The genetics of brown adipocyte induction in white fat depots.

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H+), the sarcoplasmic reticulum (Ca++), and the plasma membrane (Na+/K+). The potential energy of these gradients can be used to perfo...

journal_title：Frontiers in endocrinology

authors： Geisler CE,Kentch KP,Renquist BJ

更新日期：2017-09-01 00:00:00

abstract：Background:Repeated radioiodine (131I) treatment (RT) are commonly performed in patients with 131I-avid distant metastatic differentiated thyroid cancer (DM-DTC), but more precise indications remain indeterminate. This prospective study was conducted to explore predictors for biochemical response (BR) to next RT. Meth...

journal_title：Frontiers in endocrinology

authors： Sa R,Cheng L,Jin Y,Fu H,Shen Y,Chen L

更新日期：2020-11-16 00:00:00

abstract：:Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

journal_title：Frontiers in endocrinology

authors： Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

更新日期：2015-02-04 00:00:00

abstract：:Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced prevalence of Helicobacter pylori (Hp) infection, which is the most important cause of gastric cance...

journal_title：Frontiers in endocrinology

authors： Waldum HL,Sagatun L,Mjønes P

更新日期：2017-01-17 00:00:00

abstract：Background:The risk of spontaneous abortion in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients without PCOS, however, no definitive risk factors have been confirmed to associate with the high spontaneous abortion rate in PCOS patients under...

journal_title：Frontiers in endocrinology

authors： Sun YF,Zhang J,Xu YM,Cao ZY,Wang YZ,Hao GM,Gao BL

更新日期：2020-12-03 00:00:00

abstract：:Sleep duration has become increasingly recognized as an important influencer of health. Epidemiologic and observational studies have shown associations between short sleep duration and increased risk for chronic cardiometabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. These associatio...

journal_title：Frontiers in endocrinology

authors： Pizinger TM,Aggarwal B,St-Onge MP

更新日期：2018-07-18 00:00:00

abstract：:Background and Objectives: Clitoromegaly is an important parameter in the evaluation of ambiguous genitalia in neonates, but the normative data for clitoral size in newborns have racial/ethnic differences. The present study aimed to determine clitoral length (CL) and clitoral width (CW) values and establish cutoff mea...

journal_title：Frontiers in endocrinology

authors： Alaei M,Rohani F,Norouzi E,Hematian Boroujeni N,Tafreshi RI,Salehiniya H,Soheilipour F

更新日期：2020-06-03 00:00:00

abstract：:Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire...

journal_title：Frontiers in endocrinology

authors： Sangalli E,Tagliabue E,Sala L,Prattichizzo F,Uccellatore A,Spada D,Lorino F,de Candia P,Lupini S,Cantone L,Favero C,Madeddu P,Bollati V,Genovese S,Spinetti G

更新日期：2020-04-23 00:00:00

abstract：:Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters. Research design and methods: The study was a parallel, double-blind, placebo-controlled study where patients with diet or ...

journal_title：Frontiers in endocrinology

authors： Konya J,Sathyapalan T,Kilpatrick ES,Atkin SL

更新日期：2019-05-09 00:00:00

abstract：:Objectives: To assess the diagnostic potential of bidirectional axial transmission (BDAT) ultrasound, and high-resolution peripheral quantitative computed tomography (HR-pQCT) in X-linked hypophosphatemia (XLH, OMIM #307800), a rare genetic disorder of phosphate metabolism caused by mutations in the PHEX gene. Methods...

journal_title：Frontiers in endocrinology

authors： Raimann A,Mehany SN,Feil P,Weber M,Pietschmann P,Boni-Mikats A,Klepochova R,Krššák M,Häusler G,Schneider J,Patsch JM,Raum K

更新日期：2020-06-09 00:00:00

abstract：:Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pi...

journal_title：Frontiers in endocrinology

authors： Zimmermann A,Zwerenz R,Droste M,Schöfl C,Strasburger CJ,Plöckinger U,Ziagaki A,Honegger J,Dixius A,Millaku B,Toenges G,Beutel ME,Weber MM

更新日期：2018-07-17 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation...

journal_title：Frontiers in endocrinology

authors： Tang R,Ding X,Zhu J

更新日期：2019-05-10 00:00:00

abstract：:The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellu...

journal_title：Frontiers in endocrinology

authors： Lichardus B

更新日期：2014-11-11 00:00:00

abstract：:Hashimoto's thyroiditis (HT) is the most common cause of thyroid disease in children and adolescents. Along with significant modifications of thyroid function, HT in pediatric age can be accompanied by relevant thyroid structural alterations. Over time, benign thyroid nodules, carcinoma and, rarely, primary non-Hodgki...

