Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

Abstract:

BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary necrosis. The aim of this study was to explore the hypothesis that neutrophils, in areas of the lung with extensive cellular infiltration, contribute to clearance by phagocytosing apoptotic cells and/or cell debris derived from secondary necrosis. METHODS:Intranasal lipopolysaccharide administration was used to induce lung inflammation in mice. The animals were sacrificed at seven time points following administration, bronchoalveolar lavage was performed and tissue samples obtained. Electron microscopy and histochemistry was used to assess neutrophil phagocytosis. RESULTS:Electron microscopic studies revealed that phagocytosing neutrophils was common, at 24 h after LPS administration almost 50% of the total number of neutrophils contained phagosomes, and the engulfed material was mainly derived from other neutrophils. Histochemistry on bronchoalvolar lavage cells further showed phagocytosing neutrophils to be frequently occurring. CONCLUSION:Neutrophils are previously known to phagocytose invading pathogens and harmful particles. However, this study demonstrates that neutrophils are also able to engulf apoptotic neutrophils or cell debris resulting from secondary necrosis of neutrophils. Neutrophils may thereby contribute to clearance and resolution of inflammation, thus acting as a back up system in situations when the macrophage clearance system is insufficient and/or overwhelmed.

journal_name

Respir Res

journal_title

Respiratory research

authors

Rydell-Törmänen K,Uller L,Erjefält JS

doi

10.1186/1465-9921-7-143

subject

Has Abstract

pub_date

2006-12-14 00:00:00

pages

143

eissn

1465-9921

issn

1465-993X

pii

1465-9921-7-143

journal_volume

7

pub_type

杂志文章
  • Matrix metalloproteinases in lung biology.

    abstract::Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and r...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/rr33

    authors: Parks WC,Shapiro SD

    更新日期:2001-01-01 00:00:00

  • Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study.

    abstract:BACKGROUND:Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma. METHODS:Allergic rhinitis subjects with no asthma (n = 371) were followed...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-16

    authors: Polosa R,Russo C,Caponnetto P,Bertino G,Sarvà M,Antic T,Mancuso S,Al-Delaimy WK

    更新日期:2011-01-24 00:00:00

  • A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation.

    abstract:BACKGROUND:Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome prolif...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-018-0963-0

    authors: Morichika D,Miyahara N,Fujii U,Taniguchi A,Oda N,Senoo S,Kataoka M,Tanimoto M,Kakuta H,Kiura K,Maeda Y,Kanehiro A

    更新日期:2019-01-03 00:00:00

  • Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis.

    abstract:OBJECTIVE:To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. METHODS:A computer was used to searc...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-020-1309-2

    authors: Ge X,Zhu T,Zhang X,Liu Y,Wang Y,Zhang W

    更新日期:2020-02-06 00:00:00

  • Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

    abstract:BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-019-1163-2

    authors: Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

    更新日期:2019-08-16 00:00:00

  • Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors for the efficacy of the anti...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01582-y

    authors: Ikeda K,Chiba H,Nishikiori H,Azuma A,Kondoh Y,Ogura T,Taguchi Y,Ebina M,Sakaguchi H,Miyazawa S,Suga M,Sugiyama Y,Nukiwa T,Kudoh S,Takahashi H,Pirfenidone Clinical Study Group in Japan.

    更新日期:2020-11-30 00:00:00

  • Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章

    doi:10.1186/1465-9921-6-28

    authors: Saaresranta T,Aittokallio T,Utriainen K,Polo O

    更新日期:2005-04-04 00:00:00

  • Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction.

    abstract:BACKGROUND:Airway smooth muscle contraction is critical for maintenance of appropriate airway tone, and has been implicated in asthma pathogenesis. Smooth muscle contraction requires an "engine" (myosin activation) and a "transmission system" (actin cytoskeletal remodeling). However, the mechanisms that control actin r...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-017-0709-4

    authors: Wang Y,Rezey AC,Wang R,Tang DD

    更新日期:2018-01-05 00:00:00

  • Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells.

    abstract::The molecular mechanisms of Idiopathic Pulmonary Fibrosis (IPF) remain elusive. Transforming Growth Factor beta 1(TGF-beta1) is a key effector cytokine in the development of lung fibrosis. We used microarray and computational biology strategies to identify genes whose expression is significantly altered in alveolar ep...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-7-114

    authors: Keating DT,Sadlier DM,Patricelli A,Smith SM,Walls D,Egan JJ,Doran PP

    更新日期:2006-09-01 00:00:00

  • The natural history of progressive fibrosing interstitial lung diseases.

    abstract::A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinica...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-019-1022-1

    authors: Kolb M,Vašáková M

    更新日期:2019-03-14 00:00:00

  • Role and regulation of MKP-1 in airway inflammation.

    abstract::Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-017-0637-3

    authors: Moosavi SM,Prabhala P,Ammit AJ

    更新日期:2017-08-10 00:00:00

  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.

    abstract:BACKGROUND:Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expr...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-100

    authors: Frazier MD,Mamo LB,Ghio AJ,Turi JL

    更新日期:2011-08-02 00:00:00

  • Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.

