Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.

abstract：BACKGROUND:Recent work has established that Parkinson's disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as potentially be linked to the migration of peripheral inflammatory factors ...

journal_title：Journal of neuroinflammation

authors： Dwyer Z,Chaiquin M,Landrigan J,Ayoub K,Shail P,Rocha J,Childers CL,Storey KB,Philpott DJ,Sun H,Hayley S

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

journal_title：Journal of neuroinflammation

authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophages ...

journal_title：Journal of neuroinflammation

authors： Chu T,Zhang YP,Tian Z,Ye C,Zhu M,Shields LBE,Kong M,Barnes GN,Shields CB,Cai J

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:Chungsim-Yeunja-Tang (CYT) has been used as a medicine for cerebral infarction (CI) patients in Korea. The objective of this study was to determine precisely the effect of CYT on CI patients using peripheral blood mononuclear cells (PBMCs). METHODS:For a clinical study, 47 CI patients were identified who ha...

journal_title：Journal of neuroinflammation

authors： Jeong HJ,Choi IY,Kim MH,Kim HM,Moon PD,Hong JW,Kim SH

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer's disease (AD) pathology. However, the precise mechanism involved in the regulation of MerTK expression by amyloid-β...

journal_title：Journal of neuroinflammation

authors： Jhang KA,Park JS,Kim HS,Chong YH

更新日期：2018-03-12 00:00:00

abstract：:The complement cascade is a critical effector mechanism of the innate immune system that contributes to the rapid clearance of pathogens and dead or dying cells, as well as contributing to the extent and limit of the inflammatory immune response. In addition, some of the early components of this cascade have been clea...

journal_title：Journal of neuroinflammation

authors： Schartz ND,Tenner AJ

更新日期：2020-11-25 00:00:00

abstract：:Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavio...

journal_title：Journal of neuroinflammation

authors： Alboni S,Cervia D,Sugama S,Conti B

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

journal_title：Journal of neuroinflammation

authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission o...

journal_title：Journal of neuroinflammation

authors： Yang S,Gao L,Lu F,Wang B,Gao F,Zhu G,Cai Z,Lai J,Yang Q

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

journal_title：Journal of neuroinflammation

authors： Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind only Alzheimer's disease (AD); however, VCID is commonly found as a co-morbidity with sporadic AD. We have previously established a mouse model of VCID by inducing hyperhomocysteinemia in both w...

journal_title：Journal of neuroinflammation

authors： Weekman EM,Sudduth TL,Price BR,Woolums AE,Hawthorne D,Seaks CE,Wilcock DM

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. METHODS:Expression levels of proinflammatory cytokines were tested by QT-PCR and ELISA, levels of IDOs were...

journal_title：Journal of neuroinflammation

authors： Jiang X,Xu L,Tang L,Liu F,Chen Z,Zhang J,Chen L,Pang C,Yu X

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is an important inflammatory factor produced by activated macrophages and monocytes and plays an important role in the pathogenesis of diabetic peripheral neuropathy (DPN). To evaluate the effect of TNF-α signaling suppression and the potential of TNF-α in the treatment of DPN...

journal_title：Journal of neuroinflammation

authors： Shi X,Chen Y,Nadeem L,Xu G

更新日期：2013-06-04 00:00:00

abstract：BACKGROUND:MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are involved in neuropathic pain. ME...

journal_title：Journal of neuroinflammation

authors： Liu F,Wang Z,Qiu Y,Wei M,Li C,Xie Y,Shen L,Huang Y,Ma C

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Local and systemic inflammatory responses are initiated early after traumatic brain injury (TBI), and may play a key role in the secondary injury processes resulting in neuronal loss and neurological deficits. However, the mechanisms responsible for the rapid expansion of neuroinflammation and its long-term ...

journal_title：Journal of neuroinflammation

authors： Kumar A,Stoica BA,Loane DJ,Yang M,Abulwerdi G,Khan N,Kumar A,Thom SR,Faden AI

更新日期：2017-03-15 00:00:00

abstract：:Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previo...

journal_title：Journal of neuroinflammation

authors： Liu CH,Yang MH,Zhang GZ,Wang XX,Li B,Li M,Woelfer M,Walter M,Wang L

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, wh...

