Abstract：
OBJECTIVE:The purpose of the present study was to investigate the expression of the α2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingival (NG). STUDY DESIGN:Immunohistochemistry was performed with antibodies against α2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. RESULTS:Immunoreactivity for α2-integrin and Hsp47 was observed in the nucleus of epithelial cells of both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (p ≤ 0.05). Despite the markup α2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (p ≥ 0.05). CONCLUSIONS:Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in α2-integrin expression was observed between GF and NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Vieira-Júnior JR,de Oliveira-Santos C,Della-Coletta R,Cristianismo-Costa D,Paranaíba LM,Martelli-Júnior Hdoi
10.4317/medoral.17970subject
Has Abstractpub_date
2013-01-01 00:00:00pages
e45-8issue
1eissn
1698-4447issn
1698-6946pii
17970journal_volume
18pub_type
杂志文章abstract：OBJECTIVE:To describe and discuss the design, building and usefulness of tissue microarray (TMA) blocks for the study of salivary gland tumors (SGTs). STUDY DESIGN:Two hundred thirty-eight formalin-fixed, paraffin-embedded SGTs were arranged in blocks of TMA using a manual tissue arrayer. Three representative cores of...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18204
更新日期：2013-01-01 00:00:00
abstract：AIM:To visualize by atomic force microscopy the alterations induced on Enterococcus. faecalis surface after treatment with 2 types of laser: Erbium chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser and Diode laser. MATERIAL AND METHODS:Bacterial suspensions from overnight cultures of E. faecalis were irradia...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.19991
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:To describe the histopathological features of pleomorphic adenoma (PA) with special reference to the epithelial and mesenchymal components. STUDY DESIGN:189 PA were selected and classified as myxoid or stroma-rich, cellular or cell-rich and classic (balanced amount of epithelial and stromal components). The...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：INTRODUCTION:The temporomandibular disorders (TMDs) have been identified as the most important cause of pain in the facial region. The low level laser therapy (LLLT) has demonstrated to have an analgesic, anti-inflammatory and biostimulating effects. The LLLT is a noninvasive, quick and safe, non-pharmaceutical interve...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.18794
更新日期：2013-07-01 00:00:00
abstract：:Tooth agenesis is one of the most common congenital malformations in humans. Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be associated with a syndrome (syndromic hypodontia), highlighting the heterogeneity of the condition. Though much progress has been made to identify the d...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.19158
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVES:Oral-Health-Related Quality of Life (OHRQoL) instruments, such as the Child Perceptions Questionnaire 11-14 (CPQ11-14), are broadly used in oral health surveys around the world. However, there is a lack of these instruments in Spanish language limiting the comparison of OHRQoL outcomes among countries, cultu...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18975
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:Patients with chronic graft-versus-host disease (cGVHD) often suffer from dry mouth and oral mucosal lesions. The primary objective of this study was to investigate the safety of an intra-oral electrostimulator (GenNarino) in symptomatic cGVHD patients. The secondary objective was to study the impact on the ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,随机对照试验
doi：10.4317/medoral.19429
更新日期：2014-05-01 00:00:00
abstract：:Cowden's disease, or multiple hamartoma syndrome, is an autosomal dominant genodermatosis, characterized by the presence of multiple cutaneous hamartomas, oral fibromas and benign acral keratosis. It affects multiple organs (breast, thyroids, stomach, colon), with the strong possibility of malignant neoplasia developi...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:A series of 20 consecutive patients with an osteosarcoma of the jaws has been evaluated with regard to possible professional diagnostic delay. When set at an arbitrarily chosen period beyond three months, professional delay occurred in 15 patients, the mean being 21 months and the median 11 months. In five of the 15 p...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.24334
更新日期：2020-11-01 00:00:00
abstract：:Recently there have been reports of osteonecrosis of the jaw (ONJ) in patients with chronic therapy with bisphosphonates (Bps). So far three drugs have been linked: Pamidronate of disodium, Zoledronic acid and Alendronate of sodium. It is due to a non detected side effect in clinical trials before commercialization, a...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesis and biological aspects of these tumors would improve the success of diagnose and treatment procedures. The...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：INTRODUCTION:Frey's Syndrome is defined by facial hyperhidrosis in the preauricular region unleashed by gustatory stimulus and caused mainly by parotidectomy. Several treatment and prevention measures have been proposed, with no conclusive results. Recently, injections of Botulinum Toxin have been suggested, obtaining ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the patient s perception of the events during and after an osteogenic alveolar distraction (OAD) procedure MATERIALS AND METHODS:A total of fifty-five (55) osteogenic alveolar distraction (OAD) procedures were performed in fifty (50) patients, who then were asked to answe...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the vertical misfit between different brands of dental implants and prosthetic abutments, with or without mechanical torque, and to study their possible combination. STUDY DESIGN:Five different brands of implant were used in the study: Biofit (Castemaggiore, Italy), Bioner S.A. (Barcelona, Spain)...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.18137
