Contribution of non-reference alleles in mtDNA of Alzheimer's disease patients.

Abstract:

:Many observations suggest that mutations of mitochondrial DNA (mtDNA) could be responsible for the neurodegenerative changes of Alzheimer's disease (AD). Here we examined the signal intensity of the four alleles of each mtDNA nucleotide position (np) in whole blood of AD patients and age-matched controls using MitoChip v2.0 array. Our analysis identified 270 significantly different nps which, with one exception, showed an increased contribution of non-reference alleles in AD patients. Principal component analysis (PCA) and cluster analysis showed that five of these nps could discriminate AD from control subjects with 80% of cases correctly classified. Our data support the hypothesis of mtDNA alterations as an important factor in the etiology of AD.

journal_name

Ann Clin Transl Neurol

authors

Casoli T,Di Stefano G,Spazzafumo L,Balietti M,Giorgetti B,Giuli C,Postacchini D,Fattoretti P,Conti F

doi

10.1002/acn3.42

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

284-9

issue

4

issn

2328-9503

journal_volume

1

pub_type

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