Wegener's disease presenting with occipital condyle syndrome.

abstract：:Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in elderly patients ≥80 years have been limited to small numbers undergoing EVT with...

journal_title：Frontiers in neurology

authors： Sharobeam A,Cordato DJ,Manning N,Cheung A,Wenderoth J,Cappelen-Smith C

更新日期：2019-03-20 00:00:00

abstract：AIMS:Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts. Here, we explore the nature, the time course, and the role of the complement system in this damage. METHODS:The ...

journal_title：Frontiers in neurology

authors： Granados-Durán P,López-Ávalos MD,Cifuentes M,Pérez-Martín M,Fernández-Arjona MD,Hughes TR,Johnson K,Morgan BP,Fernández-Llebrez P,Grondona JM

更新日期：2017-03-07 00:00:00

abstract：:Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive 9-day training on the Jap...

journal_title：Frontiers in neurology

authors： Tabei KI,Satoh M,Nakano C,Ito A,Shimoji Y,Kida H,Sakuma H,Tomimoto H

更新日期：2016-09-19 00:00:00

abstract：:Introduction: Persons with MS (PwMS) have markedly reduced push-off and toe-clearance during gait compared to healthy subjects (HS). These deficits may result from alterations in neuromotor control at the ankle. To optimize rehabilitation interventions for PwMS, a crucial step is to evaluate if and how altered neuromo...

journal_title：Frontiers in neurology

authors： Jonsdottir J,Lencioni T,Gervasoni E,Crippa A,Anastasi D,Carpinella I,Rovaris M,Cattaneo D,Ferrarin M

更新日期：2020-07-24 00:00:00

abstract：OBJECT:Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen a...

journal_title：Frontiers in neurology

authors： Kiiski H,Jalkanen V,Ala-Peijari M,Hämäläinen M,Moilanen E,Peltola J,Tenhunen J

更新日期：2017-04-18 00:00:00

abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

journal_title：Frontiers in neurology

authors： Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

更新日期：2013-05-31 00:00:00

abstract：:Objective: Status epilepticus is a major emergency condition. The choice of antiepileptic drugs for second-line treatment after benzodiazepine remains controversial, including levetiracetam vs. fosphenytoin. We compare the safety of intravenous levetiracetam and fosphenytoin as a second-line treatment in patients with...

journal_title：Frontiers in neurology

authors： Nakamura K,Ohbe H,Matsui H,Takahashi Y,Marushima A,Inoue Y,Fushimi K,Yasunaga H

更新日期：2020-07-02 00:00:00

abstract：:Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respec...

journal_title：Frontiers in neurology

authors： Talhada D,Santos CRA,Gonçalves I,Ruscher K

更新日期：2019-10-18 00:00:00

abstract：:Background: Perinatal and perioperative brain injury is a fundamental problem in infants with severe congenital heart disease undergoing neonatal cardiac surgery with cardiopulmonary bypass. An impaired neuromotor and neurocognitive development is encountered and associated with a reduction in quality of life. New neu...

journal_title：Frontiers in neurology

authors： Stegeman R,Lamur KD,van den Hoogen A,Breur JMPJ,Groenendaal F,Jansen NJG,Benders MJNL

更新日期：2018-07-03 00:00:00

abstract：:Hashimoto's encephalopathy (HE) is a rare, clinically heterogeneous condition associated with positive thyroid autoantibodies. It is increasingly recognized as an important and treatable cause of autoimmune encephalopathy. Thyroid-associated antibodies such as thyroperoxidase (TPO) antibody, thyroglobulin (TG) antibod...

journal_title：Frontiers in neurology

authors： Li J,Li F

更新日期：2019-05-08 00:00:00

abstract：:Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, although most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency ...

journal_title：Frontiers in neurology

authors： Marques R,Thole H,Ruiz de Morales JG

更新日期：2020-05-15 00:00:00

abstract：:Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to i...

journal_title：Frontiers in neurology

authors： Qin L,Jiang W,Zheng J,Zhou X,Zhang Z,Liu J

更新日期：2020-07-21 00:00:00

abstract：Background:Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than o...

journal_title：Frontiers in neurology

authors： Liu C,Shi F,Chen Z,Yan S,Ding X,Lou M

更新日期：2018-02-08 00:00:00

abstract：:Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course of HAMD has not been disclosed either. Methods: A headache screening questionnaire in China based on the ICHD2 and a face-to-face intervie...

journal_title：Frontiers in neurology

authors： Gao B,Kang K,Zhang J,Zhang D,Zhao X

更新日期：2020-11-26 00:00:00

abstract：Background:Temporal lobe epilepsy (TLE) is one of the most drug-resistant types of epilepsy with about 80% of TLE patients falling into this category. Increasing evidence suggests that neuroinflammation, which has a critical role in the epileptogenesis of TLE, is associated with microglial activation. Therefore, agents...

journal_title：Frontiers in neurology

authors： Liu HJ,Lai X,Xu Y,Miao JK,Li C,Liu JY,Hua YY,Ma Q,Chen Q

更新日期：2017-12-14 00:00:00

abstract：:Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients....

journal_title：Frontiers in neurology

authors： Heath CJ,O'Callaghan C,Mason SL,Phillips BU,Saksida LM,Robbins TW,Barker RA,Bussey TJ,Sahakian BJ

