Mesenchymal cell differentiation during lymph node organogenesis.

abstract：:About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. Intriguingly, HERV...

journal_title：Frontiers in immunology

authors： Grandi N,Tramontano E

更新日期：2018-09-10 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects of lymphocyte cytotoxicity. In...

journal_title：Frontiers in immunology

authors： Wegehaupt O,Wustrau K,Lehmberg K,Ehl S

更新日期：2020-05-08 00:00:00

abstract：:Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody deficiency and identified five disease-associated variants in NFKB...

journal_title：Frontiers in immunology

authors： Schröder C,Sogkas G,Fliegauf M,Dörk T,Liu D,Hanitsch LG,Steiner S,Scheibenbogen C,Jacobs R,Grimbacher B,Schmidt RE,Atschekzei F

更新日期：2019-11-14 00:00:00

abstract：:Natural killer (NK) cells are innate immune lymphocytes with potent cytolytic and immune-regulatory activities. NK cells are well-known for their ability to kill infected and malignant cells in a fast and non-specific way without prior sensitization. For this purpose, NK cells are equipped with a set of cytotoxic mole...

journal_title：Frontiers in immunology

authors： Vandenhaute J,Wouters CH,Matthys P

更新日期：2020-01-15 00:00:00

abstract：:Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry that identify specific target peptides among the myriad HLA-bound peptides on altered cells. Ult...

journal_title：Frontiers in immunology

authors： Reinherz EL,Keskin DB,Reinhold B

更新日期：2014-09-04 00:00:00

abstract：:Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biol...

journal_title：Frontiers in immunology

authors： Rahman S,Gadjeva M

更新日期：2014-08-11 00:00:00

abstract：:Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significa...

journal_title：Frontiers in immunology

authors： Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

更新日期：2020-08-11 00:00:00

abstract：:Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In SLE and RA, extracellular chromatin may behave as a danger-associated molecular pattern (DAMP). Polymorphonuclear neutrophils...

journal_title：Frontiers in immunology

authors： Ribon M,Mussard J,Semerano L,Singer BB,Decker P

更新日期：2019-06-14 00:00:00

abstract：:HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at ...

journal_title：Frontiers in immunology

authors： Duquesnoy RJ

更新日期：2016-11-28 00:00:00

abstract：:Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may diagnose tolerance, changes in the patterns of proliferation of CD4+,...

journal_title：Frontiers in immunology

authors： Hall BM,Robinson CM,Plain KM,Verma ND,Tran GT,Nomura M,Carter N,Boyd R,Hodgkinson SJ

更新日期：2017-08-22 00:00:00

abstract：:Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...

journal_title：Frontiers in immunology

authors： Lycke NY,Bemark M

更新日期：2012-11-07 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centralized at a national l...

journal_title：Frontiers in immunology

authors： Kristensen MK,Hansen MB,Madsen MB,Hansen CB,Pilely K,Hyldegaard O,Garred P

更新日期：2020-01-31 00:00:00

abstract：:Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. In addition, BAFF promotes ...

journal_title：Frontiers in immunology

authors： Nascimento M,Huot-Marchand S,Gombault A,Panek C,Bourinet M,Fanny M,Savigny F,Schneider P,Le Bert M,Ryffel B,Riteau N,Quesniaux VFJ,Couillin I

更新日期：2020-07-29 00:00:00

abstract：:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

journal_title：Frontiers in immunology

authors： Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

更新日期：2019-01-15 00:00:00

abstract：:Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we demonstrate that defic...

journal_title：Frontiers in immunology

authors： Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

更新日期：2019-07-11 00:00:00

abstract：:The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various...

journal_title：Frontiers in immunology

authors： Motran CC,Silvane L,Chiapello LS,Theumer MG,Ambrosio LF,Volpini X,Celias DP,Cervi L

更新日期：2018-04-04 00:00:00

abstract：:Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, deve...

