Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling.

abstract：BACKGROUND:Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis an...

journal_title：Journal of neuroinflammation

authors： Clé M,Constant O,Barthelemy J,Desmetz C,Martin MF,Lapeyre L,Cadar D,Savini G,Teodori L,Monaco F,Schmidt-Chanasit J,Saiz JC,Gonzales G,Lecollinet S,Beck C,Gosselet F,Van de Perre P,Foulongne V,Salinas S,Simonin Y

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Experiences and inflammatory mediators are fundamental in the provocation of major depressive disorders (MDDs). We investigated the roles and mechanisms of inducible nitric oxide synthase (iNOS) in stress-induced depression. METHODS:We used a depressive-like state mouse model induced by unpredictable chroni...

journal_title：Journal of neuroinflammation

authors： Peng YL,Liu YN,Liu L,Wang X,Jiang CL,Wang YX

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. OBJECTIVE:This study is focused on the role of Hv1 in regulating demyelination and microglial activation through reactive oxygen species (...

journal_title：Journal of neuroinflammation

authors： Chen M,Yang LL,Hu ZW,Qin C,Zhou LQ,Duan YL,Bosco DB,Wu LJ,Zhan KB,Xu SB,Tian DS

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined t...

journal_title：Journal of neuroinflammation

authors： Pellegrini C,Fornai M,Colucci R,Tirotta E,Blandini F,Levandis G,Cerri S,Segnani C,Ippolito C,Bernardini N,Cseri K,Blandizzi C,Haskó G,Antonioli L

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate p...

journal_title：Journal of neuroinflammation

authors： Bao LH,Zhang YN,Zhang JN,Gu L,Yang HM,Huang YY,Xia N,Zhang H

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS. METHODS:Using murine brain slices of the primary auditory co...

journal_title：Journal of neuroinflammation

authors： Ghaffarian N,Mesgari M,Cerina M,Göbel K,Budde T,Speckmann EJ,Meuth SG,Gorji A

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:The mechanism of leukocyte transendothelial migration (TEM) across the highly restrictive blood-brain barrier (BBB) remains enigmatic, with paracellular TEM thought to require leukocytes to somehow navigate the obstructive endothelial tight junctions (TJs). Transient interactions between TJ proteins on the r...

journal_title：Journal of neuroinflammation

authors： Paul D,Baena V,Ge S,Jiang X,Jellison ER,Kiprono T,Agalliu D,Pachter JS

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an imbalance between pro- and anti-inflammatory mediators in the brain. We examined whether hip fracture patients who develop postoperative delirium have altered...

journal_title：Journal of neuroinflammation

authors： Westhoff D,Witlox J,Koenderman L,Kalisvaart KJ,de Jonghe JF,van Stijn MF,Houdijk AP,Hoogland IC,Maclullich AM,van Westerloo DJ,van de Beek D,Eikelenboom P,van Gool WA

更新日期：2013-10-07 00:00:00

abstract：:Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic pain accelerates AD pathogenesis. In this review, we provide evidence th...

journal_title：Journal of neuroinflammation

authors： Cao S,Fisher DW,Yu T,Dong H

更新日期：2019-11-06 00:00:00

abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

journal_title：Journal of neuroinflammation

authors： Choi J,Min HJ,Shin JS

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:Pain is one critical hallmark of inflammatory responses. A large number of studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) play an important role in immune reaction and inflammatory processes. However, ...

journal_title：Journal of neuroinflammation

authors： Yang F,Sun W,Yang Y,Wang Y,Li CL,Fu H,Wang XL,Yang F,He T,Chen J

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:This study investigated whether therapeutic hypercapnia (TH) ameliorated blood-brain barrier (BBB) damage and improved the neurologic outcome in a rat model of lateral fluid percussion injury (FPI), and explored the possible underlying mechanism. METHODS:Rats underwent lateral FPI and received inhalation of...

journal_title：Journal of neuroinflammation

authors： Yang WC,Wang Q,Chi LT,Wang YZ,Cao HL,Li WZ

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and their role in inflammatory response after SCI remained unclear. This study aimed to investigate the ...

journal_title：Journal of neuroinflammation

authors： Liu Z,Yao X,Jiang W,Li W,Zhu S,Liao C,Zou L,Ding R,Chen J

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, IL-1β, and N-methyl D-aspartate receptor subunit 2B (NR2B) genes in cochlea and inferior colliculus (...

journal_title：Journal of neuroinflammation

authors： Hwang JH,Chen JC,Yang SY,Wang MF,Chan YC

更新日期：2011-04-09 00:00:00

abstract：BACKGROUND:Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through its NK1 receptor. Incr...

