Abstract:
:In complex mixture toxicology, there is growing emphasis on testing environmentally representative doses that improve the relevance of results for health risk assessment, but are typically much lower than those used in traditional toxicology studies. Traditional experimental designs with typical sample sizes may have insufficient statistical power to detect effects caused by environmentally relevant doses. Proper study design, with adequate statistical power, is critical to ensuring that experimental results are useful for environmental health risk assessment. Studies with environmentally realistic complex mixtures have practical constraints on sample concentration factor and sample volume as well as the number of animals that can be accommodated. This article describes methodology for calculation of statistical power for non-independent observations for a multigenerational rodent reproductive/developmental bioassay. The use of the methodology is illustrated using the U.S. EPA's Four Lab study in which rodents were exposed to chlorinated water concentrates containing complex mixtures of drinking water disinfection by-products. Possible experimental designs included two single-block designs and a two-block design. Considering the possible study designs and constraints, a design of two blocks of 100 females with a 40:60 ratio of control:treated animals and a significance level of 0.05 yielded maximum prospective power (~90%) to detect pup weight decreases, while providing the most power to detect increased prenatal loss.
journal_name
Int J Environ Res Public Healthauthors
Dingus CA,Teuschler LK,Rice GE,Simmons JE,Narotsky MGdoi
10.3390/ijerph8104082subject
Has Abstractpub_date
2011-10-01 00:00:00pages
4082-101issue
10eissn
1661-7827issn
1660-4601pii
ijerph8104082journal_volume
8pub_type
杂志文章abstract::Dietary supplements cover a wide range of products, the most popular are those containing plant-based ingredients. Supplements are consumed by consumers of all ages as well as by both healthy and sick people. The lack of unified regulation in this sector increases the probability that supplements are poor chemical and...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17186837
更新日期:2020-09-18 00:00:00
abstract::This systematic review aims to assess the characteristics of, and the clinical and economic evidence provided by, economic evaluations of primary preventive physical exercise interventions, and to analyse their transferability to Germany using recommended checklists. Fifteen economic evaluations from seven different c...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph7041622
更新日期:2010-04-01 00:00:00
abstract::This study investigates the positive effects of an appropriability regime and perceived similarity to green co-innovation performance when considering green open innovation activities as the mediator. It proposes a novel construct, i.e., green open innovation activities, and employs structural equation modeling to tes...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17186677
更新日期:2020-09-14 00:00:00
abstract::The long-term effects of secondhand smoke (SHS) on dental caries among Japanese young adults remain unclear. The purpose of this cross-sectional study was to evaluate whether household exposure to SHS is associated with dental caries in permanent dentition among Japanese young adults. The study sample included 1905 fi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17228623
更新日期:2020-11-20 00:00:00
abstract::Exposure to geogenic (earth-derived) particulate matter (PM) is linked to severe bacterial infections in Australian Aboriginal communities. Experimental studies have shown that the concentration of iron in geogenic PM is associated with the magnitude of respiratory health effects, however, the mechanism is unclear. We...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18010146
更新日期:2020-12-28 00:00:00
abstract::The aim of this study was to verify the structural relationship between health perceptions, sports participation, and health promoting behavior in adolescents. A total of 507 adolescents living in Seoul, Republic of Korea, in 2020, participated in this study. This study was conducted using a preliminary survey and a m...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17186744
更新日期:2020-09-16 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a common and fatal cancer. People with HCC report higher odds of comorbidity compared with people without HCC. To explore the association between HCC and medical comorbidity, we used routinely collected clinical data and applied a network perspective. In the network perspective, we us...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17093108
更新日期:2020-04-29 00:00:00
abstract::We argue that a Nash bargaining model with behavioral factors (i.e., fairness concern and risk aversion) should be introduced to the price strategizing process in the context of a closed-loop supply chain. We consider three different pricing models: The first is when both the manufacturer and the retailer have fairnes...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15122870
更新日期:2018-12-14 00:00:00
abstract::Introduction: Alcoholism impairs female sexual functions (decreased sex drive, reduced vaginal fluid, difficulty to experience orgasm). AIM:The aim of this study was to evaluate the course of perimenopausal period and sexual life of female alcoholics. Methods: 97 women at the age of 40⁻60 years were qualified with a ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15081639
更新日期:2018-08-02 00:00:00
abstract::Physician scientists in Japan are often too busy to be sufficiently involved in research work. This cross-sectional study aimed to investigate their experiences negotiating with their superiors to improve their research environment and determine its relationship with psychological burnout. Among 1790 physician awardee...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17145221
更新日期:2020-07-20 00:00:00
abstract::The aim was to analyze the knowledge and experience of women regarding physical activity during their latest pregnancy. An anonymous questionnaire was completed electronically, in 2018, by 9345 women who gave birth at least once, with 52% of the women having performed exercises during pregnancy. Physically non-active ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17051771
更新日期:2020-03-09 00:00:00
abstract:BACKGROUND:Besides genetic factors, the occurrence of diabetes is influenced by lifestyles and environmental factors as well as trace elements in diet materials. Subjects with impaired fasting glucose (IFG) have an increased risk of developing diabetes mellitus (DM). This study aimed to explore risk factors affecting I...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph121012662
更新日期:2015-10-12 00:00:00
abstract::: While many people declare an intention to eat and snack more healthily, a large body of research has found that these intentions often do not translate into actual behavior. This failure to fulfil intentions is regularly attributed to the obesogenic environment, on which basis it is assumed that changing the food en...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17207538
