Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease.

Abstract:

INTRODUCTION:Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the disease as well. MATERIALS AND METHODS:About 22 patients (mean age: 75.9 ± 6.1 years; 14 women) with mild-to-moderate AD and 22 sex-matched healthy patients were examined. We compared the use of VEP and RNFLT using the latest high-resolution spectral domain optical coherence tomography with eye-tracking capabilities for optimized peripapillary scan centering for the first time in AD patients. RESULTS:The mean MMSE score was 22.59 ± 5.47 in the AD group, and did not significantly correlate with the VEP latencies. We found no significant difference between the VEP latencies of the AD patients and those of the control patients. No peripapillary sector of the retina had a RNFLT significantly correlated with the VEP latencies. DISCUSSION:We demonstrated that pattern VEP did not show any significant correlation despite subtle loss in RNFLT. It remains open whether additional flash VEP combined with RNFLT analysis may be useful in diagnosing AD, particularly for mild-to-moderate stages of the disease.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Kromer R,Serbecic N,Hausner L,Froelich L,Beutelspacher SC

doi

10.3389/fneur.2013.00203

subject

Has Abstract

pub_date

2013-12-16 00:00:00

pages

203

issn

1664-2295

journal_volume

4

pub_type

杂志文章
  • Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus Improves Patient Outcomes: A Nationwide Hospital-Based Survey in Japan.

    abstract::Background and Purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted a cross-sectional study using data from a nationwide epidemiological sur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00421

    authors: Nakajima M,Miyajima M,Ogino I,Akiba C,Kawamura K,Kurosawa M,Kuriyama N,Watanabe Y,Fukushima W,Mori E,Kato T,Sugano H,Karagiozov K,Arai H

    更新日期:2018-06-07 00:00:00

  • The Role of Palliative Care in Chronic Progressive Neurological Diseases-A Survey Amongst Neurologists in the Netherlands.

    abstract::Background: Chronic progressive neurological diseases like high grade glioma (HGG), Parkinson's disease (PD), and multiple sclerosis (MS) are incurable, and associated with increasing disability including cognitive impairment, and reduced life expectancy. Patients with these diseases have complex care needs. Therefore...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.01157

    authors: Walter HAW,Seeber AA,Willems DL,de Visser M

    更新日期:2019-01-14 00:00:00

  • Accuracy and Feasibility of an Android-Based Digital Assessment Tool for Post Stroke Visual Disorders-The StrokeVision App.

    abstract:Background:Visual impairment affects up to 70% of stroke survivors. We designed an app (StrokeVision) to facilitate screening for common post stroke visual issues (acuity, visual fields, and visual inattention). We sought to describe the test time, feasibility, acceptability, and accuracy of our app-based digital visua...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00146

    authors: Quinn TJ,Livingstone I,Weir A,Shaw R,Breckenridge A,McAlpine C,Tarbert CM

    更新日期:2018-03-28 00:00:00

  • The Crucial Changes of Sit-to-Stand Phases in Subacute Stroke Survivors Identified by Movement Decomposition Analysis.

    abstract:Objective:The aim of this study was to detect the key changes during sit-to-stand (STS) movement cycle in hemiparetic stroke survivors using a five-phase kinematic and kinetic analysis. Methods:Twenty-five subacute stroke survivors and 17 age-matched healthy adults participated in this study. The kinematic and kinetic...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00185

    authors: Mao YR,Wu XQ,Zhao JL,Lo WLA,Chen L,Ding MH,Xu ZQ,Bian RH,Huang DF,Li L

    更新日期:2018-03-26 00:00:00

  • Contralesional Hemisphere Regulation of Transcranial Magnetic Stimulation-Induced Kinetic Coupling in the Poststroke Lower Limb.

    abstract:BACKGROUND:The neural constraints underlying hemiparetic gait dysfunction are associated with abnormal kinetic outflow and altered muscle synergy structure. Recent evidence from our lab implicates the lesioned hemisphere in mediating the expression of abnormally coupled hip adduction and knee extension synergy, suggest...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00373

    authors: Tan AQ,Dhaher YY

    更新日期:2017-08-07 00:00:00

  • Case Report: Extreme Levels of Serum S-100B in a Patient with Chronic Subdural Hematoma.

    abstract::The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00170

    authors: Persson ME,Thelin EP,Bellander BM

    更新日期:2012-12-05 00:00:00

  • Damage in the Thalamocortical Tracts is Associated With Subsequent Thalamus Atrophy in Early Multiple Sclerosis.

    abstract::Background: In early multiple sclerosis (MS), thalamus atrophy and decreased integrity of the thalamocortical white matter (WM) tracts have been observed. Objective: To investigate the temporal association between thalamus volume and WM damage in the thalamocortical tract in subjects with early MS. Methods: At two tim...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.575611

    authors: Weeda MM,Pruis IJ,Westerveld ASR,Brouwer I,Bellenberg B,Barkhof F,Vrenken H,Lukas C,Schneider R,Pouwels PJW

