Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications.

abstract：BACKGROUND:Sudden unexpected death in epilepsy (SUDEP) is common among young people with epilepsy. Individuals who are at high risk of SUDEP exhibit regional brain structural and functional connectivity (FC) alterations compared with low-risk patients. However, less is known about network-based FC differences among cri...

journal_title：Frontiers in neurology

authors： Allen LA,Harper RM,Kumar R,Guye M,Ogren JA,Lhatoo SD,Lemieux L,Scott CA,Vos SB,Rani S,Diehl B

更新日期：2017-10-16 00:00:00

abstract：:With respect to photoreceptor function, it is well known that electroretinogram (ERG) amplitudes decrease with age, but to our knowledge, studies describing age-related changes in the pupil light response (PLR) of mice are lacking. This study recorded the PLR and ERG in C57BL/6 and Sv129S6 wild-type mice at three diff...

journal_title：Frontiers in neurology

authors： Kircher N,Crippa SV,Martin C,Kawasaki A,Kostic C

更新日期：2019-02-04 00:00:00

abstract：:SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most promi...

journal_title：Frontiers in neurology

authors： Khateb M,Bosak N,Muqary M

更新日期：2020-06-23 00:00:00

abstract：:Despite extensive research, the functions of the basal ganglia (BG) in movement control have not been fully understood. Eye movements, particularly saccades, are convenient indicators of BG function. Here, we review the main oculomotor findings reported in Parkinson's disease (PD) and genetic parkinsonian syndromes. P...

journal_title：Frontiers in neurology

authors： Pretegiani E,Optican LM

更新日期：2017-11-09 00:00:00

abstract：:Background: Educational interventions are needed to overcome knowledge-to-action gaps in clinical care. We previously tested the feasibility and potential efficacy of an educational intervention that facilitates treatment decisions in multiple sclerosis care. A demonstration of the usability of such an intervention is...

journal_title：Frontiers in neurology

authors： Saposnik G,Tobler PN,Caceres F,Terzaghi MA,Ruff C,Maurino J,Fruns Quintana M,Oh J,Montalban X,Mamdani M

更新日期：2018-07-10 00:00:00

abstract：BACKGROUND:The neural constraints underlying hemiparetic gait dysfunction are associated with abnormal kinetic outflow and altered muscle synergy structure. Recent evidence from our lab implicates the lesioned hemisphere in mediating the expression of abnormally coupled hip adduction and knee extension synergy, suggest...

journal_title：Frontiers in neurology

authors： Tan AQ,Dhaher YY

更新日期：2017-08-07 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. METHODS:PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapent...

journal_title：Frontiers in neurology

authors： Liu GJ,Karim MR,Xu LL,Wang SL,Yang C,Ding L,Wang YF

更新日期：2017-07-14 00:00:00

abstract：:Introduction: Today, half of the American homeless population is older than 50 years of age. This shift in age distribution among people experiencing homelessness has challenged our long-held views of the causes of homelessness. Age-related neurological diseases, especially neurodegenerative diseases of the brain (NDD...

journal_title：Frontiers in neurology

authors： Piña-Escudero SD,López L,Sriram S,Longoria Ibarrola EM,Miller B,Lanata S

更新日期：2021-01-13 00:00:00

abstract：:Background and Purpose: Recent findings suggested that non-stenosing atherosclerosis (NSA) may play an important pathogenic role, especially in cryptogenic strokes. Furthermore, arterial stiffness has been suggested to be a useful tool in identifying patients with embolic stroke of undetermined source (ESUS) with poor...

journal_title：Frontiers in neurology

authors： Acampa M,Lazzerini PE,Manfredi C,Guideri F,Tassi R,Domenichelli C,Cartocci A,Martini G

更新日期：2020-07-24 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacun...

journal_title：Frontiers in neurology

authors： Leonards CO,Wang L,Fiebach JB,Endres M,Ebinger M

更新日期：2013-07-10 00:00:00

abstract：:Introduction: This study was designed to evaluate risk factors and incidence of epilepsy-related injuries and accidents (ERIA) at an outpatient clinic of a German epilepsy center providing healthcare to a mixed urban and rural population of over one million inhabitants. Methods: Data acquisition was performed between ...

