Causality within the Epileptic Network: An EEG-fMRI Study Validated by Intracranial EEG.

abstract：:Hand-Arm Bimanual Intensive Therapy (HABIT) promotes hand function using intensive practice of bimanual functional and play tasks. This intervention has shown to be efficacious to improve upper-extremity (UE) function in children with unilateral spastic cerebral palsy (USCP). In addition to UE function deficits, lower...

journal_title：Frontiers in neurology

authors： Saussez G,Brandão MB,Gordon AM,Bleyenheuft Y

更新日期：2017-09-26 00:00:00

abstract：:In the present study, we investigated the genetic variation in a family with acute encephalopathy and retinitis pigmentosa. Nine of 25 people in this family underwent genetic testing. Three family members, namely, the proband and the proband's two sisters, showed symptoms resembling those of meningoencephalitis and si...

journal_title：Frontiers in neurology

authors： You C,Zeng W,Deng L,Lei Z,Gao X,Zhang VW,Wang Y

更新日期：2020-05-05 00:00:00

abstract：:This study aims to quantify passive muscle stiffness of spastic wrist flexors in stroke survivors using shear wave elastography (SWE) and to correlate with neural and non-neural contributors estimated from a biomechanical model to hyper-resistance measured during passive wrist extension. Fifteen hemiplegic individuals...

journal_title：Frontiers in neurology

authors： Leng Y,Wang Z,Bian R,Lo WLA,Xie X,Wang R,Huang D,Li L

更新日期：2019-07-10 00:00:00

abstract：:Background: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke. Objective: This study aimed to evaluate the...

journal_title：Frontiers in neurology

authors： Liu J,Sugimoto K,Cao Y,Mori M,Guo L,Tan G

更新日期：2020-09-08 00:00:00

abstract：:Introduction: Mitochondrial myopathy in children has notable clinical and genetic heterogeneity, but detailed data is lacking. Patients and Methods: In this study, we retrospectively reviewed the clinical presentation, laboratory investigation, genetic and histopathological characteristics, and follow-ups of 21 pediat...

journal_title：Frontiers in neurology

authors： Hu C,Li X,Zhao L,Shi Y,Zhou S,Wang Y

更新日期：2020-09-08 00:00:00

abstract：BACKGROUND:Amnestic mild cognitive impairment (aMCI) is considered to be the transitional stage between healthy aging and Alzheimer's disease (AD). Moreover, aMCI individuals with additional impairment in one or more non-memory cognitive domains are at higher risk of conversion to AD. Hence accurate identification of t...

journal_title：Frontiers in neurology

authors： Raamana PR,Wen W,Kochan NA,Brodaty H,Sachdev PS,Wang L,Beg MF

更新日期：2014-05-21 00:00:00

abstract：:Introduction: The headache phase of migraine could in selected cases potentially be treated by surgical decompression of one or more "trigger sites," located at frontal, temporal, nasal, and occipital sites. This systematic review with subsequent meta-analysis aims at critically evaluating the currently available evid...

journal_title：Frontiers in neurology

authors： Vincent AJPE,van Hoogstraten WS,Maassen Van Den Brink A,van Rosmalen J,Bouwen BLJ

更新日期：2019-02-14 00:00:00

abstract：:Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activity and slowing of the electroencephalogram, progressive memory disturbances, as well as a variety of other behavioral,...

journal_title：Frontiers in neurology

authors： Ehling P,Melzer N,Budde T,Meuth SG

更新日期：2015-07-15 00:00:00

abstract：:Extracellular vesicles (EVs) are involved in the development and progression of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Moreover, EVs have the capacity to modify the physiology of neuronal circuits by transferring proteins, RNA, lipids, and metabolites. The proteomic characterization...

journal_title：Frontiers in neurology

authors： Quiroz-Baez R,Hernández-Ortega K,Martínez-Martínez E

更新日期：2020-12-11 00:00:00

abstract：:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanis...

journal_title：Frontiers in neurology

authors： Cao Y,Zhang M,Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

更新日期：2019-04-09 00:00:00

abstract：:Huntington disease (HD) is caused by an abnormally expanded cytosine-adenine-guanine (CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate p...