更新日期：2019-08-09 00:00:00

abstract：:Objective: The aims of this study were to compare the characteristics of three motor subtype classifications in patients with de novo Parkinson's disease (PD) and to find the most suitable motor subtype classification for identifying non-motor symptoms (NMSs). Methods: According to previous studies, a total of 256 pat...

journal_title：Frontiers in neurology

authors： Ren J,Hua P,Li Y,Pan C,Yan L,Yu C,Zhang L,Xu P,Zhang M,Liu W

更新日期：2020-12-23 00:00:00

abstract：:Background: Spontaneous use of the more-affected arm is a meaningful indicator of stroke recovery. The Bilateral Arm Reaching Test (BART) was previously developed to quantify arm use by measuring arm choice to targets projected over a horizontal hemi-workspace. In order to improve clinical validity, we constrained the...

journal_title：Frontiers in neurology

authors： Kim S,Park H,Han CE,Winstein CJ,Schweighofer N

更新日期：2018-10-22 00:00:00

abstract：OBJECTIVE:To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS:Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytoki...

journal_title：Frontiers in neurology

authors： Zeiler FA,Thelin EP,Czosnyka M,Hutchinson PJ,Menon DK,Helmy A

更新日期：2017-07-10 00:00:00

abstract：:Over the last two decades, many experimental and clinical studies have provided solid evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to Parkinson's disease (PD) pathology. To provide an overview on the different roles of this protein, here we propose a synopsis of seminal...

journal_title：Frontiers in neurology

authors： Ghiglieri V,Calabrese V,Calabresi P

更新日期：2018-05-04 00:00:00

abstract：:The benefits of hemicraniectomy for malignant middle cerebral artery (MCA) stroke may not be apparent in the 3- to 6-months in which final outcomes are assessed in research studies. We present the case of a 15-year-old who underwent hemicraniectomy for malignant MCA stroke and was significantly disabled 3 and 6 months...

journal_title：Frontiers in neurology

authors： Mittal A,Mittal G,Partikian A,Liebeskind D,Sanossian N

更新日期：2012-08-02 00:00:00

abstract：:Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furt...

journal_title：Frontiers in neurology

authors： Troncoso-Escudero P,Parra A,Nassif M,Vidal RL

更新日期：2018-10-15 00:00:00

abstract：:Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablatio...

journal_title：Frontiers in neurology

authors： Jang C,Park HJ,Chang WS,Pae C,Chang JW

更新日期：2016-10-24 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease characterized by lesions in the central nervous system (CNS). Inflammation and demyelination are the leading causes of neuronal death and brain lesions formation. The immune reactivity is believed to be essential in the neuronal damage in MS. Cytokines play import...

journal_title：Frontiers in neurology

authors： Goyal M,Khanna D,Rana PS,Khaibullin T,Martynova E,Rizvanov AA,Khaiboullina SF,Baranwal M

更新日期：2019-07-18 00:00:00

abstract：:Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...

journal_title：Frontiers in neurology

authors： Rostami E,Engquist H,Johnson U,Howells T,Ronne-Engström E,Nilsson P,Hillered L,Lewén A,Enblad P

更新日期：2014-06-02 00:00:00

abstract：:Background: The sequence effect (SE), referring to step-to-step reduction in amplitude, is considered to lead to freezing of gait (FOG) in Parkinson's disease (PD). Visual cues may alleviate SE and help reduce freezing episodes. FOG patients show significant SE prior to turning or toward a doorway, but the SE toward a...

journal_title：Frontiers in neurology

authors： Cao SS,Yuan XZ,Wang SH,Taximaimaiti R,Wang XP

更新日期：2020-08-12 00:00:00

abstract：:Introduction: Parkinson's disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that...

journal_title：Frontiers in neurology

authors： Georgiou A,Demetriou CA,Christou YP,Heraclides A,Leonidou E,Loukaides P,Yiasoumi E,Pantziaris M,Kleopa KA,Papacostas SS,Loizidou MA,Hadjisavvas A,Zamba-Papanicolaou E

更新日期：2019-10-17 00:00:00

abstract：:Introduction: It remains unclear if tau imaging may assist diagnosis of chronic traumatic encephalopathy (CTE). Flortaucipir PET has shown superior frontal with medial temporal tau binding consistent with the provisional neuropathological criteria for mid-stage CTE in group-level analyses of retired symptomatic NFL pl...

journal_title：Frontiers in neurology

authors： Krishnadas N,Doré V,Lamb F,Groot C,McCrory P,Guzman R,Mulligan R,Huang K,O'Donnell M,Ponsford J,Hopwood M,Villemagne VL,Rowe CC

更新日期：2020-12-22 00:00:00

abstract：:Chronic subdural hematoma (cSDH) is a common disease process associated with significant morbidity that occurs most often in elderly patients. Asymptomatic patients are typically treated conservatively, with surgical intervention reserved for patients with symptomatic and/or large hematomas that cause brain compressio...

journal_title：Frontiers in neurology

authors： Catapano JS,Nguyen CL,Wakim AA,Albuquerque FC,Ducruet AF

更新日期：2020-10-20 00:00:00

abstract：:Dizziness and imbalance are clinically poorly defined terms, which affect ~30% of people over 65 years of age. In these people, it is often difficult to define the primary cause of dizziness, as it can stem from cardiovascular, vestibular, psychological, and neuromuscular causes. However, identification of the primary...

journal_title：Frontiers in neurology

authors： Chau AT,Menant JC,Hübner PP,Lord SR,Migliaccio AA

更新日期：2015-12-24 00:00:00