journal_title：Frontiers in neurology

authors： Willems LM,Watermann N,Richter S,Kay L,Hermsen AM,Knake S,Rosenow F,Strzelczyk A

更新日期：2018-06-15 00:00:00

abstract：:Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequency, it is not clear whether this is because of altered hemodynamics caused by the effects of matrix metalloproteinases (MMPs) and/or vertebral artery dominance (VAD). Therefore, we investigate the relationship between pl...

journal_title：Frontiers in neurology

authors： Zhang HL,Peng YF,Zhang DP,Li D,Liu FX,Zhao M,Yin S,Liang JX,Wei TT

更新日期：2020-08-25 00:00:00

abstract：:Current efficacious treatments for traumatic brain injury (TBI) are lacking. Establishment of a protective gut microbiota population offers a compelling therapeutic avenue, as brain injury induces disruptions in the composition of the gut microbiota, i.e., gut dysbiosis, which has been shown to contribute to TBI-relat...

journal_title：Frontiers in neurology

authors： Rice MW,Pandya JD,Shear DA

更新日期：2019-08-16 00:00:00

abstract：:A carotid-jugular fistula is a direct communication between the carotid artery and the jugular vein. Both congenital and spontaneous internal carotid-jugular fistulas are extremely rare. We describe the first case of successful endovascular treatment for a congenital internal carotid-jugular fistula. We report a 64-ye...

journal_title：Frontiers in neurology

authors： Wang M,Fan W,Mungur R,Gu J,Wan S

更新日期：2018-12-18 00:00:00

abstract：:Accurate localization of the Seizure Onset Zone (SOZ) is crucial in patients with drug-resistance focal epilepsy. EEG with fMRI recording (EEG-fMRI) has been proposed as a complementary non-invasive tool, which can give useful additional information in the pre-surgical work-up. However, fMRI maps related to interictal...

journal_title：Frontiers in neurology

authors： Vaudano AE,Avanzini P,Tassi L,Ruggieri A,Cantalupo G,Benuzzi F,Nichelli P,Lemieux L,Meletti S

更新日期：2013-11-14 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), which is TNF receptor superfamily member, contributes to several diseases pathogenesis. The aim of this research was to investigate the relevance of serum TRAIL protein levels and mRNA expression in peripheral blood mononuclear cells (PBMC) of pati...

journal_title：Frontiers in neurology

authors： Tufekci KU,Vurgun U,Yigitaslan O,Keskinoglu P,Yaka E,Kutluk K,Genc S

更新日期：2018-03-05 00:00:00

abstract：:Background: Non-invasive brain-computer interfaces (BCI) represent an emerging technology for enabling persons with impaired or lost grasping and reaching functions due to high spinal cord injury (SCI) to control assistive devices. A major drawback of BCIs is a high rate of false classifications. The robustness and pe...

journal_title：Frontiers in neurology

authors： Keyl P,Schneiders M,Schuld C,Franz S,Hommelsen M,Weidner N,Rupp R

更新日期：2019-01-31 00:00:00

abstract：OBJECTIVE:To assess the progress of the development of the vestibular implant (VI) and its feasibility short-term. DATA SOURCES:A search was performed in Pubmed, Medline, and Embase. Key words used were "vestibular prosth*" and "VI." The only search limit was language: English or Dutch. Additional sources were medical...

journal_title：Frontiers in neurology

authors： van de Berg R,Guinand N,Stokroos RJ,Guyot JP,Kingma H

更新日期：2011-08-11 00:00:00

abstract：:Background: Tuberculous meningitis (TBM) is an extremely devastating inflammation of the central nervous system; however, no available optimum treatment can effectively control the disease so far. Method: The medical records of TBM patients from May 2011 to August 2016 in West China hospital were retrospectively analy...

journal_title：Frontiers in neurology

authors： Abdulaziz ATA,Ren YM,Li W,Li JM,Zhou D

更新日期：2019-06-13 00:00:00

abstract：:Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a...

journal_title：Frontiers in neurology

authors： Fleury-Teixeira P,Caixeta FV,Ramires da Silva LC,Brasil-Neto JP,Malcher-Lopes R

