Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons.

abstract：:Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dep...

journal_title：Frontiers in neural circuits

authors： Hartmann C,Miner DC,Triesch J

更新日期：2016-01-13 00:00:00

abstract：:The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher an...

journal_title：Frontiers in neural circuits

authors： Sasakura H,Tsukada Y,Takagi S,Mori I

更新日期：2013-11-28 00:00:00

abstract：:Caspase-3 is a cysteine protease that is most commonly associated with cell death. Recent studies have shown additional roles in mediating cell differentiation, cell proliferation and development of cell morphology. We investigated the role of caspase-3 in the development of chick auditory brainstem nuclei during embr...

journal_title：Frontiers in neural circuits

authors： Rotschafer SE,Allen-Sharpley MR,Cramer KS

更新日期：2016-10-24 00:00:00

abstract：:The delay eyeblink conditioning (EBC) is a cerebellum-dependent type of associative motor learning. However, the exact roles played by the various cerebellar synapses, as well as the underlying molecular mechanisms, remain to be determined. It is also unclear whether long-term potentiation (LTP) or long-term depressio...

journal_title：Frontiers in neural circuits

authors： Emi K,Kakegawa W,Miura E,Ito-Ishida A,Kohda K,Yuzaki M

更新日期：2013-11-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncir.2018.00028.]. ...

journal_title：Frontiers in neural circuits

authors： Wen TC,Lall S,Pagnotta C,Markward J,Gupta D,Ratnadurai-Giridharan S,Bucci J,Greenwald L,Klugman M,Hill NJ,Carmel JB

更新日期：2018-09-25 00:00:00

abstract：:Recently, by using a combination of two viral vectors, we developed a technique for pathway-selective and reversible synaptic transmission blockade, and successfully induced a behavioral deficit of dexterous hand movements in macaque monkeys by affecting a population of spinal interneurons. To explore the capacity of ...

journal_title：Frontiers in neural circuits

authors： Sooksawate T,Isa K,Matsui R,Kato S,Kinoshita M,Kobayashi K,Watanabe D,Kobayashi K,Isa T

更新日期：2013-10-11 00:00:00

abstract：:Open-source software development has skyrocketed in part due to community tools like github.com, which allows publication of code as well as the ability to create branches and push accepted modifications back to the original repository. As the number and size of EM-based datasets increases, the connectomics community ...

journal_title：Frontiers in neural circuits

authors： Katz WT,Plaza SM

更新日期：2019-02-05 00:00:00

abstract：:How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and tempor...

journal_title：Frontiers in neural circuits

authors： Chen C,Rodriguez FC,Read HL,Escabí MA

更新日期：2012-09-27 00:00:00

abstract：:Since the discovery of grid cells in rat entorhinal cortex, many models of their hexagonally arrayed spatial firing fields have been suggested. We review the models and organize them according to the mechanisms they use to encode position, update the positional code, read it out in the spatial grid pattern, and learn ...

journal_title：Frontiers in neural circuits

authors： Zilli EA

更新日期：2012-04-18 00:00:00

abstract：:A moving visual figure may contain first-order signals defined by variation in mean luminance, as well as second-order signals defined by constant mean luminance and variation in luminance envelope, or higher-order signals that cannot be estimated by taking higher moments of the luminance distribution. Separating thes...

journal_title：Frontiers in neural circuits

authors： Aptekar JW,Keles MF,Mongeau JM,Lu PM,Frye MA,Shoemaker PA

更新日期：2014-10-31 00:00:00

abstract：:[This corrects the article on p. 33 in vol. 8, PMID: 24782714.]. ...

journal_title：Frontiers in neural circuits

authors： Noudoost B,Clark KL

更新日期：2014-12-02 00:00:00

abstract：:"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...

journal_title：Frontiers in neural circuits

authors： Serrano-Velez JL,Rodriguez-Alvarado M,Torres-Vazquez II,Fraser SE,Yasumura T,Vanderpool KG,Rash JE,Rosa-Molinar E

更新日期：2014-06-26 00:00:00

abstract：:MRI has been extensively used in neurodegenerative disorders, such as Alzheimer's disease (AD), frontal-temporal dementia (FTD), mild cognitive impairment (MCI), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). MRI is important for monitoring the neurodegenerative components...

journal_title：Frontiers in neural circuits

authors： Saar G,Koretsky AP

更新日期：2019-01-07 00:00:00

abstract：:Acetylcholine and the activation of muscarinic receptors influence the activity of neural networks generating locomotor behavior in the mammalian spinal cord. Using electrical stimulations of the ventral commissure, we show that commissural muscarinic (CM) depolarizations could be induced in lumbar motoneurons. We pro...

