Chronic myelogenous leukemia: treatment and monitoring.

abstract：INTRODUCTION:Autopsy studies of persons who died of cancer have shown the lungs to be the sole site of metastasis in about 20% of cases. The resection of pulmonary metastases is indicated for palliative purposes if they contain a large volume of necrotic tumor, infiltrate the thoracic wall to produce pain, or cause hem...

journal_title：Deutsches Arzteblatt international

authors： Pfannschmidt J,Egerer G,Bischof M,Thomas M,Dienemann H

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Stroke is the third most common cause of death in industrialized countries, accounting for more than 10% of deaths over age 65. Most strokes are due to arteriosclerosis. Regular physical activity lowers arterial blood pressure and body weight and improves glucose and lipid metabolism, thereby slowing the dev...

journal_title：Deutsches Arzteblatt international

authors： Reimers CD,Knapp G,Reimers AK

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Participation rates in colorectal cancer screening in Germany are low. We therefore investigated the effectiveness of different invitation models for immunological stool blood tests (fecal immunological tests, FITs). METHODS:A randomized controlled trial in 50- to 54-year-old clients of the health insurance...

journal_title：Deutsches Arzteblatt international

authors： Gruner LF,Hoffmeister M,Ludwig L,Meny S,Brenner H

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:As life expectancies rise and the number of persons over age 75 in the population increases, the proper treatment of elderly cardiac patients is becoming a matter of ever greater medical and political importance. METHODS:In collaboration with the German Federal Quality Assurance Office (Bundesgeschäftsstell...

journal_title：Deutsches Arzteblatt international

authors： Friedrich I,Simm A,Kötting J,Thölen F,Fischer B,Silber RE

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Because of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In G...

journal_title：Deutsches Arzteblatt international

authors： Tausche AK,Jansen TL,Schröder HE,Bornstein SR,Aringer M,Müller-Ladner U

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Early gastro-esophageal cancer is staged as m1 to m3 depending on the infiltration of the anatomical layers of the mucosa or, analogously, as sm1 to sm3 depending on the depth of infiltration into the submucosa. The risk of lymph node metastases is low in mucosal carcinoma but increases with the depth of inf...

journal_title：Deutsches Arzteblatt international

authors： Gockel I,Hoffmeister A

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Recent years have seen major changes in the diagnosis and treatment of solid intraocular tumors, mainly owing to an improved molecular biological understanding of their pathogenesis, new therapeutic approaches for the local treatment of tumors in children, and long-term follow-up observations in clinical tri...

journal_title：Deutsches Arzteblatt international

authors： Bornfeld N,Biewald E,Bauer S,Temming P,Lohmann D,Zeschnigk M

更新日期：2018-02-16 00:00:00

abstract：BACKGROUND:In endocrine orbitopathy (EO), disfiguring proptosis and diplopia impair patients' quality of life both at home and at work. METHODS:From late 2006 to the beginning of 2008, 250 outpatients in an interdisciplinary thyroid and eye clinic filled out a questionnaire about their quality of life, occupational di...

journal_title：Deutsches Arzteblatt international

authors： Ponto KA,Pitz S,Pfeiffer N,Hommel G,Weber MM,Kahaly GJ

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The diagnosis of soft-tissue sarcomas of the limbs is often delayed, sometimes markedly so, even though prompt and appropriate treatment improves survival and lowers the amputation rate. METHODS:On the basis of a selective literature review and consideration of the relevant guidelines, we developed an algor...

journal_title：Deutsches Arzteblatt international

authors： Bannasch H,Eisenhardt SU,Grosu AL,Heinz J,Momeni A,Stark GB

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The incidence of sudden cardiac death in persons under age 40 is roughly 3 per 100 000 persons per year in Germany and North America. Many of these deaths are found to be due to hereditary heart diseases, often a primary structural heart disease associated with arrhythmia or else a primary arrhythmia syndrom...

journal_title：Deutsches Arzteblatt international

authors： Beckmann BM,Pfeufer A,Kääb S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The treatment of Hodgkin's disease (HD; also called Hodgkin's lymphoma) in children and adolescents with radiotherapy and chemotherapy leads to high survival rates but has a number of late effects. The most serious one is the development of a secondary malignant tumor, usually in the field that was irradiate...

journal_title：Deutsches Arzteblatt international

authors： Schellong G,Riepenhausen M,Ehlert K,Brämswig J,Dörffel W,German Working Group on the Long-Term Sequelae of Hodgkin's Disease.,Schmutzler RK,Rhiem K,Bick U,German Consortium for Hereditary Breast and Ovarian Cancer.

