Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention.

abstract：:Japan recently ordered a string of death sentences for offenders with mental illness. Based on the verdicts, we describe cases where one or more psychiatrists conducted psychiatric evaluations for several months and testified in lay judge courts. We compared these cases with those in which the death penalty was avoide...

journal_title：Frontiers in psychiatry

authors： Kashiwagi H,Hirabayashi N

更新日期：2018-11-02 00:00:00

abstract：Background:Chronic insomnia is common in patients with arteriosclerotic cerebral small vessel disease (CSVD) and aggravates the cognitive impairment caused by CSVD. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients. This study was per...

journal_title：Frontiers in psychiatry

authors： Wang J,Liu S,Zhao C,Han H,Chen X,Tao J,Lu Z

更新日期：2020-06-30 00:00:00

abstract：:The human gut microbiome is emerging as a key modulator of homeostasis, with far-reaching implications for various multifactorial diseases, including anorexia nervosa (AN). Despite significant morbidity and mortality, the underlying mechanisms of this eating disorder are poorly understood, but the classical view defin...

journal_title：Frontiers in psychiatry

authors： Ghenciulescu A,Park RJ,Burnet PWJ

更新日期：2021-01-12 00:00:00

abstract：:Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate ...

journal_title：Frontiers in psychiatry

authors： Jones JL,Mateus CF,Malcolm RJ,Brady KT,Back SE

更新日期：2018-07-24 00:00:00

abstract：:The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...

journal_title：Frontiers in psychiatry

authors： Spinola O,Liotti M,Speranza AM,Tambelli R

更新日期：2020-11-17 00:00:00

abstract：:Objective: We aimed to conduct a comparative analysis of the psychological stress experienced by healthcare workers, frontline workers, and the general public and to assess the factors associated with psychological stress in each of these groups. Methods: We conducted an online survey targeting healthcare workers, fro...

journal_title：Frontiers in psychiatry

authors： Luan R,Pu W,Dai L,Yang R,Wang P

更新日期：2020-12-01 00:00:00

abstract：:Background: While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and ...

journal_title：Frontiers in psychiatry

authors： Pedrelli P,Fedor S,Ghandeharioun A,Howe E,Ionescu DF,Bhathena D,Fisher LB,Cusin C,Nyer M,Yeung A,Sangermano L,Mischoulon D,Alpert JE,Picard RW

更新日期：2020-12-18 00:00:00

abstract：:Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) associated with the first 4 years following diagnosis with schizophrenia. Whilst this finding is novel, apolipoprotein E (APOE), which mediates its activity through LRPs, has been reported by...

journal_title：Frontiers in psychiatry

authors： Gibbons AS,Thomas EA,Scarr E,Dean B

更新日期：2010-07-08 00:00:00

abstract：:Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle b...

journal_title：Frontiers in psychiatry

authors： Berardelli I,Corigliano V,Hawkins M,Comparelli A,Erbuto D,Pompili M

更新日期：2018-11-06 00:00:00

abstract：Background:In the Corona Virus Disease 2019 (COVID-19) pandemic, the primary problem is respiratory-related, but there also is increasing evidence of central nervous system (CNS) involvement. This study aims to summarize the literature on neurological manifestations of COVID-19, underlying mechanisms of CNS involvement...

journal_title：Frontiers in psychiatry

authors： Wenting A,Gruters A,van Os Y,Verstraeten S,Valentijn S,Ponds R,de Vugt M

更新日期：2020-08-21 00:00:00

abstract：BACKGROUND:The treatment of cocaine-dependent individuals (CDI) is substantially challenged by high drop-out rates, raising questions regarding contributing factors. Recently, a number of studies have highlighted the potential of greater focus on the clinical significance of neurocognitive impairments in treatment-seek...

journal_title：Frontiers in psychiatry

authors： Stevens L,Betanzos-Espinosa P,Crunelle CL,Vergara-Moragues E,Roeyers H,Lozano O,Dom G,Gonzalez-Saiz F,Vanderplasschen W,Verdejo-García A,Pérez-García M

