Frequency of elevated biomarkers in patients with cryptogenic hepatocellular carcinoma.

Abstract:

BACKGROUND:The incidence of hepatocellular carcinoma (HCC) continues to increase in Japan, but the clinical characteristics of Japanese patients with HCC have not been well described. The aim of this study was to determine the frequencies and utilities of elevated a-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) levels as biomarkers in cryptogenic HCC. MATERIAL/METHODS:A total of 2638 patients with HCC diagnosed between 1999 and 2010 in the Nagasaki Association Study of Liver (NASLD) were recruited for this study. The cause of HCC was categorized into 4 groups; HCC-B, HCC-C, HCC-BC, and HCC-nonBC. The significance of factors was examined for HCC-nonBC using logistic regression analysis in all patients. RESULTS:Multivariate analysis identified age, sex, BMI, alcohol consumption, platelet count, AST, ALT, AFP, DCP, and TNM stage as independent and significant risk factors for HCC-nonBC. According to TNM stage, the median AFP levels in HCC-nonBC with TNM stages I, II, and III were significantly lower than in either HCC-B or HCC-C. In TNM stage IV, the median AFP level in HCC-nonBC was significantly lower than in either HCC-B or HCC-BC. The median DCP levels in HCC-nonBC with TNM stages I and II were significantly higher than those in either HCC-B or HCC-C. In TNM stage III, the median DCP level in HCC-nonBC was significantly higher than that in HCC-C. CONCLUSIONS:DCP was more sensitive than AFP for the diagnosis of early stage cryptogenic HCC. DCP should be used as the main serum test for cryptogenic HCC detection.

journal_name

Med Sci Monit

authors

Taura N,Ichikawa T,Miyaaki H,Ozawa E,Tsutsumi T,Tsuruta S,Kato Y,Goto T,Kinoshita N,Fukushima M,Kato H,Ohata K,Ohba K,Masuda J,Hamasaki K,Yatsuhashi H,Nakao K

doi

10.12659/MSM.889361

subject

Has Abstract

pub_date

2013-09-06 00:00:00

pages

742-50

eissn

1234-1010

issn

1643-3750

pii

889361

journal_volume

19

pub_type

杂志文章
  • Preliminary evaluation of the capacity of surface-active phospholipids to provide semipermeability in a saline filtration environment.

    abstract:BACKGROUND:Semipermeability to fluid transport is one of the principal attributes of a tissue like articular cartilage. Consequently, this characteristic can be exploited in attempts to understand the functional roles of the biological layer of Surface Active Phospholipids (SAPL) which form on its surfaces. A previous ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Chen Y,Crawford RW,Oloyede A

    更新日期:2007-04-01 00:00:00

  • Comparative analysis of diagnostic probability estimates of some common diagnoses among family doctors, medical residents, and medical students reveals negative correlation between age and estimate of chronic obstructive pulmonary disease (COPD).

    abstract:BACKGROUND:Patients with their given complaints and symptoms expect certain diagnoses to be estimated with the same probability when seen by different family doctors. These estimations showed extreme variation among family doctors in Switzerland. The present study investigated whether there is any difference in the pro...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Vajer P,Szélvári A,Vörös K,Torzsa P,Eory A,Dunai K,Tamás F,Kalabay L

    更新日期:2010-03-01 00:00:00

  • Doxorubicin-Induced Cancer Cell Senescence Shows a Time Delay Effect and Is Inhibited by Epithelial-Mesenchymal Transition (EMT).

    abstract::BACKGROUND Senescence is a natural barrier for the body to resist the malignant transformation of its own cells. This work investigated the senescence characteristics of cancer cells in vitro. MATERIAL AND METHODS Human cervical cancer HeLa cells were treated with different concentrations of doxorubicin for 3 days, wi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.914295

    authors: Hu X,Zhang H

    更新日期:2019-05-16 00:00:00

  • Effect of a human-type communication robot on cognitive function in elderly women living alone.

    abstract:BACKGROUND:Considering the high prevalence of dementia, it would be of great value to develop effective tools to improve cognitive function. We examined the effects of a human-type communication robot on cognitive function in elderly women living alone. MATERIAL/METHODS:In this study, 34 healthy elderly female volunte...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/msm.883350

    authors: Tanaka M,Ishii A,Yamano E,Ogikubo H,Okazaki M,Kamimura K,Konishi Y,Emoto S,Watanabe Y