更新日期：2014-01-06 00:00:00

abstract：BACKGROUND:Delirium is a common complication in elderly hospitalized patients. It prolongs the length of hospital stay, raises costs, increases the workload of the nursing staff, and may necessitate transfer of the patient to a nursing home. The risk of postoperative delirium is particularly high in elderly patients wi...

journal_title：Deutsches Arzteblatt international

authors： Kratz T,Heinrich M,Schlauß E,Diefenbacher A

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTI) are among the leading reasons for treatment in adult primary care medicine, accounting for a considerable percentage of antibiotic prescriptions. Because this problem is so common and so significant in routine clinical practice, a high level of diagnostic accuracy is essential....

journal_title：Deutsches Arzteblatt international

authors： Schmiemann G,Kniehl E,Gebhardt K,Matejczyk MM,Hummers-Pradier E

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The conservative treatment of traumatic thoracolumbar vertebral fractures is often not clearly defined. METHODS:This review is based on articles retrieved by a systematic search in the PubMed and Web of Science databases for publications up to February 2018 dealing with the conservative treatment of traumat...

journal_title：Deutsches Arzteblatt international

authors： Spiegl UJ,Fischer K,Schmidt J,Schnoor J,Delank S,Josten C,Schulte T,Heyde CE

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:As of 1 April 2007, pharmacists in Germany filling prescriptions covered by the statutory health insurance system (Gesetzliche Krankenversicherung, GKV) are required, whenever possible, to dispense a preparation that contains the same active substance and for which a rebate contract is in effect. The physici...

journal_title：Deutsches Arzteblatt international

authors： Hoffmann F,Glaeske G,Pfannkuche MS

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:A number of studies have revealed higher postoperative mortality after operations that were performed toward the end of the week. It is not yet known whether a day-of-the-week effect exists after visceral surgical procedures for cancer in Germany. METHODS:Data on resections of carcinomas of the colon, rectu...

journal_title：Deutsches Arzteblatt international

authors： Anger F,Wellner U,Klinger C,Lichthardt S,Haubitz I,Löb S,Keck T,Germer CT,Buhr HJ,Wiegering A

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:When reading reports of medical research findings, one is usually confronted with p-values. Publications typically contain not just one p-value, but an abundance of them, mostly accompanied by the word "significant." This article is intended to help readers understand the problem of multiple p-values and how...

journal_title：Deutsches Arzteblatt international

authors： Victor A,Elsässer A,Hommel G,Blettner M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Recent years have seen a further decline in the nationwide case fatality rate after major trauma in Germany, but it has not been clear until now whether all centers providing trauma care achieve comparable results. We have attempted to answer this question using data from the trauma registry of the German So...

journal_title：Deutsches Arzteblatt international

authors： Hilbert P,Lefering R,Stuttmann R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Pulsatile tinnitus, unlike idiopathic tinnitus, usually has a specific, identifiable cause. Nonetheless, uncertainty often arises in clinical practice about the findings to be sought and the strategy for work-up. METHODS:Selective literature review and evaluation of our own series of patients. RESULTS:Puls...

journal_title：Deutsches Arzteblatt international

authors： Hofmann E,Behr R,Neumann-Haefelin T,Schwager K

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Crohn's disease and ulcerative colitis are chronic inflammatory diseases resulting from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This inappropriate response is promoted by certain environmental factors. Both diseases manife...

journal_title：Deutsches Arzteblatt international

authors： Baumgart DC

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Multi-center observational studies in surgery can yield important findings, as long as they are appropriately designed and monitored and employ modern methods of statistical analysis. METHODS:In a multi-center quality assurance study carried out in 346 German hospitals from 2000 to 2004, data were collected...

