Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit.

Abstract:

BACKGROUND:The need for sedation for neonates undergoing uncomfortable procedures in the neonatal intensive care unit (NICU) has often been overlooked. Proper sedation may reduce stress and avoid complications during procedures such as mechanical ventilation. Midazolam is a short acting benzodiazepine that has been increasingly used in the NICU. However, the effectiveness of intravenous midazolam as a sedative in neonates has not been systematically evaluated. OBJECTIVES:To determine whether intravenous midazolam infusion is an effective sedative, as evaluated by behavioural and/or physiologic measurements, for critically ill neonates undergoing intensive care, and to assess clinically significant short and long term adverse effects associated with its use. SEARCH STRATEGY:Literature search according to the Cochrane Neonatal Collaborative Review Group search strategy. Randomized and quasi-randomized controlled trials of intravenous midazolam use in neonates were identified by searching MEDLINE, EMBASE, the Cochrane Controlled Trials Register, reference lists of published studies, personal files, and abstracts published in Pediatric Research from 1990-1999. SELECTION CRITERIA:Randomized controlled trials of intravenous midazolam infusion in infants

authors

Ng E,Taddio A,Ohlsson A

doi

10.1002/14651858.CD002052

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

CD002052

issue

2

issn

1469-493X

pii

CD002052

pub_type

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