journal_title：Frontiers in immunology

authors： Palombo F,Focaccetti C,Barnaba V

更新日期：2014-01-06 00:00:00

abstract：:The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit...

journal_title：Frontiers in immunology

authors： Zhang Z,Liu H,Guan Q,Wang L,Yuan H

更新日期：2017-05-05 00:00:00

abstract：:Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate those environmental cues, orchestrate immunity or tolerance, and regulate tissue homeostasis. Recent advances in the field of immunometabo...

journal_title：Frontiers in immunology

authors： Wculek SK,Khouili SC,Priego E,Heras-Murillo I,Sancho D

更新日期：2019-04-25 00:00:00

abstract：:The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in...

journal_title：Frontiers in immunology

authors： Jogdand GM,Mohanty S,Devadas S

更新日期：2016-11-23 00:00:00

abstract：:The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

journal_title：Frontiers in immunology

authors： Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

更新日期：2020-09-02 00:00:00

abstract：:We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...

journal_title：Frontiers in immunology

authors： Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

更新日期：2020-08-18 00:00:00

abstract：:The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has generated a significant repercussion on the administration of adoptive cell therapies, including chimeric antigen receptor (CAR) T-cells. The closing of borders, the reduction of people transit and the confinement of the...

journal_title：Frontiers in immunology

authors： Ortiz de Landazuri I,Egri N,Muñoz-Sánchez G,Ortiz-Maldonado V,Bolaño V,Guijarro C,Pascal M,Juan M

更新日期：2020-10-15 00:00:00

abstract：Introduction:The broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity is poorly understood. We investigated the immunoregulatory effect of sulforaphane on human dendritic cells alone and in presence of pancreatic tumo...

journal_title：Frontiers in immunology

authors： Wang Y,Petrikova E,Gross W,Sticht C,Gretz N,Herr I,Karakhanova S

更新日期：2020-10-30 00:00:00

abstract：:Bone is a highly dynamic organ that is continuously being remodeled by the reciprocal interactions between bone and immune cells. We have originally established an advanced imaging system for visualizing the in vivo behavior of osteoclasts and their precursors in the bone marrow cavity using two-photon microscopy. Usi...

journal_title：Frontiers in immunology

authors： Hasegawa T,Kikuta J,Ishii M

更新日期：2019-03-26 00:00:00

abstract：:Human monocyte-derived dendritic cells (DCs) exposed to pathogen-associated molecular patterns (PAMPs) undergo bioenergetic changes that influence the immune response. We found that stimulation with PAMPs enhanced glycolysis in DCs, whereas oxidative phosphorylation remained unaltered. Glucose starvation and the hexok...

journal_title：Frontiers in immunology

authors： Márquez S,Fernández JJ,Terán-Cabanillas E,Herrero C,Alonso S,Azogil A,Montero O,Iwawaki T,Cubillos-Ruiz JR,Fernández N,Crespo MS

更新日期：2017-06-19 00:00:00

abstract：:The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for...

journal_title：Frontiers in immunology

authors： Domnich M,Riedesel J,Pylaeva E,Kürten CHL,Buer J,Lang S,Jablonska J

更新日期：2020-10-09 00:00:00

abstract：:Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we soug...

journal_title：Frontiers in immunology

authors： Mestre L,Carrillo-Salinas FJ,Mecha M,Feliú A,Espejo C,Álvarez-Cermeño JC,Villar LM,Guaza C

更新日期：2019-06-14 00:00:00

abstract：:Anaphylaxis in humans is inherently difficult to study due to the acuteness of symptoms and the lack of biomarkers serving as risk predictors. Most cases are related to IgE sensitizations to foods, insect venoms, and drugs with mastocytosis patients forming a smaller risk group. However, identifying the relatively sma...

journal_title：Frontiers in immunology

authors： Poulsen LK,Jensen BM,Esteban V,Garvey LH

更新日期：2017-08-10 00:00:00