Inositol for respiratory distress syndrome in preterm infants.

Abstract:

BACKGROUND:Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life. OBJECTIVES:To assess the effectiveness/safety of supplementary inositol in preterm infants with RDS in reducing adverse neonatal outcomes. SEARCH STRATEGY:Medline, Embase, and Reference Update Databases were searched in August 1997 using key words: inositol and infant-newborn and random allocation or controlled trial or randomized trial (RCT). The reference lists of identified RCTs, personal files and Science Citation Index were searched. Unpublished additional information was obtained from the authors of one RCT published in abstract form. SELECTION CRITERIA:All randomized controlled trials of inositol supplementation to preterm infants with a control group that received a placebo or no intervention were included. Outcomes of interest were bronchopulmonary dysplasia (BPD), death, BPD or death, retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and sepsis. DATA COLLECTION AND ANALYSIS:Data on neonatal outcomes were abstracted independently by the two researchers and any discrepancy was resolved through consensus. Revman was used for analysis of the data. MAIN RESULTS:Four reports of three RCTs were identified. One report was a duplicate publication. The outcome of death or bronchopulmonary dysplasia was reported in two trials, and was found to be significantly reduced (RR 0.56, 95% CI 0.42, 0.77; RD -0.215, 95% CI -0.323, -0.107). The outcome of death was reported in two trials and was found to be significantly reduced (RR 0.48, 95% CI 0.28, 0.80; RD -0.131, 95% CI -0.218, -0.043). Retinopathy of prematurity, stage 4 or needing therapy, was reported in two trials, and was found to be significantly reduced (RR 0.09, 95% CI 0.01, 0.67; RD -0.078, 95% CI -0.128, -0.027). Intraventricular hemorrhage, grade III-IV, was significantly decreased (RR 0.55, 95% CI 0.32, 0.95; RD -0.090, 95% CI -0.170, -0.010). Neither sepsis nor necrotizing enterocolitis outcomes were increased. When a secondary analysis was done excluding a study published in abstract form, the results differed only in that there was a significant reduction in retinopathy of prematurity, any stage (RR 0.53, 95% CI 0.29, 0.97; RD -0.082, 95% CI -0.159,-0.005). REVIEWER'S CONCLUSIONS:Inositol supplementation results in statistically significant and clinically important reductions in important short-term adverse neonatal outcomes. A multi-center RCT of appropriate size is justified to confirm these findings.

authors

Howlett A,Ohlsson A

doi

10.1002/14651858.CD000366

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

CD000366

issue

2

issn

1469-493X

pii

CD000366

pub_type

杂志文章,评审
  • Post-operative radiotherapy for ductal carcinoma in situ of the breast.

    abstract:BACKGROUND:The addition of radiotherapy (RT) following breast conserving surgery (BCS) was first shown to reduce the risk of ipsilateral recurrence in the treatment of invasive breast cancer. Ductal carcinoma in situ (DCIS) is a pre-invasive lesion. Recurrence of ipsilateral disease following BCS can be either DCIS or ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000563.pub5

    authors: Goodwin A,Parker S,Ghersi D,Wilcken N

    更新日期:2009-07-08 00:00:00

  • Hypertonic saline for peri-operative fluid management.

    abstract:BACKGROUND:Fluid excess may place patients undergoing surgery at risk for various complications. Hypertonic saline (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. OBJECTIVES:To determine the benefits and harms of HS versus IS solutions a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005576.pub2

    authors: McAlister V,Burns KE,Znajda T,Church B

    更新日期:2010-01-20 00:00:00

  • Cilostazol for intermittent claudication.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) affects between 4% and 12% of people aged 55 to 70 years, and 20% of people over 70 years. A common complaint is intermittent claudication, characterised by pain in the legs or buttocks that occurs with exercise and which subsides with rest. Compared with age-matched control...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003748.pub4

    authors: Bedenis R,Stewart M,Cleanthis M,Robless P,Mikhailidis DP,Stansby G

    更新日期:2014-10-31 00:00:00

  • Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes.

