Role of intravenous levetiracetam in seizure prophylaxis of severe traumatic brain injury patients.

Abstract:

:Traumatic brain injury (TBI) can cause seizures and the development of epilepsy. The incidence of seizures varies from 21% in patients with severe brain injuries to 50% in patients with war-related penetrating TBI. In the acute and sub-acute periods following injury, seizures can lead to increased intracranial pressure and cerebral edema, further complicating TBI management. Anticonvulsants can be used for seizure prophylaxis according to the current Parameters of Practice and Guidelines in a subset of severe TBI patients, and for a limited time window. Phenytoin is the most widely prescribed anticonvulsant in these patients. Intravenous levetiracetam, made available in 2006, is now being considered as a viable option in acute care settings if phenytoin is unavailable or not feasible due to side-effects. We discuss current data regarding the role of intravenous levetiracetam in seizure prophylaxis of severe TBI patients and the need for future studies.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Kirmani BF,Mungall D,Ling G

doi

10.3389/fneur.2013.00170

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

170

issn

1664-2295

journal_volume

4

pub_type

杂志文章,评审
  • Subtypes of Alzheimer's Disease Display Distinct Network Abnormalities Extending Beyond Their Pattern of Brain Atrophy.

    abstract::Different subtypes of Alzheimer's disease (AD) with characteristic distributions of neurofibrillary tangles and corresponding brain atrophy patterns have been identified using structural magnetic resonance imaging (MRI). However, the underlying biological mechanisms that determine this differential expression of neuro...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00524

    authors: Ferreira D,Pereira JB,Volpe G,Westman E

    更新日期:2019-05-28 00:00:00

  • The Silencing Effect of microRNA miR-17 on p21 Maintains the Neural Progenitor Pool in the Developing Cerebral Cortex.

    abstract::Expansion of the neural progenitor pool in the developing cerebral cortex is crucial for controlling brain size, since proliferation defects have been associated with the pathogenesis of microcephaly in humans. Cell cycle regulators play important roles in proliferation of neural progenitors. Here, we show that the cy...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00132

    authors: Chen Y,Bian S,Zhang J,Zhang H,Tang B,Sun T

    更新日期:2014-07-18 00:00:00

  • Poststroke Depression Biomarkers: A Narrative Review.

    abstract::Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current st...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.00577

    authors: Levada OA,Troyan AS

    更新日期:2018-07-16 00:00:00

  • The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.

    abstract::Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00152

    authors: Fernández Ó,Costa-Frossard L,Martínez-Ginés M,Montero P,Prieto JM,Ramió L

    更新日期:2020-03-17 00:00:00

  • Benefits of hemicraniectomy seen many years after malignant stroke in a young patient.

    abstract::The benefits of hemicraniectomy for malignant middle cerebral artery (MCA) stroke may not be apparent in the 3- to 6-months in which final outcomes are assessed in research studies. We present the case of a 15-year-old who underwent hemicraniectomy for malignant MCA stroke and was significantly disabled 3 and 6 months...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00123

    authors: Mittal A,Mittal G,Partikian A,Liebeskind D,Sanossian N

    更新日期:2012-08-02 00:00:00

  • Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder Evaluated in an 8-h Phase Advance Model; a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

    abstract::Background: Most travelers experience Jet Lag Disorder (JLD) symptoms due to misalignment of their circadian rhythms with respect to the new time zone. We assessed the efficacy and safety of tasimelteon (HETLIOZ®) in healthy participants using a laboratory model of JLD induced by an 8-h phase advance of the sleep-wake...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.00611

    authors: Polymeropoulos CM,Mohrman MA,Keefe MS,Brzezynski JL,Wang J,Prokosch LS,Polymeropoulos VM,Xiao C,Birznieks G,Polymeropoulos MH

    更新日期:2020-07-09 00:00:00

  • Migraine Symptoms Improvement During the COVID-19 Lockdown in a Cohort of Children and Adolescents.

