Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion.

abstract：Objectives:Granulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in peripheral lymphocytes from ...

journal_title：Frontiers in immunology

authors： Makris A,Adamidi S,Koutsianas C,Tsalapaki C,Hadziyannis E,Vassilopoulos D

更新日期：2018-01-10 00:00:00

abstract：:Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

journal_title：Frontiers in immunology

authors： Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

更新日期：2019-01-31 00:00:00

abstract：:Toll-like receptors (TLRs) form an ancient family of innate immune receptors that detect microbial structures and activate the host immune response. Most subfamilies of TLRs (including TLR3, TLR5, and TLR7) are highly conserved among vertebrate species. In contrast, TLR15, a member of the TLR1 subfamily, appears to be...

journal_title：Frontiers in immunology

authors： Voogdt CGP,Merchant ME,Wagenaar JA,van Putten JPM

更新日期：2018-11-13 00:00:00

abstract：:Formation of pathological anti-FVIII antibodies, or "inhibitors," is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from the innate immune sys...

journal_title：Frontiers in immunology

authors： Karim AF,Soltis AR,Sukumar G,Königs C,Ewing NP,Dalgard CL,Wilkerson MD,Pratt KP

更新日期：2020-06-12 00:00:00

abstract：:The adaptive immune response is initiated in lymph nodes by contact between antigen-bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells that recognize a specific antigen may proliferate into expanded clones, differentiate, and acquire an effector phenotype. Despite growing ex...

journal_title：Frontiers in immunology

authors： Azarov I,Peskov K,Helmlinger G,Kosinsky Y

更新日期：2019-06-11 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by exerting graft-vs.-leukemia (GVL) effects. However, sufficient tumor...

journal_title：Frontiers in immunology

authors： Jahnke S,Schmid H,Secker KA,Einhaus J,Duerr-Stoerzer S,Keppeler H,Schober-Melms I,Baur R,Schumm M,Handgretinger R,Bethge W,Kanz L,Schneidawind C,Schneidawind D

更新日期：2019-07-09 00:00:00

abstract：:Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled gra...

journal_title：Frontiers in immunology

authors： Matsuda Y,Sarwal MM

更新日期：2016-10-21 00:00:00

abstract：:Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at least four different virus families: Arenaviridae, Bunyaviridae,...

journal_title：Frontiers in immunology

authors： Schönrich G,Raftery MJ

更新日期：2017-09-26 00:00:00

abstract：:Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Eston...

journal_title：Frontiers in immunology

authors： Ruohtula T,de Goffau MC,Nieminen JK,Honkanen J,Siljander H,Hämäläinen AM,Peet A,Tillmann V,Ilonen J,Niemelä O,Welling GW,Knip M,Harmsen HJ,Vaarala O

更新日期：2019-10-23 00:00:00

abstract：:Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucia...

journal_title：Frontiers in immunology

authors： Paulsen M,Varese A,Pinpathomrat N,Kirsebom FCM,Paulsen M,Johansson C

更新日期：2020-10-06 00:00:00

abstract：:Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged as an attractive al...

journal_title：Frontiers in immunology

authors： Amini L,Vollmer T,Wendering DJ,Jurisch A,Landwehr-Kenzel S,Otto NM,Jürchott K,Volk HD,Reinke P,Schmueck-Henneresse M

更新日期：2019-05-28 00:00:00

abstract：:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune inflammatory brain disease that can develop a variety of neuropsychiatric presentations. However, the underlying nature of its inflammatory neuronal injury remains unclear. Mitochondrial DNA (mtDNA) is recently regarded as a damage-associated mol...

journal_title：Frontiers in immunology

authors： Peng Y,Zheng D,Zhang X,Pan S,Ji T,Zhang J,Shen HY,Wang HH

更新日期：2019-02-06 00:00:00

abstract：:Intact (146S) foot-and-mouth disease virus (FMDVs) can dissociate into specific (12S) viral capsid degradation products. FMD vaccines normally consist of inactivated virions. Vaccine quality is dependent on 146S virus particles rather than 12S particles. We earlier isolated two llama single-domain antibody fragments (...

