Tau protein and adult hippocampal neurogenesis.

abstract：:Spinocerebellar ataxia (SCA) is a part of the cerebellar neurodegenerative disease group that is diverse in genetics and phenotypes. It usually shows autosomal dominant inheritance. SCAs, always together with the cerebellar degeneration, may exhibit clinical deficits in brainstem or eye, especially retina or optic ner...

journal_title：Frontiers in neuroscience

authors： Park JY,Joo K,Woo SJ

更新日期：2020-08-21 00:00:00

abstract：:Analog arrays are a promising emerging hardware technology with the potential to drastically speed up deep learning. Their main advantage is that they employ analog circuitry to compute matrix-vector products in constant time, irrespective of the size of the matrix. However, ConvNets map very unfavorably onto analog a...

journal_title：Frontiers in neuroscience

authors： Rasch MJ,Gokmen T,Rigotti M,Haensch W

更新日期：2019-07-30 00:00:00

abstract：:Background: Tinnitus is a very common symptom that often causes distress and decreases the patient's quality of life. Apart from the well-known causes, tinnitus can in some cases be elicited by dysfunctions of the cervical spine or the temporomandibular joint (TMJ). To date however, it is unclear whether alleviation o...

journal_title：Frontiers in neuroscience

authors： Michiels S,Naessens S,Van de Heyning P,Braem M,Visscher CM,Gilles A,De Hertogh W

更新日期：2016-11-29 00:00:00

abstract：Background:Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects...

journal_title：Frontiers in neuroscience

authors： Hollis A,Zewdie E,Nettel-Aguirre A,Hilderley A,Kuo HC,Carlson HL,Kirton A

更新日期：2020-05-19 00:00:00

abstract：:For safe application of exoskeletons in people with spinal cord injury at home or in the community, it is required to have completed an exoskeleton training in which users learn to perform basic and advanced skills. So far, a framework to test exoskeleton skills is lacking. The aim of this study was to develop and tes...

journal_title：Frontiers in neuroscience

authors： van Dijsseldonk RB,Rijken H,van Nes IJW,van de Meent H,Keijsers NLW

更新日期：2017-12-12 00:00:00

abstract：:Experiments often challenge the null hypothesis that an intervention, for instance application of non-invasive brain stimulation (NIBS), has no effect on an outcome measure. In conventional statistics, a positive result rejects that hypothesis, but a null result is meaningless. Informally, however, researchers often d...

journal_title：Frontiers in neuroscience

authors： de Graaf TA,Sack AT

更新日期：2018-12-11 00:00:00

abstract：:Some studies identified hypo-connectivity, while others showed hyper-connectivity of the insula in the autism spectrum disorders (ASD). These contradictory findings leave open the question of whether and to what extent functional connectivity of the insula is altered and how functional connectivity of the insula is as...

journal_title：Frontiers in neuroscience

authors： Xu J,Wang H,Zhang L,Xu Z,Li T,Zhou Z,Zhou Z,Gan Y,Hu Q

更新日期：2018-04-11 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public health concern that affects 69 million individuals each year worldwide. Neuropsychologists report that up to 40% of individuals undergoing evaluations for TBI may be malingering neurocognitive deficits for a compensatory reward. The memory recognition test of malingering ...

journal_title：Frontiers in neuroscience

authors： Neal J,Strothkamp S,Bedingar E,Cordero P,Wagner B,Vagnini V,Jiang Y

更新日期：2019-09-25 00:00:00

abstract：:Data from animal models and Alzheimer's disease (AD) subjects provide clear evidence for an activation of inflammatory pathways during the pathogenetic course of such illness. Biochemical and neuropathological studies highlighted an important cause/effect relationship between inflammation and AD progression, revealing...

journal_title：Frontiers in neuroscience

authors： Steardo L Jr,Bronzuoli MR,Iacomino A,Esposito G,Steardo L,Scuderi C

更新日期：2015-07-29 00:00:00

abstract：:We introduce a novel recurrent neural network (RNN) approach to account for temporal dynamics and dependencies in brain networks observed via functional magnetic resonance imaging (fMRI). Our approach directly parameterizes temporal dynamics through recurrent connections, which can be used to formulate blind source se...

