Abstract:
INTRODUCTION:Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the disease as well. MATERIALS AND METHODS:About 22 patients (mean age: 75.9 ± 6.1 years; 14 women) with mild-to-moderate AD and 22 sex-matched healthy patients were examined. We compared the use of VEP and RNFLT using the latest high-resolution spectral domain optical coherence tomography with eye-tracking capabilities for optimized peripapillary scan centering for the first time in AD patients. RESULTS:The mean MMSE score was 22.59 ± 5.47 in the AD group, and did not significantly correlate with the VEP latencies. We found no significant difference between the VEP latencies of the AD patients and those of the control patients. No peripapillary sector of the retina had a RNFLT significantly correlated with the VEP latencies. DISCUSSION:We demonstrated that pattern VEP did not show any significant correlation despite subtle loss in RNFLT. It remains open whether additional flash VEP combined with RNFLT analysis may be useful in diagnosing AD, particularly for mild-to-moderate stages of the disease.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Kromer R,Serbecic N,Hausner L,Froelich L,Beutelspacher SCdoi
10.3389/fneur.2013.00203subject
Has Abstractpub_date
2013-12-16 00:00:00pages
203issn
1664-2295journal_volume
4pub_type
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abstract::[This corrects the article DOI: 10.3389/fneur.2020.00696.]. ...
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