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and size may raise the suspicion of neoplasm. MATERIAL AND METHODS:Retrospective analysis was perform...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.23933
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Diabetes and periodontal disease share common features in terms of inflammatory responses. Current scientific evidence suggests that treatment of periodontal disease might contribute to glycemic control. The objective of the study is a review of the last three years. MATERIAL AND METHODS:A literature search...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21048
更新日期：2016-07-01 00:00:00
abstract：:Since the introduction of osseointegrated implant treatment, odontology, and in particular the area of prosthodontic replacement of lost teeth, has evolved in an unimaginable way, to the extent that the age-old idea of "restitutio ad integrum" has almost become possible. Implant treatment has a high success rate that ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：
更新日期：2007-08-01 00:00:00
abstract：INTRODUCTION:Inflammatory papillary hyperplasia (IPH) is a benign lesion of the palatal mucosa. It is usually found in denture-wearers but also has been reported in patients without a history of use of a maxillary prosthesis use. OBJECTIVES:The aim of this study is to review the literature to assess the prevalence of ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.21405
更新日期：2017-01-01 00:00:00
abstract：:There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients age...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Alveolar bone grafting is a vital part of the rehabilitation of cleft patients. The factors that have been most frequently associated with the success of the graft are the age at grafting and the pre-grafting orthodontic treatment. OBJECTIVES:1) Describe the cases of alveolar bone grafts performed at the ...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.19413
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Temporal artery biopsy (TAB) is a surgical procedure with a low positive yield. The purpose of this study is to determine which variables are the most important in the giant cell arteritis (GCA) diagnosis. The objective of this evaluation is to improve the percentage of positive temporal artery biopsy and if...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.22298
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs). MATERIAL AND METHODS:A prospective analysis of 56 patients with OSCC who underwent surgical treatment of the primary lesion with simultaneous neck dissection was performe...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.20491
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To determine the changes in smoking habit among patients with oral squamous cell carcinoma (OSCC) diagnosed and treated in the Service of Stomatology (Valencia University General Hospital. Valencia, Spain). MATERIAL AND METHODS:The study involved 123 patients with a history of OSCC interviewed by telephone o...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:Several studies have focused on the relationship among serotype distribution, ethnical status and geographic populations, and periodontal conditions. Studies that have investigated the prevalence and the distribution of A. actinomycetemcomitans serotypes and the relation between the different serotypes of the...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,评审
doi：10.4317/medoral.19304
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence of dental agenesis and its possible association with other developmental dental anomalies and systemic entities. SETTING AND SAMPLE POPULATION:Descriptive transversal study, for which 1518 clinical records, of patients visited by the Odontological Service of the Primary Health Cen...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.15.e569
更新日期：2010-07-01 00:00:00
abstract：AIMS:To identify factors related to advanced-stage diagnosis of oral cancer to disclose high-risk groups and facilitate early detection strategies. STUDY DESIGN:An ambispective cohort study on 88 consecutive patients treated from January 1998 to December 2003. INCLUSION CRITERIA:pathological diagnosis of OSCC (primar...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.17399
更新日期：2012-01-01 00:00:00
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journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.23235
更新日期：2020-01-01 00:00:00
abstract：:Miescher's cheilitis granulomatosa (CG) consists of the appearance of recurrent labial edema on one or both lips, which can become persistent. It has traditionally been considered as a monosymptomatic form of the Melkersson-Rosenthal syndrome, described as the association of recurrent labial and/or recurrent facial ed...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:Chlorhexidine is a good prophylactic agent for post-extraction dry socket alveolitis. The bio-adhesive 0.2% chlorhexidine gel could improve this action since its intra-alveolar positioning would allow a more direct action on the alveolus and more prolonged action of the medication. MATERIALS AND METHOD:We pres...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acut...
journal_title：Medicina oral, patologia oral y cirugia bucal
pub_type： 杂志文章
doi：10.4317/medoral.23798
更新日期：2020-11-01 00:00:00