journal_title：Frontiers in neurology

authors： Ciarochi JA,Calhoun VD,Lourens S,Long JD,Johnson HJ,Bockholt HJ,Liu J,Plis SM,Paulsen JS,Turner JA,PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

更新日期：2016-09-21 00:00:00

abstract：:Objective: Myotonia congenita (MC) is a rare muscle disease characterized by sarcolemma over-excitability inducing skeletal muscle stiffness. It can be inherited either as an autosomal dominant (Thomsen's disease) or an autosomal recessive (Becker's disease) trait. Both types are caused by loss-of-function mutations i...

journal_title：Frontiers in neurology

authors： Altamura C,Ivanova EA,Imbrici P,Conte E,Camerino GM,Dadali EL,Polyakov AV,Kurbatov SA,Girolamo F,Carratù MR,Desaphy JF

更新日期：2020-09-04 00:00:00

abstract：:Takotsubo cardiomyopathy (TTC) is an acute and reversible cardiac wall motion abnormality of the left myocardium. Although many studies focused on etiology, diagnostic and treatment of TTC, precise clinical guidelines on TTC are not available. Research revealed emotional and physical triggering factors of TTC and emph...

journal_title：Frontiers in neurology

authors： Buchmann SJ,Lehmann D,Stevens CE

更新日期：2019-08-22 00:00:00

abstract：INTRODUCTION:We sought to determine whether compliance with scheduled nimodipine in subarachnoid hemorrhage patients impacted patient outcomes, with the intent of guiding future nimodipine management in patients who experience nimodipine-induced hypotension. METHODS:We performed a retrospective analysis of 118 consecu...

journal_title：Frontiers in neurology

authors： Wessell A,Kole MJ,Badjatia N,Parikh G,Albrecht JS,Schreibman DL,Simard JM

更新日期：2017-06-09 00:00:00

abstract：:Maternal smoking is a risk factor for both sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death syndrome (SIUDS). Both SIDS and SIUDS are more frequently observed in infants of smoking mothers. The global prevalence of smoking during pregnancy is 1.7% and up to 8.1% of women in Europe smoke du...

journal_title：Frontiers in neurology

authors： Bednarczuk N,Milner A,Greenough A

更新日期：2020-10-23 00:00:00

abstract：:Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2* Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance Imaging (MRI) sequences, corresponding to areas of hemosiderin breakdown products from prior microscopic hemorrhages. They occur in the setting of impa...

journal_title：Frontiers in neurology

authors： Yates PA,Villemagne VL,Ellis KA,Desmond PM,Masters CL,Rowe CC

更新日期：2014-01-06 00:00:00

abstract：:Cortical neurodegeneration-induced non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a clinical syndrome characterized by non-fluent speech, such as apraxia of speech or agrammatism. We describe the case of an 80-year-old right-handed woman who exhibited nfvPPA. Atypically, our patient also pres...

journal_title：Frontiers in neurology

authors： Watanabe H,Ikeda M,Mori E

更新日期：2020-06-26 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is a prevalent sleep-related complaint across the general population and has been reported to be associated with headache. Tension-type headache (TTH) is the most commonly encountered headache and accounts for a significant amount of disease burden. However, the association between E...

journal_title：Frontiers in neurology

authors： Kim KM,Kim J,Cho SJ,Kim WJ,Yang KI,Yun CH,Chu MK

更新日期：2019-12-03 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive neuromuscular disorders caused by mutations in DMD. A high-quality database of DMD/BMD is essential not only for clinical practice but also for fundamental research. Here, we aimed to build the largest Chinese national dystrop...

journal_title：Frontiers in neurology

authors： Tong YR,Geng C,Guan YZ,Zhao YH,Ren HT,Yao FX,Ling C,Wang DC,Chen L,Cui LY,Zhang SY,Dai Y

更新日期：2020-09-30 00:00:00

abstract：UNLABELLED:Management of West syndrome is unsatisfactory. In our clinic we observed that a significant proportion of patients respond to usual dose of valproate. OBJECTIVE:To prospectively assess the efficacy of valproate in controlling infantile spasms in West syndrome. METHODS:Consecutive patients presenting with W...