    abstract:BACKGROUND:In the previous version of this review, the effectiveness of interventions tailored to barriers to change was found to be uncertain. OBJECTIVES:To assess the effectiveness of interventions tailored to address identified barriers to change on professional practice or patient outcomes. SEARCH STRATEGY:For th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005470.pub2

    authors: Baker R,Camosso-Stefinovic J,Gillies C,Shaw EJ,Cheater F,Flottorp S,Robertson N

    更新日期:2010-03-17 00:00:00

  • Culture-specific programs for children and adults from minority groups who have asthma.

    abstract:BACKGROUND:People with asthma who come from minority groups often have poorer asthma outcomes, including more acute asthma-related doctor visits for flare-ups. Various programmes used to educate and empower people with asthma have previously been shown to improve certain asthma outcomes (e.g. adherence outcomes, asthma...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006580.pub5

    authors: McCallum GB,Morris PS,Brown N,Chang AB

    更新日期:2017-08-22 00:00:00

  • Pin site care for preventing infections associated with external bone fixators and pins.

    abstract:BACKGROUND:Metal pins are used to apply skeletal traction or external fixation devices in the management of orthopaedic fractures. These pins protrude through the skin (described as 'percutaneous') and the way in which they are treated after insertion may affect the incidence of pin site infection. This review set out ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004551.pub2

    authors: Lethaby A,Temple J,Santy J

    更新日期:2008-10-08 00:00:00

  • Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke.

    abstract:BACKGROUND:Stroke is one of the leading causes of disability worldwide. Functional impairment, resulting in poor performance in activities of daily living (ADLs) among stroke survivors is common. Current rehabilitation approaches have limited effectiveness in improving ADL performance, function, muscle strength and cog...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009645.pub3

    authors: Elsner B,Kugler J,Pohl M,Mehrholz J

    更新日期:2016-03-21 00:00:00

  • Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma.

    abstract:BACKGROUND:Long-acting inhaled beta2-adrenergic agonists are recommended as 'add-on' medication to inhaled corticosteroids in the maintenance therapy of asthmatic adults and children aged two years and above. OBJECTIVES:To quantify in asthmatic patients the safety and efficacy of the addition of long-acting beta2-agon...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005535

    authors: Ni Chroinin M,Greenstone IR,Danish A,Magdolinos H,Masse V,Zhang X,Ducharme FM

    更新日期:2005-10-19 00:00:00

  • Zinc supplementation for the prevention of type 2 diabetes mellitus.

    abstract:BACKGROUND:The chronic hyperglycaemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The risk of developing type 2 diabetes increases with age, obesity, and lack of physical activity. Insulin resistance is a fu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005525.pub2

    authors: Beletate V,El Dib RP,Atallah AN

    更新日期:2007-01-24 00:00:00

  • Physical activity programs for promoting bone mineralization and growth in preterm infants.

    abstract:BACKGROUND:Lack of physical stimulation may contribute to metabolic bone disease of preterm infants, resulting in poor bone mineralization and growth. Physical activity programs combined with adequate nutrition might help to promote bone mineralization and growth. OBJECTIVES:The primary objective was to assess whether...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005387.pub3

    authors: Schulzke SM,Kaempfen S,Trachsel D,Patole SK

    更新日期:2014-04-22 00:00:00

  • Mobility management to prevent, reduce, or delay driving a car in teenagers.

    abstract:BACKGROUND:Rates of injury and death caused by car crashes with teenage drivers remain high in most high-income countries. In addition to injury and death, car use includes other non-traffic risks; these may be health-related, such as physical inactivity or respiratory disease caused by air pollution, or have global si...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD009438.pub2

    authors: Ward A,Lewis SR,Weiss H

    更新日期:2020-08-16 00:00:00

  • Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia.

    abstract:BACKGROUND:Antipsychotic drugs are the core treatment for schizophrenia. Treatment guidelines state that there is no difference in efficacy between any other antipsychotic compounds, however, low-potency antipsychotic drugs are often perceived as less efficacious than high-potency compounds by clinicians, and they also...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009396.pub2

    authors: Tardy M,Dold M,Engel RR,Leucht S

    更新日期:2014-07-08 00:00:00

  • Psychological interventions for needle-related procedural pain and distress in children and adolescents.