journal_title：Frontiers in neuroscience

authors： Hjelm RD,Damaraju E,Cho K,Laufs H,Plis SM,Calhoun VD

更新日期：2018-09-20 00:00:00

abstract：:Ablation of adult neurogenesis in mice has revealed that young adult-born granule cells (abGCs) are required for some of the behavioral responses to antidepressants (ADs), yet the mechanism by which abGCs contribute to AD action remains unknown. During their maturation process, these immature neurons exhibit unique pr...

journal_title：Frontiers in neuroscience

authors： Tannenholz L,Hen R,Kheirbek MA

更新日期：2016-05-31 00:00:00

abstract：:Anorexia nervosa (AN) has the highest mortality rate of any psychiatric disease, yet available pharmacological treatments are largely ineffective due, in part, to an inadequate understanding of the neurobiological drivers that underpin the condition. The recent resurgence of research into the clinical applications of ...

journal_title：Frontiers in neuroscience

authors： Foldi CJ,Liknaitzky P,Williams M,Oldfield BJ

更新日期：2020-02-04 00:00:00

abstract：:Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 be...

journal_title：Frontiers in neuroscience

authors： Lorke DE,Petroianu GA

更新日期：2019-05-22 00:00:00

abstract：:Social conflict is a major source of stress in humans. Animals also experience social conflicts and cope with them by stress responses that facilitate arousal and activate sympathetic and neuroendocrine systems. The effect of acute social defeat (SoD) stress on the sleep/wake behavior of mice has been reported in seve...

journal_title：Frontiers in neuroscience

authors： Fujii S,Kaushik MK,Zhou X,Korkutata M,Lazarus M

更新日期：2019-04-03 00:00:00

abstract：:Brain functional connectivity network (BFCN) analysis has been widely used in the diagnosis of mental disorders, such as schizophrenia. In BFCN methods, brain network construction is one of the core tasks due to its great influence on the diagnosis result. Most of the existing BFCN construction methods only consider t...

journal_title：Frontiers in neuroscience

authors： Zhu Q,Li H,Huang J,Xu X,Guan D,Zhang D

更新日期：2019-06-14 00:00:00

abstract：:The sliding-window-based dynamic functional connectivity networks (D-FCNs) derived from resting-state functional magnetic resonance imaging (rs-fMRI) are effective methods for diagnosing various neurological diseases, including autism spectrum disorder (ASD). However, traditional D-FCNs are low-order networks based on...

journal_title：Frontiers in neuroscience

authors： Zhao F,Chen Z,Rekik I,Lee SW,Shen D

更新日期：2020-04-28 00:00:00

abstract：:Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreERT2-Lox system are widely used. In this study, we made use of a Nestin-CreERT2/R26R-YFP transgenic mouse ...

journal_title：Frontiers in neuroscience

authors： Rotheneichner P,Romanelli P,Bieler L,Pagitsch S,Zaunmair P,Kreutzer C,König R,Marschallinger J,Aigner L,Couillard-Després S

更新日期：2017-02-01 00:00:00

abstract：:Williams syndrome (WS) is a clinical condition, involving cognitive deficits and an uneven language profile, which has been the object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozen genes in chromosome 7, no gene has yet been probed to account for, or contribute...

journal_title：Frontiers in neuroscience

authors： Benítez-Burraco A,Kimura R

更新日期：2019-03-26 00:00:00

abstract：:Emerging neuroimaging studies emphasize the dynamic organization of spontaneous brain activity in both human and non-human primates, even under anesthesia. In a recent study, we were able to characterize the heterogeneous architecture of intrinsic functional flexibility in the awake, resting human brain using time-res...

journal_title：Frontiers in neuroscience

authors： Yin D,Zhang Z,Wang Z,Zeljic K,Lv Q,Cai D,Wang Y,Wang Z

更新日期：2019-02-28 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson's disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intriguingly, the presenc...

journal_title：Frontiers in neuroscience

authors： Dues DJ,Moore DJ

更新日期：2020-07-08 00:00:00

abstract：:Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the content of neuronal injury. As well-accepted, inflammation, and neuron...