更新日期：2019-10-31 00:00:00

abstract：:Background: Phosphatidylinositol binding clathrin assembly protein (PICALM) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk. Nevertheless, the exact mechanisms through which the variant exert its disease-relevant association remain to be elucidated...

journal_title：Frontiers in neurology

authors： Zhuang L,Liu X,Shi Y,Liu X,Luo B

更新日期：2019-05-08 00:00:00

abstract：:Background/Objective: Stroke is a leading global cause of adult disability. As the population ages as well as suffers co-morbidities, it is expected that the stroke burden will increase further. There are no established safe and effective restorative treatments to facilitate a good functional outcome in stroke patient...

journal_title：Frontiers in neurology

authors： Mu J,Bakreen A,Juntunen M,Korhonen P,Oinonen E,Cui L,Myllyniemi M,Zhao S,Miettinen S,Jolkkonen J

更新日期：2019-03-26 00:00:00

abstract：:A decrease in glutamate in the medial prefrontal cortex (mPFC) has been extensively found in animal models of chronic pain. Given that the mPFC is implicated in emotional appraisal, cognition and extinction of fear, could a potential decrease in glutamate be associated with increased pessimistic thinking, fear and wor...

journal_title：Frontiers in neurology

authors： Naylor B,Hesam-Shariati N,McAuley JH,Boag S,Newton-John T,Rae CD,Gustin SM

更新日期：2019-12-03 00:00:00

abstract：:Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autoc...

journal_title：Frontiers in neurology

authors： Delezie J,Handschin C

更新日期：2018-08-24 00:00:00

abstract：BACKGROUND:A possible link between 3D movies and headache (HA) has never been a target of specific and systematic investigations. The aim of this study was to investigate the relationship between 3D cinema and HA and to evaluate possible risk factors of developing HA during or after watching a 3D movie. METHODS:This w...

journal_title：Frontiers in neurology

authors： Braschinsky M,Raidvee A,Sabre L,Zmachinskaja N,Zukovskaja O,Karask A,Saar B,Rakitin A

更新日期：2016-03-23 00:00:00

abstract：:Localization of the epileptogenic zone (EZ) is crucial in the surgical treatment of focal epilepsy. Recently, EEG studies have revealed that the EZ exhibits abnormal connectivity, which has led investigators to now consider connectivity as a biomarker to localize the EZ. Further, abnormal connectivity of the EZ may pr...

journal_title：Frontiers in neurology

authors： Gupta K,Grover P,Abel TJ

更新日期：2020-11-25 00:00:00

abstract：:Studies suggest that microRNAs that regulate expression of matrix metalloproteinase (MMP)-9 may be involved in hemorrhagic transformation (HT) after cardioembolic stroke, so we examined whether such microRNAs could predict HT in acute cardioembolic stroke patients. Blood samples were prospectively collected from patie...

journal_title：Frontiers in neurology

authors： Zheng L,Xiong Y,Liu J,Yang X,Wang L,Zhang S,Liu M,Wang D

更新日期：2019-09-06 00:00:00

abstract：:Background and objective: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic arteriopathy, the classic feature of which is small vessel lesions. Studies on intracranial large arteries in CADASIL are not common. We aim to evaluate intracranial l...

journal_title：Frontiers in neurology

authors： Zhang C,Li W,Li S,Niu S,Wang X,Yu X,Zhang Z

更新日期：2020-08-18 00:00:00

abstract：OBJECTIVE:Effective stroke care does not end with acute treatment during hospitalization, but extends through rehabilitation and secondary stroke prevention. In transitions across care environments, stroke patients are vulnerable to errors in communication of diagnosis and treatment. This study aimed to demonstrate tha...

journal_title：Frontiers in neurology

authors： Hill CE,Varma P,Lenrow D,Price RS,Kasner SE

更新日期：2015-10-27 00:00:00

abstract：:Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural conditions, i.e., in the home environment. Iron accumulation in the basal ganglia is deleterious in Parkinson's disease (i.e., iron accumulation with lower striatal level of dopamine). The ...

journal_title：Frontiers in neurology

authors： Hopfner F,Hobert MA,Maetzler C,Hansen C,Pham MH,Moreau C,Berg D,Devos D,Maetzler W,Fair-Park II study group.

更新日期：2019-08-08 00:00:00