journal_title：Frontiers in neurology

authors： Chandra S,Bhave A,Bhargava R,Kumar C,Kumar R

更新日期：2012-11-23 00:00:00

abstract：:Objective: The objective of this study was to investigate the roles and mechanisms of inflammatory mediators NLRP3 and IL-1β in refractory temporal epilepsy brain injury. Method: First, the brain tissue and the peripheral blood of children undergoing intractable temporal lobe epilepsy surgery were analyzed as research...

journal_title：Frontiers in neurology

authors： Wu C,Zhang G,Chen L,Kim S,Yu J,Hu G,Chen J,Huang Y,Zheng G,Huang S

更新日期：2020-02-07 00:00:00

abstract：:Background: Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke. In Asians, intracranial atherosclerotic disease leads to 33-50% of ischemic events. At present, treatment with medication vs. endovascular therapy (EVT) for symptomatic ICAS (sICAS) patients is still debatable. The clini...

journal_title：Frontiers in neurology

authors： Zhang J,Zhang K,Jia B,Qi Z,Mo D,Ma N,Gao F,Miao Z

更新日期：2020-11-06 00:00:00

abstract：:While the spread of some neurodegenerative disease-associated proteinopathies, such as tau and α-synuclein, is well studied and clearly implicates transsynaptic pathology transmission, research into the progressive spread of amyloid-β pathology has been less clear. In fact, prior analyses of transregional amyloid-β pa...

journal_title：Frontiers in neurology

authors： Mezias C,Raj A

更新日期：2017-12-18 00:00:00

abstract：INTRODUCTION:Options currently available to individuals with upper limb loss range from prosthetic hands that can perform many movements, but require more cognitive effort to control, to simpler terminal devices with limited functional abilities. We attempted to address this issue by designing a myoelectric control sys...

journal_title：Frontiers in neurology

authors： Gailey A,Artemiadis P,Santello M

更新日期：2017-02-01 00:00:00

abstract：:Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship bet...

journal_title：Frontiers in neurology

authors： Terrazzino S,Cargnin S,Viana M,Sances G,Tassorelli C

更新日期：2017-05-01 00:00:00

abstract：:Stroke is a leading cause of death and disability worldwide. While various risk factors have been identified, sleep has only been considered a risk factor more recently. Various epidemiologic studies have associated stroke with sleep such as sleep duration, and laboratory and clinical studies have proposed various und...

journal_title：Frontiers in neurology

authors： Phua CS,Jayaram L,Wijeratne T

更新日期：2017-08-08 00:00:00

abstract：:Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular end-organ disease, and it is one of the first causes of access to the emergency room. The moment of migration of the otoconial debris in a semicircular canal does not necessarily coincide with the moment of detachment of the debris th...

journal_title：Frontiers in neurology

authors： Gufoni M,Vianini M,Casani AP

更新日期：2020-10-23 00:00:00

abstract：:Background/Objective: Stroke is a leading global cause of adult disability. As the population ages as well as suffers co-morbidities, it is expected that the stroke burden will increase further. There are no established safe and effective restorative treatments to facilitate a good functional outcome in stroke patient...

journal_title：Frontiers in neurology

authors： Mu J,Bakreen A,Juntunen M,Korhonen P,Oinonen E,Cui L,Myllyniemi M,Zhao S,Miettinen S,Jolkkonen J

更新日期：2019-03-26 00:00:00

abstract：:Background: Phosphatidylinositol binding clathrin assembly protein (PICALM) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk. Nevertheless, the exact mechanisms through which the variant exert its disease-relevant association remain to be elucidated...

journal_title：Frontiers in neurology

authors： Zhuang L,Liu X,Shi Y,Liu X,Luo B

更新日期：2019-05-08 00:00:00

abstract：:Objective: To assess the relation between a sum score of imaging markers indicative of cerebral amyloid angiopathy (CAA) and cognitive impairment, stroke, dementia, and mortality in a general population. Methods: One thousand six hundred twenty-two stroke-free and dementia-free participants of the population-based Rot...

journal_title：Frontiers in neurology

authors： Yilmaz P,Ikram MA,Ikram MK,Niessen WJ,Viswanathan A,Charidimou A,Vernooij MW

更新日期：2019-12-06 00:00:00