journal_title：Frontiers in endocrinology

authors： Penta L,Cofini M,Lanciotti L,Leonardi A,Principi N,Esposito S

更新日期：2018-10-09 00:00:00

abstract：:In neuroendocrine cells, prohormones move from the endoplasmic reticulum to the Golgi complex (GC), where they are sorted and packed into secretory granules. The GC is considered the central station of the secretory pathway of proteins and lipids en route to their final destination. In most mammalian cells, it is form...

journal_title：Frontiers in endocrinology

authors： Martínez-Alonso E,Tomás M,Martínez-Menárguez JA

更新日期：2013-03-28 00:00:00

abstract：:The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and ev...

journal_title：Frontiers in endocrinology

authors： Grasso D,Vaccaro MI

更新日期：2014-09-29 00:00:00

abstract：:Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orall...

journal_title：Frontiers in endocrinology

authors： Alonso N,Julián MT,Puig-Domingo M,Vives-Pi M

更新日期：2012-09-07 00:00:00

abstract：:During mammalian pregnancy, highly specialized mechanisms of immune tolerance are triggered in order to allow the semi-allogeneic fetus to grow within the maternal uterus in harmony with the maternal immune system. Among other mechanisms, changes in the endocrine status have been proposed to be at least part of the ma...

journal_title：Frontiers in endocrinology

authors： Muzzio D,Zygmunt M,Jensen F

更新日期：2014-04-01 00:00:00

abstract：Introduction:The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect G...

journal_title：Frontiers in endocrinology

authors： Nyiraty S,Pesei F,Orosz A,Coluzzi S,Vági OE,Lengyel C,Ábrahám G,Frontoni S,Kempler P,Várkonyi T

更新日期：2018-04-19 00:00:00

abstract：:Type 2 diabetes affects racial/ethnic minorities at an alarming rate in the US and in many countries around the world. The quality of health care provided to these groups is often suboptimal, resulting in worse patient-related outcomes when compared to those in mainstream populations. Understanding the complex biologi...

journal_title：Frontiers in endocrinology

authors： Caballero AE

更新日期：2018-08-28 00:00:00

abstract：:Both males and females of heliothine moths utilize sex-pheromones during the mating process. Females produce and release a sex pheromone for the long-range attraction of males for mating. Production of sex pheromone in females is controlled by the peptide hormone (pheromone biosynthesis activating neuropeptide, PBAN)....

journal_title：Frontiers in endocrinology

authors： Jurenka R,Rafaeli A

更新日期：2011-10-10 00:00:00

abstract：:Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we deter...

journal_title：Frontiers in endocrinology

authors： Ho LT,Hsu YP,Hsiao CF,Ting CT,Shih KC,Chuang LM,Masaki K,Grove J,Quertermous T,Juan CC,Lin MW,Chiang SC,Chen YD

更新日期：2013-11-28 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and ...

journal_title：Frontiers in endocrinology

authors： Cansell C,Denis RG,Joly-Amado A,Castel J,Luquet S

更新日期：2012-12-27 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are al...

journal_title：Frontiers in endocrinology

authors： Stephens SBZ,Kauffman AS

更新日期：2017-08-07 00:00:00

abstract：:Remodeling of the cellular distribution of gap junctions formed mainly by connexin-43 (Cx43) can be related to the increased incidence of cardiac arrhythmias. It has been shown that adaptation to chronic intermittent hypobaric hypoxia (IHH) attenuates the incidence and severity of ischemic and reperfusion ventricular ...

journal_title：Frontiers in endocrinology

authors： Kohutova J,Elsnicova B,Holzerova K,Neckar J,Sebesta O,Jezkova J,Vecka M,Vebr P,Hornikova D,Szeiffova Bacova B,Egan Benova T,Hlavackova M,Tribulova N,Kolar F,Novakova O,Zurmanova JM

更新日期：2019-01-25 00:00:00

abstract：:The essential amino acid L-tryptophan (Trp) is the precursor of the monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Numerous studies have shown that elevated dietary Trp has a suppressive effect on aggressive behavior and post-stress plasma cortisol concentrations in vertebrates, including teleos...

journal_title：Frontiers in endocrinology

authors： Höglund E,Øverli Ø,Winberg S

更新日期：2019-04-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fendo.2019.00668.]. ...

journal_title：Frontiers in endocrinology

authors： Wee NKY,Lorenz MR,Bekirov Y,Jacquin MF,Scheller EL

更新日期：2020-01-22 00:00:00