journal_title：Frontiers in immunology

authors： Harmsen MM,Seago J,Perez E,Charleston B,Eblé PL,Dekker A

更新日期：2017-08-17 00:00:00

abstract：:Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication. Cell types other than CD4 T cells such as monocytes/macrophage, dendritic cells, and granulocytes (collectively known as myeloid cells), are generally not consider...

journal_title：Frontiers in immunology

authors： Murray SM,Zhang Y,Douek DC,Sekaly RP

更新日期：2020-03-04 00:00:00

abstract：:Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...

journal_title：Frontiers in immunology

authors： Boyce BF,Li J,Xing L,Yao Z

更新日期：2018-09-28 00:00:00

abstract：:DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can be quickly modified to combat emerging infectious threats, but often fail to generate a strong immunologic response limiting enthusiasm for their use in humans ...

journal_title：Frontiers in immunology

authors： Solodushko V,Bitko V,Barrington R,Fouty B

更新日期：2019-10-11 00:00:00

abstract：:CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostas...

journal_title：Frontiers in immunology

authors： Li Z,Ju X,Silveira PA,Abadir E,Hsu WH,Hart DNJ,Clark GJ

更新日期：2019-06-07 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

journal_title：Frontiers in immunology

authors： Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

更新日期：2020-10-23 00:00:00

abstract：:The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictl...

journal_title：Frontiers in immunology

authors： Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

更新日期：2016-06-24 00:00:00

abstract：:Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation determinants on glycoproteins trafficking through the shared biosynt...

journal_title：Frontiers in immunology

authors： Lee LY,Lin CH,Fanayan S,Packer NH,Thaysen-Andersen M

更新日期：2014-08-25 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combi...

journal_title：Frontiers in immunology

authors： Roselli E,Araya P,Núñez NG,Gatti G,Graziano F,Sedlik C,Benaroch P,Piaggio E,Maccioni M

更新日期：2019-03-20 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene therapy and, recently, to the market approval of an AAV-based drug in Europe. With...

journal_title：Frontiers in immunology

authors： Basner-Tschakarjan E,Mingozzi F

更新日期：2014-07-23 00:00:00

abstract：:A previous report has shown that regulatory T cells (Treg) were markedly more sensitive to adenosine-5'-triphosphate (ATP) than conventional T cells (Tconv). Another one has shown that Tregs and CD45RBlow Tconvs, but not CD45RBhigh Tconvs, displayed similar high sensitivity to ATP. We have previously reported that CD4...

journal_title：Frontiers in immunology

authors： Safya H,Mellouk A,Legrand J,Le Gall SM,Benbijja M,Kanellopoulos-Langevin C,Kanellopoulos JM,Bobé P

更新日期：2018-02-27 00:00:00

abstract：:Mycobacterial infections are major causes of morbidity and mortality in cattle and are also potential zoonotic agents with implications for human health. Despite the implementation of comprehensive animal surveillance programs, many mycobacterial diseases have remained recalcitrant to eradication in several industrial...

journal_title：Frontiers in immunology

authors： Rue-Albrecht K,Magee DA,Killick KE,Nalpas NC,Gordon SV,MacHugh DE

更新日期：2014-11-05 00:00:00

abstract：:A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

journal_title：Frontiers in immunology

authors： Andrieu JM,Chen S,Lai C,Guo W,Lu W

更新日期：2014-06-30 00:00:00

abstract：:Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, w...

journal_title：Frontiers in immunology

authors： Wu J,Del Duca E,Espino M,Gontzes A,Cueto I,Zhang N,Estrada YD,Pavel AB,Krueger JG,Guttman-Yassky E

更新日期：2020-11-23 00:00:00

abstract：:Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid...

journal_title：Frontiers in immunology

authors： Lee SM,Yip TF,Yan S,Jin DY,Wei HL,Guo RT,Peiris JSM

更新日期：2018-03-16 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00