Abstract：
OBJECTIVES:To assess the effectiveness of vaccination against Pseudomonas aeruginosa in patients with cystic fibrosis. SEARCH STRATEGY:The Cochrane Cystic Fibrosis and Genetic Disorders Group specialist trials register which comprises references identified from comprehensive electronic database searches, handsearching relevant journals and handsearching abstract books of conference proceedings. Date of the most recent search of the Group's specialised register: November 1999. SELECTION CRITERIA:All randomised or pseudorandomised trials (published or unpublished) comparing Pseudomonas aeruginosa vaccines (oral, parenteral or intranasal) with control vaccines or no intervention in patients with cystic fibrosis. DATA COLLECTION AND ANALYSIS:We planned to assess the following outcomes: time to infection with Pseudomonas aeruginosa, pulmonary function, body mass index, Schwachman score, frequency of pulmonary infective exacerbations, days of antibiotic usage, days unable to carry out normal daily activities, adverse events, mortality, antibody levels to Pseudomonas aeruginosa and T cell proliferation and cytokine production in response to Pseudomonas aeruginosa. MAIN RESULTS:One trial which included 17 vaccinated patients, with follow up reported to 10 years met the inclusion criteria. Finding only a single trial, and the lack of information on our predefined outcomes limited analysis. REVIEWER'S CONCLUSIONS:There is a paucity of randomised controlled trials assessing the effectiveness of vaccination against Pseudomonas aeruginosa in cystic fibrosis. Increased understanding of modulation of the immune response by vaccination has led to the development of alternative vaccines. We suggest that there is an urgent need for newer vaccines to be evaluated in adequately-powered, multicentre randomised controlled trials examining clinically relevant end-points in addition to immunological variables. Such a trial should assess effectiveness over several years, and include follow-up of vaccinees who become colonised with Pseudomonas aeruginosa.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Keogan MT,Johansen HKdoi
10.1002/14651858.CD001399keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
CD001399issue
2issn
1469-493Xpii
CD001399pub_type
杂志文章,评审abstract：BACKGROUND:Vascular dementia represents the second most common type of dementia. The classification of vascular dementia broadly follows three clinico-pathological processes: multi-infarct dementia, single strategic infarct dementia and subcortical dementia. As not all victims fulfil strict criteria for dementia and ma...
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doi：10.1002/14651858.CD004744.pub2
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journal_title：The Cochrane database of systematic reviews
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doi：10.1002/14651858.CD003819.pub3
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doi：10.1002/14651858.CD008455.pub2
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journal_title：The Cochrane database of systematic reviews
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doi：10.1002/14651858.CD005516.pub2
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doi：10.1002/14651858.CD002798
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更新日期：2011-08-10 00:00:00
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doi：10.1002/14651858.CD008000.pub2
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更新日期：2018-05-30 00:00:00
abstract：BACKGROUND:Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travellers to malaria-endemic areas. Despite its high efficacy, there is controversy about its psychological side effects. OBJECTIVES:To summarize the efficacy and safety of mefloquine used as prophylaxis for malari...
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doi：10.1002/14651858.CD006491.pub4
更新日期：2017-10-30 00:00:00
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pub_type： 杂志文章,meta分析,评审
doi：10.1002/14651858.CD009178.pub2
更新日期：2014-03-21 00:00:00
abstract：BACKGROUND:Cystic Fibrosis is characterised by chest infection, the antibiotic treatment of which has significantly improved the outlook for people with this condition. The unusual nature of organisms that infect the chest of individuals with cystic fibrosis has restricted antibiotic choice. In particular the bacteria,...
journal_title：The Cochrane database of systematic reviews
pub_type： 杂志文章,评审
doi：10.1002/14651858.CD002203
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doi：10.1002/14651858.CD012940.pub2
更新日期：2019-07-08 00:00:00
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doi：10.1002/14651858.CD005437.pub2
更新日期：2008-01-23 00:00:00
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pub_type： 杂志文章,评审
doi：10.1002/14651858.CD000453.pub2
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doi：10.1002/14651858.CD006177.pub3
更新日期：2012-10-17 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) carries a high risk of stroke and other thromboembolic events. Appropriate use of drugs to prevent thromboembolism in patients with AF involves comparing the patient's risk of stroke to the risk of hemorrhage from medication use. OBJECTIVES:To quantify risk of stroke, major hemorrha...
journal_title：The Cochrane database of systematic reviews
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doi：10.1002/14651858.CD001938.pub2
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abstract：BACKGROUND:Adolescents with asthma are at high risk of poor adherence with treatment. This may be compounded by activities that worsen asthma, in particular smoking. Additional support above and beyond routine care has the potential to encourage good self-management. We wanted to find out whether sessions led by their ...
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journal_title：The Cochrane database of systematic reviews
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更新日期：2013-05-31 00:00:00
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更新日期：2012-07-11 00:00:00
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更新日期：2011-02-16 00:00:00
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更新日期：2013-02-28 00:00:00
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journal_title：The Cochrane database of systematic reviews
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更新日期：2002-01-01 00:00:00
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doi：10.1002/14651858.CD003718.pub3
更新日期：2007-07-18 00:00:00