    abstract::Background: Pediatric migraine is among the most common primary or comorbid neurologic disorders in children. Psychological stressors are widely acknowledged as potential triggers involved in recurring episodes of pediatric migraine. As the COVID-19 emergency may have affected the levels of stress perceived by childre...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.579047

    authors: Dallavalle G,Pezzotti E,Provenzi L,Toni F,Carpani A,Borgatti R

    更新日期:2020-10-08 00:00:00

  • A Family With a Complex Phenotype Caused by Two Different Rare Metabolic Disorders: GLUT1 and Very-Long-Chain Fatty Acid Dehydrogenase (VLCAD) Deficiencies.

    abstract::GLUT1 Deficiency Syndrome (GLUT1-DS) is a rare and potentially treatable neurometabolic condition, caused by a reduced glucose transport into the brain and clinically characterized by an epileptic encephalopathy with movement disorders. A wide inter-intrafamilial phenotypic variability has been reported. Very-long-cha...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00514

    authors: Musumeci O,Ferlazzo E,Rodolico C,Gambardella A,Gagliardi M,Aguglia U,Toscano A

    更新日期:2020-06-23 00:00:00

  • Regional Cerebral Oximetry as an Indicator of Acute Brain Injury in Adults Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation-A Prospective Pilot Study.

    abstract::Background: Regional cerebral oxygen saturation (rScO2) measured by near-infrared spectroscopy (NIRS) can be used to monitor brain oxygenation in extracorporeal membrane oxygenation (ECMO). ECMO patients that develop acute brain injuries (ABIs) are observed to have worse outcomes. We evaluated the association between ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00993

    authors: Khan I,Rehan M,Parikh G,Zammit C,Badjatia N,Herr D,Kon Z,Hogue C,Mazzeffi M

    更新日期:2018-11-23 00:00:00

  • Alterations Functional Connectivity in Temporal Lobe Epilepsy and Their Relationships With Cognitive Function: A Longitudinal Resting-State fMRI Study.

    abstract::Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to i...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00625

    authors: Qin L,Jiang W,Zheng J,Zhou X,Zhang Z,Liu J

    更新日期:2020-07-21 00:00:00

  • Neurocysticercosis and Hippocampal Atrophy: MRI Findings and the Evolution of Viable or Calcified Cysts in Patients With Neurocysticercosis.

    abstract::Neurocysticercosis (NC) is the most common parasitic infection of the central nervous system (CNS). Several studies have reported an association between NC and mesial temporal lobe epilepsy (MTLE). We intended to evaluate the frequency of hippocampal atrophy (HA), clinical evolution and imaging findings in patients wi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00449

    authors: Jama-António JMC,Yasuda CL,Cendes F

    更新日期:2019-04-30 00:00:00

  • Intracerebral hemorrhage after intravenous thrombolysis in patients with cerebral microbleeds and cardiac myxoma.

    abstract:BACKGROUND AND PURPOSE:Cardiac myxoma is a rare etiology of stroke. Both cerebral microbleeds and cardiac myxoma may increase the risk of intracerebral hemorrhage after intravenous (IV) thrombolysis. However, data are still limited. We report a case of multiple cerebral microbleeds treated with IV thrombolysis with lat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00252

    authors: Chutinet A,Roongpiboonsopit D,Suwanwela NC

    更新日期:2014-12-01 00:00:00

  • Correlative Magnetic Resonance Imaging and Histopathology in Small Ruminant Listeria Rhombencephalitis.

    abstract::Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to def...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.518697

    authors: Precht C,Vermathen P,Henke D,Staudacher A,Lauper J,Seuberlich T,Oevermann A,Schweizer-Gorgas D

    更新日期:2020-12-14 00:00:00

  • Functional magnetic resonance imaging in narcolepsy and the kleine-levin syndrome.

    abstract::This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine-Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functio...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2014.00105

    authors: Engström M,Hallböök T,Szakacs A,Karlsson T,Landtblom AM

    更新日期:2014-06-25 00:00:00

  • Mandibular Movements As Accurate Reporters of Respiratory Effort during Sleep: Validation against Diaphragmatic Electromyography.