journal_title：Journal of neuroinflammation

authors： Kasanmoentalib ES,Valls Seron M,Ferwerda B,Tanck MW,Zwinderman AH,Baas F,van der Ende A,Schwaeble WJ,Brouwer MC,van de Beek D

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was to gain more insight into the frequency, distribution and cellular architecture...

journal_title：Journal of neuroinflammation

authors： van Horssen J,Singh S,van der Pol S,Kipp M,Lim JL,Peferoen L,Gerritsen W,Kooi EJ,Witte ME,Geurts JJ,de Vries HE,Peferoen-Baert R,van den Elsen PJ,van der Valk P,Amor S

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Ischemic stroke is a leading cause of disability worldwide and characteristically accompanied by downregulation of the Wnt/β-catenin signaling. Activation of Wnt/β-catenin signaling emerges to attenuate neuroinflammation after ischemic stroke; however, its effect on modulating microglial polarization is larg...

journal_title：Journal of neuroinflammation

authors： Song D,Zhang X,Chen J,Liu X,Xue J,Zhang L,Lan X

更新日期：2019-12-06 00:00:00

abstract：OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

journal_title：Journal of neuroinflammation

authors： Alabdali A,Al-Ayadhi L,El-Ansary A

更新日期：2014-01-08 00:00:00

abstract：BACKGROUND:The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complication...

journal_title：Journal of neuroinflammation

authors： Guo Z,Yu S,Xiao L,Chen X,Ye R,Zheng P,Dai Q,Sun W,Zhou C,Wang S,Zhu W,Liu X

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation. Inflammation may be involved in the subsequent development of neurodegenerative diseases and post-injury seizures. The p75 neurot...

journal_title：Journal of neuroinflammation

authors： Lee S,Mattingly A,Lin A,Sacramento J,Mannent L,Castel MN,Canolle B,Delbary-Gossart S,Ferzaz B,Morganti JM,Rosi S,Ferguson AR,Manley GT,Bresnahan JC,Beattie MS

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Atypical chemokine receptor 3 (ACKR3, synonym CXCR7) is increasingly considered relevant in neuroinflammatory conditions, in which its upregulation contributes to compromised endothelial barrier function and may ultimately allow inflammatory brain injury. While an impact of ACKR3 has been recognized in sever...

journal_title：Journal of neuroinflammation

authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Buttmann M,Glaser K

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully unde...

journal_title：Journal of neuroinflammation

authors： Coelho-Santos V,Gonçalves J,Fontes-Ribeiro C,Silva AP

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Retinal ischemia results in neuronal degeneration and contributes to the pathogenesis of multiple blinding diseases. Recently, the fumaric acid ester dimethyl fumarate (DMF) has been FDA-approved for the treatment of multiple sclerosis, based on its neuroprotective and anti-inflammatory effects. Its potentia...

journal_title：Journal of neuroinflammation

authors： Cho H,Hartsock MJ,Xu Z,He M,Duh EJ

更新日期：2015-12-21 00:00:00

abstract：BACKGROUND:Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far. METHODS...

journal_title：Journal of neuroinflammation

authors： Ma L,Piirainen S,Kulesskaya N,Rauvala H,Tian L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells). Thus, a strict separation between the two T cell subsets in the context of experimental ...

journal_title：Journal of neuroinflammation

authors： Loos J,Schmaul S,Noll TM,Paterka M,Schillner M,Löffel JT,Zipp F,Bittner S

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. METHODS:A perioperative neurocognitive disorders (PND) mouse model was generated...

journal_title：Journal of neuroinflammation

authors： Li D,Chen M,Meng T,Fei J

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory reaction in response to bacterial brain invasion. Metformin-a biguanide...

journal_title：Journal of neuroinflammation

authors： Muri L,Le ND,Zemp J,Grandgirard D,Leib SL

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood. OBJECTIVE:We explored the central nervous system consequences of subchronic exposure to diesel exhaust (DE) and addr...

journal_title：Journal of neuroinflammation

authors： Levesque S,Surace MJ,McDonald J,Block ML

更新日期：2011-08-24 00:00:00