The intralaminar thalamus-an expressway linking visual stimuli to circuits determining agency and action selection.

Abstract:

:Anatomical investigations have revealed connections between the intralaminar thalamic nuclei and areas such as the superior colliculus (SC) that receive short latency input from visual and auditory primary sensory areas. The intralaminar nuclei in turn project to the major input nucleus of the basal ganglia, the striatum, providing this nucleus with a source of subcortical excitatory input. Together with a converging input from the cerebral cortex, and a neuromodulatory dopaminergic input from the midbrain, the components previously found necessary for reinforcement learning in the basal ganglia are present. With this intralaminar sensory input, the basal ganglia are thought to play a primary role in determining what aspect of an organism's own behavior has caused salient environmental changes. Additionally, subcortical loops through thalamic and basal ganglia nuclei are proposed to play a critical role in action selection. In this mini review we will consider the anatomical and physiological evidence underlying the existence of these circuits. We will propose how the circuits interact to modulate basal ganglia output and solve common behavioral learning problems of agency determination and action selection.

journal_name

Front Behav Neurosci

authors

Fisher SD,Reynolds JN

doi

10.3389/fnbeh.2014.00115

subject

Has Abstract

pub_date

2014-04-02 00:00:00

pages

115

issn

1662-5153

journal_volume

8

pub_type

杂志文章,评审
  • A New 3-Day Standardized Eyeblink Conditioning Protocol to Assess Extinction Learning From Infancy to Adulthood.

    abstract::Associative learning can be observed from the neonatal period onward, providing opportunities to examine changes in basic learning and memory abilities. One method that is suitable to study associative learning is classical eyeblink conditioning (EBC) which is dependent on the cerebellum. Extinction learning can be sy...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00135

    authors: Konrad C,Adolph D,Herbert JS,Neuhoff L,Mohr C,Jagusch-Poirier J,Seehagen S,Weigelt S,Schneider S

    更新日期:2020-08-14 00:00:00

  • Evidence for spatially-responsive neurons in the rostral thalamus.

    abstract::Damage involving the anterior thalamic and adjacent rostral thalamic nuclei may result in a severe anterograde amnesia, similar to the amnesia resulting from damage to the hippocampal formation. Little is known, however, about the information represented in these nuclei. To redress this deficit, we recorded units in t...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00256

    authors: Jankowski MM,Passecker J,Islam MN,Vann S,Erichsen JT,Aggleton JP,O'Mara SM

    更新日期:2015-10-13 00:00:00

  • Effects of sleep deprivation on different phases of memory in the rat: dissociation between contextual and tone fear conditioning tasks.

    abstract::Numerous studies show that sleep deprivation (SD) impacts negatively on cognitive processes, including learning and memory. Memory formation encompasses distinct phases of which acquisition, consolidation and retrieval are better known. Previous studies with pre-training SD induced by the platform method have shown im...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00389

    authors: Rossi VC,Tiba PA,Moreira KD,Ferreira TL,Oliveira MG,Suchecki D

    更新日期:2014-11-07 00:00:00

  • Social behavioral changes in MPTP-treated monkey model of Parkinson's disease.

    abstract::Parkinsonian patients experience not only the physical discomfort of motor disorders but also the considerable psychological distress caused by cognitive deficits and behavioral disorders. These two factors can result in a disruption of social relationships during the symptomatic and even the presymptomatic motor stat...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00042

    authors: Durand E,Petit O,Tremblay L,Zimmer C,Sgambato-Faure V,Chassain C,Laurent M,Pereira B,Silberberg C,Durif F

    更新日期:2015-02-26 00:00:00

  • Spatiotemporal Patterns of Contact Across the Rat Vibrissal Array During Exploratory Behavior.

    abstract::The rat vibrissal system is an important model for the study of somatosensation, but the small size and rapid speed of the vibrissae have precluded measuring precise vibrissal-object contact sequences during behavior. We used a laser light sheet to quantify, with 1 ms resolution, the spatiotemporal structure of whiske...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00356

    authors: Hobbs JA,Towal RB,Hartmann MJ

    更新日期:2016-01-05 00:00:00

  • Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice.

    abstract::Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.589176

    authors: Zhang K,Lian N,Ding R,Guo C,Dong X,Li Y,Wei S,Jiao Q,Yu Y,Shen H

    更新日期:2020-11-23 00:00:00

  • Consequences of early postnatal benzodiazepines exposure in rats. I. Cognitive-like behavior.

    abstract::Clinical and experimental studies suggest possible risks associated with the repeated administration of benzodiazepines (BZDs) during the prenatal or early postnatal period on further development and behavior. In the present study, we assess short- and long-term effects of early exposure to clonazepam (CZP) on cogniti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00101

    authors: Mikulecká A,Subrt M,Stuchlík A,Kubová H

    更新日期:2014-03-28 00:00:00

  • Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.

