Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze.

Abstract:

:Globally, it is estimated that nearly 10 million people sustain severe brain injuries leading to hospitalization and/or death every year. Amongst survivors, traumatic brain injury (TBI) results in a wide variety of physical, emotional and cognitive deficits. The most common cognitive deficit associated with TBI is memory loss, involving impairments in spatial reference and working memory. However, the majority of research thus far has characterized the deficits associated with TBI on either reference or working memory systems separately, without investigating how they interact within a single task. Thus, we examined the effects of TBI on short-term working and long-term reference memory using the radial 8-arm maze (RAM) with a sequence of four baited and four unbaited arms. Subjects were given 10 daily trials for 6 days followed by a memory retrieval test 2 weeks after training. Multiple training trials not only provide robust training, but also test the subjects' ability to frequently update short-term memory while learning the reference rules of the task. Our results show that TBI significantly impaired short-term working memory function on previously acquired spatial information but has little effect on long-term reference memory. Additionally, TBI significantly increased working memory errors during acquisition and reference memory errors during retention testing 2 weeks later. With a longer recovery period after TBI, the robust RAM training mitigated the reference memory deficit in retention but not the short-term working memory deficit during acquisition. These results identify the resiliency and vulnerabilities of short-term working and long-term reference memory to TBI in the context of robust training. The data highlight the role of cognitive training and other behavioral remediation strategies implicated in attenuating deficits associated with TBI.

journal_name

Front Behav Neurosci

authors

Sebastian V,Diallo A,Ling DS,Serrano PA

doi

10.3389/fnbeh.2013.00038

subject

Has Abstract

pub_date

2013-05-03 00:00:00

pages

38

issn

1662-5153

journal_volume

7

pub_type

杂志文章
  • Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats.

    abstract::Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00142

    authors: Rapley SA,Prickett TCR,Dalrymple-Alford JC,Espiner EA

    更新日期:2018-07-19 00:00:00

  • Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior.

    abstract::The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00069

    authors: Porseryd T,Volkova K,Reyhanian Caspillo N,Källman T,Dinnetz P,Porsh Hällström I

    更新日期:2017-04-20 00:00:00

  • Lack of motor prediction, rather than perceptual conflict, evokes an odd sensation upon stepping onto a stopped escalator.

    abstract::When stepping onto a stopped escalator, we often perceive an "odd sensation" that is never felt when stepping onto stairs. The sight of an escalator provides a strong contextual cue that, in expectation of the backward acceleration when stepping on, triggers an anticipatory forward postural adjustment driven by a habi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00077

    authors: Gomi H,Sakurada T,Fukui T

    更新日期:2014-03-20 00:00:00

  • Perinatal exposure to methoxychlor enhances adult cognitive responses and hippocampal neurogenesis in mice.

    abstract::During perinatal life, sex steroids, such as estradiol, have marked effects on the development and function of the nervous system. Environmental estrogens or xenoestrogens are man-made chemicals, which animal and human population encounter in the environment and which are able to disrupt the functioning of the endocri...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00202

    authors: Martini M,Calandreau L,Jouhanneau M,Mhaouty-Kodja S,Keller M

    更新日期:2014-06-16 00:00:00

  • High Salt Intake Lowers Behavioral Inhibition.

    abstract::Stress-related neuropsychiatric (e.g., anxiety, depression) and cardiovascular diseases are frequently comorbid, though discerning the directionality of their association has been challenging. One of the most controllable risk factors for cardiovascular disease is salt intake. Though high salt intake is implicated in ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00271

    authors: Gilman TL,George CM,Andrade MA,Mitchell NC,Toney GM,Daws LC

    更新日期:2019-12-13 00:00:00

  • No Evidence for a Relationship Between Hair Testosterone Concentrations and 2D:4D Ratio or Risk Taking.

    abstract::Using a recently developed alternative assay procedure to measure hormone levels from hair samples, we examined the relationships between testosterone, cortisol, 2D:4D ratio, overconfidence and risk taking. A total of 162 (53 male) participants provided a 3 cm sample of hair, a scanned image of their right and left ha...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00030

    authors: Ronay R,van der Meij L,Oostrom JK,Pollet TV

    更新日期:2018-03-05 00:00:00

  • Common Recruitment of Angular Gyrus in Episodic Autobiographical Memory and Bodily Self-Consciousness.

    abstract::Parietal cortex and adjacent parts of the temporal cortex have recently been associated with bodily self-consciousness (BSC). Similarly, growing evidence suggests that the lateral parietal cortex is crucial for the subjective aspects of episodic autobiographical memory (EAM), which is based on the conscious experience...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00270

    authors: Bréchet L,Grivaz P,Gauthier B,Blanke O

    更新日期:2018-11-14 00:00:00

  • Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.

