Abstract:
:Concerns regarding a drought in psychopharmacology have risen from many quarters. From one perspective, the wellspring of bedrock medications for anxiety disorders, depression, and schizophrenia was serendipitously discovered over 30 year ago, the swell of pharmaceutical investment in drug discovery has receded, and the pipeline's flow of medications with unique mechanisms of action (i.e., glutamatergic agents, CRF antagonists) has slowed to a trickle. Might oxytocin (OT)-based therapeutics be an oasis? Though a large basic science literature and a slowly increasing number of studies in human diseases support this hope, the bulk of extant OT studies in humans are single-dose studies on normals, and do not directly relate to improvements in human brain-based diseases. Instead, these studies have left us with a field pregnant with therapeutic possibilities, but barren of definitive treatments. In this clinically oriented review, we discuss the extant OT literature with an eye toward helping OT deliver on its promise as a therapeutic agent. To this end, we identify 10 key questions that we believe future OT research should address. From this overview, several conclusions are clear: (1) the OT system represents an extremely promising target for novel CNS drug development; (2) there is a pressing need for rigorous, randomized controlled clinical trials targeting actual patients; and (3) in order to inform the design and execution of these vital trials, we need further translational studies addressing the questions posed in this review. Looking forward, we extend a cautious hope that the next decade of OT research will birth OT-targeted treatments that can truly deliver on this system's therapeutic potential.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Macdonald K,Feifel Ddoi
10.3389/fnins.2013.00035subject
Has Abstractpub_date
2013-03-15 00:00:00pages
35eissn
1662-4548issn
1662-453Xjournal_volume
7pub_type
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroscience
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doi:10.3389/fnins.2018.00527
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journal_title:Frontiers in neuroscience
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更新日期:2017-11-14 00:00:00
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2016.00242
更新日期:2016-05-31 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroscience
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doi:10.3389/fnins.2012.00123
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journal_title:Frontiers in neuroscience
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doi:10.3389/neuro.01.025.2009
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journal_title:Frontiers in neuroscience
pub_type: 已发布勘误
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
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journal_title:Frontiers in neuroscience
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pub_type: 杂志文章
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pub_type: 杂志文章
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