更新日期：2013-11-15 00:00:00

abstract：:Objectives: While evidence that episodes of mania in bipolar I are associated with changes in bioenergetic and regional cerebral blood flow (rCBF) and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. Therefore, we determined the pattern of regional cereb...

journal_title：Frontiers in psychiatry

authors： Wang Y,Liu X,Li P,Zhou H,Yang L,Zheng L,Xie P,Li L,Liao DJ,Liu Q,Fang D

更新日期：2018-07-04 00:00:00

abstract：:Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addict...

journal_title：Frontiers in psychiatry

authors： Verdejo-Garcia A,Lorenzetti V,Manning V,Piercy H,Bruno R,Hester R,Pennington D,Tolomeo S,Arunogiri S,Bates ME,Bowden-Jones H,Campanella S,Daughters SB,Kouimtsidis C,Lubman DI,Meyerhoff DJ,Ralph A,Rezapour T,Tavakoli H

更新日期：2019-12-23 00:00:00

abstract：:Recently, imaging biomarkers have gained importance for the characterization of patients with Alzheimer's disease; however, the relationship between regional biomarker expression and cognitive function remains unclear. In our study, we investigated associations between scores on CERAD neuropsychological assessment bat...

journal_title：Frontiers in psychiatry

authors： Hedderich DM,Drost R,Goldhardt O,Ortner M,Müller-Sarnowski F,Diehl-Schmid J,Zimmer C,Förstl H,Yakushev I,Jahn T,Grimmer T

更新日期：2020-08-13 00:00:00

abstract：:In depression, brain and behavioral correlates of decision-making differ between individuals with and without suicidal thoughts and behaviors. Though promising, it remains unknown if these potential biomarkers of suicidality will generalize to other high-risk clinical populations. To preliminarily assess whether brain...

journal_title：Frontiers in psychiatry

authors： Barredo J,Aiken E,van 't Wout-Frank M,Greenberg BD,Carpenter LL,Philip NS

更新日期：2019-02-12 00:00:00

abstract：:Burnout syndrome is a state of total exhaustion related to work conditions and stress from work. Recent findings suggest that logotherapy and the concepts of existential meaning and life fulfilment could provide a useful framework for explaining and potentially preventing burnout. This review article summarizes and re...

journal_title：Frontiers in psychiatry

authors： Riethof N,Bob P

更新日期：2019-06-14 00:00:00

abstract：:Background: Voxel-based morphometry studies have repeatedly highlighted the presence of distributed gray matter changes in schizophrenia, but to date, it is not clear if clinically useful prognostic information can be gleaned from structural imaging. The suspected association between gray matter volume (GMV) and durat...

journal_title：Frontiers in psychiatry

authors： Li M,Li X,Das TK,Deng W,Li Y,Zhao L,Ma X,Wang Y,Yu H,Meng Y,Wang Q,Palaniyappan L,Li T

更新日期：2019-04-15 00:00:00

abstract：:Depression is one of the most prevalent and serious mental disorders with a worldwide significant health burden. Metabolic abnormalities and disorders in patients with depression have attracted great research attention. Thirty-six metabolic biomarkers of clinical plasma metabolomics were detected by platform technolog...

journal_title：Frontiers in psychiatry

authors： Gao Y,Xu T,Zhao YX,Ling-Hu T,Liu SB,Tian JS,Qin XM

更新日期：2020-07-15 00:00:00

abstract：:Introduction: Clozapine is the most effective antipsychotic used for treatment resistant schizophrenia and recurrent suicidal behavior in schizophrenia or schizoaffective disorder. However, it has been underutilized due to its adverse reaction profile. Although clozapine is typically associated with neutropenia leadin...

journal_title：Frontiers in psychiatry

authors： Torrico T,Crandall RO,Meza C,Abdijadid S

更新日期：2020-10-14 00:00:00

abstract：Objective:There is increasing interest in the utility of gamma-band activity for assessing various brain functions, including perception, language, memory, and cognition. The auditory steady-state response (ASSR) involves neural activity in the brain elicited by trains of a click sound, and its maximum response is obta...

