Prophylactic synthetic surfactant for preventing morbidity and mortality in preterm infants.


BACKGROUND:This section is under preparation and will be included in the next issue. OBJECTIVES:To assess the effect of prophylactic administration of synthetic surfactant in preterm newborns at risk for developing respiratory distress syndrome (RDS). SEARCH STRATEGY:Searches were made of the Oxford Database of Perinatal Trials, Medline (MeSH terms: pulmonary surfactant; limits: age groups, newborn infants; publication type, clinical trial), previous reviews including cross-references, abstracts, conference and symposia proceedings, expert informants, and journal hand searching in the English language. SELECTION CRITERIA:Randomized, controlled trials which compared the effect of prophylactic synthetic surfactant administered to high risk preterm newborns at or shortly after birth in order to prevent respiratory distress syndrome and other complications of prematurity. DATA COLLECTION AND ANALYSIS:Data regarding clinical outcomes including the incidence of pneumothorax, pulmonary interstitial emphysema, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage (any grade and severe intraventricular hemorrhage), bronchopulmonary dysplasia, mortality, bronchopulmonary dysplasia or death, retinopathy of prematurity (any retinopathy, and retinopathy stages 3-4) mortality to one year of age, and cerebral palsy was excerpted from the report of the clinical trials by the reviewer. Data were analyzed according to the standards of the Cochrane Neonatal Review Group. MAIN RESULTS:Studies of prophylactic administration of synthetic surfactant note a variable improvement in the respiratory status and a decrease in respiratory distress syndrome in infants who receive prophylactic synthetic surfactant. The meta-analysis supports a decrease in the risk of pneumothorax (typical relative risk 0.67, 95% CI 0.50, 0.90; typical risk difference -0.05, 95% CI -0.09, -0. 02), a decrease in the risk of pulmonary interstitial emphysema (typical relative risk 0.68, 95% CI 0.50, 0.93; typical risk difference -0.06, 95% CI -0.11, -0.01), and a decrease in risk of neonatal mortality (typical relative risk 0.70, 95% CI 0.58, 0.85; typical risk difference -0.07, 95% CI -0.11, -0.03). No differences were seen in the risk of intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, retinopathy of prematurity and cerebral palsy. The meta-analysis supports an increase in the risk of patent ductus arteriosus associated with prophylactic synthetic surfactant administration (typical relative risk 1.11, 95% CI 1.00, 1.22; typical risk difference 0.05, 95% CI 0. 00,0.10), and an increase in the risk of pulmonary hemorrhage (typical relative risk 3.28, 95% CI 1.50, 7.16; typical risk difference 0.03, 95% CI 0.01, 0.05). REVIEWER'S CONCLUSIONS:Prophylactic intratracheal administration of synthetic surfactant to infants judged to be at risk of developing respiratory distress syndrome has been demonstrated to improve clinical outcome. Infants who receive prophylactic synthetic surfactant have a decreased risk of pneumothorax, a decreased risk of pulmonary interstitial emphysema, and a decreased risk of neonatal mortality. Infants who receive prophylactic synthetic surfactant have an increased risk of developing patent ductus arteriosus and pulmonary hemorrhage.


Soll RF





Has Abstract


2000-01-01 00:00:00










  • Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.

    abstract:BACKGROUND:Fear of dental pain is a major barrier to children needing dental care. The use of preoperative analgesics has the potential to reduce postoperative discomfort. In addition it might also reduce intraoperative pain. Reviewing the available evidence will determine whether further research is warranted and will...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ashley PF,Parekh S,Moles DR,Anand P,Behbehani A

    更新日期:2012-09-12 00:00:00

  • Maintenance chemotherapy for ovarian cancer.

    abstract:BACKGROUND:Epithelial ovarian cancer accounts for about 90% of all cases of ovarian cancer. Debulking surgery and six courses of platinum-based chemotherapy results in complete clinical remission (CCR) in up to 75% of cases. However, 75% of the responders will relapse within a median time of 18 to 28 months and only 20...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mei L,Chen H,Wei DM,Fang F,Liu GJ,Xie HY,Wang X,Zou J,Han X,Feng D

    更新日期:2010-09-08 00:00:00

  • Antioxidants for chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a significant risk factor for premature cardiovascular disease and death. Increased oxidative stress in people with CKD has been implicated as a potential causative factor for some cardiovascular diseases. Antioxidant therapy may reduce cardiovascular mortality and morbidity i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Jun M,Venkataraman V,Razavian M,Cooper B,Zoungas S,Ninomiya T,Webster AC,Perkovic V

