Nile Fever is a zoonotic disease caused by a mosquito-borne flavivirus, WNV. By its clinical sensitivity to the disease, the horse is a useful sentinel of infection. Because of the virus' low-level, short-term viraemia in horses, the primary tools used to diagnose WNV are serological tests. Inter-laboratory profi...

journal_title：PLoS neglected tropical diseases

authors： Beck C,Lowenski S,Durand B,Bahuon C,Zientara S,Lecollinet S

更新日期：2017-09-15 00:00:00

abstract：:Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural change...

journal_title：PLoS neglected tropical diseases

authors： Brookes VJ,Dürr S,Ward MP

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommend...

journal_title：PLoS neglected tropical diseases

authors： Irish SR,Al-Amin HM,Paulin HN,Mahmood ASMS,Khan RK,Muraduzzaman AKM,Worrell CM,Flora MS,Karim MJ,Shirin T,Shamsuzzaman AKM,Tahmina S,Lenhart A,Dubray C

更新日期：2018-07-26 00:00:00

abstract：BACKGROUND:The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the new leprosy cases among contacts can help identify the source of infection and interrupt the transmission chain. This study aims to determine the detect...

journal_title：PLoS neglected tropical diseases

authors： Pedrosa VL,Dias LC,Galban E,Leturiondo A,Palheta J Jr,Santos M,Moraes MO,Talhari C

更新日期：2018-02-26 00:00:00

abstract：:The major weaknesses of subunit vaccines are their low immunogenicity and poor efficacy. Adjuvants can help to overcome some of these inherent defects with subunit vaccines. Here, we evaluated the efficacy of the newly developed water-in-oil-in-water multiphase emulsion system, termed PELC, in potentiating the protect...

journal_title：PLoS neglected tropical diseases

authors： Chiang CY,Huang MH,Hsieh CH,Chen MY,Liu HH,Tsai JP,Li YS,Chang CY,Liu SJ,Chong P,Leng CH,Chen HW

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The parasite Onchocerca volvulus has, until recently, been regarded as the cause of a chronic yet non-fatal condition. Recent analyses, however, have indicated that in addition to blindness, the parasite can also be directly associated with human mortality. Such analyses also suggested that the relationship ...

journal_title：PLoS neglected tropical diseases

authors： Walker M,Little MP,Wagner KS,Soumbey-Alley EW,Boatin BA,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：:This paper reports the prevalence and intensity of soil-transmitted helminth (STH) infections measured in Zimbabwe before and after a control intervention based on annual deworming of school-age children (SAC) conducted from 2012 to 2018. In 2010, epidemiological data were collected from 13 195 SAC in 255 randomly sel...

journal_title：PLoS neglected tropical diseases

authors： Midzi N,Montresor A,Mutsaka-Makuvaza MJ,Fronterre C,Manangazira P,Phiri I,Johnson O,Mhlanga G,Diggle PJ

更新日期：2020-10-23 00:00:00

abstract：:The agents of sleeping sickness disease, Trypanosoma brucei complex parasites, are transmitted to mammalian hosts through the bite of an infected tsetse. Information on tsetse-trypanosome interactions in the salivary gland (SG) tissue, and on mammalian infective metacyclic (MC) parasites present in the SG, is sparse. ...

journal_title：PLoS neglected tropical diseases

authors： Telleria EL,Benoit JB,Zhao X,Savage AF,Regmi S,Alves e Silva TL,O'Neill M,Aksoy S

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Most commonly used malaria diagnostic tests, including microscopy and antigen-detecting rapid tests, cannot reliably detect low-density infections which are frequent in low transmission settings. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive but remain too laborious for field...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Martínez NL,González IJ,Arévalo-Herrera M,Herrera S

更新日期：2015-01-08 00:00:00

abstract：:Over two-thirds of the world's population lives in regions where rabies is endemic, resulting in over 15 million people receiving multi-dose post-exposure prophylaxis (PEP) and over 55,000 deaths per year globally. A major goal in rabies virus (RABV) research is to develop a single-dose PEP that would simplify vaccina...

journal_title：PLoS neglected tropical diseases

authors： Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Schistosome cercariae are the human-infectious stage of the Schistosoma parasite. They are shed by snail intermediate hosts living in freshwater, and penetrate the skin of the human host to develop into schistosomes, resulting in schistosomiasis infection. Water treatment (e.g. filtration or chlorination) is...