journal_title：Deutsches Arzteblatt international

authors： Kube R,Gastinger I,Mroczkowski P,Ptok H,Wolff S,Lippert H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Few reliable data are available on the epidemiology and treatment of spontaneous pneumothorax. We studied the sex and age distribution, frequency of hospitalization, mortality, and conservative versus surgical care of this condition in Germany in order to draw well-founded conclusions about its in-hospital d...

journal_title：Deutsches Arzteblatt international

authors： Schnell J,Koryllos A,Lopez-Pastorini A,Lefering R,Stoelben E

更新日期：2017-11-03 00:00:00

abstract：INTRODUCTION:The purpose of this article is to present the results of microsurgical clipping or endovascular coil obliteration of unruptured intracranial aneurysms (UIA), in a single cerebrovascular center with regard to successful obliteration and periprocedural complications. METHODS:Data concerning patients with UI...

journal_title：Deutsches Arzteblatt international

authors： Seifert V,Gerlach R,Raabe A,Güresir E,Beck J,Szelényi A,Setzer M,Vatter H,Du Mesnil de Rochemont R,Zanella F,Sitzer M,Berkefeld J

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Numerous studies from around the world have shown a positive association between case numbers and the quality of medical care. The evidence to date suggests that conformity to guidelines for the treatment of patients with breast cancer is better in German hospitals that have higher case numbers. METHODS:We ...

journal_title：Deutsches Arzteblatt international

authors： Köster C,Heller G,Wrede S,König T,Handstein S,Szecsenyi J

更新日期：2015-08-31 00:00:00

abstract：BACKGROUND:The past decade has seen much progress in intrauterine surgery. Randomized trials have documented the benefit of some procedures of this type for the unborn child. METHOD:Selective literature review RESULTS:Randomized trials have demonstrated the benefit of fetoscopic laser coagulation of placental anastom...

journal_title：Deutsches Arzteblatt international

authors： Diemert A,Diehl W,Glosemeyer P,Deprest J,Hecher K

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Epilepsy is the third most common disease affecting the brain in the elderly. Current demographic trends will lead to an increased prevalence of epilepsy in the general population. METHOD:A selective literature search revealed 102 relevant publications as of September 2008, 50 of which were original article...

journal_title：Deutsches Arzteblatt international

authors： Werhahn KJ

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Age-related macular degeneration (AMD) is a common retinal disease in older people. In Europe, about 1.6% of persons over age 65 and more than 13% of persons over age 85 have late-stage AMD, which can severely impair vision. The development of AMD is influenced both by environmental factors and by a strong h...

journal_title：Deutsches Arzteblatt international

authors： Weber BH,Charbel Issa P,Pauly D,Herrmann P,Grassmann F,Holz FG

更新日期：2014-02-21 00:00:00

abstract：BACKGROUND:Patients with acquired brain injury who have been discharged from inpatient neurological rehabilitation often continue to suffer from limited independence, participation, and quality of life. Participation-focused outpatient treatment (in German: teilhabeorientierte ambulan. METHODS:In a randomized, control...

journal_title：Deutsches Arzteblatt international

authors： Bender A,Adrion C,Fischer L,Huber M,Jawny K,Straube A,Mansmann U

更新日期：2016-09-23 00:00:00

abstract：BACKGROUND:Basically two types of sweating exist: thermoregulatory and emotional sweating. They are controlled by different centers: thermo regulatory sweating is regulated predominantly by the hypothalamus, emotional sweating predominantly by the limbic system. Enhanced sweating, called hyperhidrosis, can be generaliz...

journal_title：Deutsches Arzteblatt international

authors： Schlereth T,Dieterich M,Birklein F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Dermatologists, paediatricians, and general practitioners are often consulted by worried parents for the evaluation of a cutaneous tumor. METHODS:Selective literature review. RESULTS:Only 1-2% of skin tumors excised in children turn out to be malignant when examined histologically. Warning signs of maligna...

journal_title：Deutsches Arzteblatt international

authors： Hamm H,Höger PH

更新日期：2011-05-01 00:00:00