    更新日期:2012-10-17 00:00:00

  • Glutamine supplementation for young infants with severe gastrointestinal disease.

    abstract:BACKGROUND:Endogenous glutamine biosynthesis may be insufficient to meet the needs of infants with severe gastrointestinal disease. Studies using animal models of gastrointestinal disease and controlled trials in adult patients have suggested that glutamine supplementation improves clinical outcomes. OBJECTIVES:To ass...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Grover Z,Tubman R,McGuire W

    更新日期:2007-01-24 00:00:00

  • Vedolizumab for induction and maintenance of remission in ulcerative colitis.

    abstract:BACKGROUND:Cellular adhesion molecules play an important role in the pathogenesis of ulcerative colitis, making selective blockade of these molecules a promising therapeutic strategy. Vedolizumab, a recombinant humanized IgG1 monoclonal antibody, inhibits adhesion and migration of leukocytes into the gastrointestinal t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Bickston SJ,Behm BW,Tsoulis DJ,Cheng J,MacDonald JK,Khanna R,Feagan BG

    更新日期:2014-08-08 00:00:00

  • Interventions for tubal ectopic pregnancy.

    abstract:BACKGROUND:The diagnosis of ectopic pregnancy can now often be made by non-invasive methods due to sensitive pregnancy tests (in urine and serum) and high resolution transvaginal sonography, which have been integrated in diagnostic algorithms. These algorithms, in combination with the increased awareness and knowledge ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Hajenius PJ,Mol BW,Bossuyt PM,Ankum WM,Van Der Veen F

    更新日期:2000-01-01 00:00:00

  • Methotrexate as a steroid sparing agent for asthma in adults.

    abstract:BACKGROUND:Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chronic oral steroid dependent asthma. OBJECTIVES:The obje...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Davies H,Olson L,Gibson P

    更新日期:2000-01-01 00:00:00

  • Hospital at home: home-based end of life care.

    abstract:BACKGROUND:The policy in a number of countries is to provide people with a terminal illness the choice of dying at home. This policy is supported by surveys indicating that the general public and patients with a terminal illness would prefer to receive end of life care at home. OBJECTIVES:To determine if providing hom...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Shepperd S,Wee B,Straus SE

    更新日期:2011-07-06 00:00:00

  • Antidepressants for smoking cessation.

    abstract:BACKGROUND:There are two reasons to believe antidepressants might help in smoking cessation. First, depression may be a symptom of nicotine withdrawal, and smoking cessation sometimes precipitates depression. Second, smoking appears to be due, in part, to deficits in dopamine, serotonin and norepinephrine, all of which...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Hughes JR,Stead LF,Lancaster T

    更新日期:2000-01-01 00:00:00

  • Interventions for acute auricular haematoma.

    abstract:BACKGROUND:Acute haematoma of the pinna is a condition where a collection of blood forms beneath the perichondrial layer of the pinna. It is usually caused by blunt trauma, and if untreated will ultimately result in a deformity commonly known as 'cauliflower ear' or 'wrestler's ear'. Various treatments are employed to ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Jones SE,Mahendran S

    更新日期:2004-01-01 00:00:00

  • Pulmonary rehabilitation for interstitial lung disease.

    abstract:BACKGROUND:Interstitial lung disease (ILD) is characterised by reduced functional capacity, dyspnoea and exercise-induced hypoxia. Pulmonary rehabilitation, an intervention that includes exercise training, is beneficial for people with other chronic lung conditions; however its effects in ILD have not been well charact...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Dowman L,Hill CJ,Holland AE

    更新日期:2014-10-06 00:00:00

  • Low molecular weight heparins versus unfractionated heparin for acute coronary syndromes.

    abstract:BACKGROUND:Acute coronary syndromes (ACS) are an important source of morbidity and mortality. Despite weak evidence for the use of unfractionated heparin (UFH) for acute coronary syndromes it is considered an accepted treatment for unstable angina and non-ST segment elevation myocardial infarction (MI). However, eviden...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Magee KD,Sevcik W,Moher D,Rowe BH

    更新日期:2003-01-01 00:00:00

  • Baclofen for alcohol withdrawal.

