Abstract:
:It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyrosine phosphatase 1B (PTP-1B) in the liver of old rats. Aging rats were subjected to swimming for two 1.5-h long bouts, separated by a 45 min rest period. Sixteen hours after the exercise, the rats were sacrificed and proteins from the insulin signaling pathway were analyzed by immunoblotting. Our results show that the fat mass was increased in old rats. The reduction in glucose disappearance rate (Kitt) observed in aged rats was restored 16 h after exercise. Aging increased the content of PTP-1B and attenuated insulin signaling in the liver of rats, a phenomenon that was reversed by exercise. Aging rats also increased the IRβ/PTP-1B and IRS-1/PTP-1B association in the liver when compared with young rats. Conversely, in the liver of exercised old rats, IRβ/PTP-1B and IRS-1/PTP-1B association was markedly decreased. Moreover, in the hepatic tissue of old rats, the insulin signalling was decreased and PEPCK and G6Pase levels were increased when compared with young rats. Interestingly, 16 h after acute exercise, the PEPCK and G6Pase protein level were decreased in the old exercised group. These results provide new insights into the mechanisms by which exercise restores insulin signalling in liver during aging.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
de Moura LP,Souza Pauli LS,Cintra DE,de Souza CT,da Silva ASR,Marinho R,de Melo MAR,Ropelle ER,Pauli JRdoi
10.1186/1742-4933-10-8subject
Has Abstractpub_date
2013-02-25 00:00:00pages
8issue
1issn
1742-4933pii
1742-4933-10-8journal_volume
10pub_type
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
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abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,已发布勘误
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更新日期:2018-08-21 00:00:00
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
pub_type: 社论
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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更新日期:2005-11-03 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-10
更新日期:2005-06-27 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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更新日期:2019-02-23 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-36
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-5-11
更新日期:2008-09-24 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-6
更新日期:2013-02-21 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-10
更新日期:2010-08-20 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-6
更新日期:2010-05-27 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-4-7
更新日期:2007-09-29 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-26
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-11-10
更新日期:2014-05-16 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0060-5
更新日期:2016-02-16 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
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更新日期:2015-11-04 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
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