Brainstem: neglected locus in neurodegenerative diseases.

abstract：:Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and epilepsy. Comprehending how these interact with each other may help to advance our understanding of the pathophysiology of epilepsy and develop new treatment strategies to improve seizure control by reducing the medication side ...

journal_title：Frontiers in neurology

authors： Jin B,Aung T,Geng Y,Wang S

更新日期：2020-05-08 00:00:00

abstract：:Resting-state imaging designs are powerful in modeling functional networks in movement disorders because they eliminate task performance related confounds. However, the most common metric for quantifying functional connectivity, i.e., bivariate magnitude coherence (Coh), can sometimes be contaminated by spurious corre...

journal_title：Frontiers in neurology

authors： Hinkley LB,Sekihara K,Owen JP,Westlake KP,Byl NN,Nagarajan SS

更新日期：2013-10-10 00:00:00

abstract：:Epilepsy is associated with abnormal spatiotemporal changes in resting-state brain connectivity, but how these changes are characterized in interhemispheric coupling remains unclear. This study aimed to characterize frequency-dependent alterations in voxel-wise mirrored homotopic connectivity (VMHC) measured by restin...

journal_title：Frontiers in neurology

authors： Jiang L,Ma X,Li S,Luo H,Zhang G,Wang Y,Zhang T

更新日期：2020-07-29 00:00:00

abstract：:Background: Prolonged static whole-body roll-tilt has been shown to bias estimates of the direction of gravity when assessed by static paradigms such as the subjective visual vertical and the subjective haptic vertical. Objective: We hypothesized that these shifts are paradigm-independent and thus predicted a post-til...

journal_title：Frontiers in neurology

authors： Wedtgrube A,Bockisch CJ,Straumann D,Tarnutzer AA

更新日期：2020-10-15 00:00:00

abstract：:Parkinson's disease (PD) is not a single entity but rather a heterogeneous neurodegenerative disorder. The present study aims to conduct a critical systematic review of the literature to describe the main pharmacological strategies to treat cognitive dysfunction and major depressive disorder in PD patients. We perform...

journal_title：Frontiers in neurology

authors： Sandoval-Rincón M,Sáenz-Farret M,Miguel-Puga A,Micheli F,Arias-Carrión O

更新日期：2015-03-31 00:00:00

abstract：:Excessive daytime sleepiness (EDS) is a prevalent sleep-related complaint across the general population and has been reported to be associated with headache. Tension-type headache (TTH) is the most commonly encountered headache and accounts for a significant amount of disease burden. However, the association between E...

journal_title：Frontiers in neurology

authors： Kim KM,Kim J,Cho SJ,Kim WJ,Yang KI,Yun CH,Chu MK

更新日期：2019-12-03 00:00:00

abstract：:Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery. Their practical clinical utilization is curtailed by the inability to discriminate them from physiological oscillations due to frequency overlap. Although it ...

journal_title：Frontiers in neurology

authors： Kudlacek J,Chvojka J,Posusta A,Kovacova L,Hong SB,Weiss S,Volna K,Marusic P,Otahal J,Jiruska P

更新日期：2017-12-21 00:00:00

abstract：:We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding...

journal_title：Frontiers in neurology

authors： Leibetseder A,Wagner J,Tomasits J,Haring HP,Hutterer M,Trenkler J,von Oertzen TJ

更新日期：2019-11-26 00:00:00

abstract：:Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, although most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency ...

journal_title：Frontiers in neurology

authors： Marques R,Thole H,Ruiz de Morales JG

更新日期：2020-05-15 00:00:00

abstract：:Background and Purpose: The effect of uric acid (UA) levels on severity and prognosis of spontaneous intracerebral hemorrhage (ICH) remains controversial. We aimed to explore the association of admission UA levels with stroke severity and outcomes in ICH patients. Materials and Methods: The patients enrolled in this s...