journal_title：Frontiers in neural circuits

authors： Bertrand SS,Cazalets JR

更新日期：2011-11-04 00:00:00

abstract：:Spike-timing dependent plasticity (STDP) is a biologically constrained unsupervised form of learning that potentiates or depresses synaptic connections based on the precise timing of pre-synaptic and post-synaptic firings. The effects of on-going STDP on the topology of evolving model neural networks were assessed in ...

journal_title：Frontiers in neural circuits

authors： Stone DB,Tesche CD

更新日期：2013-04-18 00:00:00

abstract：:We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised...

journal_title：Frontiers in neural circuits

authors： Elliott KL,Kersigo J,Pan N,Jahan I,Fritzsch B

更新日期：2017-04-13 00:00:00

abstract：:The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still ...

journal_title：Frontiers in neural circuits

authors： Zhang Z,Zhang H,Wen P,Zhu X,Wang L,Liu Q,Wang J,He X,Wang H,Xu F

更新日期：2017-07-28 00:00:00

abstract：:The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...

journal_title：Frontiers in neural circuits

authors： Smith JB,Watson GD,Alloway KD,Schwarz C,Chakrabarti S

更新日期：2015-09-30 00:00:00

abstract：:Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...

journal_title：Frontiers in neural circuits

authors： Leung LC,Wang GX,Mourrain P

更新日期：2013-04-24 00:00:00

abstract：:The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subty...

journal_title：Frontiers in neural circuits

authors： Kubota Y,Karube F,Nomura M,Kawaguchi Y

更新日期：2016-04-25 00:00:00

abstract：:Multiple components of "γ-oscillations" between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations. However, it remains unclear whether the different sub-bands are generate...

journal_title：Frontiers in neural circuits

authors： Balakrishnan S,Pearce RA

更新日期：2015-01-12 00:00:00

abstract：:Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays ...

journal_title：Frontiers in neural circuits

authors： Williams AJ,Zhou C,Sun QQ

更新日期：2016-11-10 00:00:00

abstract：:Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult bra...

journal_title：Frontiers in neural circuits

authors： McVea DA,Murphy TH,Mohajerani MH

更新日期：2016-12-21 00:00:00

abstract：:Optogenetic stimulation of the mouse cortex can be used to generate motor maps that are similar to maps derived from electrode-based stimulation. Here we present a refined set of procedures for repeated light-based motor mapping in ChR2-expressing mice implanted with a bilateral thinned-skull chronic window and a chro...

journal_title：Frontiers in neural circuits

authors： Silasi G,Boyd JD,Ledue J,Murphy TH

更新日期：2013-07-25 00:00:00

abstract：:Mitral and tufted cells (MTCs) of the mammalian olfactory bulb are connected via dendrodendritic synapses with inhibitory interneurons in the external plexiform layer. The range, spatial layout, and temporal properties of inhibitory interactions between MTCs mediated by inhibitory interneurons remain unclear. Therefor...

journal_title：Frontiers in neural circuits

authors： Lehmann A,D'Errico A,Vogel M,Spors H

更新日期：2016-03-22 00:00:00

abstract：:The trace amines (TAs), tryptamine, tyramine, and β-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC). We explored their role in the neuromodulation of neonatal rat spinal cord motor circuits. We first showed that the spinal cord contains the substrates for TA ...

journal_title：Frontiers in neural circuits

authors： Gozal EA,O'Neill BE,Sawchuk MA,Zhu H,Halder M,Chou CC,Hochman S

更新日期：2014-11-07 00:00:00

abstract：:In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiologic...

journal_title：Frontiers in neural circuits

authors： Connelly WM,Laing M,Errington AC,Crunelli V

更新日期：2016-01-14 00:00:00

abstract：:Many studies have demonstrated that vestibular sensory input is important for spatial learning and memory. However, it has been unclear what contributions the different parts of the vestibular system - the semi-circular canals and otoliths - make to these processes. The advent of mutant otolith-deficient mice has made...

journal_title：Frontiers in neural circuits

authors： Smith PF

更新日期：2019-10-18 00:00:00

abstract：:Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In "driver" thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC ...

journal_title：Frontiers in neural circuits

authors： Ferrati G,Martini FJ,Maravall M

更新日期：2016-02-23 00:00:00

abstract：:In this study, we explore the functional role of striatal cholinergic interneurons, hereinafter referred to as tonically active neurons (TANs), via computational modeling; specifically, we investigate the mechanistic relationship between TAN activity and dopamine variations and how changes in this relationship affect ...

journal_title：Frontiers in neural circuits

authors： Kim T,Capps RA,Hamade KC,Barnett WH,Todorov DI,Latash EM,Markin SN,Rybak IA,Molkov YI

更新日期：2019-02-21 00:00:00