    abstract:CONTEXT:Mandibular movements (MM) are considered as reliable reporters of respiratory effort (RE) during sleep and sleep disordered breathing (SDB), but MM accuracy has never been validated against the gold standard diaphragmatic electromyography (EMG-d). OBJECTIVES:To assess the degree of agreement between MM and EMG...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00353

    authors: Martinot JB,Le-Dong NN,Cuthbert V,Denison S,Silkoff PE,Guénard H,Gozal D,Pepin JL,Borel JC

    更新日期:2017-07-21 00:00:00

  • A Novel TTC19 Mutation in a Patient With Neurological, Psychological, and Gastrointestinal Impairment.

    abstract::Mitochondrial complex III deficiency nuclear type 2 is an autosomal-recessive disorder caused by mutations in TTC19 gene. TTC19 is involved in the preservation of mitochondrial complex III, which is responsible for transfer of electrons from reduced coenzyme Q to cytochrome C and thus, contributes to the formation of ...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00944

    authors: Habibzadeh P,Inaloo S,Silawi M,Dastsooz H,Farazi Fard MA,Sadeghipour F,Faghihi Z,Rezaeian M,Yavarian M,Böhm J,Faghihi MA

    更新日期:2019-09-04 00:00:00

  • Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

    abstract::[This corrects the article DOI: 10.3389/fneur.2018.01033.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误

    doi:10.3389/fneur.2020.00863

    authors: VanElzakker MB,Brumfield SA,Lara Mejia PS

    更新日期:2020-09-17 00:00:00

  • Different Therapeutic Effects of CO2 and Diode Laser Irradiation on Tooth Movement-Related Pain.

    abstract::Although orthodontic treatment is common, orthodontic force often induced pain. Low-level laser therapy (LLLT) has been investigated to improve therapeutic comfort. In dentistry, LLLT is mainly applied using two types of lasers, CO2 and diode lasers, whose biological actions are thought to be associated with wavelengt...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00481

    authors: Tsuchiya T,Hasegawa N,Yugawa M,Sasaki A,Suda N,Adachi K

    更新日期:2020-06-05 00:00:00

  • Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease.

    abstract::Non-motor symptoms of Parkinson's disease (PD) have been receiving increasing attention. Approximately half of patients with PD have experience PD-related pain. We investigated the effect and mechanism of acupuncture in patients with PD who have pain. PD patients with pain were divided into acupuncture group and contr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01114

    authors: Yu SW,Lin SH,Tsai CC,Chaudhuri KR,Huang YC,Chen YS,Yeh BY,Wu YR,Wang JJ

    更新日期:2019-10-22 00:00:00

  • Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.

    abstract::The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures per se can interfere with the biological rhythm output, including circadian...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00632

    authors: Matos HC,Koike BDV,Pereira WDS,de Andrade TG,Castro OW,Duzzioni M,Kodali M,Leite JP,Shetty AK,Gitaí DLG

    更新日期:2018-08-02 00:00:00

  • Access to Expert Stroke Care with Telemedicine: REACH MUSC.

    abstract::Stroke is a leading cause of death and disability, and recombinant tissue plasminogen activator (rtPA) can significantly reduce the long-term impact of acute ischemic stroke (AIS) if given within 3 h of symptom onset. South Carolina is located in the "stroke belt" and has a high rate of stroke and stroke mortality. Ma...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00044

    authors: Kazley AS,Wilkerson RC,Jauch E,Adams RJ

    更新日期:2012-03-21 00:00:00

  • Role of Decompressive Craniectomy in the Management of Cerebral Venous Sinus Thrombosis.

    abstract::Cerebral venous sinus thrombosis (CVST) is a relatively uncommon cause of stroke more often affecting women and younger individuals. Blockage of the venous outflow rapidly causes edema and space-occupying venous infarctions and it seems intuitive that decompressive craniectomy (DC) can effectively reduce intracranial ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00511

    authors: Avanali R,Gopalakrishnan MS,Devi BI,Bhat DI,Shukla DP,Shanbhag NC

    更新日期:2019-05-15 00:00:00

  • Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs.