journal_title：Frontiers in neurology

authors： Liu X,Cao Z,Gu H,Yang K,Ji R,Li Z,Zhao X,Wang Y

更新日期：2020-12-03 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidence for alterations in insulin signaling and their relation to clinical...

journal_title：Frontiers in neurology

authors： Nieuwenhuis S,Okkersen K,Widomska J,Blom P,'t Hoen PAC,van Engelen B,Glennon JC

更新日期：2019-11-26 00:00:00

abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

journal_title：Frontiers in neurology

authors： Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

更新日期：2013-05-31 00:00:00

abstract：:Background: Headache associated with Moyamoya disease (HAMD) in the Chinese population is not well-described. The long-term outcome of surgical revascularization and natural course of HAMD has not been disclosed either. Methods: A headache screening questionnaire in China based on the ICHD2 and a face-to-face intervie...

journal_title：Frontiers in neurology

authors： Gao B,Kang K,Zhang J,Zhang D,Zhao X

更新日期：2020-11-26 00:00:00

abstract：:Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are neurodegenerative diseases with characteristic inflammatory demyelination in the central nervous system, including the optic nerve. Neuronal and axonal damage is considered to be the main cause of long-term disability in p...

journal_title：Frontiers in neurology

authors： Quinn TA,Dutt M,Shindler KS

更新日期：2011-08-02 00:00:00

abstract：:The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid-vertebrobasilar anastomosis, with an incidence of 0.027-0.26%. PPHAs change the hemodynamics of the carotid and vertebrobasilar system and may be associated with intracranial vascular anomalies, but basilar bifurcation aneu...

journal_title：Frontiers in neurology

authors： Wang M,Gu J,Lan P,Wan S,Zhou Y,Zheng X,Zhan R

更新日期：2017-04-26 00:00:00

abstract：:Stroke is a leading cause of death and disability worldwide. While various risk factors have been identified, sleep has only been considered a risk factor more recently. Various epidemiologic studies have associated stroke with sleep such as sleep duration, and laboratory and clinical studies have proposed various und...

journal_title：Frontiers in neurology

authors： Phua CS,Jayaram L,Wijeratne T

更新日期：2017-08-08 00:00:00

abstract：:Introduction: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma-inactivated 1 autoantibodies. How these deficits influence the return...

journal_title：Frontiers in neurology

authors： Day GS,Babulal GM,Rajasekar G,Stout S,Roe CM

更新日期：2020-07-28 00:00:00

abstract：:Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in t...

journal_title：Frontiers in neurology

authors： Almendros I,Martínez-García MÁ,Campos-Rodríguez F,Riveiro-Falkenbach E,Rodríguez-Peralto JL,Nagore E,Martorell-Calatayud A,Hernández Blasco L,Bañuls Roca J,Chiner Vives E,Sánchez-de-la-Torre A,Abad-Capa J,Montserrat JM,Pérez-Gi

更新日期：2018-04-26 00:00:00

abstract：:Glaucoma is a multifactorial syndrome in which the development of pro-apoptotic signals are the causes for retinal ganglion cell (RGC) loss. Most of the research progress in the glaucoma field have been based on experimentally inducible glaucoma animal models, which provided results about RGC loss after either the cra...

journal_title：Frontiers in neurology

authors： Tirendi S,Saccà SC,Vernazza S,Traverso C,Bassi AM,Izzotti A

更新日期：2020-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of a...

journal_title：Frontiers in neurology

authors： Hanslik KL,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Background: Late latency auditory evoked potentials (LLAEPs) provide objective evidence of an individual's central auditory processing abilities. Electrically evoked cortical auditory evoked potentials (eCAEPs) are a type of LLAEP that provides an objective measure of aided speech perception and auditory processing ab...

journal_title：Frontiers in neurology

authors： Pike M,Biagio-de Jager L,le Roux T,Hofmeyr LM

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Public awareness of and attitude toward disease is an important issue for patients. Public awareness of essential tremor (ET) has never been studied. METHODS:We administered a 10-min, 31-item questionnaire to 250 consecutive enrollees. These included three samples carefully chosen to have a potential range ...

