Finding a roadmap to achieve large neuromorphic hardware systems.

abstract：:Spike-Timing-Dependent Plasticity (STDP) is a bio-inspired local incremental weight update rule commonly used for online learning in spike-based neuromorphic systems. In STDP, the intensity of long-term potentiation and depression in synaptic efficacy (weight) between neurons is expressed as a function of the relative...

journal_title：Frontiers in neuroscience

authors： Pedroni BU,Joshi S,Deiss SR,Sheik S,Detorakis G,Paul S,Augustine C,Neftci EO,Cauwenberghs G

更新日期：2019-04-24 00:00:00

abstract：:Developing new standardized tools to characterize brain recording devices is critical to evaluate neural probes and for translation to clinical use. The signal-to-noise ratio (SNR) measurement is the gold standard for quantifying the performance of brain recording devices. Given the drawbacks with the SNR measure, our...

journal_title：Frontiers in neuroscience

authors： Suarez-Perez A,Gabriel G,Rebollo B,Illa X,Guimerà-Brunet A,Hernández-Ferrer J,Martínez MT,Villa R,Sanchez-Vives MV

更新日期：2018-11-29 00:00:00

abstract：:Objects: Sensorineural hearing loss (SNHL) involves wide-ranging functional reorganization, and is associated with accumulating risk of cognitive and emotional dysfunction. The coordination of multiple functional networks supports normal brain functions. Here, we aimed to evaluate the functional connectivity (FC) patt...

journal_title：Frontiers in neuroscience

authors： Luan Y,Wang C,Jiao Y,Tang T,Zhang J,Teng GJ

更新日期：2019-02-05 00:00:00

abstract：:The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularl...

journal_title：Frontiers in neuroscience

authors： Rhea EM,Banks WA

更新日期：2019-06-04 00:00:00

abstract：:Objectives: This prospective cohort study explored whether two distinguished sensory parameters predicted acupuncture effects in chronic pain patients; namely high temporal summation of pain (TS) indicating spinal synaptic facilitation as well as a low vibration detection threshold (VDT) indicating a loss of Aβ-fiber ...

journal_title：Frontiers in neuroscience

authors： Baeumler PI,Conzen P,Irnich D

更新日期：2019-07-11 00:00:00

abstract：:The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tes...

journal_title：Frontiers in neuroscience

authors： Eissa N,Khan N,Ojha SK,Łazewska D,Kieć-Kononowicz K,Sadek B

更新日期：2018-02-12 00:00:00

abstract：:Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by in...

journal_title：Frontiers in neuroscience

authors： Dobryakova YV,Volobueva MN,Manolova AO,Medvedeva TM,Kvichansky AA,Gulyaeva NV,Markevich VA,Stepanichev MY,Bolshakov AP

更新日期：2019-03-12 00:00:00

abstract：:In the brain, glucose homeostasis of extracellular fluid is crucial to the point that systems specifically dedicated to glucose sensing are found in areas involved in energy regulation and feeding behavior. Olfaction is a major sensory modality regulating food consumption. Nutritional status in turn modulates olfactor...

journal_title：Frontiers in neuroscience

authors： Al Koborssy D,Palouzier-Paulignan B,Salem R,Thevenet M,Romestaing C,Julliard AK

更新日期：2014-10-29 00:00:00

abstract：:Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...

journal_title：Frontiers in neuroscience

authors： Yu Y,Li Z,Lin Y,Yu J,Peng G,Zhang K,Jia X,Luo B

更新日期：2019-12-17 00:00:00

abstract：:Recent intriguing evidence suggests that metabolites of amyloid precursor protein (APP), mutated in familial forms of Alzheimer's disease (AD), play critical roles in developmental and postnatal neurogenesis. Of note is soluble APPα (sAPPα) that regulates neural progenitor cell proliferation. The APP family encompasse...

journal_title：Frontiers in neuroscience

authors： Lazarov O,Demars MP

更新日期：2012-06-04 00:00:00

abstract：:Prior research has shown that musical beats are salient at the level of the cortex in humans. Yet below the cortex there is considerable sub-cortical processing that could influence beat perception. Some biases, such as a tempo preference and an audio frequency bias for beat timing, could result from sub-cortical proc...

journal_title：Frontiers in neuroscience

authors： Zuk NJ,Carney LH,Lalor EC

更新日期：2018-05-29 00:00:00

abstract：:Emerging evidence suggest an impaired endocannabinoid activity in the pathophysiology of binge eating disorder (BED). Herein, we investigated whether endocannabinoid tone could be modified as a consequence of dietary-induced binge eating in female rats. For this purpose, brain levels of the endocannabinoids anandamide...

journal_title：Frontiers in neuroscience

authors： Satta V,Scherma M,Piscitelli F,Usai P,Castelli MP,Bisogno T,Fratta W,Fadda P

更新日期：2018-02-02 00:00:00

abstract：:Here, we present the first description of an isolation syndrome in a patient who suffered prolonged cardiac arrest and underwent a standard therapeutic hypothermia protocol. Two years after the arrest, the patient demonstrated no motor responses to commands, communication capabilities, or visual tracking at the bedsid...

journal_title：Frontiers in neuroscience

authors： Forgacs PB,Fridman EA,Goldfine AM,Schiff ND

更新日期：2016-06-09 00:00:00

abstract：:Accuracy in auditory distance perception can improve with practice and varies for sounds differing in familiarity. Here, listeners were trained to judge the distances of English, Bengali, and backwards speech sources pre-recorded at near (2-m) and far (30-m) distances. Listeners' accuracy was tested before and after t...