    abstract:BACKGROUND:This is the second update of a Cochrane Review (Issue 4, 2006). Pain and distress from needle-related procedures are common during childhood and can be reduced through use of psychological interventions (cognitive or behavioral strategies, or both). Our first review update (Issue 10, 2013) showed efficacy of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD005179.pub4

    authors: Birnie KA,Noel M,Chambers CT,Uman LS,Parker JA

    更新日期:2018-10-04 00:00:00

  • Culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus.

    abstract:BACKGROUND:Ethnic minority groups in upper-middle-income and high-income countries tend to be socioeconomically disadvantaged and to have a higher prevalence of type 2 diabetes than is seen in the majority population. OBJECTIVES:To assess the effectiveness of culturally appropriate health education for people in ethni...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006424.pub3

    authors: Attridge M,Creamer J,Ramsden M,Cannings-John R,Hawthorne K

    更新日期:2014-09-04 00:00:00

  • Nebulised hypertonic saline solution for acute bronchiolitis in infants.

    abstract:BACKGROUND:Airway oedema and mucus plugging are the predominant pathological features in infants with acute viral bronchiolitis. Nebulised hypertonic saline solution may reduce these pathological changes and decrease airway obstruction. OBJECTIVES:To assess the effects of nebulised hypertonic (≥ 3%) saline solution in...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006458.pub3

    authors: Zhang L,Mendoza-Sassi RA,Wainwright C,Klassen TP

    更新日期:2013-07-31 00:00:00

  • Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia.

    abstract:BACKGROUND:Chronic antipsychotic drug treatment may cause tardive dyskinesia (TD), a long-term movement disorder. The gamma-aminobutyric acid (GABA) agonist drugs have been trialed as a treatment for TD, but these drugs have intense sedative properties and can possibly exacerbate psychotic symptoms. OBJECTIVES:To dete...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000203

    authors: Soares KV,McGrath JJ,Deeks JJ

    更新日期:2000-01-01 00:00:00

  • Exercise for women receiving adjuvant therapy for breast cancer.

    abstract:BACKGROUND:A huge clinical research database on adjuvant cancer treatment has verified improvements in breast cancer outcomes such as recurrence and mortality rates. On the other hand, adjuvant therapy with agents such as hormone therapy, chemotherapy and radiotherapy impacts on quality of life due to substantial short...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005001.pub2

    authors: Markes M,Brockow T,Resch KL

    更新日期:2006-10-18 00:00:00

  • Liposomal bupivacaine peripheral nerve block for the management of postoperative pain.

    abstract:BACKGROUND:Postoperative pain remains a significant issue with poor perioperative pain management associated with an increased risk of morbidity and mortality. Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochloride encapsulated within multiple, non-concentric lipid bi-layers offering a novel meth...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011476.pub2

    authors: Hamilton TW,Athanassoglou V,Trivella M,Strickland LH,Mellon S,Murray D,Pandit HG

    更新日期:2016-08-25 00:00:00

  • Oral calorie supplements for cystic fibrosis.

    abstract:BACKGROUND:Poor nutrition occurs frequently in people with cystic fibrosis (CF) and is associated with other adverse outcomes. Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000406.pub2

    authors: Smyth R,Walters S

    更新日期:2007-01-24 00:00:00

  • Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures.

    abstract:BACKGROUND:Surgical site infection and other hospital-acquired infections cause significant morbidity after internal fixation of fractures. The administration of antibiotics may reduce the frequency of infections. OBJECTIVES:To determine whether the prophylactic administration of antibiotics in people undergoing surgi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000244.pub2

    authors: Gillespie WJ,Walenkamp GH

    更新日期:2010-03-17 00:00:00

  • Optical coherence tomography for diagnosing skin cancer in adults.

    abstract:BACKGROUND:Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC)...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD013189

    authors: Ferrante di Ruffano L,Dinnes J,Deeks JJ,Chuchu N,Bayliss SE,Davenport C,Takwoingi Y,Godfrey K,O'Sullivan C,Matin RN,Tehrani H,Williams HC,Cochrane Skin Cancer Diagnostic Test Accuracy Group.