    abstract:BACKGROUND:Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane Review p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Liu J,Wang LN

    更新日期:2017-08-20 00:00:00

  • Propofol for procedural sedation/anaesthesia in neonates.

    abstract:BACKGROUND:Elective medical or surgical procedures are commonplace for neonates admitted to NICU. Agents such as opioids are commonly used for achieving sedation/analgesia/anaesthesia for such procedures; however, these agents are associated with adverse effects. Propofol is used widely in paediatric and adult populati...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Shah PS,Shah VS

    更新日期:2011-03-16 00:00:00

  • Disposable nappies for preventing napkin dermatitis in infants.

    abstract:BACKGROUND:Napkin dermatitis is a common condition that occurs in otherwise healthy infants. It causes discomfort to infants, anxiety to parents and caregivers and contributes to the load on the health care system. A large variety of napkins, both disposable and non-disposable, are available. Evidence is required to as...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Baer EL,Davies MW,Easterbrook KJ

    更新日期:2006-07-19 00:00:00

  • Herbal medicines for viral myocarditis.

    abstract:BACKGROUND:Herbal medicines are being used as a treatment for viral diseases such as viral myocarditis and numerous clinical trials have been conducted to investigate their efficacy. Despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis is yet to be established. This is an ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Liu ZL,Liu ZJ,Liu JP,Kwong JS

    更新日期:2012-11-14 00:00:00

  • WITHDRAWN: Conjugate vaccines for preventing Haemophilus influenzae type B infections.

    abstract:BACKGROUND:Haemophilus influenzae (H. influenzae) is an important cause of meningitis and pneumonia in children. Vaccine cost is a significant barrier to use in low income countries. Determining the size of the effects of the vaccine will enable cost-effectiveness comparisons with competing priorities in low income cou...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Swingler GH,Michaels D,Hussey GG

    更新日期:2009-10-07 00:00:00

  • Trifluoperazine for schizophrenia.

    abstract:BACKGROUND:Trifluoperazine is an inexpensive accessible 'high potency' antipsychotic drug, widely used to treat schizophrenia or related psychoses. OBJECTIVES:To estimate the effects of trifluoperazine compared with placebo and other drugs. SEARCH STRATEGY:Searches of the Cochrane Schizophrenia Group's register of tr...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Marques LO,Lima MS,Soares BG

    更新日期:2004-01-01 00:00:00

  • Pharmacological interventions for non-ulcer dyspepsia.

    abstract:BACKGROUND:The commonest cause of upper gastrointestinal symptoms is non-ulcer dyspepsia (NUD) and yet the pathophysiology of this condition has been poorly characterised and the optimum treatment is uncertain. It is estimated that pound450 million is spent on dyspepsia drugs in the UK each year. OBJECTIVES:This revie...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Soo S,Moayyedi P,Deeks J,Delaney B,Innes M,Forman D

    更新日期:2000-01-01 00:00:00

  • Anti-vascular endothelial growth factor for control of wound healing in glaucoma surgery.

    abstract:BACKGROUND:Trabeculectomy is performed as a treatment for glaucoma to lower intraocular pressure (IOP). The surgical procedure involves creating a channel through the wall of the eye. However scarring during wound healing can block this channel which will lead to the operation failing. Anti-vascular endothelial growth ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Cheng JW,Cheng SW,Wei RL,Lu GC

    更新日期:2016-01-15 00:00:00

  • Continuous glucose monitoring systems for type 1 diabetes mellitus.

    abstract:BACKGROUND:Self-monitoring of blood glucose is essential to optimise glycaemic control in type 1 diabetes mellitus. Continuous glucose monitoring (CGM) systems measure interstitial fluid glucose levels to provide semi-continuous information about glucose levels, which identifies fluctuations that would not have been id...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Langendam M,Luijf YM,Hooft L,Devries JH,Mudde AH,Scholten RJ

    更新日期:2012-01-18 00:00:00

  • Frenotomy for tongue-tie in newborn infants.

    abstract:BACKGROUND:Tongue-tie, or ankyloglossia, is a condition whereby the lingual frenulum attaches near the tip of the tongue and may be short, tight and thick. Tongue-tie is present in 4% to 11% of newborns. Tongue-tie has been cited as a cause of poor breastfeeding and maternal nipple pain. Frenotomy, which is commonly pe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: O'Shea JE,Foster JP,O'Donnell CP,Breathnach D,Jacobs SE,Todd DA,Davis PG