journal_title：Frontiers in neuroscience

authors： Hohmann U,Pelzer M,Kleine J,Hohmann T,Ghadban C,Dehghani F

更新日期：2019-11-07 00:00:00

abstract：:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective therapy for obsessive compulsive disorder (OCD) and is currently under investigation as a treatment for eating disorders. DBS of this area is associated with altered food intake and pharmacological treatment of OCD is associated with the risk ...

journal_title：Frontiers in neuroscience

authors： Diepenbroek C,van der Plasse G,Eggels L,Rijnsburger M,Feenstra MG,Kalsbeek A,Denys D,Fliers E,Serlie MJ,la Fleur SE

更新日期：2013-12-10 00:00:00

abstract：:The neuropeptide oxytocin plays a central role in prosocial and parental behavior in non-human mammals as well as humans. It has been suggested that oxytocin may affect visual processing of infant faces and emotional reaction to infants. Healthy male volunteers (N = 13) were tested for their ability to detect infant o...

journal_title：Frontiers in neuroscience

authors： Saito A,Hamada H,Kikusui T,Mogi K,Nagasawa M,Mitsui S,Higuchi T,Hasegawa T,Hiraki K

更新日期：2014-07-29 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive brain disorder with gradual memory loss that correlates to cognitive deficits in the elderly population. Recent studies have shown the potentials of machine learning algorithms to identify biomarkers and functional brain activity patterns across various AD stages using electro...

journal_title：Frontiers in neuroscience

authors： Fan M,Yang AC,Fuh JL,Chou CA

更新日期：2018-10-04 00:00:00

abstract：:The habenular neural circuit is attracting increasing attention from researchers in fields as diverse as neuroscience, medicine, behavior, development, and evolution. Recent studies have revealed that this part of the limbic system in the dorsal diencephalon is involved in reward, addiction, and other behaviors and it...

journal_title：Frontiers in neuroscience

authors： Beretta CA,Dross N,Guiterrez-Triana JA,Ryu S,Carl M

更新日期：2012-04-23 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by T helper (h)1 and/or Th17 CD4 T cells that drive inflammatory lesion development along with demyelination and neuronal damage. Defects in immune regulatory mechanisms are thought to play a role in the pathogenesis of MS. W...

journal_title：Frontiers in neuroscience

authors： Miller NM,Wang J,Tan Y,Dittel BN

更新日期：2015-08-18 00:00:00

abstract：:Wireless electroencephalography (EEG) of small animal subjects typically utilizes miniaturized EEG devices which require a robust recording and electrode assembly that remains in place while also being well-tolerated by the animal so as not to impair the ability of the animal to perform normal living activities or exp...

journal_title：Frontiers in neuroscience

authors： Vogler EC,Flynn DT,Busciglio F,Bohannan RC,Tran A,Mahavongtrakul M,Busciglio JA

更新日期：2017-11-14 00:00:00

abstract：:Compared to standard laboratory protocols, the measurement of psychophysiological signals in real world experiments poses technical and methodological challenges due to external factors that cannot be directly controlled. To address this problem, we propose a hybrid approach based on an immersive and human accessible ...

journal_title：Frontiers in neuroscience

authors： Betella A,Zucca R,Cetnarski R,Greco A,Lanatà A,Mazzei D,Tognetti A,Arsiwalla XD,Omedas P,De Rossi D,Verschure PF

更新日期：2014-09-24 00:00:00

abstract：:There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on pr...

journal_title：Frontiers in neuroscience

authors： Iva P,Fielding J,Clough M,White O,Godic B,Martin R,Rajan R

更新日期：2020-12-23 00:00:00

abstract：:Emotional stimuli have been shown to modulate attentional orienting through signals sent by subcortical brain regions that modulate visual perception at early stages of processing. Fewer studies, however, have investigated a similar effect of emotional stimuli on attentional orienting in the auditory domain together w...

journal_title：Frontiers in neuroscience

authors： Ceravolo L,Frühholz S,Grandjean D

更新日期：2016-05-12 00:00:00