    更新日期:2020-11-17 00:00:00

  • The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.

    abstract::Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00152

    authors: Fernández Ó,Costa-Frossard L,Martínez-Ginés M,Montero P,Prieto JM,Ramió L

    更新日期:2020-03-17 00:00:00

  • Role of Decompressive Craniectomy in Ischemic Stroke.

    abstract::Ischemic stroke is one of the leading causes for death and disability worldwide. In patients with large space-occupying infarction, the subsequent edema complicated by transtentorial herniation poses a lethal threat. Especially in patients with malignant middle cerebral artery infarction, brain swelling secondary to t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.01119

    authors: Pallesen LP,Barlinn K,Puetz V

    更新日期:2019-01-09 00:00:00

  • Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits.

    abstract::In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00358

    authors: James ND,Angéria M,Bradbury EJ,Damberg P,McMahon SB,Risling M,Carlstedt T

    更新日期:2017-07-24 00:00:00

  • Longitudinal Bedside Assessments of Brain Networks in Disorders of Consciousness: Case Reports From the Field.

    abstract::Clinicians are regularly faced with the difficult challenge of diagnosing consciousness after severe brain injury. As such, as many as 40% of minimally conscious patients who demonstrate fluctuations in arousal and awareness are known to be misdiagnosed as unresponsive/vegetative based on clinical consensus. Further, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00676

    authors: Bareham CA,Allanson J,Roberts N,Hutchinson PJA,Pickard JD,Menon DK,Chennu S

    更新日期:2018-08-21 00:00:00

  • A Novel PKD1 Mutation Associated With Autosomal Dominant Kidney Disease and Cerebral Cavernous Malformation.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either PKD1 or PKD2 genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Ex...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2018.00383

    authors: Thomas C,Zühlsdorf A,Hörtnagel K,Mulahasanovic L,Grauer OM,Kümpers P,Wiendl H,Meuth SG

    更新日期:2018-05-25 00:00:00

  • Cerebral Blood Flow Measurement in Healthy Children and Children Suffering Severe Traumatic Brain Injury-What Do We Know?

    abstract::Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00274

    authors: Rostami E,Nilsson P,Enblad P

    更新日期:2020-04-16 00:00:00

  • Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy.

    abstract::The electrophysiological EEG features such as high frequency oscillations, spikes and functional connectivity are often used for delineation of epileptogenic tissue and study of the normal function of the brain. The epileptogenic activity is also known to be suppressed by cognitive processing. However, differences bet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.578571

    authors: Cimbalnik J,Pail M,Klimes P,Travnicek V,Roman R,Vajcner A,Brazdil M

    更新日期:2020-10-27 00:00:00

  • The Maximum Bite Force for Treatment Evaluation in Severely Affected Adult SMA Patients-Protocol for a Longitudinal Study.

    abstract::Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of motor neurons in the spinal cord, and comprises a broad clinical spectrum. With the advent of new therapies (e.g., Nusinersen) for patients of all ages and disease stages, sensitive clinical measures are needed to det...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00139

    authors: Kruse T,Lehmann HC,Braumann B,Fink GR,Wunderlich G

    更新日期:2020-02-25 00:00:00

  • Endoscope-Assisted Surgery vs. Burr-Hole Craniostomy for the Treatment of Chronic Subdural Hematoma: A Systemic Review and Meta-Analysis.

    abstract::Objectives: This article aims to evaluate the safety and effectiveness of endoscope-assisted surgery for chronic subdural hematoma (cSDH) in comparison with the burr-hole craniostomy. Methods: An electronic literature research was performed in MEDLINE, the Cochrane library, and EMBASE from the inception to February 18...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.540911

    authors: Guo S,Gao W,Cheng W,Liang C,Wu A

    更新日期:2020-11-05 00:00:00

  • The Differential Effects of Repetitive Magnetic Stimulation in an In Vitro Neuronal Model of Ischemia/Reperfusion Injury.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive therapy that has been implicated in treatment of serious neurological disorders. However, the neurobiological mechanisms underlying the effects of rTMS remain unclear. Therefore, this study examined the differential effects of repetitive magnetic st...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00050

    authors: Baek A,Kim JH,Pyo S,Jung JH,Park EJ,Kim SH,Cho SR

    更新日期:2018-02-13 00:00:00

  • Case Report: Candida dubliniensis as a Cause of Chronic Meningitis.

    abstract::Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host. Case Presentation: A...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.601242

    authors: Tahir M,Peseski AM,Jordan SJ

    更新日期:2020-12-08 00:00:00

  • Corrigendum: Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases.