    abstract::Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01353

    authors: Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

    更新日期:2020-02-10 00:00:00

  • N-acetylcysteine Amide Ameliorates Blast-Induced Changes in Blood-Brain Barrier Integrity in Rats.

    abstract::Traumatic brain injury resulting from exposure to blast overpressure (BOP) is associated with neuropathology including impairment of the blood-brain barrier (BBB). This study examined the effects of repeated exposure to primary BOP and post-blast treatment with an antioxidant, N-acetylcysteine amide (NACA) on the inte...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00650

    authors: Kawoos U,Abutarboush R,Zarriello S,Qadri A,Ahlers ST,McCarron RM,Chavko M

    更新日期:2019-06-26 00:00:00

  • Improved Gait of Persons With Multiple Sclerosis After Rehabilitation: Effects on Lower Limb Muscle Synergies, Push-Off, and Toe-Clearance.

    abstract::Introduction: Persons with MS (PwMS) have markedly reduced push-off and toe-clearance during gait compared to healthy subjects (HS). These deficits may result from alterations in neuromotor control at the ankle. To optimize rehabilitation interventions for PwMS, a crucial step is to evaluate if and how altered neuromo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00668

    authors: Jonsdottir J,Lencioni T,Gervasoni E,Crippa A,Anastasi D,Carpinella I,Rovaris M,Cattaneo D,Ferrarin M

    更新日期:2020-07-24 00:00:00

  • The involvement of noradrenaline in rapid eye movement sleep mentation.

    abstract::Noradrenaline, one of the main brain monoamines, has powerful central influences on forebrain neurobiological processes which support the mental activities occurring during the sleep-waking cycle. Noradrenergic neurons are activated during waking, decrease their firing rate during slow wave sleep, and become silent du...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2011.00081

    authors: Gottesmann C

    更新日期:2011-12-12 00:00:00

  • Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury.

    abstract::The endothelium is a thin monolayer of specialized cells that lines the luminal wall of blood vessels and constitutes the critical innermost portion of the physical barrier between the blood and the brain termed the blood-brain barrier (BBB). Aberrant changes in the endothelium occur in many neuropathological states, ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00582

    authors: Lutton EM,Farney SK,Andrews AM,Shuvaev VV,Chuang GY,Muzykantov VR,Ramirez SH

    更新日期:2019-06-06 00:00:00

  • Rate and Determinants of Recurrence at 1 Year and 5 Years After Stroke in a Low-Income Population in Rural China.

    abstract::Recurrent stroke is becoming an increasingly important public health issue owing to the increased risk of disability and death. However, population-based studies investigating the rate of recurrent stroke in China are rare. We explored the rate and determinants of recurrent stroke within 1 and 5 years after the initia...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00002

    authors: Han J,Mao W,Ni J,Wu Y,Liu J,Bai L,Shi M,Tu J,Ning X,Wang J

    更新日期:2020-01-23 00:00:00

  • Wegener's disease presenting with occipital condyle syndrome.

    abstract::Tumors or chronic inflammatory lesions of the occipital condyle may cause occipital pain associated with an ipsilateral hypoglossal nerve injury (occipital condyle syndrome). We describe a young woman with recurrent otitis media and occipital condyle syndrome associated with a limited form of Wegener's disease. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00053

    authors: Hornik A,Rodriguez-Porcel F,Ersahin CH,Kadanoff R,Biller J

    更新日期:2012-04-12 00:00:00

  • Shining a Light on Awareness: A Review of Functional Near-Infrared Spectroscopy for Prolonged Disorders of Consciousness.

    abstract::Qualitative clinical assessments of the recovery of awareness after severe brain injury require an assessor to differentiate purposeful behavior from spontaneous behavior. As many such behaviors are minimal and inconsistent, behavioral assessments are susceptible to diagnostic errors. Advanced neuroimaging tools can b...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2018.00350

    authors: Rupawala M,Dehghani H,Lucas SJE,Tino P,Cruse D

    更新日期:2018-05-22 00:00:00