journal_title：Frontiers in neurology

authors： Shalaby S,Indes J,Keung B,Gottschalk CH,Machado D,Patel A,Robakis D,Louis ED

更新日期：2016-04-22 00:00:00

abstract：:Objective: To investigate the diagnostic efficiency of truncal-type occlusion and branching-site occlusion in determining the etiology of intracranial large artery occlusion related acute ischemic stroke (AIS). Methods: Patients with intracranial large artery occlusion related AIS who received stent retriever (SR) thr...

journal_title：Frontiers in neurology

authors： Chuming H,Yifan H,Ke X,Chukai X,Weijie Z,Hui L,Guoyi P,Xiaoyong Z,Peifeng Z,Chuwei C

更新日期：2020-10-22 00:00:00

abstract：:Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature. Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with ...

journal_title：Frontiers in neurology

authors： Murphy OC,Kalaitzidis G,Vasileiou E,Filippatou AG,Lambe J,Ehrhardt H,Pellegrini N,Sotirchos ES,Luciano NJ,Liu Y,Fitzgerald KC,Prince JL,Calabresi PA,Saidha S

更新日期：2020-12-15 00:00:00

abstract：:Objectives: To identify and compare the cerebrospinal fluid (CSF) parameters that predict the presence of neonatal bacterial meningitis using optimal cutoff values, and to derive and compare predictive profiles based on a combination of individual parameters for the same purpose. Study Design: The retrospective compon...

journal_title：Frontiers in neurology

authors： Huang H,Tan J,Gong X,Li J,Wang L,Xu M,Zhang X,Zhang Y,Huang L

更新日期：2019-01-23 00:00:00

abstract：:Several studies have demonstrated the advantages of the bilateral vs. unilateral cochlear implantation in listeners with bilateral severe to profound hearing loss. However, it remains unclear to what extent bilaterally implanted listeners have access to binaural cues, e.g., accurate processing of interaural timing dif...

journal_title：Frontiers in neurology

authors： Ausili SA,Agterberg MJH,Engel A,Voelter C,Thomas JP,Brill S,Snik AFM,Dazert S,Van Opstal AJ,Mylanus EAM

更新日期：2020-09-30 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy has been suggested a treatment option in order to reduce the development of secondary insults succeeding traumatic brain injury. This case report studied the course of a 23-year-old gentleman with a close range transhemispheric gunshot wound. The biochemical parameters, using a multi-mo...

journal_title：Frontiers in neurology

authors： Thelin EP,Bellander BM,Nekludov M

更新日期：2015-03-23 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely characterized by the selective vulnerability of motor neurons and the poor life expectancy of afflicted patients. Limited disease-modifying therapies currently exist, which only further attests to the substantial heterogeneity...

journal_title：Frontiers in neurology

authors： Gaur N,Perner C,Witte OW,Grosskreutz J

更新日期：2020-05-27 00:00:00

abstract：:Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healt...

journal_title：Frontiers in neurology

authors： Sartoretti E,Sartoretti T,Wyss M,Becker AS,Schwenk Á,van Smoorenburg L,Najafi A,Binkert C,Thoeny HC,Zhou J,Jiang S,Graf N,Czell D,Sartoretti-Schefer S,Reischauer C

更新日期：2019-12-10 00:00:00

abstract：:Background: Tract-based spatial statistics (TBSS) is suitable for the assessment of voxel-wise changes in fiber integrity in WM tracts in the entire brain. Longitudinal TBSS analyses of early multiple sclerosis (MS) using 3 Tesla magnetic resonance imaging (MRI) are not common. Objective: To characterize microstructur...

journal_title：Frontiers in neurology

authors： Schneider R,Genç E,Ahlborn C,Gold R,Lukas C,Bellenberg B

更新日期：2019-11-05 00:00:00