    abstract::Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genom...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00001

    authors: Bubier JA,Wilcox TD,Jay JJ,Langston MA,Baker EJ,Chesler EJ

    更新日期:2016-01-21 00:00:00

  • Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.

    abstract::Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction of the ubiquitin-proteas...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00068

    authors: Bentea E,Van der Perren A,Van Liefferinge J,El Arfani A,Albertini G,Demuyser T,Merckx E,Michotte Y,Smolders I,Baekelandt V,Massie A

    更新日期:2015-03-31 00:00:00

  • Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions.

    abstract::Maternal exposure to infection occurring mid-gestation produces a three-fold increase in the risk of schizophrenia in the offspring. The critical initiating factor appears to be the maternal immune activation (MIA) that follows infection. This process can be induced in rodents by exposure of pregnant dams to the viral...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2013.00217

    authors: Dickerson DD,Bilkey DK

    更新日期:2013-12-27 00:00:00

  • To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making.

    abstract::Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamin...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2015.00336

    authors: Hernandez G,Cheer JF

    更新日期:2015-12-17 00:00:00

  • Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.

    abstract::Subchronic treatment with the psychotomimetic phencyclidine (PCP) has been proposed as a rodent model of the negative and cognitive/executive symptoms of schizophrenia. There has, however, been a paucity of studies on this model in mice, despite the growing use of the mouse as a subject in genetic and molecular studie...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.002.2009

    authors: Brigman JL,Ihne J,Saksida LM,Bussey TJ,Holmes A

    更新日期:2009-02-23 00:00:00

  • Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment.

    abstract::Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has n...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00297

    authors: Zhang Y,Crofton EJ,Li D,Lobo MK,Fan X,Nestler EJ,Green TA

    更新日期:2014-08-29 00:00:00

  • Cognitive and Neurophysiological Effects of Non-invasive Brain Stimulation in Stroke Patients after Motor Rehabilitation.

    abstract::The primary aim of this study was to evaluate and compare the effectiveness of two specific Non-Invasive Brain Stimulation (NIBS) paradigms, the repetitive Transcranial Magnetic Stimulation (rTMS), and transcranial Direct Current Stimulation (tDCS), in the upper limb rehabilitation of patients with stroke. Short and l...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00135

    authors: D'Agata F,Peila E,Cicerale A,Caglio MM,Caroppo P,Vighetti S,Piedimonte A,Minuto A,Campagnoli M,Salatino A,Molo MT,Mortara P,Pinessi L,Massazza G

    更新日期:2016-06-24 00:00:00

  • The Dorsal Medial Prefrontal Cortex Is Recruited by High Construal of Non-social Stimuli.

    abstract::The dorsomedial prefrontal cortex (dmPFC) is part of the mentalizing network, a set of brain regions consistently engaged in inferring mental states. However, its precise function in this network remains unclear. It has recently been proposed that the dmPFC is involved in high-level abstract (i.e., categorical) identi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00044

    authors: Baetens KL,Ma N,Van Overwalle F

    更新日期:2017-03-14 00:00:00

  • Pain-related stress during the Neonatal Intensive Care Unit stay and SLC6A4 methylation in very preterm infants.

    abstract::Very preterm (VPT) infants need long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU) during which they are daily exposed to pain-related stress. Alterations of DNA methylation at the promoter region of the SLC6A4 have been associated with early adverse experiences in infants. The main aim of the pre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00099

    authors: Provenzi L,Fumagalli M,Sirgiovanni I,Giorda R,Pozzoli U,Morandi F,Beri S,Menozzi G,Mosca F,Borgatti R,Montirosso R

    更新日期:2015-04-21 00:00:00

  • Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

    abstract::Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00234

    authors: Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

    更新日期:2016-12-20 00:00:00

  • Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing.

    abstract:Background:Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigate...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00232

    authors: von Düring F,Ristow I,Li M,Denzel D,Colic L,Demenescu LR,Li S,Borchardt V,Liebe T,Vogel M,Walter M

    更新日期:2019-10-02 00:00:00

  • Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

    abstract::The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of acetylcholine to the interpeduncular nucleus (IPN), the sole output regio...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00017

    authors: Kobayashi Y,Sano Y,Vannoni E,Goto H,Suzuki H,Oba A,Kawasaki H,Kanba S,Lipp HP,Murphy NP,Wolfer DP,Itohara S

    更新日期:2013-03-12 00:00:00

  • The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear.