journal_title：PLoS neglected tropical diseases

authors： Braun L,Hazell L,Webb AJ,Allan F,Emery AM,Templeton MR

更新日期：2020-03-26 00:00:00

abstract：:Apicomplexa tick-borne hemoparasites, including Babesia bovis, Babesia microti, and Theileria equi are responsible for bovine and human babesiosis and equine theileriosis, respectively. These parasites of vast medical, epidemiological, and economic impact have complex life cycles in their vertebrate and tick hosts. La...

journal_title：PLoS neglected tropical diseases

authors： Alzan HF,Knowles DP,Suarez CE

更新日期：2016-11-10 00:00:00

abstract：:Rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium Klebsiella pneumoniae subsp. rhinoscleromatis. The disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. As a consequence, and despite available antibiotherapy, some patients evolve adva...

journal_title：PLoS neglected tropical diseases

authors： Fevre C,Passet V,Deletoile A,Barbe V,Frangeul L,Almeida AS,Sansonetti P,Tournebize R,Brisse S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：:We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA)-which we refer to as 'adherence' and 'non-adherence'. The probability models developed can be informed by observed adherence be...

journal_title：PLoS neglected tropical diseases

authors： Hardwick RJ,Truscott JE,Oswald WE,Werkman M,Halliday KE,Pullan RL,Anderson RM

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Patients with New World cutaneous leishmaniasis (NWCL) caused by Leishmania Viannia are treated with parenteral sodium stibogluconate (SbV) to reduce the risk of development of mucocutanous leishmaniasis. Our centre manages patients with NWCL on an outpatient-basis. This study was conducted to assess the saf...

journal_title：PLoS neglected tropical diseases

authors： Wise ES,Armstrong MS,Watson J,Lockwood DN

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Continued exposure to malaria-causing parasites in endemic regions of malaria induces significant levels of acquired immunity in adult individuals. A better understanding of the transcriptional basis for this acquired immunological response may provide insight into how the immune system can be boosted during...

journal_title：PLoS neglected tropical diseases

authors： Rojas-Peña ML,Vallejo A,Herrera S,Gibson G,Arévalo-Herrera M

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm's economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control o...

journal_title：PLoS neglected tropical diseases

authors： Bartsch SM,Hotez PJ,Asti L,Zapf KM,Bottazzi ME,Diemert DJ,Lee BY

更新日期：2016-09-08 00:00:00

abstract：:Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strat...

journal_title：PLoS neglected tropical diseases

authors： Huang XH,Qian MB,Zhu GH,Fang YY,Hao YT,Lai YS

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:The Asian bush mosquito Aedes japonicus is invading Europe and was first discovered in Lelystad, the Netherlands in 2013, where it has established a permanent population. In this study, we investigated the vector competence of Ae. japonicus from the Netherlands for the emerging Zika virus (ZIKV) and zoonotic...

journal_title：PLoS neglected tropical diseases

authors： Abbo SR,Visser TM,Wang H,Göertz GP,Fros JJ,Abma-Henkens MHC,Geertsema C,Vogels CBF,Koopmans MPG,Reusken CBEM,Hall-Mendelin S,Hall RA,van Oers MM,Koenraadt CJM,Pijlman GP

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is a soil saprophytic bacterium that causes melioidosis. The infection occurs through cutaneous inoculation, inhalation or ingestion. Bacteriophages (phages) in the same ecosystem may significantly impact the biology of this bacterium in the environment, and in their culturability i...

journal_title：PLoS neglected tropical diseases

authors： Withatanung P,Chantratita N,Muangsombut V,Saiprom N,Lertmemongkolchai G,Klumpp J,Clokie MR,Galyov EE,Korbsrisate S

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

journal_title：PLoS neglected tropical diseases

authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

更新日期：2011-02-08 00:00:00

abstract：:Soil-transmitted helminthiases (STHs) constitute a public health problem that requires immediate action to resolve the morbidity of those harboring the parasites in their guts, to prevent infection in all those at risk, and to interrupt the vicious circle of poverty and disease in the affected communities, structural ...

journal_title：PLoS neglected tropical diseases

authors： Krolewiecki AJ

更新日期：2018-09-13 00:00:00

abstract：INTRODUCTION:Previous studies of Ebola Virus Disease (EVD) have focused on clinical symptoms and Ebola virus (EBOV) cycle threshold (CT) values recorded at patient triage. Our study explores EVD symptoms and EBOV CT values from onset of illness to recovery or death in a diverse population of patients. METHODOLOGY/PRIN...

journal_title：PLoS neglected tropical diseases

authors： Skrable K,Roshania R,Mallow M,Wolfman V,Siakor M,Levine AC

更新日期：2017-07-19 00:00:00