    更新日期:2018-12-04 00:00:00

  • Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic encephalopathy in adults with cirrhosis.

    abstract:BACKGROUND:Hepatic encephalopathy is a common complication of cirrhosis, with high related morbidity and mortality. Its presence is associated with a wide spectrum of change ranging from clinically obvious neuropsychiatric features, known as 'overt' hepatic encephalopathy, to abnormalities manifest only on psychometric...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD012334.pub2

    authors: Zacharias HD,Zacharias AP,Gluud LL,Morgan MY

    更新日期:2019-06-17 00:00:00

  • Interventions for treating fractures of the patella in adults.

    abstract:BACKGROUND:Fractures of the patella (kneecap) account for around 1% of all human fractures. The treatment of these fractures can be surgical or conservative (such as immobilisation with a cast or brace). There are many different surgical and conservative interventions for treating fractures of the patella in adults. O...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009651.pub2

    authors: Sayum Filho J,Lenza M,Teixeira de Carvalho R,Pires OG,Cohen M,Belloti JC

    更新日期:2015-02-27 00:00:00

  • Aerosolized prostacyclins for acute respiratory distress syndrome (ARDS).

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) is a critical condition that is associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far.This review was originally published in 2010 and updated in 2017. OBJECTIVES:To...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007733.pub3

    authors: Afshari A,Bastholm Bille A,Allingstrup M

    更新日期:2017-07-24 00:00:00

  • Population-based interventions for reducing sexually transmitted infections, including HIV infection.

    abstract:BACKGROUND:Sexually transmitted infections (STI) are common in developing countries. The World Health Organisation (WHO) estimates that in 1995, 333 million new cases of syphilis, gonorrhoea, chlamydial infection and trichomoniasis occurred. Human immunodeficiency virus (HIV) infection is also common in developing coun...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001220

    authors: Wilkinson D,Rutherford G

    更新日期:2001-01-01 00:00:00

  • Open versus closed surgical exposure of canine teeth that are displaced in the roof of the mouth.

    abstract:BACKGROUND:Palatal canines are upper permanent canine (eye) teeth that have become displaced in the roof of the mouth. They are a frequently occurring anomaly, present in 2% to 3% of the population. Management of this problem is both time consuming and expensive and involves surgical exposure (uncovering) followed by f...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006966.pub2

    authors: Parkin N,Benson PE,Thind B,Shah A

    更新日期:2008-10-08 00:00:00

  • Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery.

    abstract:BACKGROUND:Pain following brain surgery can compromise recovery. Several pharmacological interventions have been used to prevent pain after craniotomy; however, there is currently a lack of evidence regarding which interventions are most effective. OBJECTIVES:The objectives are to assess the effectiveness of pharmacol...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD011931.pub2

    authors: Galvin IM,Levy R,Day AG,Gilron I

    更新日期:2019-11-21 00:00:00

  • Pentoxifylline for endometriosis.

    abstract:BACKGROUND:Endometriosis is a chronic, recurring condition that occurs during the reproductive years. It is characterized by endometrial tissue developing outside the uterine cavity. This endometrial tissue development is dependent on oestrogen produced primarily by the ovaries and, therefore, traditional management ha...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007677.pub3

    authors: Lu D,Song H,Li Y,Clarke J,Shi G

    更新日期:2012-01-18 00:00:00

  • WITHDRAWN: Transcutaneous electrical nerve stimulation and acupuncture-like transcutaneous electrical nerve stimulation for chronic low back pain.

    abstract:BACKGROUND:In view of the claims and counter-claims of the effectiveness of transcutaneous electrical nerve stimulation, it would seem appropriate to systematically review the literature. OBJECTIVES:To determine the effectiveness of transcutaneous electrical nerve stimulation in reducing pain and improving range of mo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000210.pub2

    authors: Gadsby JG,Flowerdew MW

    更新日期:2007-07-18 00:00:00

  • Bronchodilators delivered by nebuliser versus pMDI with spacer or DPI for exacerbations of COPD.

    abstract:BACKGROUND:Bronchodilators are a central component for treating exacerbations of chronic obstructive pulmonary disease (COPD) all over the world. Clinicians often use nebulisers as a mode of delivery, especially in the acute setting, and many patients seem to benefit from them. However, evidence supporting this choice ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011826.pub2

    authors: van Geffen WH,Douma WR,Slebos DJ,Kerstjens HA

    更新日期:2016-08-29 00:00:00