Abstract:
:Globally, it is estimated that nearly 10 million people sustain severe brain injuries leading to hospitalization and/or death every year. Amongst survivors, traumatic brain injury (TBI) results in a wide variety of physical, emotional and cognitive deficits. The most common cognitive deficit associated with TBI is memory loss, involving impairments in spatial reference and working memory. However, the majority of research thus far has characterized the deficits associated with TBI on either reference or working memory systems separately, without investigating how they interact within a single task. Thus, we examined the effects of TBI on short-term working and long-term reference memory using the radial 8-arm maze (RAM) with a sequence of four baited and four unbaited arms. Subjects were given 10 daily trials for 6 days followed by a memory retrieval test 2 weeks after training. Multiple training trials not only provide robust training, but also test the subjects' ability to frequently update short-term memory while learning the reference rules of the task. Our results show that TBI significantly impaired short-term working memory function on previously acquired spatial information but has little effect on long-term reference memory. Additionally, TBI significantly increased working memory errors during acquisition and reference memory errors during retention testing 2 weeks later. With a longer recovery period after TBI, the robust RAM training mitigated the reference memory deficit in retention but not the short-term working memory deficit during acquisition. These results identify the resiliency and vulnerabilities of short-term working and long-term reference memory to TBI in the context of robust training. The data highlight the role of cognitive training and other behavioral remediation strategies implicated in attenuating deficits associated with TBI.
journal_name
Front Behav Neuroscijournal_title
Frontiers in behavioral neuroscienceauthors
Sebastian V,Diallo A,Ling DS,Serrano PAdoi
10.3389/fnbeh.2013.00038subject
Has Abstractpub_date
2013-05-03 00:00:00pages
38issn
1662-5153journal_volume
7pub_type
杂志文章abstract::Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00142
更新日期:2018-07-19 00:00:00
abstract::The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00069
更新日期:2017-04-20 00:00:00
abstract::When stepping onto a stopped escalator, we often perceive an "odd sensation" that is never felt when stepping onto stairs. The sight of an escalator provides a strong contextual cue that, in expectation of the backward acceleration when stepping on, triggers an anticipatory forward postural adjustment driven by a habi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00077
更新日期:2014-03-20 00:00:00
abstract::During perinatal life, sex steroids, such as estradiol, have marked effects on the development and function of the nervous system. Environmental estrogens or xenoestrogens are man-made chemicals, which animal and human population encounter in the environment and which are able to disrupt the functioning of the endocri...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00202
更新日期:2014-06-16 00:00:00
abstract::Stress-related neuropsychiatric (e.g., anxiety, depression) and cardiovascular diseases are frequently comorbid, though discerning the directionality of their association has been challenging. One of the most controllable risk factors for cardiovascular disease is salt intake. Though high salt intake is implicated in ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00271
更新日期:2019-12-13 00:00:00
abstract::Using a recently developed alternative assay procedure to measure hormone levels from hair samples, we examined the relationships between testosterone, cortisol, 2D:4D ratio, overconfidence and risk taking. A total of 162 (53 male) participants provided a 3 cm sample of hair, a scanned image of their right and left ha...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00030
更新日期:2018-03-05 00:00:00
abstract::Parietal cortex and adjacent parts of the temporal cortex have recently been associated with bodily self-consciousness (BSC). Similarly, growing evidence suggests that the lateral parietal cortex is crucial for the subjective aspects of episodic autobiographical memory (EAM), which is based on the conscious experience...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00270
更新日期:2018-11-14 00:00:00
abstract::Identifying the biological substrates of complex neurobehavioral traits such as alcohol dependency pose a tremendous challenge given the diverse model systems and phenotypic assessments used. To address this problem we have developed a platform for integrated analysis of high-throughput or genome-wide functional genom...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00001
更新日期:2016-01-21 00:00:00
abstract::Humans value rewards less when these are delivered in the future as opposed to immediately, a phenomenon referred to as delay discounting. While delay discounting has been studied during the anticipation of rewards and in the context of intertemporal decision-making, little is known about its neural correlates in the ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00280
更新日期:2015-10-29 00:00:00
abstract::The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use disorder via the mesolimbic pathway remain elusive. In this mini...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2018.00309
更新日期:2018-12-21 00:00:00
abstract::Associative learning can be observed from the neonatal period onward, providing opportunities to examine changes in basic learning and memory abilities. One method that is suitable to study associative learning is classical eyeblink conditioning (EBC) which is dependent on the cerebellum. Extinction learning can be sy...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.00135
更新日期:2020-08-14 00:00:00
abstract::This study investigated the effects of early institutional care on memory and executive functioning. Subjects were participants in the Bucharest Early Intervention Project (BEIP) and included institutionalized children, children with a history of institutionalization who were assigned to a foster care intervention, an...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.016.2009
更新日期:2009-09-01 00:00:00
