Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis.

abstract：:The multifunctional CD36 scavenger receptor facilitates fatty acid (FA) uptake and oxidation and it has been involved in the pathophysiology related to dysfunctional FA metabolism. The common variant in the CD36 gene, rs1761667 (A/G), whose allele A is characterized by a reduced protein expression, has been associated...

journal_title：Frontiers in physiology

authors： Melis M,Carta G,Pintus S,Pintus P,Piras CA,Murru E,Manca C,Di Marzo V,Banni S,Tomassini Barbarossa I

更新日期：2017-12-06 00:00:00

abstract：Objective:Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology and pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations of varicose veins by detecting differentially expressed genes, pathways and ...

journal_title：Frontiers in physiology

authors： Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

更新日期：2019-03-19 00:00:00

abstract：:Pinocembrin (PIN) is a natural flavonoid widely found in bee propolis with potent gastrointestinal protective effects. In consequence, PIN has great potential in preventing inflammatory bowel diseases (IBDs) while scant information is available. In this study, a dextran sulfate sodium (DSS)-induced rats ulcerative col...

journal_title：Frontiers in physiology

authors： Hu L,Wu C,Zhang Z,Liu M,Maruthi Prasad E,Chen Y,Wang K

更新日期：2019-07-19 00:00:00

abstract：:High-intensity interval training (HIT) is an effective approach for improving a range of physiological markers associated with physical fitness. A considerable body of work has demonstrated substantial improvements in cardiorespiratory fitness following short-term training programmes, while emerging evidence suggests ...

journal_title：Frontiers in physiology

authors： Hurst C,Scott JPR,Weston KL,Weston M

更新日期：2019-05-22 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative ...

journal_title：Frontiers in physiology

authors： Smith JF,Starr EG,Goodman MA,Hanson RB,Palmer TA,Woolstenhulme JB,Weyand JA,Marchant AD,Bueckers SL,Nelson TK,Sterling MT,Rose BJ,Porter JP,Eggett DL,Kooyman DL

更新日期：2020-02-18 00:00:00

abstract：:The integrated pest management (IPM) strategy was developed and used in combination with pesticides and beneficial biological control agents. To further develop IPM efficiency, it is important to evaluate the side effects of pesticides on biological control agents. Aphidius gifuensis is one of the most important aphid...

journal_title：Frontiers in physiology

authors： Kang ZW,Liu FH,Pang RP,Tian HG,Liu TX

更新日期：2018-12-11 00:00:00

abstract：:Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5) from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in leng...

journal_title：Frontiers in physiology

authors： Huang Y,Han K,Ren Q

更新日期：2018-03-05 00:00:00

abstract：:Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of the initial injury, renal fibrosis is the common final pathway leading to end stage renal disease. Although the underlying mechanisms are not fully defined, evidence indicates that besides inflammation, oxidative stress plays a c...

journal_title：Frontiers in physiology

authors： Lv W,Booz GW,Fan F,Wang Y,Roman RJ

更新日期：2018-02-16 00:00:00

abstract：:Trace conditioning is a form of associative learning that can be induced by presenting a conditioned stimulus (CS) and an unconditioned stimulus (US) following each other, but separated by a temporal gap. This gap distinguishes trace conditioning from classical delay conditioning, where the CS and US overlap. To bridg...

journal_title：Frontiers in physiology

authors： Dylla KV,Galili DS,Szyszka P,Lüdke A

更新日期：2013-08-23 00:00:00

abstract：:The paired cranial sensory organs and peripheral nervous system of vertebrates arise from a thin strip of cells immediately adjacent to the developing neural plate. The neural plate border region comprises progenitors for four key populations of cells: neural plate cells, neural crest cells, the cranial placodes, and ...

journal_title：Frontiers in physiology

authors： Thawani A,Groves AK

更新日期：2020-12-07 00:00:00

abstract：:Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action o...

journal_title：Frontiers in physiology

authors： Bittel DC,Jaiswal JK

更新日期：2019-07-18 00:00:00

abstract：:This study examined the selective influences of one-repetition maximum (1RM) values [assessed in the half-squat (HS)] and bar-power production [assessed in both HS and jump squat (JS) exercises] on the physical performance of male and female team sport athletes from four different sports. Three-hundred and three elite...

journal_title：Frontiers in physiology

authors： Loturco I,Suchomel T,James LP,Bishop C,Abad CCC,Pereira LA,McGuigan MR

更新日期：2018-12-17 00:00:00

abstract：:Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior. Understanding the molecular mechanisms of preterm brain injuries is...

journal_title：Frontiers in physiology

authors： Pregnolato S,Chakkarapani E,Isles AR,Luyt K

更新日期：2019-04-24 00:00:00

abstract：:A recent experiment proves the therapeutic effect of arm-in-arm walking, showing that if an aged participant walks in close synchrony with a young companion, the complexity matching effect results in the restoration of complexity in the former. A clear manifestation of complexity restoration is a perfect synchronizati...

journal_title：Frontiers in physiology

authors： Mahmoodi K,West BJ,Grigolini P

更新日期：2020-09-30 00:00:00

abstract：:We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...

journal_title：Frontiers in physiology

authors： Šket R,Debevec T,Kublik S,Schloter M,Schoeller A,Murovec B,Vogel Mikuš K,Makuc D,Pečnik K,Plavec J,Mekjavić IB,Eiken O,Prevoršek Z,Stres B

