Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings.


BACKGROUND:Venom recurrence or persistence in the circulation after antivenom treatment has been documented many times in viper envenoming. However, it has not been associated with clinical recurrence for many snakes, including Russell's viper (Daboia spp.). We compare the recovery of coagulopathy to the recurrence or persistence of venom in patients with Russell's viper envenoming. METHODOLOGY/PRINCIPAL FINDINGS:The study included patients with Russell's viper (D. russelii) envenoming presenting over a 30 month period who had Russell's viper venom detected by enzyme immunoassay. Demographics, information on the snake bite, and clinical effects were collected for all patients. All patients had serum collected for venom specific enzyme immunoassay and citrate plasma to measure fibrinogen levels and prothrombin time (international normalised ratio; INR). Patients with venom recurrence/persistence were compared to those with no detectable recurrence of venom. There were 55 patients with confirmed Russell's viper envenoming and coagulopathy with low fibrinogen concentrations: 31 with venom recurrence/persistence, and 24 with no venom detected post-antivenom. Fibrinogen concentrations increased and INR decreased after antivenom in both the recurrence and non-recurrence patients. Clinical features, laboratory parameters, antivenom dose and length of hospital were similar for both groups. Pre-antivenom venom concentrations were higher in patients with venom recurrence/persistence with a median venom concentration of 385 ng/mL (16-1521 ng/mL) compared to 128 ng/mL (14-1492 ng/mL; p = 0.008). CONCLUSION:Recurrence of Russell's viper venom was not associated with a recurrence of coagulopathy and length of hospital stay. Further work is required to determine if the detection of venom recurrence is due to the venom specific enzyme immunoassay detecting both venom-antivenom complexes as well as free venom.


PLoS Negl Trop Dis


Maduwage K,O'Leary MA,Scorgie FE,Shahmy S,Mohamed F,Abeysinghe C,Karunathilake H,Lincz LF,Gnanathasan CA,Isbister GK




Has Abstract


2014-12-18 00:00:00














  • A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

    abstract:BACKGROUND:Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Tsuda Y,Caposio P,Parkins CJ,Botto S,Messaoudi I,Cicin-Sain L,Feldmann H,Jarvis MA

    更新日期:2011-08-01 00:00:00

  • Temperature modulates dengue virus epidemic growth rates through its effects on reproduction numbers and generation intervals.

    abstract::Epidemic growth rate, r, provides a more complete description of the potential for epidemics than the more commonly studied basic reproduction number, R0, yet the former has never been described as a function of temperature for dengue virus or other pathogens with temperature-sensitive transmission. The need to unders...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Siraj AS,Oidtman RJ,Huber JH,Kraemer MUG,Brady OJ,Johansson MA,Perkins TA

    更新日期:2017-07-19 00:00:00

  • Health-related impact on quality of life and coping strategies for chikungunya: A qualitative study in Curaçao.

    abstract:INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Elsinga J,Grobusch MP,Tami A,Gerstenbluth I,Bailey A

    更新日期:2017-10-09 00:00:00

  • Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

    abstract::The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Trypanosoma brucei muta...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Graf FE,Ludin P,Wenzler T,Kaiser M,Brun R,Pyana PP,Büscher P,de Koning HP,Horn D,Mäser P

    更新日期:2013-10-10 00:00:00

  • Animal reservoir, natural and socioeconomic variations and the transmission of hemorrhagic fever with renal syndrome in Chenzhou, China, 2006-2010.

    abstract:BACKGROUND:China has the highest incidence of hemorrhagic fever with renal syndrome (HFRS) worldwide. Reported cases account for 90% of the total number of global cases. By 2010, approximately 1.4 million HFRS cases had been reported in China. This study aimed to explore the effect of the rodent reservoir, and natural ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Xiao H,Tian HY,Gao LD,Liu HN,Duan LS,Basta N,Cazelles B,Li XJ,Lin XL,Wu HW,Chen BY,Yang HS,Xu B,Grenfell B