journal_title：Frontiers in neuroscience

authors： Wisniewski MG,Mercado E 3rd,Church BA,Gramann K,Makeig S

更新日期：2014-12-09 00:00:00

abstract：:Mu/beta rhythms are well-studied brain activities that originate from sensorimotor cortices. These rhythms reveal spectral changes in alpha and beta bands induced by movements of different body parts, e.g., hands and limbs, in electroencephalography (EEG) signals. However, less can be revealed in them about movements ...

journal_title：Frontiers in neuroscience

authors： Xiao R,Ding L

更新日期：2015-09-01 00:00:00

abstract：:This paper presents a real-time, low-complexity neuromorphic speech recognition system using a spiking silicon cochlea, a feature extraction module and a population encoding method based Neural Engineering Framework (NEF)/Extreme Learning Machine (ELM) classifier IC. Several feature extraction methods with varying mem...

journal_title：Frontiers in neuroscience

authors： Acharya J,Patil A,Li X,Chen Y,Liu SC,Basu A

更新日期：2018-03-28 00:00:00

abstract：:Alzheimer's disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running behavior both early and late in disease progression in a novel dual Tg m...

journal_title：Frontiers in neuroscience

authors： Lippi SLP,Kakalec PA,Smith ML,Flinn JM

更新日期：2020-08-14 00:00:00

abstract：:Neural stem cells-based therapies have shown great potential for central nervous system regeneration, with three-dimensional (3D) culture systems representing a key technique for tissue engineering applications, as well as disease modeling and drug screenings. Self-assembling peptides (SAPs), providing biomimetic synt...

journal_title：Frontiers in neuroscience

authors： Marchini A,Favoino C,Gelain F

更新日期：2020-05-05 00:00:00

abstract：:Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often d...

journal_title：Frontiers in neuroscience

authors： de Graaf TA,Sack AT

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND AND AIMS:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS:Activity of human submucous ...

journal_title：Frontiers in neuroscience

authors： Ostertag D,Buhner S,Michel K,Pehl C,Kurjak M,Götzberger M,Schulte-Frohlinde E,Frieling T,Enck P,Phillip J,Schemann M

更新日期：2015-12-16 00:00:00

abstract：:While convolutional neural networks (CNNs) continue to renew state-of-the-art performance across many fields of machine learning, their hardware implementations tend to be very costly and inflexible. Neuromorphic hardware, on the other hand, targets higher efficiency but their inference accuracy lags far behind that o...

journal_title：Frontiers in neuroscience

authors： Sim H,Lee J

更新日期：2020-12-23 00:00:00

abstract：:One of the most sought-after applications of neuroengineering is the communication between the arm and an artificial prosthetic device for the replacement of an amputated hand or the treatment of peripheral nerve injuries. For that, an electrode is placed around or inside the median nerve to serve as interface for rec...

journal_title：Frontiers in neuroscience

authors： Delgado-Martínez I,Badia J,Pascual-Font A,Rodríguez-Baeza A,Navarro X

更新日期：2016-07-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of ...

journal_title：Frontiers in neuroscience

authors： Forde NJ,Ronan L,Zwiers MP,Alexander-Bloch AF,Faraone SV,Oosterlaan J,Heslenfeld DJ,Hartman CA,Buitelaar JK,Hoekstra PJ

更新日期：2017-04-20 00:00:00

abstract：:Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders entailing social and cognitive deficits, including marked problems with language. Numerous genes have been associated with ASD, but it is unclear how language deficits arise from gene mutation or dysregulation. It is also unclear why ASD shows ...

journal_title：Frontiers in neuroscience

authors： Benítez-Burraco A,Lattanzi W,Murphy E

更新日期：2016-08-29 00:00:00

abstract：:Modern high field and ultra high field magnetic resonance imaging (MRI) experiments routinely collect multi-dimensional data with high spatial resolution, whether multi-parametric structural, diffusion or functional MRI. While diffusion and functional imaging have benefited from recent advances in multi-dimensional si...

journal_title：Frontiers in neuroscience

authors： Bazin PL,Alkemade A,van der Zwaag W,Caan M,Mulder M,Forstmann BU

更新日期：2019-10-09 00:00:00

abstract：:The global prevalence of obesity has been steadily increasing. Although pharmacotherapy and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may lose long-term effectiveness. Obesity result largely from unbalanced energy homeostasis. Palatable and densely caloric foods may affect th...

journal_title：Frontiers in neuroscience

authors： Formolo DA,Gaspar JM,Melo HM,Eichwald T,Zepeda RJ,Latini A,Okun MS,Walz R

更新日期：2019-04-18 00:00:00

abstract：:Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet c...

journal_title：Frontiers in neuroscience

authors： Nuno-Perez A,Tchenio A,Mameli M,Lecca S

更新日期：2018-07-23 00:00:00

abstract：:Central sleep apnea is a sudden arrest of breathing during sleep caused by the central commands to the thoracoabdominal muscles. It is a widespread phenomenon in both healthy and diseased people, as well as in some animals. However, there is an ongoing debate whether it can be considered as a pathological deviation of...

journal_title：Frontiers in neuroscience

authors： Limanskaya AV,Busygina II,Levichkina EV,Pigarev IN

更新日期：2020-06-17 00:00:00

abstract：:The classification of electroencephalogram (EEG) signals is of significant importance in brain-computer interface (BCI) systems. Aiming to achieve intelligent classification of EEG types with high accuracy, a classification methodology using sparse representation (SR) and fast compression residual convolutional neural...

journal_title：Frontiers in neuroscience

authors： Huang JS,Li Y,Chen BQ,Lin C,Yao B

更新日期：2020-09-30 00:00:00

abstract：:Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have ...

journal_title：Frontiers in neuroscience

authors： Li W,Yu G,Liu Y,Sha L

更新日期：2019-02-20 00:00:00