Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity.

abstract：:Combined administration of transcranial direct current-stimulation (tDCS) with either pergolide (PER) or d-cycloserine (d-CYC) can prolong the excitability-diminishing effects of cathodal, or the excitability enhancing effect of anodal stimulation for up to 24 h poststimulation. However, it remains unclear whether the...

journal_title：Frontiers in psychiatry

authors： Chaieb L,Antal A,Terney D,Paulus W

更新日期：2012-07-05 00:00:00

abstract：Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

journal_title：Frontiers in psychiatry

authors： Holper L

更新日期：2020-07-28 00:00:00

abstract：Background:Previous studies have revealed the efficacy of metacognitive training for schizophrenia. However, the underlying mechanisms of metacognitive training on brain function alterations, including the default-mode network (DMN), remain unknown. The present study explored treatment effects of metacognitive training...

journal_title：Frontiers in psychiatry

authors： Shan X,Liao R,Ou Y,Ding Y,Liu F,Chen J,Zhao J,Guo W,He Y

更新日期：2020-03-27 00:00:00

abstract：:Objectives: This study aimed to examine the rate of remission in individuals experiencing early-onset poststroke depression (PSD) in China and to identify predictors of remission during a 3-month follow-up. This study also explored the interaction between cognitive impairment and depression. Methods: A total of 820 pa...

journal_title：Frontiers in psychiatry

authors： Huang J,Zhou FC,Guan B,Zhang N,Wang A,Yu P,Zhou L,Wang CY,Wang C

更新日期：2019-01-08 00:00:00

abstract：:Objective: We aimed to determine the prevalence of burnout among hospital healthcare workers in Libya during the coronavirus disease (COVID-19) pandemic and civil war. Methods: A cross-sectional study was conducted from April 18 to May 2, 2020 among Libyan healthcare workers. Data on participant characteristics were c...

journal_title：Frontiers in psychiatry

authors： Elhadi M,Msherghi A,Elgzairi M,Alhashimi A,Bouhuwaish A,Biala M,Abuelmeda S,Khel S,Khaled A,Alsoufi A,Elmabrouk A,Alshiteewi FB,Hamed TB,Alhadi B,Alhaddad S,Elhadi A,Zaid A

更新日期：2020-12-11 00:00:00

abstract：:Virtual reality (VR) offers children with autism spectrum disorder (ASD) an inexpensive and motivating medium to learn and practice skills in a personalized, controlled, and safe setting; however, outcomes of VR interventions can vary widely. In particular, there is a need to understand the predictors of VR experience...

journal_title：Frontiers in psychiatry

authors： Malihi M,Nguyen J,Cardy RE,Eldon S,Petta C,Kushki A

更新日期：2020-08-04 00:00:00

abstract：:Aim: Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. Most patients improve if properly diagnosed and treated expediently with immunotherapy. Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have...

journal_title：Frontiers in psychiatry

authors： Tang C,Tan K,Lim G,Tan L,Tay KY,Kandiah N,Abdin E,Verma SK

更新日期：2019-12-13 00:00:00

abstract：:Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate ...

journal_title：Frontiers in psychiatry

authors： Jones JL,Mateus CF,Malcolm RJ,Brady KT,Back SE

更新日期：2018-07-24 00:00:00

abstract：Background:From birth, the human propensity to selectively attend and respond to critical super-stimuli forms the basis of future socio-emotional development and health. In particular, the first super-stimuli to preferentially engage and elicit responses in the healthy newborn are the physical touch, voice and face/eye...

journal_title：Frontiers in psychiatry

authors： Doyle FL,Mendoza Diaz A,Eapen V,Frick PJ,Kimonis ER,Hawes DJ,Moul C,Richmond JL,Mehta D,Sareen S,Morgan BG,Dadds MR

更新日期：2020-06-19 00:00:00

abstract：:Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

journal_title：Frontiers in psychiatry

authors： Raymond JG,Steele JD,Seriès P

更新日期：2017-01-23 00:00:00

abstract：:Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

journal_title：Frontiers in psychiatry

authors： Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

更新日期：2020-12-17 00:00:00

abstract：:Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked to excessive drinking. Morphine exerts its actions mainly via the seven transmembrane G-protein-coupled mu opioid recept...

journal_title：Frontiers in psychiatry

authors： Chang SL,Huang W,Han H,Sariyer IK

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:A small number of previous studies have provided evidence that cocaine users (CU) exhibit impairments in complex social cognition tasks, while the more basic facial emotion recognition is widely unaffected. However, prosody and cross-modal emotion processing has not been systematically investigated in CU so ...

journal_title：Frontiers in psychiatry

authors： Hulka LM,Preller KH,Vonmoos M,Broicher SD,Quednow BB

更新日期：2013-09-05 00:00:00

abstract：:The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity. The BD syndrome also involves heterogeneous symptomatology, including cognitive dysfunctions and i...

journal_title：Frontiers in psychiatry

authors： Steardo L Jr,de Filippis R,Carbone EA,Segura-Garcia C,Verkhratsky A,De Fazio P

更新日期：2019-07-18 00:00:00

abstract：Background:Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods:In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bun...

journal_title：Frontiers in psychiatry

authors： Gögler N,Papazova I,Oviedo-Salcedo T,Filipova N,Strube W,Funk J,Müller HJ,Finke K,Hasan A

更新日期：2017-11-29 00:00:00

abstract：Background:Anorexia nervosa (AN) is characterized by severe malnutrition as well as inefficiencies in neurocognitive functioning, which are believed to contribute to the maintenance of disordered eating. The aim of this study was to examine the impact of individual cognitive remediation therapy (CRT) on neurocognition ...