journal_title：Frontiers in psychiatry

authors： Hirano Y,Nakamura I,Tamura S,Onitsuka T

更新日期：2020-09-02 00:00:00

abstract：:Background: Anorexia nervosa (AN) is a psychiatric illness that without early effective treatment becomes chronic with high physical, psychological and social morbidity and high mortality. Pilates exercises can improve quality of life and increase body awareness in different clinical and healthy populations. The aim o...

journal_title：Frontiers in psychiatry

authors： Martínez-Sánchez SM,Martínez-García C,Martínez-García TE,Munguía-Izquierdo D

更新日期：2020-10-30 00:00:00

abstract：:Background: People with severe mental illness have difficulties finding and maintaining competitive employment. This is particularly so for those living in supported housing who, by definition, have significant day-to-day support needs: in the Netherlands only 3 to 5% of people with serious mental health problems who ...

journal_title：Frontiers in psychiatry

authors： Roeg D,de Winter L,Bergmans C,Couwenbergh C,McPherson P,Killaspy H,van Weeghel J

更新日期：2021-01-14 00:00:00

abstract：:Background: The issue of treatment resistance in eating disorder care is controversial. Prior research has identified multiple failed treatment attempts as a common criterion for severe and enduring anorexia nervosa, but little is known about patients who have multiple failed treatment attempts. This study was designe...

journal_title：Frontiers in psychiatry

authors： Smith S,Woodside DB

更新日期：2021-01-08 00:00:00

abstract：:This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) ...

journal_title：Frontiers in psychiatry

authors： Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D

更新日期：2019-04-16 00:00:00

abstract：:Objective: We aimed to determine the prevalence of burnout among hospital healthcare workers in Libya during the coronavirus disease (COVID-19) pandemic and civil war. Methods: A cross-sectional study was conducted from April 18 to May 2, 2020 among Libyan healthcare workers. Data on participant characteristics were c...

journal_title：Frontiers in psychiatry

authors： Elhadi M,Msherghi A,Elgzairi M,Alhashimi A,Bouhuwaish A,Biala M,Abuelmeda S,Khel S,Khaled A,Alsoufi A,Elmabrouk A,Alshiteewi FB,Hamed TB,Alhadi B,Alhaddad S,Elhadi A,Zaid A

更新日期：2020-12-11 00:00:00

abstract：:Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellectual disabilities and/or cognitive decline. We previously developed th...

journal_title：Frontiers in psychiatry

authors： Startin CM,Lowe B,Hamburg S,Hithersay R,Strydom A,LonDownS Consortium.

更新日期：2019-04-16 00:00:00

abstract：:This article discusses yoga as a potential tool for children to deal with stress and regulate themselves. Yoga provides training of mind and body to bring emotional balance. We argue that children and young people need such tools to listen inward to their bodies, feelings, and ideas. Yoga may assist them in developing...

journal_title：Frontiers in psychiatry

authors： Hagen I,Nayar US

更新日期：2014-04-02 00:00:00

abstract：:Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certain...

journal_title：Frontiers in psychiatry

authors： Shao X,Zhu G

更新日期：2020-05-13 00:00:00

abstract：:Background: Young adults regularly using cannabis represent a uniquely vulnerable yet heterogeneous cohort. Few studies have examined user profiles using cannabis use motives and expectations. The association between user profiles and psychosocial functioning among only regular users remains unexplored. This explorati...

journal_title：Frontiers in psychiatry

authors： Amiet D,Youssef GJ,Hagg LJ,Lorenzetti V,Parkes L,Solowij N,Yücel M

更新日期：2020-12-15 00:00:00

abstract：Background:From birth, the human propensity to selectively attend and respond to critical super-stimuli forms the basis of future socio-emotional development and health. In particular, the first super-stimuli to preferentially engage and elicit responses in the healthy newborn are the physical touch, voice and face/eye...

journal_title：Frontiers in psychiatry

authors： Doyle FL,Mendoza Diaz A,Eapen V,Frick PJ,Kimonis ER,Hawes DJ,Moul C,Richmond JL,Mehta D,Sareen S,Morgan BG,Dadds MR

更新日期：2020-06-19 00:00:00