    abstract::Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genom...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00001

    authors: Bubier JA,Wilcox TD,Jay JJ,Langston MA,Baker EJ,Chesler EJ

    更新日期:2016-01-21 00:00:00

  • Delay discounting without decision-making: medial prefrontal cortex and amygdala activations reflect immediacy processing and correlate with impulsivity and anxious-depressive traits.

    abstract::Humans value rewards less when these are delivered in the future as opposed to immediately, a phenomenon referred to as delay discounting. While delay discounting has been studied during the anticipation of rewards and in the context of intertemporal decision-making, little is known about its neural correlates in the ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00280

    authors: Ludwig VU,Nüsser C,Goschke T,Wittfoth-Schardt D,Wiers CE,Erk S,Schott BH,Walter H

    更新日期:2015-10-29 00:00:00

  • Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators.

    abstract::The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use disorder via the mesolimbic pathway remain elusive. In this mini...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2018.00309

    authors: Mukhara D,Banks ML,Neigh GN

    更新日期:2018-12-21 00:00:00

  • A New 3-Day Standardized Eyeblink Conditioning Protocol to Assess Extinction Learning From Infancy to Adulthood.

    abstract::Associative learning can be observed from the neonatal period onward, providing opportunities to examine changes in basic learning and memory abilities. One method that is suitable to study associative learning is classical eyeblink conditioning (EBC) which is dependent on the cerebellum. Extinction learning can be sy...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00135

    authors: Konrad C,Adolph D,Herbert JS,Neuhoff L,Mohr C,Jagusch-Poirier J,Seehagen S,Weigelt S,Schneider S

    更新日期:2020-08-14 00:00:00

  • Effects of early psychosocial deprivation on the development of memory and executive function.

    abstract::This study investigated the effects of early institutional care on memory and executive functioning. Subjects were participants in the Bucharest Early Intervention Project (BEIP) and included institutionalized children, children with a history of institutionalization who were assigned to a foster care intervention, an...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.016.2009

    authors: Bos KJ,Fox N,Zeanah CH,Nelson Iii CA

    更新日期:2009-09-01 00:00:00

  • Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood.

    abstract::This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1-21, PD1-21) and environmental enrichment (EE) during adolescence (PD 21-42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a simi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00195

    authors: Berardo LR,Fabio MC,Pautassi RM

    更新日期:2016-10-13 00:00:00

  • Eye Gaze Patterns of Decision Process in Prosocial Behavior.

    abstract::Understanding human behavior remains a grand challenge across disciplines. We used eye tracking to investigate how visual perception is associated with a strategic behavior in the decision process. Gaze activity and eye movement patterns were measured in 14 human participants with different decision strategies. We als...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.525087

    authors: Peshkovskaya A,Myagkov M

    更新日期:2020-10-22 00:00:00

  • Improvements in Attention Following Cognitive Training With the Novel "Decoder" Game on an iPad.

    abstract::Work and study increasingly rely on the use of technologies requiring individuals to switch attention rapidly between emails, texts and tasks. This has led to healthy people having problems of attention and concentration and difficulties getting into the "flow," which impedes goal attainment and task completion. Possi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00002

    authors: Savulich G,Thorp E,Piercy T,Peterson KA,Pickard JD,Sahakian BJ

    更新日期:2019-01-21 00:00:00

  • Contextual Fear Conditioning and Fear Generalization in Individuals With Panic Attacks.

    abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00152

    authors: Neueder D,Andreatta M,Pauli P

    更新日期:2019-07-17 00:00:00

  • Assessing the construct validity of aberrant salience.

    abstract::We sought to validate the psychometric properties of a recently developed paradigm that aims to measure salience attribution processes proposed to contribute to positive psychotic symptoms, the Salience Attribution Test (SAT). The "aberrant salience" measure from the SAT showed good face validity in previous results, ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.08.058.2009

    authors: Schmidt K,Roiser JP

    更新日期:2009-12-23 00:00:00

  • Moral Violations and the Experience of Disgust and Anger.

    abstract::Disgust is a natural defensive emotion that has evolved to protect against potential sources of contamination and has been recently linked to moral judgements in many studies. However, that people often report feelings of disgust when thinking about feces or moral transgressions alike does not necessarily mean that th...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00179

    authors: Oaten M,Stevenson RJ,Williams MA,Rich AN,Butko M,Case TI

    更新日期:2018-08-22 00:00:00

  • Two Strains of Lymnaea stagnalis and the Progeny from Their Mating Display Differential Memory-Forming Ability on Associative Learning Tasks.

    abstract::The pond snail Lymnaea stagnalis learns and forms long-term memory (LTM) following both operant conditioning of aerial respiratory behavior and classical conditioning of taste aversive behavior. In the present study, we examined whether there are interstrain differences in the ability to form LTM following these two t...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00161

    authors: Sunada H,Totani Y,Nakamura R,Sakakibara M,Lukowiak K,Ito E

    更新日期:2017-09-11 00:00:00

  • Tympanic Membrane Rupture During Stereotaxic Surgery Disturbs the Normal Feeding Behavior in Rats.

