Abstract：
OBJECTIVES:To compare the efficacy and safety of adjunct lisuride therapy versus bromocriptine in patients with Parkinson's disease, already established on levodopa and suffering the long-term complications of therapy. SEARCH STRATEGY:Electronic searches of MEDLINE, EMBASE and the Cochrane Controlled Trials Register. Handsearching of the neurology literature as part of the Cochrane Movement Disorders Group's strategy. Examination of the reference lists of identified studies and other reviews. Contact with Cambridge Laboratories, Roche Products Limited and Sandoz Limited. SELECTION CRITERIA:Randomised controlled trials of lisuride versus bromocriptine in patients with a clinical diagnosis of idiopathic Parkinson's disease and long-term complications of levodopa therapy. DATA COLLECTION AND ANALYSIS:Data was abstracted independently by each author and differences settled by discussion. MAIN RESULTS:Only one randomised cross-over trial including 20 patients has compared lisuride with bromocriptine as adjunct therapy in Parkinson's disease. Both lisuride and bromocriptine improved motor fluctuations with no significant differences between the agonists. However, this conclusion is based on an unvalidated 4 point rating scale which could only record positive outcomes. This, combined with the small size of the trial, suggests that firm conclusions on motor fluctuations should not be drawn. Lisuride and bromocriptine produced similar benefits in parkinsonian impairments according to the Columbia Rating Scale. Adverse events were similar with the two agonists and no withdrawals were reported from either drug. REVIEWER'S CONCLUSIONS:The small size of this study and other methodological problems do not allow any firm conclusions to be drawn regarding the efficacy and safety of lisuride compared with bromocriptine in advanced Parkinson's disease with motor complications.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Clarke CE,Speller JMdoi
10.1002/14651858.CD001514keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
CD001514issue
2issn
1469-493Xpii
CD001514pub_type
杂志文章,评审abstract：BACKGROUND:This review is one in a series of reviews of interventions for lateral elbow pain. Lateral elbow pain, or tennis elbow, is a common condition causing pain in the lateral elbow and forearm and lack of strength and function of the elbow and wrist. Surgery is sometimes recommended in treating chronic cases of l...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD003525
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Traumatic hyphema is the entry of blood into the anterior chamber (the space between the cornea and iris) subsequent to a blow or a projectile striking the eye. Hyphema uncommonly causes permanent loss of vision. Associated trauma (e.g., corneal staining, traumatic cataract, angle recession glaucoma, optic a...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005431.pub2
更新日期：2011-01-19 00:00:00
abstract：BACKGROUND:Much of the brain swelling in ischaemic stroke is due to cytotoxic oedema, which is related to cell membrane dysfunction. Early treatment with corticosteroids may help reduce the swelling and improve the outcomes after a stroke. OBJECTIVES:The objective of this review was to assess the effect of corticoster...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000064
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Although pregnancy was once thought of as a time of emotional well-being for many women, conferring 'protection' against psychiatric disorders, a recent meta-analysis of 21 studies suggests the mean prevalence rate for depression across the antenatal period is 10.7%, ranging from 7.4% in the first trimester ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006795.pub2
更新日期：2008-10-08 00:00:00
abstract：BACKGROUND:Radiotherapy as part of head and neck cancer treatment leaves patients requiring much dental rehabilitation in a compromised environment that is difficult for the patient and the dental team to manage. OBJECTIVES:To assess the effects of maintaining the patient's natural dentition during radiotherapy in com...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD008857.pub2
更新日期：2013-02-28 00:00:00
abstract：BACKGROUND:Buerger's disease (thromboangiitis obliterans) is a non-atherosclerotic, segmental inflammatory pathology that most commonly affects the small and medium sized arteries, veins, and nerves in the upper and lower extremities. The aetiology is unknown, but involves hereditary susceptibility, tobacco exposure, i...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析
doi：10.1002/14651858.CD011033.pub4
更新日期：2020-05-04 00:00:00
