Altered cortical thickness following prenatal sodium valproate exposure.

Abstract:

:Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

journal_name

Ann Clin Transl Neurol

authors

Wood AG,Chen J,Barton S,Nadebaum C,Anderson VA,Catroppa C,Reutens DC,O'Brien TJ,Vajda F

doi

10.1002/acn3.74

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

497-501

issue

7

issn

2328-9503

journal_volume

1

pub_type

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