    abstract::Stereotactic surgery is a widely used procedure in neuroscience research to study the brain's regulation of feeding behavior. In line with this notion, this study aims to assess how food consumption and feeding patterns are affected in response to the use of auditory bars that preserve or damage the tympanic membrane ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.591204

    authors: Barahona MJ,Rojas J,Uribe EA,García-Robles MA

    更新日期:2020-12-01 00:00:00

  • Long-term habituation of the gill-withdrawal reflex in aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels.

    abstract::Although habituation is possibly the simplest form of learning, we still do not fully understand the neurobiological basis of habituation in any organism. To advance the goal of a comprehensive understanding of habituation, we have studied long-term habituation (LTH) of the gill-withdrawal reflex (GWR) in the marine s...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00181

    authors: Esdin J,Pearce K,Glanzman DL

    更新日期:2010-11-29 00:00:00

  • Neural Dynamics of Emotional Salience Processing in Response to Voices during the Stages of Sleep.

    abstract::Sleep has been related to emotional functioning. However, the extent to which emotional salience is processed during sleep is unknown. To address this concern, we investigated night sleep in healthy adults regarding brain reactivity to the emotionally (happily, fearfully) spoken meaningless syllables dada, along with ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00117

    authors: Chen C,Sung JY,Cheng Y

    更新日期:2016-06-14 00:00:00

  • Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice.

    abstract::The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of inc...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00278

    authors: Calpe-López C,García-Pardo MP,Martínez-Caballero MA,Santos-Ortíz A,Aguilar MA

    更新日期:2020-01-09 00:00:00

  • Deafferented controllers: a fundamental failure mechanism in cortical neuroprosthetic systems.

    abstract::Brain-machine interface (BMI) research assumes that patients with disconnected neural pathways could naturally control a prosthetic device by volitionally modulating sensorimotor cortical activity usually responsible for movement coordination. However, computational approaches to motor control challenge this view. Thi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00186

    authors: Galán F,Baker SN

    更新日期:2015-07-17 00:00:00

  • Hypothalamic Gene Expression and Postpartum Behavior in a Genetic Rat Model of Depression.

    abstract::Postpartum depression is a complex illness that often occurs in genetically predisposed individuals. Closely related inbred rat strains are a great resource to identify novel causative genes and mechanisms underlying complex traits such as postpartum behavior. We report differences in these behaviors between the inbre...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.589967

    authors: Luo W,Lim PH,Wert SL,Gacek SA,Chen H,Redei EE

    更新日期:2020-10-22 00:00:00

  • Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.

    abstract::We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2012.00021

    authors: Unal CT,Golowasch JP,Zaborszky L

    更新日期:2012-05-08 00:00:00

  • Olfactory Memory Impairment Differs by Sex in a Rodent Model of Pediatric Radiotherapy.

    abstract::Although an effective treatment for pediatric brain tumors, cranial radiation therapy (CRT) damages surrounding healthy tissue, thereby disrupting brain development. Animal models of pediatric CRT have primarily relied on visual tasks to assess cognitive impairment. Moreover, there has been a lack of sex comparisons a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00158

    authors: Perez EC,Rodgers SP,Inoue T,Pedersen SE,Leasure JL,Gaber MW

    更新日期:2018-08-02 00:00:00

  • The RUB Cage: Respiration-Ultrasonic Vocalizations-Behavior Acquisition Setup for Assessing Emotional Memory in Rats.

    abstract::In animals, emotional memory is classically assessed through pavlovian fear conditioning in which a neutral novel stimulus (conditioned stimulus) is paired with an aversive unconditioned stimulus. After conditioning, the conditioned stimulus elicits a fear response characterized by a wide range of behavioral and physi...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2011.00025

    authors: Hegoburu C,Shionoya K,Garcia S,Messaoudi B,Thévenet M,Mouly AM

    更新日期:2011-05-19 00:00:00

  • Memory accessibility and medical decision-making for significant others: the role of socially shared retrieval-induced forgetting.

    abstract::Medical decisions will often entail a broad search for relevant information. No sources alone may offer a complete picture, and many may be selective in their presentation. This selectivity may induce forgetting for previously learned material, thereby adversely affecting medical decision-making. In the study phase of...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00072

    authors: Coman D,Coman A,Hirst W

    更新日期:2013-06-14 00:00:00

  • Development of brain mechanisms for processing affective touch.

    abstract::Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00024

    authors: Björnsdotter M,Gordon I,Pelphrey KA,Olausson H,Kaiser MD

    更新日期:2014-02-04 00:00:00