Antibiotics for treating salmonella gut infections.


BACKGROUND:Antibiotic treatment of salmonella infections aims to shorten illness and prevent serious complications. There are also concerns about increasing antibiotic drug resistance. OBJECTIVES:The objective of this review was to assess the effects of antibiotics in adults and children with diarrhoea who have salmonella. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group trials register, the Cochrane Controlled Trials Register, Medline, Science Citation Index, African Index Medicus, Lilacs, Extra Med and reference lists of relevant articles. We also contacted experts in the field. SELECTION CRITERIA:Randomised and quasi-randomised trials comparing antibiotic therapy with placebo or no antibiotic therapy for salmonella infections in symptomatic or asymptomatic adults or children. Typhoid and paratyphoid salmonella infections were excluded. DATA COLLECTION AND ANALYSIS:Trial quality assessment and data were extracted independently by two reviewers. MAIN RESULTS:Twelve trials involving 778 participants (with at least 258 infants and children) were included. There were no significant differences in length of illness, diarrhoea or fever between any antibiotic regimen and placebo. The weighted mean difference for length of illness was -0.07 days, 95% confidence interval -0.55 to 0.40; diarrhoea -0.03 days, 95% confidence interval -0.53 to 0.48; fever -0.45 days, 95% confidence interval -0. 98 to 0.08. Antibiotic regimens resulted in more negative cultures during the first week of treatment. Relapses were more frequent in those receiving antibiotics, and there were more cases with positive cultures in the antibiotic groups after three weeks. Adverse drug reactions were more common in the antibiotic groups (odds ratio 1.67, 95% confidence interval 1.05 to 2.67). REVIEWER'S CONCLUSIONS:There appears to be no evidence of a clinical benefit of antibiotic therapy in otherwise healthy children and adults with non-severe salmonella diarrhoea. Antibiotics appear to increase adverse effects and they also tend to prolong salmonella detection in stools.


Sirinavin S,Garner P





Has Abstract


2000-01-01 00:00:00










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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Howlett A,Ohlsson A

    更新日期:2000-01-01 00:00:00

  • Cognitive-behavioural training interventions for assisting foster carers in the management of difficult behaviour.

    abstract:BACKGROUND:The provision of training for foster carers is now seen as an important factor contributing to the successful outcome of foster care placements. It is believed to be associated with enhancing caring attitudes and skills, reducing behaviour problems in foster children, improving relationships between foster c...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Turner W,Macdonald GM,Dennis JA

    更新日期:2005-04-18 00:00:00

  • Non-pharmacological interventions for epilepsy in people with intellectual disabilities.

    abstract:BACKGROUND:Approximately 30% of epilepsy patients remain refractory to drug treatment and continue to experience seizures whilst taking one or more antiepileptic drugs. There are a number of non-pharmacological interventions available to refractory patients which may be used in conjunction with or as an alternative to ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Beavis J,Kerr M,Marson AG

    更新日期:2007-10-17 00:00:00

  • Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.

    abstract:BACKGROUND:Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood. Adults in this group have a high rate of other psychiatric problems and functional difficulties in a number of key areas such as academic achievement, interpersonal relationships, and empl...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Epstein T,Patsopoulos NA,Weiser M

    更新日期:2014-09-18 00:00:00

  • Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection.

    abstract:BACKGROUND:Blood loss during liver resection is considered one of the most important factors affecting the peri-operative outcomes of patients undergoing liver resection. OBJECTIVES:To determine the benefits and harms of cardiopulmonary interventions to decrease blood loss and to decrease allogeneic blood transfusion ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Gurusamy KS,Li J,Vaughan J,Sharma D,Davidson BR

    更新日期:2012-05-16 00:00:00

  • Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.

    abstract:BACKGROUND:Elevated plasma levels of the amino acid homocysteine (hyperhomocysteinaemia) are associated with narrowing or blocking of the arteries (atherosclerosis). Treatment to lower homocysteine levels has been shown to be both effective and cheap in healthy volunteers. However, the impact of reducing homocysteine l...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Andras A,Stansby G,Hansrani M

    更新日期:2013-07-19 00:00:00

  • Rapid diagnostic tests for plague.

    abstract:BACKGROUND:Plague is a severe disease associated with high mortality. Late diagnosis leads to advance stage of the disease with worse outcomes and higher risk of spread of the disease. A rapid diagnostic test (RDT) could help in establishing a prompt diagnosis of plague. This would improve patient care and help appropr...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Jullien S,Dissanayake HA,Chaplin M

    更新日期:2020-06-26 00:00:00

  • Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications.

    abstract:BACKGROUND:Sickle cell disease is a group of genetic diseases which is especially prevalent in tropical and subtropical regions; however, forced migration and ongoing population movement have spread it throughout the world, with estimated birth rates reaching 0.49 per 1000 in the Americas, 0.07 per 1000 in Europe, 0.68...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Asnani MR,Quimby KR,Bennett NR,Francis DK

    更新日期:2016-10-06 00:00:00

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    abstract:BACKGROUND:Oral analgesia is a convenient and widely used form of pain relief following caesarean section. It includes various medications used at different doses alone or in adjunction to other form of analgesia. OBJECTIVES:To determine the effectiveness, safety and cost-effectiveness of oral analgesia for post-caesa...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mkontwana N,Novikova N

    更新日期:2015-03-29 00:00:00

  • Glutamine supplementation to prevent morbidity and mortality in preterm infants.

    abstract:BACKGROUND:Glutamine is a conditionally essential amino acid. Endogenous biosynthesis may be insufficient for tissue needs in states of metabolic stress. Evidence exists that glutamine supplementation improves clinical outcomes in critically ill adults. It has been suggested that glutamine supplementation may also bene...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Moe-Byrne T,Brown JV,McGuire W