    更新日期:2012-09-01 00:00:00

  • Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

    abstract:BACKGROUND:Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definitio...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.881982

    authors: Tryniszewski W,Gadzicki M,Górska-Chrząstek M,Rysz J,Maziarz Z

    更新日期:2011-10-01 00:00:00

  • Incidence of anorectal malformations in Łódź province.

    abstract:PURPOSE:It is difficult to obtain reliable figures on incidence of anorectal malformations (ARM) from literature. The aim of the present study was to reveal the real incidence of these defects in a given area. MATERIAL AND METHODS:Between 1992 and 1997, 86 children with ARM were treated at the departments of paediatri...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Niedzielski J

    更新日期:2000-01-01 00:00:00

  • Decreased endothelin-1 plasma levels in multiple sclerosis patients: a possible factor of vascular dysregulation?

    abstract:BACKGROUND:Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system with possible involvement of vascular dysregulation secondary to endothelial dysfunction caused by destruction of the vessel wall. Vascular dysregulation leads to excessive vasoconstriction or insufficient vasodilatat...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.890899

    authors: Jankowska-Lech I,Terelak-Borys B,Grabska-Liberek I,Palasik W,Bik W,Wolińska-Witort E

    更新日期:2015-04-13 00:00:00

  • Neuropsychological follow-up into young adulthood of term infants born small for gestational age.

    abstract:BACKGROUND:The aim of the study was to investigate whether children born small for gestational age without other complications nor signs of neurological impairment or developmental delay before 18 months of age may display neuropsychological impairments later in life. MATERIAL/METHODS:Neuropsychological outcome, schoo...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Viggedal G,Lundalv E,Carlsson G,Kjellmer I

    更新日期:2004-01-01 00:00:00

  • Behavioral and Emotional Problems in Early-Treated Brazilian Children and Adolescents with Phenylketonuria.

    abstract::BACKGROUND Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene. When untreated, PKU leads to a significant intellectual deficiency. Although early initiation of dietary therapy allows normal cognitive development, low adherence to treatment may result ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.909146

    authors: Vieira Neto E,Maia Filho HS,Monteiro CB,Carvalho LM,da Cruz TS,de Barros BV,Ribeiro MG

    更新日期:2018-10-30 00:00:00

  • The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, and Choroidal Thickness.

    abstract::BACKGROUND The aim of this study was to evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), and choroidal thickness (CT). MATERIAL AND METHODS A total of 24 healthy women taking monophasic OCP (3 mg drospirenone and 0.03 mg ethinylestradiol) for contraception only...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.905183

    authors: Madendag Y,Acmaz G,Atas M,Sahin E,Tayyar AT,Madendag IÇ,Özdemir F,Senol V

    更新日期:2017-11-27 00:00:00

  • Association of STin2 VNTR Polymorphism of Serotonin Transporter Gene with Lifelong Premature Ejaculation: A Case-Control Study in Han Chinese Subjects.

    abstract::BACKGROUND The STin2 VNTR polymorphism has a variable number of tandem repeats in intron 2 of the serotonin transporter gene. We aimed to explore the relationship between STin2 VNTR polymorphism and lifelong premature ejaculation (LPE). MATERIAL AND METHODS We recruited a total of 115 outpatients who complained of eja...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.897720

    authors: Huang Y,Zhang X,Gao J,Tang D,Gao P,Peng D,Liang C

    更新日期:2016-10-07 00:00:00

  • Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.

    abstract:BACKGROUND:Several HIV protease mutations, which are resistant to clinical HIV protease inhibitors (PIs), have been identified. There is a great need for second-generation PIs with different chemical structures and/or with an alternative mode of inhibition. Ginkgolic acid is a natural herbal substance and a major compo...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.883261

    authors: Lü JM,Yan S,Jamaluddin S,Weakley SM,Liang Z,Siwak EB,Yao Q,Chen C

    更新日期:2012-08-01 00:00:00

  • Treatment of Osteoporosis, with a Focus on 2 Monoclonal Antibodies.