更新日期：2018-03-13 00:00:00

abstract：BACKGROUND:Human labor is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labor, one hypothesis suggests that maturation of the fetus releases a signal in the amniotic fluid that will be transmitted to m...

journal_title：Frontiers in physiology

authors： Alzamil HA,Pawade J,Fortier MA,Bernal AL

更新日期：2014-07-30 00:00:00

abstract：:With the advent of high-throughput technologies, the field of systems biology has amassed an abundance of "omics" data, quantifying thousands of cellular components across a variety of scales, ranging from mRNA transcript levels to metabolite quantities. Methods are needed to not only integrate this omics data but to ...

journal_title：Frontiers in physiology

authors： Blazier AS,Papin JA

更新日期：2012-08-06 00:00:00

abstract：:Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart ra...

journal_title：Frontiers in physiology

authors： Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

更新日期：2018-10-30 00:00:00

abstract：:Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using phenylephrine (PE) ...

journal_title：Frontiers in physiology

authors： Gu J,Hu W,Song ZP,Chen YG,Zhang DD,Wang CQ

更新日期：2016-03-18 00:00:00

abstract：:The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many critical biomedical applications such as drug development. Limited resources, high costs, and low hit...

journal_title：Frontiers in physiology

authors： Kandoi G,Acencio ML,Lemke N

更新日期：2015-12-08 00:00:00

abstract：Rationale:Pulmonary hypertension (PH) is a rare but fatal disease characterized by elevated pulmonary pressures and vascular remodeling, leading to right ventricular failure and death. Recently, neuroinflammation has been suggested to be involved in the sympathetic activation in experimental PH. Whether PH is associate...

journal_title：Frontiers in physiology

authors： Vaillancourt M,Chia P,Medzikovic L,Cao N,Ruffenach G,Younessi D,Umar S

更新日期：2019-09-20 00:00:00

abstract：:Ocean acidification (OA) and warming seas are significant concerns for coastal systems and species. The Atlantic longfin squid, Doryteuthis pealeii, a core component of the Northwest Atlantic trophic web, has demonstrated impacts, such as reduced growth and delayed development, under high chronic exposure to acidifica...

journal_title：Frontiers in physiology

authors： Zakroff CJ,Mooney TA

更新日期：2020-05-20 00:00:00

abstract：:Lepidopteran species detect CO2 via a specialized organ located on the peripheral segment of the labial palps, the labial palp pit organ (LPO). Based on tracing of LPO sensory neurons targeting one distinct antennal-lobe glomerulus, Kent and her colleagues described the projections originating from the LPO in the sphi...

journal_title：Frontiers in physiology

authors： Kc P,Chu X,Kvello P,Zhao XC,Wang GR,Berg BG

更新日期：2020-03-17 00:00:00

abstract：:Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of ca...

journal_title：Frontiers in physiology

authors： van Bel F,Vaes J,Groenendaal F

更新日期：2019-03-20 00:00:00

abstract：:Alcohol use disorder (AUD) is a major health, social and economic problem for which there are few effective treatments. The opiate antagonist naltrexone is currently prescribed clinically with mixed success. We have used naltrexone in an established behavioral assay (CAFE) in Drosophila melanogaster that measures the ...

journal_title：Frontiers in physiology

authors： Koyyada R,Latchooman N,Jonaitis J,Ayoub SS,Corcoran O,Casalotti SO

更新日期：2018-03-14 00:00:00

abstract：:Mollusk shells are products of biomineralization and possess excellent mechanical properties, and shell matrix proteins (SMPs) have important functions in shell formation. A novel SMP with a PDZ domain (PDZ-domain-containing-protein-1, PDCP-1) was identified from the shell matrices of Mytilus coruscus. In this study, ...

journal_title：Frontiers in physiology

authors： Sun Q,Jiang Y,Yan X,Fan M,Zhang X,Xu H,Liao Z

更新日期：2020-10-02 00:00:00

abstract：:Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small leuci...

journal_title：Frontiers in physiology

authors： Zvackova I,Matalova E,Lesot H

更新日期：2017-08-02 00:00:00

abstract：:Insect β-1,3-glucanases belong to Glycoside Hydrolase Family 16 (GHF16) and are involved in digestion of detritus and plant hemicellulose. In this work, we investigated the role of GHF16 genes in Aedes aegypti larvae, due to their detritivore diet. Aedes aegypti genome has six genes belonging to GHF16 (Aae GH16.1 - Aa...

journal_title：Frontiers in physiology

authors： Souza RS,Gama MDVF,Schama R,Lima JBP,Diaz-Albiter HM,Genta FA

更新日期：2019-02-28 00:00:00

abstract：:Introduction: Heart Rate Variability (HRV) and Pulse Rate Variability (PRV), are non-invasive techniques for monitoring changes in the cardiac cycle. Both techniques have been used for assessing the autonomic activity. Although highly correlated in healthy subjects, differences in HRV and PRV have been observed under ...

journal_title：Frontiers in physiology

authors： Mejía-Mejía E,Budidha K,Abay TY,May JM,Kyriacou PA

更新日期：2020-07-23 00:00:00

abstract：:Background: The severity of wildland fires is increasing due to continually hotter and drier summers. Firefighters are required to make life altering decisions on the fireground, which requires analytical thinking, problem solving, and situational awareness. This study aimed to determine the effects of very hot (45°C;...

journal_title：Frontiers in physiology

authors： Williams-Bell FM,Aisbett B,Murphy BA,Larsen B

更新日期：2017-10-24 00:00:00