abstract::This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1-21, PD1-21) and environmental enrichment (EE) during adolescence (PD 21-42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a simi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00195
更新日期:2016-10-13 00:00:00
abstract::Understanding human behavior remains a grand challenge across disciplines. We used eye tracking to investigate how visual perception is associated with a strategic behavior in the decision process. Gaze activity and eye movement patterns were measured in 14 human participants with different decision strategies. We als...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.525087
更新日期:2020-10-22 00:00:00
abstract::Work and study increasingly rely on the use of technologies requiring individuals to switch attention rapidly between emails, texts and tasks. This has led to healthy people having problems of attention and concentration and difficulties getting into the "flow," which impedes goal attainment and task completion. Possi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00002
更新日期:2019-01-21 00:00:00
abstract::Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a vi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00152
更新日期:2019-07-17 00:00:00
abstract::We sought to validate the psychometric properties of a recently developed paradigm that aims to measure salience attribution processes proposed to contribute to positive psychotic symptoms, the Salience Attribution Test (SAT). The "aberrant salience" measure from the SAT showed good face validity in previous results, ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.058.2009
更新日期:2009-12-23 00:00:00
abstract::Disgust is a natural defensive emotion that has evolved to protect against potential sources of contamination and has been recently linked to moral judgements in many studies. However, that people often report feelings of disgust when thinking about feces or moral transgressions alike does not necessarily mean that th...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00179
更新日期:2018-08-22 00:00:00
abstract::The pond snail Lymnaea stagnalis learns and forms long-term memory (LTM) following both operant conditioning of aerial respiratory behavior and classical conditioning of taste aversive behavior. In the present study, we examined whether there are interstrain differences in the ability to form LTM following these two t...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00161
更新日期:2017-09-11 00:00:00
abstract::Stereotactic surgery is a widely used procedure in neuroscience research to study the brain's regulation of feeding behavior. In line with this notion, this study aims to assess how food consumption and feeding patterns are affected in response to the use of auditory bars that preserve or damage the tympanic membrane ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.591204
更新日期:2020-12-01 00:00:00
abstract::Although habituation is possibly the simplest form of learning, we still do not fully understand the neurobiological basis of habituation in any organism. To advance the goal of a comprehensive understanding of habituation, we have studied long-term habituation (LTH) of the gill-withdrawal reflex (GWR) in the marine s...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2010.00181
更新日期:2010-11-29 00:00:00
abstract::Sleep has been related to emotional functioning. However, the extent to which emotional salience is processed during sleep is unknown. To address this concern, we investigated night sleep in healthy adults regarding brain reactivity to the emotionally (happily, fearfully) spoken meaningless syllables dada, along with ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00117
更新日期:2016-06-14 00:00:00
abstract::The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of inc...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00278
更新日期:2020-01-09 00:00:00
abstract::Brain-machine interface (BMI) research assumes that patients with disconnected neural pathways could naturally control a prosthetic device by volitionally modulating sensorimotor cortical activity usually responsible for movement coordination. However, computational approaches to motor control challenge this view. Thi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00186
更新日期:2015-07-17 00:00:00
abstract::Postpartum depression is a complex illness that often occurs in genetically predisposed individuals. Closely related inbred rat strains are a great resource to identify novel causative genes and mechanisms underlying complex traits such as postpartum behavior. We report differences in these behaviors between the inbre...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.589967
更新日期:2020-10-22 00:00:00
abstract::We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00021
更新日期:2012-05-08 00:00:00
abstract::Although an effective treatment for pediatric brain tumors, cranial radiation therapy (CRT) damages surrounding healthy tissue, thereby disrupting brain development. Animal models of pediatric CRT have primarily relied on visual tasks to assess cognitive impairment. Moreover, there has been a lack of sex comparisons a...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00158
更新日期:2018-08-02 00:00:00
abstract::In animals, emotional memory is classically assessed through pavlovian fear conditioning in which a neutral novel stimulus (conditioned stimulus) is paired with an aversive unconditioned stimulus. After conditioning, the conditioned stimulus elicits a fear response characterized by a wide range of behavioral and physi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2011.00025
更新日期:2011-05-19 00:00:00
abstract::Medical decisions will often entail a broad search for relevant information. No sources alone may offer a complete picture, and many may be selective in their presentation. This selectivity may induce forgetting for previously learned material, thereby adversely affecting medical decision-making. In the study phase of...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00072
更新日期:2013-06-14 00:00:00
abstract::Affective tactile stimulation plays a key role in the maturation of neural circuits, but the development of brain mechanisms processing touch is poorly understood. We therefore used functional magnetic resonance imaging (fMRI) to study brain responses to soft brush stroking of both glabrous (palm) and hairy (forearm) ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00024
更新日期:2014-02-04 00:00:00