journal_title：Journal of neuroinflammation

authors： Martinez AN,Ramesh G,Jacobs MB,Philipp MT

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Cranial radiotherapy is used to treat tumors of the central nervous system (CNS), as well as non-neoplastic conditions such as arterio-venous malformations; however, its use is limited by the tolerance of adjacent normal CNS tissue, which can lead to devastating long-term sequelae for patients. Despite decad...

journal_title：Journal of neuroinflammation

authors： Moravan MJ,Olschowka JA,Williams JP,O'Banion MK

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroinflammatory responses elicited...

journal_title：Journal of neuroinflammation

authors： Kolosowska N,Gotkiewicz M,Dhungana H,Giudice L,Giugno R,Box D,Huuskonen MT,Korhonen P,Scoyni F,Kanninen KM,Ylä-Herttuala S,Turunen TA,Turunen MP,Koistinaho J,Malm T

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases. Autoimmunity may have a role in the pathogenesis of autism in ...

journal_title：Journal of neuroinflammation

authors： Mostafa GA,Al-Ayadhi LY

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous mediator of analgesia and...

journal_title：Journal of neuroinflammation

authors： Wang S,Zhang H,Geng B,Xie Q,Li W,Deng Y,Shi W,Pan Y,Kang X,Wang J

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomography (PET) radiotracer, (4S)-4...

journal_title：Journal of neuroinflammation

authors： Hoehne A,James ML,Alam IS,Ronald JA,Schneider B,D'Souza A,Witney TH,Andrews LE,Cropper HC,Behera D,Gowrishankar G,Ding Z,Wyss-Coray T,Chin FT,Biswal S,Gambhir SS

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturate...

journal_title：Journal of neuroinflammation

authors： Hammer A,Schliep A,Jörg S,Haghikia A,Gold R,Kleinewietfeld M,Müller DN,Linker RA

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and microglia-dominated neuroinflammation. The Nogo/NgR signal pathway is involved in AD pathological features, but the detailed mechanism needs further investigation. Our previous studies have ...

journal_title：Journal of neuroinflammation

authors： Fang Y,Yao L,Li C,Wang J,Wang J,Chen S,Zhou XF,Liao H

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:In meningitis, the cerebrospinal fluid contains high levels of innate immune molecules (e.g. complement) which are essential to ward off the infectious challenge and to promote the infiltration of phagocytes (neutrophils, monocytes). However, epithelial cells of either the ependymal layer, one of the establi...

journal_title：Journal of neuroinflammation

authors： Canova C,Neal JW,Gasque P

更新日期：2006-09-02 00:00:00

abstract：BACKGROUND:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation i...

journal_title：Journal of neuroinflammation

authors： Hosoya T,Fukumoto D,Kakiuchi T,Nishiyama S,Yamamoto S,Ohba H,Tsukada H,Ueki T,Sato K,Ouchi Y

更新日期：2017-03-29 00:00:00

abstract：BACKGROUND:Recent evidence suggests that reactive astrocytes play an important role in neuroinflammation and neurodegenerative diseases. Thus, controlling astrocyte reactivity has been suggested as a promising strategy for treating neurodegenerative diseases. In the present study, we investigated whether a matrix metal...

journal_title：Journal of neuroinflammation

authors： Lee EJ,Park JS,Lee YY,Kim DY,Kang JL,Kim HS

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disorder of the central nervous system (CNS) and is the leading cause of nontraumatic disability among young adults. Activated microglial cells are important effectors of demyelination and neurodegeneration, by secreting cytokines and others n...

journal_title：Journal of neuroinflammation

authors： Virgili N,Espinosa-Parrilla JF,Mancera P,Pastén-Zamorano A,Gimeno-Bayon J,Rodríguez MJ,Mahy N,Pugliese M

更新日期：2011-11-02 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer's disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In ...

journal_title：Journal of neuroinflammation

authors： Heras-Sandoval D,Pedraza-Chaverri J,Pérez-Rojas JM

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the exact mechanisms for RPE degen...

journal_title：Journal of neuroinflammation

authors： Gao J,Cui JZ,To E,Cao S,Matsubara JA

更新日期：2018-01-12 00:00:00

abstract：:The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome is a member of the NLR family of innate immune cell sensors. These are crucial regulators of cytokine secretions, which promote ischemic cell death and insulin resistance. This review summarizes rece...

journal_title：Journal of neuroinflammation

authors： Hong P,Gu RN,Li FX,Xiong XX,Liang WB,You ZJ,Zhang HF

更新日期：2019-06-07 00:00:00

abstract：:Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality ...

journal_title：Journal of neuroinflammation

authors： Shukla V,Shakya AK,Perez-Pinzon MA,Dave KR

更新日期：2017-01-23 00:00:00