    更新日期:2014-01-09 00:00:00

  • Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense.

    abstract::Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for the detection of antibodies to Trypanosoma congo...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Fleming JR,Sastry L,Crozier TW,Napier GB,Sullivan L,Ferguson MA

    更新日期:2014-06-12 00:00:00

  • Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein.

    abstract::The enteric protozoa Entamoeba histolytica is the causative agent of amebiasis, which is one of the most common parasitic diseases in developed and developing countries. Entamoeba nuttalli is the genetically closest species to E. histolytica in current phylogenetic analyses of Entamoeba species, and is prevalent in wi...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Tanaka M,Makiuchi T,Komiyama T,Shiina T,Osaki K,Tachibana H

    更新日期:2019-12-05 00:00:00

  • IL-33/ST2 correlates with severity of haemorrhagic fever with renal syndrome and regulates the inflammatory response in Hantaan virus-infected endothelial cells.

    abstract:BACKGROUND:Hantaan virus (HTNV) causes a severe lethal haemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of the abundant production of pro-inflammatory cytokines has been widely recognized. Interleukin 33 (IL-33) has been demonstrated to...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Zhang Y,Zhang C,Zhuang R,Ma Y,Zhang Y,Yi J,Yang A,Jin B

    更新日期:2015-02-06 00:00:00

  • Phylogeography of recently emerged DENV-2 in southern Viet Nam.

    abstract::Revealing the dispersal of dengue viruses (DENV) in time and space is central to understanding their epidemiology. However, the processes that shape DENV transmission patterns at the scale of local populations are not well understood, particularly the impact of such factors as human population movement and urbanizatio...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Rabaa MA,Ty Hang VT,Wills B,Farrar J,Simmons CP,Holmes EC

    更新日期:2010-07-27 00:00:00

  • Using the prevalence of individual species of intestinal nematode worms to estimate the combined prevalence of any species.

    abstract:OBJECTIVES:To assess if a probabilistic model could be used to estimate the combined prevalence of infection with any species of intestinal nematode worm when only the separate prevalence of each species is reported, and to estimate the extent to which simply taking the highest individual species prevalence underestima...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: de Silva N,Hall A

    更新日期:2010-04-13 00:00:00

  • Hydrological Regime and Water Shortage as Drivers of the Seasonal Incidence of Diarrheal Diseases in a Tropical Montane Environment.

    abstract:BACKGROUND:The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowled...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Boithias L,Choisy M,Souliyaseng N,Jourdren M,Quet F,Buisson Y,Thammahacksa C,Silvera N,Latsachack K,Sengtaheuanghoung O,Pierret A,Rochelle-Newall E,Becerra S,Ribolzi O

    更新日期:2016-12-09 00:00:00

  • Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells.

    abstract::Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Middle East, affecting both humans and ruminants. There are no licensed vaccines or antivirals available for humans, whereas research using RVF virus (RVFV) is strictly regulated in many countries with safety concerns. Nonpathogenic...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Hallam HJ,Lokugamage N,Ikegami T

    更新日期:2019-11-21 00:00:00

  • Characterization of a Trichinella spiralis putative serine protease. Study of its potential as sero-diagnostic tool.

    abstract:BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

    更新日期:2018-05-14 00:00:00

  • Distribution and seasonal fluctuations of Ae. aegypti and Ae. albopictus larval and pupae in residential areas in an urban landscape.

    abstract::Dengue, a vector-borne disease spread by Aedes mosquitoes, is a global threat. In the absence of an efficacious dengue vaccine, vector control is the key intervention tool in Singapore. A good understanding of vector habitats is essential to formulate operational strategies. We examined the distribution, long-term tre...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Rajarethinam J,Ong J,Neo ZW,Ng LC,Aik J

    更新日期:2020-04-20 00:00:00

  • Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study.