abstract：BACKGROUND:Anti-cholinergic agents and beta2-agonist drugs are both bronchodilators used to reverse acute bronchospasm in children with asthma. These drugs have different modes of action, so may have complementary or additive effects. OBJECTIVES:The objective of this review was to assess the effects of adding inhaled ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000060
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:The myelodysplastic syndrome (MDS) comprises a diverse group of haematopoietic stem cell disorders. Due to symptomatic anaemia, most people with MDS require supportive therapy including repeated red blood cell (RBC) transfusions. In combination with increased iron absorption, this contributes to the accumula...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD007461.pub3
更新日期：2014-10-28 00:00:00
abstract：BACKGROUND:Self-monitoring of blood glucose is essential to optimise glycaemic control in type 1 diabetes mellitus. Continuous glucose monitoring (CGM) systems measure interstitial fluid glucose levels to provide semi-continuous information about glucose levels, which identifies fluctuations that would not have been id...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD008101.pub2
更新日期：2012-01-18 00:00:00
abstract：BACKGROUND:For early squamous cell carcinoma of the uterine cervix, the outcome is similar after either primary surgery or primary radiotherapy. There are reports that this is not the case for early adenocarcinoma (AC) of the uterine cervix: some studies have reported that the outcome is better after primary surgery. T...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006248.pub2
更新日期：2010-01-20 00:00:00
abstract：BACKGROUND:Peripheral nerve block (infiltration of local anaesthetic around a nerve) is used for anaesthesia or analgesia. A limitation to its use for postoperative analgesia is that the analgesic effect lasts only a few hours, after which moderate to severe pain at the surgical site may result in the need for alternat...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD011770.pub2
更新日期：2017-11-09 00:00:00
abstract：BACKGROUND:The reinforcing properties of nicotine may be mediated through release of various neurotransmitters both centrally and systemically. Smokers report positive effects such as pleasure, arousal, and relaxation as well as relief of negative affect, tension, and anxiety. Opioid (narcotic) antagonists are of parti...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD003086.pub2
更新日期：2006-10-18 00:00:00
abstract：BACKGROUND:Surgery remains a mainstay of treatment for malignant tumours; however, surgical manipulation leads to a significant systemic release of tumour cells. Whether these cells lead to metastases is largely dependent on the balance between aggressiveness of the tumour cells and resilience of the body. Surgical str...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD008877.pub2
更新日期：2014-11-07 00:00:00
abstract：BACKGROUND:Urinary tract infection (UTI) is the most common hospital-acquired infection. The major associated cause is indwelling urethral catheters. Several measures have been introduced to reduce catheter-associated urinary tract infections (CAUTIs). One of these measures is the introduction of specialised urethral c...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004013.pub4
更新日期：2014-09-23 00:00:00
abstract：BACKGROUND:There is increasing focus on providing high quality care for people at the end of life, irrespective of disease or cause, and in all settings. In the last ten years the use of care pathways to aid those treating patients at the end of life has become common worldwide. The use of the Liverpool Care Pathway in...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD011056.pub2
更新日期：2014-05-29 00:00:00
abstract：BACKGROUND:Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane Review p...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD008502.pub5
更新日期：2017-08-20 00:00:00
abstract：BACKGROUND:Amnioinfusion aims to relieve umbilical cord compression during labour by infusing a liquid into the uterine cavity. OBJECTIVES:The objective of this review was to assess the effects of prophylactic amnioinfusion for oligohydramnios compared with therapeutic amnioinfusion only if fetal heart rate decelerati...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000176
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Anthelminthic drugs may shrink brain cysts in neurocysticercosis, but can also cause severe adverse effects. OBJECTIVES:The objective of this review was to assess the effects of drug treatment in human neurocysticercosis in relation to survival, cyst persistence, subsequent seizures and hydrocephalus. SEAR...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000215
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Obesity is increasing throughout the industrialised world. If left unchecked it will have major implications for both population health and costs to health services. OBJECTIVES:To assess whether health professionals' management or the organisation of care for overweight and obese people could be improved. ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000984