    abstract::Osteoporosis is a common skeletal disease characterized by bone loss and subsequent increased risk of fragility fractures. Recent advances in our mechanistic understanding of molecular communications among osteoblasts, osteoclasts, and osteocytes give insight into the important roles of the canonical Wnt/β-catenin pat...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:10.12659/MSM.912309

    authors: Chang B,Quan Q,Li Y,Qiu H,Peng J,Gu Y

    更新日期:2018-12-03 00:00:00

  • RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.

    abstract:BACKGROUND:The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.881902

    authors: Theocharis S,Klijanienko J,Giaginis C,Rodriguez J,Jouffroy T,Girod A,Tsourouflis G,Sastre-Garau X

    更新日期:2011-08-01 00:00:00

  • Outcomes of Laparoscopic Treatment in Women with Cesarean Scar Syndrome.

    abstract::BACKGROUND The aim of this study was to evaluate the outcomes of laparoscopic treatment of women with severe defect of a Cesarean section (CS) scar and Cesarean scar syndrome. MATERIAL AND METHODS A prospective longitudinal study was conducted in 11 women who were treated for Cesarean scar syndrome. Ultrasound examina...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.902720

    authors: Dosedla E,Calda P

    更新日期:2017-08-22 00:00:00

  • Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment.

    abstract::BACKGROUND The aim of this study was to investigate the association between mean platelet volume (MPV), C-reactive protein (CRP), and prognosis in patients with acute ischemic stroke (AIS) following intravenous (IV) thrombolytic treatment. MATERIAL AND METHODS A retrospective clinical study included 129 patients withi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.906813

    authors: İnanç Y,Giray S,İnanç Y

    更新日期:2018-06-05 00:00:00

  • Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China.

    abstract::BACKGROUND The aim of this study was to investigate the association between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) in hypertensive males. MATERIAL AND METHODS Altogether, 14 866 male hypertensive participants were included in the analysis. Participants were divided into 3 groups: low BMI ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.914881

    authors: Huang J,Chen Z,Yuan J,Zhang C,Chen H,Wu W,Chen Z,Liu Y,Zheng M,Chen S,Wu S,Chen Y

    更新日期:2019-07-15 00:00:00

  • Non-invasive assessment of hemispheric language dominance by optical topography during a brief passive listening test: a pilot study.

    abstract:BACKGROUND:The Wada test is usually used for pre-surgical assessment of language lateralization. Considering its invasiveness and risk of complications, alternative methods have been proposed but they are not always applicable to non-cooperative patients. In this study we explored the possibility of using optical topog...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.882128

    authors: Bembich S,Demarini S,Clarici A,Massaccesi S,Grasso DL

    更新日期:2011-12-01 00:00:00

  • Effects of interaction between cadmium and selenium on heart metabolism in mice: the study of RNA, protein, ANP synthesis activities and ultrastructure in mouse heart.

    abstract::Heavy metals tend to occur in increasingly many aspects of human activities. Studies of cadmium (Cd) have revealed that it is extremely toxic in its effects. It is known that selenium (Se) may suppress deleterious effects of Cd. We investigated the effects of dietary Cd-intoxication on the incorporation of precursors ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Skowerski M,Jasik K,Konecki J

    更新日期:2000-03-01 00:00:00

  • Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.

    abstract::BACKGROUND The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients. MATERIAL AND METHODS Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906507

    authors: Zhang C,Huang J,Chen Y,Shi W

    更新日期:2018-04-02 00:00:00

  • Effectiveness of Antibiotic Use Management in Tianjin (2011-2013): A Quasi-Experimental Study.

    abstract::BACKGROUND In this study we investigated changes in the status of antibiotic use in Tianjin since the implementation of the Antibiotic Stewardship Program (ASP) (2011-2013), as well as existing problems, strategies, and outcomes to promote rational clinical antibiotic use. MATERIAL AND METHODS A quasi-experimental stu...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.899848

    authors: Zhang HH,Du Y,Liu W,Song SD,Zhao W,Huang GW,Wang HS

    更新日期:2017-02-09 00:00:00

  • Effects of magnetic resonance imaging on polymorphonuclear neutrophil adhesion.

