Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors.

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life. Studies investigating the central nerv...

journal_title：Frontiers in immunology

authors： Süß P,Rothe T,Hoffmann A,Schlachetzki JCM,Winkler J

更新日期：2020-12-10 00:00:00

abstract：:A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irrad...

journal_title：Frontiers in immunology

authors： Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J

更新日期：2019-02-27 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of breast milk or formula ...

journal_title：Frontiers in immunology

authors： Parigi SM,Eldh M,Larssen P,Gabrielsson S,Villablanca EJ

更新日期：2015-08-19 00:00:00

abstract：:Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mong...

journal_title：Frontiers in immunology

authors： Yao Y,Yang H,Shi L,Liu S,Li C,Chen J,Zhou Z,Sun M,Shi L

更新日期：2019-03-08 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune neurological disorder typified by skeletal muscle fatigue and most often production of autoantibodies against the nicotinic acetylcholine receptor (AChR). The present study was undertaken to assess the extent of AChR-peptide recognition in MG patients using co-culturing (DC:TC) ...

journal_title：Frontiers in immunology

authors： Sharma S,Malmeström C,Lindberg C,Meisel S,Schön K,Verolin M,Lycke NY

更新日期：2017-10-24 00:00:00

abstract：:Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 t...

journal_title：Frontiers in immunology

authors： Bowers JS,Majchrzak K,Nelson MH,Aksoy BA,Wyatt MM,Smith AS,Bailey SR,Neal LR,Hammerbacher JE,Paulos CM

更新日期：2017-09-29 00:00:00

abstract：:Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in o...

journal_title：Frontiers in immunology

authors： Camaioni A,Klinger FG,Campagnolo L,Salustri A

更新日期：2018-11-29 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as well in murine Mtb infection models. However, the interaction of mycobacteria with MDSCs and its role in TB infection is not well studied. Here, we investigated the role of Ca...

journal_title：Frontiers in immunology

authors： John V,Kotze LA,Ribechini E,Walzl G,Du Plessis N,Lutz MB

更新日期：2019-12-03 00:00:00

abstract：:Tumors must evade the immune system to survive and metastasize, although the mechanisms that lead to tumor immunoediting and their evasion of immune surveillance are far from clear. The first line of defense against metastatic invasion is the innate immune system that provides immediate defense through humoral immunit...

journal_title：Frontiers in immunology

authors： Benito-Martin A,Di Giannatale A,Ceder S,Peinado H

更新日期：2015-02-24 00:00:00

abstract：:Hyaluronan (HA), the major extracellular matrix component, is often anchored to CD44, a family of structurally/functionally important cell surface receptors. Recent results indicate that UV irradiation (UVR)-induced cutaneous squamous cell carcinomas (SCC) overexpress a variety of CD44 variant isoforms (CD44v), with d...

journal_title：Frontiers in immunology

authors： Bourguignon LY,Bikle D

更新日期：2015-05-13 00:00:00

abstract：:Adenosine triphosphate (ATP) is released by bacteria and host cells during bacterial infection as well as sterile tissue injury, acting as an inducer of inflammasome activation. Previous studies have shown that ATP treatment leads to AMP-activated protein kinase (AMPK) activation. However, it is unclear whether AMPK s...

journal_title：Frontiers in immunology

authors： Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

更新日期：2016-12-12 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies. However, high costs for mono- or combination therapies, associated with adverse effects or possible development of resistance in some patients, warra...

journal_title：Frontiers in immunology

authors： Tobias J,Battin C,De Sousa Linhares A,Lebens M,Baier K,Ambroz K,Drinić M,Högler S,Inic-Kanada A,Garner-Spitzer E,Preusser M,Kenner L,Kundi M,Zielinski CC,Steinberger P,Wiedermann U

更新日期：2020-05-27 00:00:00

abstract：:The immunization of allogeneic hematopoietic cell transplantation (HCT) recipients against vaccine-preventable diseases is a part of posttransplantation guidelines. We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective...

journal_title：Frontiers in immunology

authors： Piekarska A,Wisniewski P,Lewandowski K,Gil L,Trzonkowski P,Bieniaszewska M,Zaucha JM

更新日期：2020-11-24 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-a...