    abstract:BACKGROUND:Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each other and how they are ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01495-w

    authors: Zeng H,Li T,He X,Cai S,Luo H,Chen P,Chen Y

    更新日期:2020-09-03 00:00:00

  • CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

    abstract:BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01513-x

    authors: Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

    更新日期:2020-10-13 00:00:00

  • CD8+ T lymphocytes in lung tissue from patients with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Several studies have implicated a role of inflammation in the pathogenesis of lung damage in idiopathic pulmonary fibrosis (IPF). Parenchymal lung damage leads to defects in mechanics and gas exchange and clinically manifests with exertional dyspnea. Investigations of inflammatory cells in IPF have shown tha...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章

    doi:10.1186/1465-9921-6-81

    authors: Daniil Z,Kitsanta P,Kapotsis G,Mathioudaki M,Kollintza A,Karatza M,Milic-Emili J,Roussos C,Papiris SA

    更新日期:2005-07-24 00:00:00

  • Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

    abstract:BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12931-018-0950-5

    authors: Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

    更新日期:2018-12-07 00:00:00

  • CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible chronic inflammatory disease of the lung. The nature of the immune reaction in COPD raises the possibility that IL-17 and related cytokines may contribute to this disorder. This study analyzed the expression of IL-17A and IL-17F a...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-43

    authors: Chang Y,Nadigel J,Boulais N,Bourbeau J,Maltais F,Eidelman DH,Hamid Q

    更新日期:2011-04-10 00:00:00

  • 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.

    abstract:BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-13-63

    authors: Koarai A,Yanagisawa S,Sugiura H,Ichikawa T,Kikuchi T,Furukawa K,Akamatsu K,Hirano T,Nakanishi M,Matsunaga K,Minakata Y,Ichinose M

    更新日期:2012-07-31 00:00:00

  • Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects.

    abstract:BACKGROUND:Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the pr...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-017-0616-8

    authors: Hein M,Lanquart JP,Loas G,Hubain P,Linkowski P

    更新日期:2017-07-06 00:00:00

  • Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids - a Swedish observational cohort study (PACEHR).

    abstract:BACKGROUND:Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish asthma patients. METHODS:Primary care medical records data were linked to data from Swedish nation...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-018-0855-3

    authors: Janson C,Lisspers K,Ställberg B,Johansson G,Telg G,Thuresson M,Nordahl Christensen H,Larsson K

    更新日期:2018-09-03 00:00:00

  • Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations.

    abstract:BACKGROUND:Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflammation and tissue remodeling. However, few studies have explored whether YKL-40 is associated with i...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1051-9

    authors: Liu L,Zhang X,Liu Y,Zhang L,Zheng J,Wang J,Hansbro PM,Wang L,Wang G,Hsu AC

    更新日期:2019-05-22 00:00:00

  • Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.

    abstract:BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章

    doi:10.1186/1465-9921-6-95

    authors: de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

    更新日期:2005-08-16 00:00:00

  • BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials.

    abstract:BACKGROUND:There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protec...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-019-1209-5

    authors: Sun Y,Milne S,Jaw JE,Yang CX,Xu F,Li X,Obeidat M,Sin DD

    更新日期:2019-10-29 00:00:00

  • Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Impaired skeletal muscle regeneration could contribute to the progression of muscle atrophy in patients with chronic obstructive pulmonary disease (COPD). METHODS:Satellite cells and myogenesis-related proteins were compared between healthy subjects and patients with COPD, with or without muscle atrophy. Sa...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-15-35

    authors: Thériault ME,Paré MÈ,Lemire BB,Maltais F,Debigaré R

    更新日期:2014-03-25 00:00:00

  • Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms underlying this defect in phagocytosis are not clearly defined. MATERIALS AND METHO...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-1297-2

    authors: Tanno A,Fujino N,Yamada M,Sugiura H,Hirano T,Tanaka R,Sano H,Suzuki S,Okada Y,Ichinose M

    更新日期:2020-01-28 00:00:00

  • Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensive care units with associated high care costs. There are many potential...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-018-0856-2

    authors: Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS

    更新日期:2018-08-22 00:00:00

  • Chronic exposure of diesel exhaust particles induces alveolar enlargement in mice.

    abstract:BACKGROUND:Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by chronic exposure to air pollution remain to be clar...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-015-0172-z

    authors: Yoshizaki K,Brito JM,Moriya HT,Toledo AC,Ferzilan S,Ligeiro de Oliveira AP,Machado ID,Farsky SH,Silva LF,Martins MA,Saldiva PH,Mauad T,Macchione M

    更新日期:2015-02-07 00:00:00

  • Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

    abstract:BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12931-019-1009-y

    authors: Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

    更新日期:2019-02-22 00:00:00

  • Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients.

    abstract:BACKGROUND:Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced and spontaneous sputum from COPD patients sampled during the same consultation. METHODS:COPD patien...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-017-0645-3

    authors: Tangedal S,Aanerud M,Grønseth R,Drengenes C,Wiker HG,Bakke PS,Eagan TM

    更新日期:2017-08-29 00:00:00

  • The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry.

    abstract:BACKGROUND:Quality of life (QoL) is profoundly impaired in patients with idiopathic pulmonary fibrosis (IPF). However, data is limited regarding the course of QoL. We therefore analysed longitudinal data from the German INSIGHTS-IPF registry. METHODS:Clinical status and QoL were assessed at enrollment and subsequently...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12931-019-1020-3

    authors: Kreuter M,Swigris J,Pittrow D,Geier S,Klotsche J,Prasse A,Wirtz H,Koschel D,Andreas S,Claussen M,Grohé C,Wilkens H,Hagmeyer L,Skowasch D,Meyer JF,Kirschner J,Gläser S,Kahn N,Welte T,Neurohr C,Schwaiblmair M,Held

    更新日期:2019-03-15 00:00:00