journal_title：Frontiers in psychiatry

authors： Leppanen J,Adamson J,Tchanturia K

更新日期：2018-03-20 00:00:00

abstract：:Background: Mental disorders are highly prevalent among university students. Distance-learning students are particularly burdened and have limited access to conventional university health services. Interventions for stress are sought after in distance learners and may help increase treatment coverage. Internet-based i...

journal_title：Frontiers in psychiatry

authors： Harrer M,Apolinário-Hagen J,Fritsche L,Drüge M,Krings L,Beck K,Salewski C,Zarski AC,Lehr D,Baumeister H,Ebert DD

更新日期：2019-05-21 00:00:00

abstract：:Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

journal_title：Frontiers in psychiatry

authors： Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

更新日期：2014-01-29 00:00:00

abstract：:Task-based connectivity studies facilitate the understanding of how the brain functions during cognition, which is commonly impaired in schizophrenia (SZ). Our aim was to investigate functional connectivity during a working memory task in SZ. We hypothesized that the task-negative (default mode) network and the cognit...

journal_title：Frontiers in psychiatry

authors： Godwin D,Ji A,Kandala S,Mamah D

更新日期：2017-12-22 00:00:00

abstract：:While psychological treatments have been shown to be effective in treating psychiatric disorders, the mechanism of their therapeutic effect is less well understood. An improved mechanistic understanding of psychiatric disorders and their treatments would enable refinement of existing interventions, and more targeted i...

journal_title：Frontiers in psychiatry

authors： Griffin B,Saunders KEA

更新日期：2020-01-17 00:00:00

abstract：:In clinical settings, nitrous oxide gas is a safe anesthetic used during childbirth, in dentistry, and to relieve anxiety in emergencies. Colloquially known as "hippy crack"' or "laughing gas," it is increasingly taken recreationally for its euphoric and relaxing effects and hallucinogenic properties. Using a self-rep...

journal_title：Frontiers in psychiatry

authors： Ehirim EM,Naughton DP,Petróczi A

更新日期：2018-01-22 00:00:00

abstract：:Recently, imaging biomarkers have gained importance for the characterization of patients with Alzheimer's disease; however, the relationship between regional biomarker expression and cognitive function remains unclear. In our study, we investigated associations between scores on CERAD neuropsychological assessment bat...

journal_title：Frontiers in psychiatry

authors： Hedderich DM,Drost R,Goldhardt O,Ortner M,Müller-Sarnowski F,Diehl-Schmid J,Zimmer C,Förstl H,Yakushev I,Jahn T,Grimmer T

更新日期：2020-08-13 00:00:00

abstract：:There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry under...

journal_title：Frontiers in psychiatry

authors： Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

更新日期：2015-12-18 00:00:00

abstract：Background:High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-c...

journal_title：Frontiers in psychiatry

authors： Shi J,Wang L,Yao Y,Su N,Zhan C,Mao Z,Zhao X

更新日期：2017-10-23 00:00:00

abstract：:Third-generation neuroimaging research has been enriched by advances in magnetic resonance spectroscopy (MRS) measuring the concentration of important neurotrasmitters, such as the inhibitory amino acid GABA. Here, we performed a systematic mini-review on brain MRS studies measuring GABA concentration in patients affe...

journal_title：Frontiers in psychiatry

authors： Chiapponi C,Piras F,Piras F,Caltagirone C,Spalletta G

更新日期：2016-04-19 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share neurocognitive deficits. One such shared impairment is in duration discrimination. However, no studies using functional magnetic resonance imaging (fMRI) have investigated whether these duration discrimination d...

journal_title：Frontiers in psychiatry

authors： Lukito SD,O'Daly OG,Lythgoe DJ,Whitwell S,Debnam A,Murphy CM,Ashwood K,Stoencheva V,Simonoff E,Rubia K

更新日期：2018-11-14 00:00:00

abstract：Objectives:Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations in DTNBP1 confer susceptibility to SZ and clinical symptoms. H...

journal_title：Frontiers in psychiatry

authors： Yang Y,Zhang L,Guo D,Zhang L,Yu H,Liu Q,Su X,Shao M,Song M,Zhang Y,Ding M,Lu Y,Liu B,Li W,Yue W,Fan X,Yang G,Lv L

更新日期：2020-05-25 00:00:00

abstract：:Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson's disease (PD) affecting 50% of patients. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four gro...

journal_title：Frontiers in psychiatry

authors： Herzallah MM,Khdour HY,Taha AB,Elmashala AM,Mousa HN,Taha MB,Ghanim Z,Sehwail MM,Misk AJ,Balsdon T,Moustafa AA,Myers CE,Gluck MA

更新日期：2017-06-12 00:00:00

abstract：BACKGROUND:The project "Quality Assurance in Ambulatory Psychotherapy in Bavaria" (QS-PSY-BAY) focuses on the quality assurance of outpatient psychotherapy (OPT) in Germany in terms of symptom reduction and cost reduction under naturalistic conditions. In this study, we examined the effectiveness of psychotherapy in te...

journal_title：Frontiers in psychiatry

authors： Altmann U,Zimmermann A,Kirchmann HA,Kramer D,Fembacher A,Bruckmayer E,Pfaffinger I,von Heymann F,Auch E,Steyer R,Strauss BM

更新日期：2016-06-13 00:00:00

abstract：:The view that anatomically distinct memory systems differentially contribute to the development of drug addiction and relapse has received extensive support. The present brief review revisits this hypothesis as it was originally proposed 20 years ago (1) and highlights several recent developments. Extensive research e...

journal_title：Frontiers in psychiatry

authors： Goodman J,Packard MG

更新日期：2016-02-25 00:00:00