    abstract:BACKGROUND:Limited research has been performed concerning the effects of MR imaging on the immune system. In this study the influence of MR imaging exposure on polymorphonuclear neutrophil (PMN) adhesion was evaluated. MATERIAL AND METHODS:In vivo and in vitro studies were performed in 10 patients undergoing an MR ima...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Minczykowski A,Paprzycki W,Smielecki J,Dworacki G,Szczepanik A,Zeromski J,Wysocki H

    更新日期:2001-05-01 00:00:00

  • Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study.

    abstract:BACKGROUND:Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrhosis. MATERIAL/METHO...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896153

    authors: Zhang X,Qi X,De Stefano V,Hou F,Ning Z,Zhao J,Peng Y,Li J,Deng H,Li H,Guo X

    更新日期:2016-03-24 00:00:00

  • Erosive gastroduodenitis and Helicobacter pylori infection.

    abstract:BACKGROUND:This study was aimed at evaluating the role of Helicobacter pylori in erosive gastroduodenitis and the necessity for its eradication. MATERIAL/METHODS:A total of forty-nine consecutive patients who presented with hematemesis and or melena and proved to have erosive gastroduodenitis on endoscopy were include...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Shankar RR,Vikram K,Ananthakrishnan N,Harish BN,Jayanthi S

    更新日期:2003-06-01 00:00:00

  • Relation Between Neck Pain and Modic Changes in Cervical Spondylotic Myelopathy.

    abstract::BACKGROUND Modic changes on magnetic resonance imaging (MRI) represent lesions in the bone marrow of the vertebral body that may be associated with pain. This study investigated the relationship between neck pain and cervical Modic changes, and risk factors for neck pain (NP). MATERIAL AND METHODS This study included ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.923908

    authors: Sun Y,Yan C,Shen Y,Wu Z

    更新日期:2020-09-03 00:00:00

  • Identification of Apolipoprotein C-I Peptides as a Potential Biomarker and its Biological Roles in Breast Cancer.

    abstract:BACKGROUND:Breast cancer (BC) is one of the most common cancers and is among the main causes of death in females around the world. Although several serum biomarkers have been identified for breast cancer, due to lack of adequate sensitivity and specificity they do not adequately distinguish BC from confounding conditio...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896531

    authors: Sun Y,Zhang J,Guo F,Zhao W,Zhan Y,Liu C,Fan Y,Wang J

    更新日期:2016-04-07 00:00:00

  • Acoustic rhinometry in the assessment of adenoid hypertrophy in allergic children.

    abstract:BACKGROUND:Due to the difficulties involved in assessing adenoidal tissue and the nasopharyngeal airway in children, it is necessary to find an accurate pre-operative method of measuring these structures. MATERIAL/METHODS:We used acoustic rhinometry and endoscopy both to the evaluate results of surgical and medical tr...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Modrzyński M,Mierzwinski J,Zawisza E,Piziewicz A

    更新日期:2004-07-01 00:00:00

  • Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway.

    abstract::BACKGROUND Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as an endogenous TLR4 ligand. Ligand activation of TLR4 activates nuclear factor-kappaB (NF-κB) and the transcription of NF-κB-regulated inflammatory cytokines, which are involved in the development of atherosc...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.906450

    authors: Zhou ZB,Yang B,Li X,Liu H,Lei G

    更新日期:2018-07-13 00:00:00

  • Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer.

    abstract::This article is retracted due to authors' claims in regards to errors in data and statistical analyses. Authors' message: We greatly regret to inform you that we just discovered some fatal errors in the statistical analysis, in which we mistakenly used the cultured cells TCR sequencing data as the results of CD8+ LAG3...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,撤回出版物

    doi:10.12659/MSM.917907

    authors: Huang L,Qiao G,Wu J,Ren J

    更新日期:2019-06-13 00:00:00

  • Diagnosis of Congenital Coarctation of the Aorta and Accompany Malformations in Infants by Multi-Detector Computed Tomography Angiography and Transthoracic Echocardiography: A Chinese Clinical Study.

    abstract::BACKGROUND The purpose of this study was to evaluate the utility of multi-detector computed tomography (MDCT) angiography and transthoracic echocardiography (TTE) in the diagnosis of congenital coarctation of the aorta (CoA) and accompanying malformations in infants. MATERIAL AND METHODS From January 2012 and December...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.901928

    authors: Huang F,Chen Q,Huang WH,Wu H,Li WC,Lai QQ

    更新日期:2017-05-16 00:00:00