    abstract:BACKGROUND:Schistosomiasis remains a global public health challenge, with 93% of the ~237 million infections occurring in sub-Saharan Africa. Though rarely fatal, its recurring nature makes it a lifetime disorder with significant chronic health burdens. Much of its negative health impact is due to non-specific conditio...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Terer CC,Bustinduy AL,Magtanong RV,Muhoho N,Mungai PL,Muchiri EM,Kitron U,King CH,Mutuku FM

    更新日期:2013-01-01 00:00:00

  • Barriers to Buruli ulcer treatment completion in the Ashanti and Central Regions, Ghana.

    abstract:BACKGROUND:Buruli ulcer is a chronic ulcerating skin condition, with the highest burden found in Central and West Africa where it disproportionately affects the most vulnerable populations. Treatment is demanding, comprising eight-weeks of daily antibiotics, regular wound care and possible surgical intervention. Treatm...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Collinson S,Frimpong VNB,Agbavor B,Montgomery B,Oppong M,Frimpong M,Amoako YA,Marks M,Phillips RO

    更新日期:2020-05-26 00:00:00

  • Video as a public health knowledge transfer tool in Burkina Faso: A mixed evaluation comparing three narrative genres.

    abstract:BACKGROUND:The dengue virus is endemic in many low- and middle-income countries. In Burkina Faso, the proportion of fevers that could be due to dengue is growing. In 2013, a dengue epidemic spread there, followed by other seasonal outbreaks. Dengue is often confused with malaria, and health workers are not trained to d...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Hébert C,Dagenais C,Mc Sween-Cadieux E,Ridde V

    更新日期:2020-06-10 00:00:00

  • Mosquito-disseminated pyriproxyfen yields high breeding-site coverage and boosts juvenile mosquito mortality at the neighborhood scale.

    abstract:BACKGROUND:Mosquito-borne pathogens pose major public health challenges worldwide. With vaccines or effective drugs still unavailable for most such pathogens, disease prevention heavily relies on vector control. To date, however, mosquito control has proven difficult, with low breeding-site coverage during control camp...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Abad-Franch F,Zamora-Perea E,Ferraz G,Padilla-Torres SD,Luz SL

    更新日期:2015-04-07 00:00:00

  • Updated global burden of cholera in endemic countries.

    abstract:BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ali M,Nelson AR,Lopez AL,Sack DA

    更新日期:2015-06-04 00:00:00

  • The genus Madurella: Molecular identification and epidemiology in Sudan.

    abstract::Eumycetoma (mycotic mycetoma) is the fungal form of mycetoma, a subcutaneous infection occurring in individuals living in endemic areas of the disease. The Sudan is hyperendemic for mycetoma, with the highest incidence being reported from Gezira State, Central Sudan. The present study was conducted at the Gezira Mycet...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ahmed EA,Nour BYM,Abakar AD,Hamid S,Mohamadani AA,Daffalla M,Mahmoud M,Altayb HN,Desnos-Ollivier M,de Hoog S,Ahmed SA

    更新日期:2020-07-30 00:00:00

  • Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.

    abstract::Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever, a systemic human infection with a burden exceeding 20 million cases each year that occurs disproportionately among children in low and middle income countries. Antimicrobial therapy is the mainstay for treatment, but resistance to mu...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Ingle DJ,Nair S,Hartman H,Ashton PM,Dyson ZA,Day M,Freedman J,Chattaway MA,Holt KE,Dallman TJ

    更新日期:2019-09-12 00:00:00

  • Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis.

    abstract::Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histon...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章,评审


    authors: de Oliveira FL,Carneiro K,Brito JM,Cabanel M,Pereira JX,Paiva LA,Syn W,Henderson NC,El-Cheikh MC

    更新日期:2017-02-23 00:00:00

  • FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.

    abstract::Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function r...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Novozhilova E,Kimber MJ,Qian H,McVeigh P,Robertson AP,Zamanian M,Maule AG,Day TA