    更新日期:2017-03-11 00:00:00

  • Surgical versus conservative interventions for treating fractures of the middle third of the clavicle.

    abstract:BACKGROUND:Clavicle fractures are common, accounting for 2.6% to 4% of all fractures. Eighty per cent of clavicle fractures are located in the middle third of the clavicle. Although treatment of these fractures is usually non-surgical, displaced clavicle fractures may be considered for surgical treatment because of the...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Lenza M,Buchbinder R,Johnston RV,Belloti JC,Faloppa F

    更新日期:2013-06-06 00:00:00

  • Empiric antibiotic coverage of atypical pathogens for community-acquired pneumonia in hospitalized adults.

    abstract:BACKGROUND:Community-acquired pneumonia (CAP) is caused by various pathogens, traditionally divided into 'typical' and 'atypical'. Initial antibiotic treatment of CAP is usually empirical, customarily covering both typical and atypical pathogens. To date, no sufficient evidence exists to support this broad coverage, wh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Eliakim-Raz N,Robenshtok E,Shefet D,Gafter-Gvili A,Vidal L,Paul M,Leibovici L

    更新日期:2012-09-12 00:00:00

  • Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less.

    abstract:BACKGROUND:Vitamin A deficiency is a significant public health problem in low and middle income countries. Vitamin A supplementation (VAS) provided to lactating postpartum mothers or to infants less than six months of age are two possible strategies to improve the nutrition of infants at high risk of vitamin A deficien...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Gogia S,Sachdev HS

    更新日期:2011-10-05 00:00:00

  • Strategies to improve the implementation of workplace-based policies or practices targeting tobacco, alcohol, diet, physical activity and obesity.

    abstract:BACKGROUND:Given the substantial period of time adults spend in their workplaces each day, these provide an opportune setting for interventions addressing modifiable behavioural risk factors for chronic disease. Previous reviews of trials of workplace-based interventions suggest they can be effective in modifying a ran...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Wolfenden L,Goldman S,Stacey FG,Grady A,Kingsland M,Williams CM,Wiggers J,Milat A,Rissel C,Bauman A,Farrell MM,Légaré F,Ben Charif A,Zomahoun HTV,Hodder RK,Jones J,Booth D,Parmenter B,Regan T,Yoong SL

    更新日期:2018-11-14 00:00:00

  • Chinese herbal medicine for schizophrenia.

    abstract:BACKGROUND:Traditional Chinese medicine (TCM) was the main form of treatment in China for psychiatric illnesses until the development of antipsychotic drugs in the 1950's. Antipsychotic drugs have become the primary intervention for schizophrenia, although herbal medicines can still form part of the treatment. OBJECTI...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rathbone J,Zhang L,Zhang M,Xia J,Liu X,Yang Y

    更新日期:2005-10-19 00:00:00

  • Antioxidant supplementation for lung disease in cystic fibrosis.

    abstract:BACKGROUND:Airway infection leads to progressive damage of the lungs in cystic fibrosis (CF) and oxidative stress has been implicated in the etiology. Supplementation of antioxidant micronutrients (vitamin E, vitamin C, beta-carotene and selenium) or N-acetylcysteine (NAC) as a source of glutathione, may therefore pote...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Ciofu O,Smith S,Lykkesfeldt J

    更新日期:2019-10-03 00:00:00

  • Patellar tendon versus hamstring tendon autograft for anterior cruciate ligament rupture in adults.

    abstract:BACKGROUND:Reconstruction of the anterior cruciate ligament (ACL) commonly involves patellar tendon (PT) or hamstring tendon(s) (HT) autografts. There is no consensus with respect to the choice between these two grafts in ACL surgery. OBJECTIVES:This review compared the outcomes of ACL reconstruction using PT versus H...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mohtadi NG,Chan DS,Dainty KN,Whelan DB

    更新日期:2011-09-07 00:00:00

  • Ibuprofen with or without an antiemetic for acute migraine headaches in adults.

    abstract:BACKGROUND:Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers do not seek professional help, relying instead on over-the-counter analgesics. Co-therapy with an antiemetic should help to reduce symptoms commonly associated with migraine headaches. OBJE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rabbie R,Derry S,Moore RA,McQuay HJ

    更新日期:2010-10-06 00:00:00