Abstract：
:1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate smooth muscle contraction, we examined the developmental processes of CCh-induced desensitization to histamine and high K(+) and compared it with that to CCh. 2. Under Ca(2+)-containing physiological conditions, treatment with 10(-4) mol/L CCh for 30 min induced heterologous desensitization to histamine and high K(+). The development of desensitization to histamine was interrupted by a transient resensitization at 1 min in a manner similar to that to CCh. In contrast, CCh-induced desensitization to high K(+) reached a peak at 1 min and was followed by a gradual resensitization up to a partial restoration at 30 min. 3. Under Ca(2+)-free conditions containing 0.2 mmol/L EGTA, treatment with 10(-4) mol/L CCh for 30 min failed to induce heterologous desensitization to either histamine or high K(+), whereas the CCh treatment developed homologous desensitization to CCh in a simple time-dependent manner without a resensitization phase. 4. These results suggest that cellular responsiveness to receptor agonists and non-receptor-mediated depolarizing stimulation is differentially regulated by Ca(2+)-dependent heterologous desensitization in smooth muscle.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Hishinuma S,Matsumoto Y,Sato R,Saito Mdoi
10.1111/j.1440-1681.2007.04530.xsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
15-21issue
1-2eissn
0305-1870issn
1440-1681pii
CEP4530journal_volume
34pub_type
杂志文章abstract：:1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...
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