Meta-analysis of kindling-induced gene expression changes in the rat hippocampus.

abstract：:The prevalence of depressive disorders is growing worldwide, notably due to stagnation in the development of drugs with greater antidepressant efficacy, the continuous large proportion of patients who do not respond to conventional antidepressants, and the increasing rate of chronic medical conditions associated with ...

journal_title：Frontiers in neuroscience

authors： Vancassel S,Capuron L,Castanon N

更新日期：2018-07-24 00:00:00

abstract：:Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid β and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction. However, AD is also accompanied by various secondary symptoms such as depression, sl...

journal_title：Frontiers in neuroscience

authors： Kim S,Nam Y,Shin SJ,Park YH,Jeon SG,Kim JI,Kim MJ,Moon M

更新日期：2020-09-24 00:00:00

abstract：OBJECTIVES:The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic a...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Glahn DC,Nichols TE,Winkler AM,Hong EL,Holcomb HH,Stein JL,Thompson PM,Curran JE,Carless MA,Olvera RL,Johnson MP,Cole SA,Kochunov V,Kent J,Blangero J

更新日期：2011-10-19 00:00:00

abstract：:Asiatic acid (AA), a pentacyclic triterpene derived from the tropical medicinal plant Centella asiatica, has been widely used as an antioxidant and anti-inflammatory agent. Evidence regarding the neuroprotective properties of AA is emerging. However, the protective effects of AA and its mechanism in glaucoma are poorl...

journal_title：Frontiers in neuroscience

authors： Huang W,Gao F,Hu F,Huang J,Wang M,Xu P,Zhang R,Chen J,Sun X,Zhang S,Wu J

更新日期：2018-07-20 00:00:00

abstract：:Transcutaneous vagus nerve stimulation (tVNS) is widely used for clinical applications, but its mechanism of action is poorly understood. One candidate pathway that might mediate the effects of tVNS is an increase in GABAergic neurotransmission. In this study, we investigated the effect of tVNS on visual bistable perc...

journal_title：Frontiers in neuroscience

authors： Keute M,Boehrer L,Ruhnau P,Heinze HJ,Zaehle T

更新日期：2019-03-08 00:00:00

abstract：:Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes....

journal_title：Frontiers in neuroscience

authors： Lunde CE,Sieberg CB

更新日期：2020-03-26 00:00:00

abstract：:The utility of premovement electroencephalography (EEG) for decoding movement intention during a reaching task has been demonstrated. However, the kind of information the brain represents regarding the intended target during movement preparation remains unknown. In the present study, we investigated which movement par...

journal_title：Frontiers in neuroscience

authors： Kim H,Yoshimura N,Koike Y

更新日期：2019-11-01 00:00:00

abstract：:Recent evidence demonstrates that humans are not the only species to respond negatively to inequitable outcomes which are to their disadvantage. Several species respond negatively if they subsequently receive a less good reward than a social partner for completing the same task. While these studies suggest that the ne...

journal_title：Frontiers in neuroscience

authors： Brosnan SF

更新日期：2011-04-05 00:00:00

abstract：:The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, ...

journal_title：Frontiers in neuroscience

authors： Greco R,Demartini C,Zanaboni AM,Piomelli D,Tassorelli C

更新日期：2018-03-19 00:00:00

abstract：Objective:To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods:We e...

journal_title：Frontiers in neuroscience

authors： Wang X,Guo Y,Zhang Y,Li J,Gao Z,Li Y,Zhou T,Zhang H,He J,Cong F

更新日期：2020-04-28 00:00:00

abstract：:Intracortical electrodes for brain-machine interfaces rely on intimate contact with tissues for recording signals and stimulating neurons. However, the long-term viability of intracortical electrodes in vivo is poor, with a major contributing factor being the development of a glial scar. In vivo approaches for evaluat...

journal_title：Frontiers in neuroscience

authors： Gilmour A,Poole-Warren L,Green RA

更新日期：2019-12-17 00:00:00

abstract：:Traditionally, the visual motion area (MT) is considered as a brain region specialized for visual motion perception. However, accumulating evidence showed that MT is also related to various functions, suggesting that it is a complex functional area and different functional subregions might exist in this area. To delin...

journal_title：Frontiers in neuroscience

authors： Gao J,Zeng M,Dai X,Yang X,Yu H,Chen K,Hu Q,Xu J,Cheng B,Wang J

更新日期：2020-05-27 00:00:00

abstract：:Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

journal_title：Frontiers in neuroscience

authors： Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

更新日期：2020-06-16 00:00:00

abstract：:Neurodegenerative diseases are a challenge for drug discovery, as the biological mechanisms are complex and poorly understood, with a paucity of models that faithfully recapitulate these disorders. Recent advances in stem cell technology have provided a paradigm shift, providing researchers with tools to generate huma...

journal_title：Frontiers in neuroscience

authors： Han C,Chaineau M,Chen CX,Beitel LK,Durcan TM

更新日期：2018-02-06 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00

abstract：Background:The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global measures of neurodegeneration, and cognition. Methods:145 participants underwent ...

journal_title：Frontiers in neuroscience

authors： Low A,Mak E,Stefaniak JD,Malpetti M,Nicastro N,Savulich G,Chouliaras L,Markus HS,Rowe JB,O'Brien JT

更新日期：2020-03-19 00:00:00

abstract：:Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been interpreted as reconsolidation at the synaptic level. The model implement...