更新日期:2020-10-16 00:00:00
abstract::This study aims to identify the relevant empirical work, to synthesize its findings, and to thus attain a general understanding of the application of the Transtheoretical Model (TTM) in transport behavior research. An integrative literature review was used to determine whether or not the implemented interventions impa...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph14060581
更新日期:2017-05-30 00:00:00
abstract::The bio-engineering technologies of medical devices through nano-structuring and coating was recently proposed to improve biocompatibility and to reduce microbial adhesion in the prevention of implantable device-related infections. Our aim was to evaluate the ability of new nano-structured and coated materials to prev...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17031013
更新日期:2020-02-05 00:00:00
abstract::There has recently been a huge number of publications concerning various aspects of vitamin D, from the physiological to therapeutic fields. However, as a consequence of this very fast-growing scientific area, some issues still remain surrounded by uncertainties, without a final agreement having been reached. Examples...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph16020189
更新日期:2019-01-11 00:00:00
abstract::Obesity is becoming a pandemic and percutaneous electrical stimulation (PENS) of dermatome T6 has been demonstrated to reduce stomach motility and appetite, allowing greater weight loss than isolated hypocaloric diets. However, modulation of intestinal microbiota could improve this effect and control cardiovascular ri...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197239
更新日期:2020-10-03 00:00:00
abstract::Examining health-related quality of life (HRQOL) in a rural setting can be beneficial for improving rural household policies and fostering public health promotion. The objective of this study was to measure the HRQOL and associated socioeconomic characteristics as well as test the reliability of the Amharic version of...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17082709
更新日期:2020-04-15 00:00:00
abstract::Objective The purpose of this study is to identify the high-risk areas of children's lead poisoning in Syracuse, NY, USA, using spatial modeling techniques. The relationships between the number of children's lead poisoning cases and three socio-economic and environmental factors (i.e., building year and town taxable v...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15091792
更新日期:2018-08-21 00:00:00
abstract:BACKGROUND:We used the Taiwan National Health Insurance Research Database (NHIRD) to determine the differences in mortality and medical burden between patients with chronic obstructive pulmonary disease (COPD) with and without stroke. METHODS:We enrolled participants aged ≥20 years and defined four subgroups in this s...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17072550
更新日期:2020-04-08 00:00:00
abstract::Previous research showed a positive relationship between physical activity and self-regulation in older children and adolescents, but few publications focused on young children. Therefore, the purpose of this review was to examine the impact of physical activity (PA) on the cognitive aspects of self-regulation (inhibi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17186576
更新日期:2020-09-09 00:00:00
abstract::The study reports the use of three biomarkers i.e. total arsenic in hair and nails, total arsenic in blood, and total arsenic in urine to identify or quantify arsenic exposure and concomitant health effects. The main source of arsenic was inorganic exposure through drinking water. The arsenic levels and the health eff...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph2007010003
更新日期:2007-03-01 00:00:00
abstract::Maintaining a healthy work-life balance is important for both males and females. Nevertheless, gender segregation still exists in labor markets in South Korea. Therefore, this study aimed to investigate differences in occupational characteristics, job quality indices, and work-life balance between male and female empl...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17134819
更新日期:2020-07-04 00:00:00
abstract::Coronary heart disease is a public health problem and is one of the leading causes of loss of quality of life, disability, and death worldwide. The main procedure these patients undergo is cardiac catheterisation, which helps improve their quality of life, symptoms of myocardial ischemia, and ventricular function, thu...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17228439
更新日期:2020-11-14 00:00:00
abstract::The U.S. has merely 4% of the world population, but contains 25% of the world's COVID-19 cases. Since the COVID-19 outbreak in the U.S., Massachusetts has been leading other states in the total number of COVID-19 cases. Racial residential segregation is a fundamental cause of racial disparities in health. Moreover, di...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17249528
更新日期:2020-12-19 00:00:00
abstract::A traditional structural analysis of scaffolding structures requires loading conditions that are only possible during design, but not in operation. Thus, this study proposes a method that can be used during operation to make an automated safety prediction for scaffolds. It implements a divide-and-conquer technique wit...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17072391
更新日期:2020-04-01 00:00:00
abstract::Regular physical activity leads to physical and mental health benefits. Previous studies have shown physical activity to be associated with body image and gender. The aim of this cross-sectional study was to explore the associations of body image with physical activity of adolescents and whether gender modifies this a...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph111111167
更新日期:2014-10-27 00:00:00
abstract::On-call work is prevalent worldwide and is associated with adverse outcomes, including disrupted sleep, impaired leisure time, and difficulties in mentally detaching from work. Limited studies specifically explored whether men and women experience on-call differently; therefore, our aim was to investigate whether sex ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16030370
更新日期:2019-01-29 00:00:00
abstract::The effects of cold air on cardiovascular and cerebrovascular diseases were investigated in an experimental study examining blood pressure and biochemical indicators. Zhangye, a city in Gansu Province, China, was selected as the experimental site. Health screening and blood tests were conducted, and finally, 30 cardio...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110302472
更新日期:2014-02-27 00:00:00
abstract::Ischemic heart disease (IHD) is among the leading causes of death worldwide. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been associated with IHD risk, but the findings presented with heterogeneity. The purpose of the present meta-analysis was to provide an updated evaluation by integrating machine-...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,meta分析
doi:10.3390/ijerph15071453
更新日期:2018-07-10 00:00:00