    abstract::[This corrects the article DOI: 10.3389/fneur.2020.00696.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误

    doi:10.3389/fneur.2020.607331

    authors: Lin N,Hao H,Guan H,Sun H,Liu Q,Lu Q,Jin L,Ren H,Huang Y

    更新日期:2020-10-30 00:00:00

  • A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer's Disease.

    abstract:Introduction:There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs. Aim:We investigated the differences in cognitive decline in AD compared to DLB over 4 ye...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00124

    authors: Breitve MH,Chwiszczuk LJ,Brønnick K,Hynninen MJ,Auestad BH,Aarsland D,Rongve A

    更新日期:2018-03-06 00:00:00

  • Biases in the Visual and Haptic Subjective Vertical Reveal the Role of Proprioceptive/Vestibular Priors in Child Development.

    abstract::Investigation of the perception of verticality permits to disclose the perceptual mechanisms that underlie balance control and spatial navigation. Estimation of verticality in unusual body orientation with respect to gravity (e.g., laterally tilted in the roll plane) leads to biases that change depending on the encodi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.01151

    authors: Cuturi LF,Gori M

    更新日期:2019-01-07 00:00:00

  • The goldilocks dilemma in acute ischemic stroke.

    abstract::Despite the advent of and exciting advances in novel endovascular therapies, t-PA remains the only proven treatment for acute ischemic stroke to date. Although a variety of reasons likely underlie why past trials of endovascular strategies have been unsuccessful, we address in this perspective piece one critical unkno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2013.00164

    authors: Tansy AP,Liebeskind DS

    更新日期:2013-10-21 00:00:00

  • Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.

    abstract::Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during normal aging, suggesting t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00675

    authors: Martín-Segura A,Casadomé-Perales Á,Fazzari P,Mas JM,Artigas L,Valls R,Nebreda AR,Dotti CG

    更新日期:2019-06-25 00:00:00

  • A Method for Whole Brain Ex Vivo Magnetic Resonance Imaging with Minimal Susceptibility Artifacts.

    abstract::Magnetic resonance imaging (MRI) is a non-destructive technique that is capable of localizing pathologies and assessing other anatomical features (e.g., tissue volume, microstructure, and white matter connectivity) in postmortem, ex vivo human brains. However, when brains are removed from the skull and cerebrospinal f...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00208

    authors: Shatil AS,Matsuda KM,Figley CR

    更新日期:2016-11-29 00:00:00

  • The Gaps Between Current Management of Intracerebral Hemorrhage and Evidence-Based Practice Guidelines in Beijing, China.

    abstract::Background: The leading cause of death in China is stroke, a condition that also contributes heavily to the disease burden. Nontraumatic intracerebral hemorrhage (ICH) is the second most common cause of stroke. Compared to Western countries, in China the proportion of ICH is significantly higher. Standardized treatmen...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.01091

    authors: Li D,Sun H,Ru X,Sun D,Guo X,Jiang B,Luo Y,Tao L,Fu J,Wang W

    更新日期:2018-12-11 00:00:00

  • Protectiveness of Artesunate Given Prior Ischemic Cerebral Infarction Is Mediated by Increased Autophagy.

    abstract::Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis. The aim of this study is to explore the possible neuroprotective effects of artesunate ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00634

    authors: Shao M,Shen Y,Sun H,Meng D,Huo W,Qi X

    更新日期:2018-08-17 00:00:00

  • Daith Piercing in a Case of Chronic Migraine: A Possible Vagal Modulation.

    abstract::Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering fro...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00624

    authors: Cascio Rizzo A,Paolucci M,Altavilla R,Brunelli N,Assenza F,Altamura C,Vernieri F

    更新日期:2017-11-27 00:00:00

  • Amide Proton Transfer Weighted Imaging Shows Differences in Multiple Sclerosis Lesions and White Matter Hyperintensities of Presumed Vascular Origin.

    abstract::Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healt...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01307

    authors: Sartoretti E,Sartoretti T,Wyss M,Becker AS,Schwenk Á,van Smoorenburg L,Najafi A,Binkert C,Thoeny HC,Zhou J,Jiang S,Graf N,Czell D,Sartoretti-Schefer S,Reischauer C

    更新日期:2019-12-10 00:00:00

  • Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy.

    abstract::Antiphospholipid syndrome (APS) is an autoimmune antibody-mediated condition characterized by thrombotic events and/or pregnancy morbidity in association with persistent positivity to antiphospholipid antibodies (aPL). The nervous system is frequently affected, as intracranial vessels are the most frequent site of art...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.01001

    authors: Fleetwood T,Cantello R,Comi C

    更新日期:2018-11-26 00:00:00

  • Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

    abstract::Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigate...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00636

    authors: Seo T,Shiraishi K,Kobayashi T,Fujita T,Saito K,Doi K

    更新日期:2018-08-03 00:00:00