    更新日期:2010-08-10 00:00:00

  • Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging.

    abstract:OBJECTIVE:Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Grab DJ,Nikolskaia OV,Courtioux B,Thekisoe OMM,Magez S,Bogorad M,Dumler JS,Bisser S

    更新日期:2019-08-19 00:00:00

  • Tracing the tiger: population genetics provides valuable insights into the Aedes (Stegomyia) albopictus invasion of the Australasian Region.

    abstract:BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

    更新日期:2013-08-08 00:00:00

  • Impact of repeated annual community directed treatment with ivermectin on loiasis parasitological indicators in Cameroon: Implications for onchocerciasis and lymphatic filariasis elimination in areas co-endemic with Loa loa in Africa.

    abstract:BACKGROUND:Loiasis is a filarial infection endemic in the rainforest zone of west and central Africa particularly in Cameroon, Gabon, Republic of Congo, and Democratic Republic of the Congo. Repeated treatments with ivermectin have been delivered using the annual community directed treatment with ivermectin (CDTI) appr...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Wanji S,Chounna Ndongmo WP,Fombad FF,Kengne-Ouafo JA,Njouendou AJ,Longang Tchounkeu YF,Koudou B,Bockarie M,Fobi G,Roungou JB,Enyong PA

    更新日期:2018-09-18 00:00:00

  • Vector competence of Aedes aegypti, Culex tarsalis, and Culex quinquefasciatus from California for Zika virus.

    abstract::Zika virus (ZIKV) has emerged since 2013 as a significant global human health threat following outbreaks in the Pacific Islands and rapid spread throughout South and Central America. Severe congenital and neurological sequelae have been linked to ZIKV infections. Assessing the ability of common mosquito species to tra...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Main BJ,Nicholson J,Winokur OC,Steiner C,Riemersma KK,Stuart J,Takeshita R,Krasnec M,Barker CM,Coffey LL

    更新日期:2018-06-21 00:00:00

  • Clinical and molecular epidemiology of Crimean-Congo hemorrhagic fever in Oman.

    abstract:BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a serious disease with a high fatality rate reported in many countries. The first case of CCHF in Oman was detected in 1995 and serosurveys have suggested widespread infection of humans and livestock throughout the country. METHODOLOGY:Cases of CCHF reported to the ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Al-Abri SS,Hewson R,Al-Kindi H,Al-Abaidani I,Al-Jardani A,Al-Maani A,Almahrouqi S,Atkinson B,Al-Wahaibi A,Al-Rawahi B,Bawikar S,Beeching NJ

    更新日期:2019-04-25 00:00:00

  • Common host-derived chemicals increase catches of disease-transmitting mosquitoes and can improve early warning systems for Rift Valley fever virus.

    abstract::Rift Valley fever (RVF), a mosquito-borne zoonosis, is a major public health and veterinary problem in sub-Saharan Africa. Surveillance to monitor mosquito populations during the inter-epidemic period (IEP) and viral activity in these vectors is critical to informing public health decisions for early warning and contr...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Tchouassi DP,Sang R,Sole CL,Bastos AD,Teal PE,Borgemeister C,Torto B

    更新日期:2013-01-01 00:00:00

  • Mycobacterium africanum is associated with patient ethnicity in Ghana.

    abstract::Mycobacterium africanum is a member of the Mycobacterium tuberculosis complex (MTBC) and an important cause of human tuberculosis in West Africa that is rarely observed elsewhere. Here we genotyped 613 MTBC clinical isolates from Ghana, and searched for associations between the different phylogenetic lineages of MTBC ...

    journal_title:PLoS neglected tropical diseases

    pub_type: 杂志文章


    authors: Asante-Poku A,Yeboah-Manu D,Otchere ID,Aboagye SY,Stucki D,Hattendorf J,Borrell S,Feldmann J,Danso E,Gagneux S

    更新日期:2015-01-08 00:00:00