journal_title：Frontiers in immunology

authors： Kaipe H,Raffetseder J,Ernerudh J,Solders M,Tiblad E

更新日期：2020-08-19 00:00:00

abstract：:In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clin...

journal_title：Frontiers in immunology

authors： Owen A,Newsome PN

更新日期：2020-06-19 00:00:00

abstract：:NH36 is a vital enzyme of the DNA metabolism and a specific target for anti-Leishmania chemotherapy. We developed second-generation vaccines composed of the FML complex or its main native antigen, the NH36 nucleoside hydrolase of Leishmania (L.) donovani and saponin, and a DNA vaccine containing the NH36 gene. All the...

journal_title：Frontiers in immunology

authors： Palatnik-de-Sousa CB

更新日期：2019-04-16 00:00:00

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progressi...

journal_title：Frontiers in immunology

authors： Terry S,Buart S,Chouaib S

更新日期：2017-11-24 00:00:00

abstract：:Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

journal_title：Frontiers in immunology

authors： Nelson SA,Sant AJ

更新日期：2019-05-07 00:00:00

abstract：:Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, w...

journal_title：Frontiers in immunology

authors： Wu J,Del Duca E,Espino M,Gontzes A,Cueto I,Zhang N,Estrada YD,Pavel AB,Krueger JG,Guttman-Yassky E

更新日期：2020-11-23 00:00:00

abstract：:The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly virulent in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of...

journal_title：Frontiers in immunology

authors： Reche PA

更新日期：2020-10-16 00:00:00

abstract：:Plasma cells (PCs), the B lineage cells responsible for producing and secreting antibodies (Abs), are critical cellular components of the humoral immune system. While most of the antibody-secreting cells in the body have a rather short lifetime of a few days, some of them can become long-lived and persist in the body ...

journal_title：Frontiers in immunology

authors： Lindquist RL,Niesner RA,Hauser AE

更新日期：2019-04-24 00:00:00

abstract：:Worldwide, breast cancer (BC) is the leading cause of cancer death among women. For many patients the most effective treatment is a resection surgery that removes the tumor. Within this subset, patients sometimes receive chemotherapy treatment (CT) prior to surgery aiming to reduce tumor size in order to preserve heal...

journal_title：Frontiers in immunology

authors： Valdés-Ferrada J,Muñoz-Durango N,Pérez-Sepulveda A,Muñiz S,Coronado-Arrázola I,Acevedo F,Soto JA,Bueno SM,Sánchez C,Kalergis AM

更新日期：2020-07-09 00:00:00

abstract：:Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological ...

journal_title：Frontiers in immunology

authors： Luo Y,Meyer N,Jiao Q,Scheffel J,Zimmermann C,Metz M,Zenclussen A,Maurer M,Siebenhaar F

更新日期：2019-10-15 00:00:00

abstract：:CD4+ regulatory T cells have been intensively studied during aging, but little is still known about age-related changes of other regulatory T cell subsets. It was, therefore, the goal of the present study to analyze CD8+human leukocyte antigen-antigen D related (HLADR)+ T cells in old age, a cell population reported t...

journal_title：Frontiers in immunology

authors： Lukas Yani S,Keller M,Melzer FL,Weinberger B,Pangrazzi L,Sopper S,Trieb K,Lobina M,Orrù V,Fiorillo E,Cucca F,Grubeck-Loebenstein B

更新日期：2018-06-04 00:00:00

abstract：:The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity (ADCC) responses in the observed protection, highlighting the importance of assessing such responses in ongoing and future HIV-1 vaccine trials. However, in vi...

journal_title：Frontiers in immunology

authors： Fisher L,Zinter M,Stanfield-Oakley S,Carpp LN,Edwards RW,Denny T,Moodie Z,Laher F,Bekker LG,McElrath MJ,Gilbert PB,Corey L,Tomaras G,Pollara J,Ferrari G

更新日期：2019-11-27 00:00:00

abstract：:Recently, a second individual (the "London patient") with HIV-1 infection and concomitant leukemia was cured of both diseases by a conditioning myeloablative regimen followed by transplantation of stem cells bearing the homozygous CCR5 Δ32 mutation. The substantial risks and cost associated with this procedure render ...

journal_title：Frontiers in immunology

authors： Gavegnano C,Savarino A,Owanikoko T,Marconi VC

更新日期：2019-10-04 00:00:00