Abstract:
:Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi Vdoi
10.18632/aging.100459subject
Has Abstractpub_date
2012-05-01 00:00:00pages
330-49issue
5issn
1945-4589pii
100459journal_volume
4pub_type
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