journal_title：Frontiers in neuroscience

authors： Kastner DB,Schwalger T,Ziegler L,Gerstner W

更新日期：2016-05-18 00:00:00

abstract：:Interoception has been determined to be an elemental aspect of the neural foundations of physiological homeostasis, subjective experience, and motivated behavior. This paper reviews current neuroscience research regarding interoception and forms of interoceptive dysfunction that may result in psychopathology, focusing...

journal_title：Frontiers in neuroscience

authors： Duquette P

更新日期：2017-03-21 00:00:00

abstract：:Resting-state functional magnetic resonance imaging (rs-fMRI) is a widely used technique for mapping the brain's functional architecture, so delineating the main sources of variance comprising the signal is crucial. Low frequency oscillations (LFO) that are not of neural origin, but which are driven by mechanisms rela...

journal_title：Frontiers in neuroscience

authors： Whittaker JR,Driver ID,Venzi M,Bright MG,Murphy K

更新日期：2019-05-07 00:00:00

abstract：Introduction:Low back pain (LBP) is a complex and growing global health problem in need of more effective pain management strategies. Spinal mobilization (SM) is a non-pharmacological approach recommended by most clinical guidelines for LBP, but greater utilization and treatment optimization are hampered by a lack of m...

journal_title：Frontiers in neuroscience

authors： Reed WR,Little JW,Lima CR,Sorge RE,Yarar-Fisher C,Eraslan M,Hurt CP,Ness TJ,Gu JG,Martins DF,Li P

更新日期：2020-04-30 00:00:00

abstract：:The hypothalamo-pituitary system developed in early vertebrates. Prolactin is an ancient vertebrate hormone released from the pituitary that exerts particularly diverse functions. The purpose of the review is to take a comparative approach in the description of prolactin, its secretion from pituitary lactotrophs, and ...

journal_title：Frontiers in neuroscience

authors： Dobolyi A,Oláh S,Keller D,Kumari R,Fazekas EA,Csikós V,Renner É,Cservenák M

更新日期：2020-06-16 00:00:00

abstract：:Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

journal_title：Frontiers in neuroscience

authors： Villavicencio M,Moreno MG,Simon SA,Gutierrez R

更新日期：2018-05-04 00:00:00

abstract：:EEG-based Brain-Computer Interfaces (BCIs) are becoming a new tool for neurorehabilitation. BCIs are used to help stroke patients to improve the functional capability of the impaired limbs, and to communicate and assess the level of consciousness in Disorder of Consciousness (DoC) patients. BCIs based on a motor image...

journal_title：Frontiers in neuroscience

authors： Dinarès-Ferran J,Ortner R,Guger C,Solé-Casals J

更新日期：2018-05-11 00:00:00

abstract：:The finding that the adult mammalian brain is still capable of producing neurons has ignited a new field of research aiming to identify the molecular mechanisms regulating adult neurogenesis. An improved understanding of these mechanisms could lead to the development of novel approaches to delay cognitive decline and ...

journal_title：Frontiers in neuroscience

authors： Stappert L,Klaus F,Brüstle O

更新日期：2018-11-05 00:00:00

abstract：:Frontotemporal Dementia (FTD) is a focal neurodegenerative disease, with a strong genetic background, that causes early onset dementia. The present knowledge about the risk loci and causative mutations of FTD mainly derives from genetic linkage analysis, studies of candidate genes, Genome-Wide Association Studies (GWA...

journal_title：Frontiers in neuroscience

authors： Ciani M,Benussi L,Bonvicini C,Ghidoni R

更新日期：2019-05-16 00:00:00

abstract：:Recent non-invasive brain stimulation techniques in combination with motor training can enhance neuroplasticity and learning. It is reasonable to assume that such neuroplasticity-based interventions constitute a useful rehabilitative tool for patients with Parkinson's Disease (PD). Regarding motor skill training, many...

journal_title：Frontiers in neuroscience

authors： Horiba M,Ueki Y,Nojima I,Shimizu Y,Sahashi K,Itamoto S,Suzuki A,Yamada G,Matsukawa N,Wada I

更新日期：2019-06-19 00:00:00

abstract：:Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co...

journal_title：Frontiers in neuroscience

authors： Tsetsos F,Padmanabhuni SS,Alexander J,Karagiannidis I,Tsifintaris M,Topaloudi A,Mantzaris D,Georgitsi M,Drineas P,Paschou P

更新日期：2016-07-22 00:00:00

abstract：:The decoding of selective auditory attention from noninvasive electroencephalogram (EEG) data is of interest in brain computer interface and auditory perception research. The current state-of-the-art approaches for decoding the attentional selection of listeners are based on linear mappings between features of sound s...

journal_title：Frontiers in neuroscience

authors： Wong DDE,Fuglsang SA,Hjortkjær J,Ceolini E,Slaney M,de Cheveigné A

更新日期：2018-08-07 00:00:00

abstract：:Transcutaneous Vagus Nerve Stimulation (tVNS) on the auricular branch of the vagus nerve has been receiving attention due to its therapeutic potential for neuropsychiatric disorders. Although the mechanism of tVNS is not yet completely understood, studies have demonstrated the potential role of vagal afferent nerve st...

journal_title：Frontiers in neuroscience

authors： Jin Y,Kong J

更新日期：2017-01-20 00:00:00

abstract：:We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital neuromorphic hardware built with very-low-power ARM processors. The parallel, event-based data processing in SpiNNaker makes it viable for building massively parallel n...

journal_title：Frontiers in neuroscience

authors： Sen-Bhattacharya B,Serrano-Gotarredona T,Balassa L,Bhattacharya A,Stokes AB,Rowley A,Sugiarto I,Furber S

更新日期：2017-08-09 00:00:00