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Interstitial lung disease (ILD) is characterised by reduced functional capacity, dyspnoea and exercise-induced hypoxia. Pulmonary rehabilitation, an intervention that includes exercise training, is beneficial for people with other chronic lung conditions; however its effects in ILD have not been well charact...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD006322.pub3
更新日期：2014-10-06 00:00:00
abstract：BACKGROUND:Iodine deficiency is the main cause of potentially preventable mental retardation in childhood, as well as causing goitre and hypothyroidism in people of all ages. It is still prevalent in large parts of the world. OBJECTIVES:To assess the effects of iodine supplementation overall, and of different forms an...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章
doi：10.1002/14651858.CD003819.pub3
更新日期：2018-11-29 00:00:00
abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be affected. These outcomes are a major cause of patient dissatisfaction and may lead to prolonged hospital stay and higher costs of care along with more severe complications. Many antiem...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析
doi：10.1002/14651858.CD012859.pub2
更新日期：2020-10-19 00:00:00
abstract：BACKGROUND:Neck disorders are common, disabling and costly. The effectiveness of exercise as a physiotherapy intervention remains unclear. OBJECTIVES:To improve pain, disability, function, patient satisfaction, quality of life and global perceived effect in adults with neck pain. SEARCH METHODS:Computerized searches ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004250.pub4
更新日期：2012-08-15 00:00:00
abstract：BACKGROUND:There is an increasing global burden of disease from injuries. Models of trauma care initially developed in high-income countries are also being adopted in low and middle-income countries (LMIC). Amongst these ambulance crews with Advanced Life Support (ALS) training are being promoted in LMIC as a strategy ...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD003109
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:A huge clinical research database on adjuvant cancer treatment has verified improvements in breast cancer outcomes such as recurrence and mortality rates. On the other hand, adjuvant therapy with agents such as hormone therapy, chemotherapy and radiotherapy impacts on quality of life due to substantial short...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005001.pub2
更新日期：2006-10-18 00:00:00
abstract：BACKGROUND:A previous meta-analysis investigated the role of chemotherapy in head and neck locally advanced carcinoma. This work had not been performed on nasopharyngeal carcinoma. OBJECTIVES:The aim of the project was to study the effect of adding chemotherapy to radiotherapy on overall survival (OS) and event-free s...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD004329.pub2
更新日期：2006-10-18 00:00:00
abstract：BACKGROUND:Steroidal contraceptive use has been associated with changes in bone mineral density in women. Whether such changes increase the risk of fractures later in life is not clear. However, osteoporosis is a major public health concern. Age-related decline in bone mass increases the risk of fracture, especially of...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD006033.pub2
更新日期：2006-10-18 00:00:00
abstract：BACKGROUND:Myopia (near-sightedness or short-sightedness) is one of the three commonly detected refractive (focusing) errors. Acupuncture is the stimulation of acupuncture points by various methods including needle insertion and acupressure. It is often used by traditional Chinese medicine practitioners to treat myopia...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD007842.pub2
更新日期：2011-09-07 00:00:00
abstract：BACKGROUND:Numerous medications are available for the acute treatment of migraine in adults, and some have now been approved for use in children and adolescents in the ambulatory setting. A systematic review of acute treatment of migraine medication trials in children and adolescents will help clinicians make evidence-...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD005220.pub2
更新日期：2016-04-19 00:00:00
abstract：BACKGROUND:Remote ischaemic conditioning (RIC) has been developed as a neuroprotective strategy to prevent and treat ischaemic stroke. It usually involves restricting blood flow to limbs and then releasing the ischaemic blood to promote a neuroprotective effect. Preclinical studies have suggested that RIC may have bene...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD012503.pub2
更新日期：2018-07-05 00:00:00