    更新日期:2016-01-12 00:00:00

  • Gastro-oesophageal reflux treatment for asthma in adults and children.

    abstract:BACKGROUND:Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association bet...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Gibson PG,Henry RL,Coughlan JL

    更新日期:2003-01-01 00:00:00

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    abstract:BACKGROUND:Heel lance has been the conventional method of blood sampling in neonates for screening tests. Neonates undergoing this procedure experience pain. Despite various studies evaluating the role of pharmacological and non-pharmacological interventions to date, there are no effective and practical methods to alle...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Shah V,Ohlsson A

    更新日期:2001-01-01 00:00:00

  • Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular hemorrhage in preterm infants.

    abstract:BACKGROUND:Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular ve...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Romantsik O,Calevo MG,Bruschettini M

    更新日期:2017-07-20 00:00:00

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    abstract:BACKGROUND:Self-management education programmes are complex interventions specifically targeted at patient education and behaviour modification. They are designed to encourage people with chronic disease to take an active self-management role to supplement medical care and improve outcomes. OBJECTIVES:To assess the ef...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Kroon FP,van der Burg LR,Buchbinder R,Osborne RH,Johnston RV,Pitt V

    更新日期:2014-01-15 00:00:00

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    abstract:BACKGROUND:Acute lateral ankle ligament injuries (ankle sprains) are common problems in acute medical care. The treatment variation observed for the acutely injured lateral ankle ligament complex suggests a lack of evidence-based management strategies for this problem. OBJECTIVES:The objective of this review was to as...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Kerkhoffs GM,Rowe BH,Assendelft WJ,Kelly K,Struijs PA,van Dijk CN

    更新日期:2002-01-01 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


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    abstract:BACKGROUND:Comprehensive geriatric assessment (CGA) is a multi-dimensional, multi-disciplinary diagnostic and therapeutic process conducted to determine the medical, mental, and functional problems of older people with frailty so that a co-ordinated and integrated plan for treatment and follow-up can be developed. This...

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    journal_title:The Cochrane database of systematic reviews

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    authors: Stan CM,Boulvain M,Pfister R,Hirsbrunner-Almagbaly P

    更新日期:2013-11-04 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Candy B,Jones L,Vickerstaff V,Tookman A,King M

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    abstract:BACKGROUND:Therapeutic exercise is used as one modality to treat people with osteoarthritis (OA). OBJECTIVES:To evaluate the effectiveness of therapeutic exercise of differing intensities on objective and subjective measures of disease activity in people with OA. SEARCH STRATEGY:We searched MEDLINE, EMBASE, Pedro, Cu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Brosseau L,MacLeay L,Robinson V,Wells G,Tugwell P

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    abstract:BACKGROUND:All major guidelines for antihypertensive therapy recommend weight loss; anti-obesity drugs might be a helpful option. OBJECTIVES: PRIMARY OBJECTIVES:To assess the long-term effects of pharmacologically induced reduction in body weight with orlistat, sibutramine or rimonabant on:- all cause mortality - car...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Siebenhofer A,Horvath K,Jeitler K,Berghold A,Stich AK,Matyas E,Pignitter N,Siering U

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    abstract:BACKGROUND:Carpal tunnel syndrome is a common problem and surgical decompression of the carpal tunnel is the most effective treatment. After surgical decompression, the palmar skin may be closed using either absorbable or non-absorbable sutures. To date, there is conflicting evidence regarding the ideal suture material...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wade RG,Wormald JC,Figus A

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Sankar MJ,Sankar J,Mehta M,Bhat V,Srinivasan R

    更新日期:2016-01-01 00:00:00

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    abstract:BACKGROUND:Delirium is a common clinical syndrome defined as alterations in attention with an additional disturbance in cognition or perception, which develop over a short period of time and tend to fluctuate during the course of the episode. Delirium is commonly treated in hospitals or community settings and is often ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Yu A,Wu S,Zhang Z,Dening T,Zhao S,Pinner G,Xia J,Yang D

    更新日期:2018-06-28 00:00:00

  • Families and Schools Together (FAST) for improving outcomes for children and their families.

    abstract:BACKGROUND:Parents and carers have a major influence on children's learning and development from birth, through the school years, and into adulthood. Parental contributions to education include providing a secure environment in which to learn, providing intellectual stimulation, transmitting social norms and values, sh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Valentine JC,Leach SM,Fowler AP,Stojda DK,Macdonald G

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    abstract:BACKGROUND:In the recent years, a variety of bronchoscopic lung volume reduction (BLVR) procedures have emerged that may provide a treatment option to participants suffering from moderate to severe chronic obstructive pulmonary disease (COPD). OBJECTIVES:To assess the effects of BLVR on the short- and long-term health...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: van Agteren JE,Hnin K,Grosser D,Carson KV,Smith BJ

    更新日期:2017-02-23 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Wadman RI,Bosboom WM,van der Pol WL,van den Berg LH,Wokke JH,Iannaccone ST,Vrancken AF

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Verhagen AP,Bierma-Zeinstra SM,Boers M,Cardoso JR,Lambeck J,de Bie RA,de Vet HC

    更新日期:2007-10-17 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Luttjeboer F,Harada T,Hughes E,Johnson N,Lilford R,Mol BW

    更新日期:2007-07-18 00:00:00

  • Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women.

    abstract:BACKGROUND:About a third of women have urinary incontinence and up to a tenth have faecal incontinence after childbirth. Pelvic floor muscle training is commonly recommended during pregnancy and after birth both for prevention and treatment of incontinence. OBJECTIVES:To determine the effect of pelvic floor muscle tra...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Hay-Smith J,Mørkved S,Fairbrother KA,Herbison GP

    更新日期:2008-10-08 00:00:00