    abstract::Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be extinguished, extinction memories are fragile. The resilience of fear memories to extinction may contribute to the maintenance of disorders of fear and anxiety, including post-traumatic stress disorder (PTSD). As such, considerabl...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2015.00298

    authors: Giustino TF,Maren S

    更新日期:2015-11-09 00:00:00

  • The Impact of Early Postnatal and Juvenile Social Environments on the Effects of Chronic Intranasal Oxytocin in the Prairie Vole.

    abstract::Interactions between social experiences at different stages of development (e.g., with parents as juveniles and peers as subadults) can profoundly shape the expression of social behavior. Rarely are the influences of more than one stage of developmental sensitivity to social environment investigated simultaneously. Fu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00206

    authors: Prounis GS,Ophir AG

    更新日期:2019-09-13 00:00:00

  • Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence.

    abstract::Somatostatin (SOM) and somatostatin receptors (SSTR1-4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses. In this work, histological, viral tracing and transgenic approaches were used to characterize SOM c...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00061

    authors: Nocera S,Simon A,Fiquet O,Chen Y,Gascuel J,Datiche F,Schneider N,Epelbaum J,Viollet C

    更新日期:2019-04-09 00:00:00

  • High Salt Intake Lowers Behavioral Inhibition.

    abstract::Stress-related neuropsychiatric (e.g., anxiety, depression) and cardiovascular diseases are frequently comorbid, though discerning the directionality of their association has been challenging. One of the most controllable risk factors for cardiovascular disease is salt intake. Though high salt intake is implicated in ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00271

    authors: Gilman TL,George CM,Andrade MA,Mitchell NC,Toney GM,Daws LC

    更新日期:2019-12-13 00:00:00

  • Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity.

    abstract::Recent studies have used conditional knockout mice to selectively delete the D2 autoreceptor; however, these approaches result in global deletion of D2 autoreceptors early in development. The present study takes a different approach using RNA interference (RNAi) to knockdown the expression of the D2 receptors (D2R) in...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00248

    authors: Budygin EA,Oleson EB,Lee YB,Blume LC,Bruno MJ,Howlett AC,Thompson AC,Bass CE

    更新日期:2017-01-19 00:00:00

  • Immune-Endocrine Links to Gregariousness in Wild House Mice.

    abstract::Social interactions are critically important for survival and impact overall-health, but also impose costs on animals, such as exposure to contagious agents. The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behavior...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00010

    authors: Lopes PC,Carlitz EHD,Kindel M,König B

    更新日期:2020-02-05 00:00:00

  • Visual cues for manual control of headway.

    abstract::The ability to maintain appropriate gaps to objects in one's environment is important when navigating through a three-dimensional world. Previous research has shown that the visual angle subtended by a lead/approaching object and its rate of change are important variables for timing interceptions, collision avoidance,...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00045

    authors: Hosking SG,Davey CE,Kaiser MK

    更新日期:2013-05-21 00:00:00

  • Perception of biological motion in visual agnosia.

    abstract::Over the past 25 years, visual processing has been discussed in the context of the dual stream hypothesis consisting of a ventral ("what") and a dorsal ("where") visual information processing pathway. Patients with brain damage of the ventral pathway typically present with signs of visual agnosia, the inability to ide...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00056

    authors: Huberle E,Rupek P,Lappe M,Karnath HO

    更新日期:2012-08-28 00:00:00

  • Adolescent Social Defeat Induced Alterations in Social Behavior and Cognitive Flexibility in Adult Mice: Effects of Developmental Stage and Social Condition.

    abstract::Negative social experiences during adolescence increase the risk of psychiatric disorders in adulthood. Using "resident-intruder" stress, the present study aimed to investigate the effects of adolescent social defeat on emotional and cognitive symptoms associated with psychiatric disorders during adulthood and the eff...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00149

    authors: Zhang F,Yuan S,Shao F,Wang W

    更新日期:2016-07-20 00:00:00

  • Behavioral Plasticity of Audiovisual Perception: Rapid Recalibration of Temporal Sensitivity but Not Perceptual Binding Following Adult-Onset Hearing Loss.

    abstract::The ability to accurately integrate or bind stimuli from more than one sensory modality is highly dependent on the features of the stimuli, such as their intensity and relative timing. Previous studies have demonstrated that the ability to perceptually bind stimuli is impaired in various clinical conditions such as au...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00256

    authors: Schormans AL,Allman BL

    更新日期:2018-10-31 00:00:00

  • Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood.

    abstract::This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1-21, PD1-21) and environmental enrichment (EE) during adolescence (PD 21-42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a simi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00195

    authors: Berardo LR,Fabio MC,Pautassi RM

    更新日期:2016-10-13 00:00:00